{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:12:57Z","timestamp":1761059577116},"reference-count":65,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Biomed Sci"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>The NKG2D receptor confers important activating signals to NK cells via ligands expressed during cellular stress and viral infection. This receptor has generated great interest because not only is it expressed on NK cells, but it is also seen in virtually all CD8<jats:sup>+<\/jats:sup> cytotoxic T cells and is classically considered absent in CD4<jats:sup>+<\/jats:sup> T cells. However, recent studies have identified a distinctive population of CD4<jats:sup>+<\/jats:sup> T cells that do express NKG2D, which could represent a particular cytotoxic effector population involved in viral infections and chronic diseases. On the other hand, increased incidence of human papillomavirus-associated lesions in CD4<jats:sup>+<\/jats:sup> T cell-immunocompromised individuals suggests that CD4<jats:sup>+<\/jats:sup> T cells play a key role in controlling the viral infection. Therefore, this study was focused on identifying the frequency of NKG2D-expressing CD4<jats:sup>+<\/jats:sup> T cells in patients with cervical intraepithelial neoplasia (CIN) 1. Additionally, factors influencing CD4<jats:sup>+<\/jats:sup>NKG2D<jats:sup>+<\/jats:sup> T cell expansion were also measured.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Close to 50% of patients with CIN 1 contained at least one of the 37 HPV types detected by our genotyping system. A tendency for increased CD4<jats:sup>+<\/jats:sup> T cells and CD8<jats:sup>+<\/jats:sup> T cells and decreased NK cells was found in CIN 1 patients. The percentage of circulating CD4<jats:sup>+<\/jats:sup> T cells co-expressing the NKG2D receptor significantly increased in women with CIN 1 <jats:italic>versus<\/jats:italic> control group. Interestingly, the increase of CD4<jats:sup>+<\/jats:sup>NKG2D<jats:sup>+<\/jats:sup> T cells was seen in patients with CIN 1, despite the overall levels of CD4<jats:sup>+<\/jats:sup> T cells did not significantly increase. We also found a significant increase of soluble MICB in CIN 1 patients; however, no correlation with the presence of CD4<jats:sup>+<\/jats:sup>NKG2D<jats:sup>+<\/jats:sup> T cells was seen. While TGF-beta was significantly decreased in the group of CIN 1 patients, both TNF-alpha and IL-15 showed a tendency to increase in this group.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Taken together, our results suggest that the significant increase within the CD4<jats:sup>+<\/jats:sup>NKG2D<jats:sup>+<\/jats:sup> T cell population in CIN 1 patients might be the result of a chronic exposure to viral and\/or pro-inflammatory factors, and concomitantly might also influence the clearance of CIN 1-type lesion.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1423-0127-20-60","type":"journal-article","created":{"date-parts":[[2013,8,16]],"date-time":"2013-08-16T08:14:15Z","timestamp":1376640855000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Substantial increase in the frequency of circulating CD4+NKG2D+ T cells in patients with cervical intraepithelial neoplasia grade 1"],"prefix":"10.1186","volume":"20","author":[{"given":"Mariel","family":"Garcia-Chagollan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis F","family":"Jave-Suarez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesse","family":"Haramati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro E","family":"Sanchez-Hernandez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Aguilar-Lemarroy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam R","family":"Bueno-Topete","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana L","family":"Pereira-Suarez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Fafutis-Morris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angel","family":"Cid-Arregui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana","family":"del Toro-Arreola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,8,16]]},"reference":[{"issue":"Suppl 2","key":"507_CR1","doi-asserted-by":"publisher","first-page":"SII23","DOI":"10.1016\/S0140-6736(97)90017-9","volume":"349","author":"P Boyle","year":"1997","unstructured":"Boyle P: Global burden of cancer. Lancet. 1997, 349 (Suppl 2): SII23-SII26.","journal-title":"Lancet"},{"issue":"2","key":"507_CR2","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.bpobgyn.2005.10.007","volume":"20","author":"R Sankaranarayanan","year":"2006","unstructured":"Sankaranarayanan R, Ferlay J: Worldwide burden of gynaecological cancer: the size of the problem. Best Pract Res Clin Obstet Gynaecol. 2006, 20 (2): 207-225. 10.1016\/j.bpobgyn.2005.10.007.","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"issue":"4","key":"507_CR3","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1136\/jcp.55.4.244","volume":"55","author":"FX Bosch","year":"2002","unstructured":"Bosch FX, Lorincz A, Munoz N, Meijer CJ, Shah KV: The causal relation between human papillomavirus and cervical cancer. J Clin Pathol. 2002, 55 (4): 244-265. 10.1136\/jcp.55.4.244.","journal-title":"J Clin Pathol"},{"issue":"1","key":"507_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1128\/CMR.16.1.1-17.2003","volume":"16","author":"EM Burd","year":"2003","unstructured":"Burd EM: Human papillomavirus and cervical cancer. Clin Microbiol Rev. 2003, 16 (1): 1-17. 10.1128\/CMR.16.1.1-17.2003.","journal-title":"Clin Microbiol Rev"},{"issue":"1","key":"507_CR5","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1038\/sj.bjc.6600688","volume":"88","author":"GM Clifford","year":"2003","unstructured":"Clifford GM, Smith JS, Plummer M, Munoz N, Franceschi S: Human papillomavirus types in invasive cervical cancer worldwide: a meta-analysis. Br J Cancer. 2003, 88 (1): 63-73. 10.1038\/sj.bjc.6600688.","journal-title":"Br J Cancer"},{"issue":"1\u20132","key":"507_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S1386-6532(00)00125-6","volume":"19","author":"N Munoz","year":"2000","unstructured":"Munoz N: Human papillomavirus and cancer: the epidemiological evidence. J Clin Virol. 2000, 19 (1\u20132): 1-5.","journal-title":"J Clin Virol"},{"issue":"2","key":"507_CR7","first-page":"F55","volume":"1288","author":"H zur Hausen","year":"1996","unstructured":"zur Hausen H: Papillomavirus infections--a major cause of human cancers. Biochim Biophys Acta. 1996, 1288 (2): F55-F78.","journal-title":"Biochim Biophys Acta"},{"issue":"Suppl 1","key":"507_CR8","doi-asserted-by":"publisher","first-page":"s5","DOI":"10.1097\/01.gco.0000216315.72572.fb","volume":"18","author":"JT Cox","year":"2006","unstructured":"Cox JT: The development of cervical cancer and its precursors: what is the role of human papillomavirus infection?. Curr Opin Obstet Gynecol. 2006, 18 (Suppl 1): s5-s13. 10.1097\/01.gco.0000216315.72572.fb.","journal-title":"Curr Opin Obstet Gynecol"},{"issue":"3","key":"507_CR9","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1002\/ijc.11222","volume":"106","author":"V Dalstein","year":"2003","unstructured":"Dalstein V, Riethmuller D, Pretet JL, Le Bail CK, Sautiere JL, Carbillet JP, Kantelip B, Schaal JP, Mougin C: Persistence and load of high-risk HPV are predictors for development of high-grade cervical lesions: a longitudinal French cohort study. Int J Cancer. 2003, 106 (3): 396-403. 10.1002\/ijc.11222.","journal-title":"Int J Cancer"},{"issue":"2","key":"507_CR10","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1002\/path.1866","volume":"208","author":"PJ Snijders","year":"2006","unstructured":"Snijders PJ, Steenbergen RD, Heideman DA, Meijer CJ: HPV-mediated cervical carcinogenesis: concepts and clinical implications. J Pathol. 2006, 208 (2): 152-164. 10.1002\/path.1866.","journal-title":"J Pathol"},{"issue":"3B","key":"507_CR11","first-page":"1763","volume":"28","author":"N Bansal","year":"2008","unstructured":"Bansal N, Wright JD, Cohen CJ, Herzog TJ: Natural history of established low grade cervical intraepithelial (CIN 1) lesions. Anticancer Res. 2008, 28 (3B): 1763-1766.","journal-title":"Anticancer Res"},{"issue":"3","key":"507_CR12","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1093\/jnci\/91.3.252","volume":"91","author":"P Holowaty","year":"1999","unstructured":"Holowaty P, Miller AB, Rohan T, To T: Natural history of dysplasia of the uterine cervix. J Natl Cancer Inst. 1999, 91 (3): 252-258. 10.1093\/jnci\/91.3.252.","journal-title":"J Natl Cancer Inst"},{"issue":"6","key":"507_CR13","first-page":"485","volume":"12","author":"H Richardson","year":"2003","unstructured":"Richardson H, Kelsall G, Tellier P, Voyer H, Abrahamowicz M, Ferenczy A, Coutlee F, Franco EL: The natural history of type-specific human papillomavirus infections in female university students. Cancer Epidemiol Biomarkers Prev. 2003, 12 (6): 485-490.","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"17","key":"507_CR14","doi-asserted-by":"publisher","first-page":"1336","DOI":"10.1093\/jnci\/djg037","volume":"95","author":"NF Schlecht","year":"2003","unstructured":"Schlecht NF, Platt RW, Duarte-Franco E, Costa MC, Sobrinho JP, Prado JC, Ferenczy A, Rohan TE, Villa LL, Franco EL: Human papillomavirus infection and time to progression and regression of cervical intraepithelial neoplasia. J Natl Cancer Inst. 2003, 95 (17): 1336-1343. 10.1093\/jnci\/djg037.","journal-title":"J Natl Cancer Inst"},{"issue":"4","key":"507_CR15","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1158\/1055-9965.EPI-10-1108","volume":"20","author":"RL Winer","year":"2011","unstructured":"Winer RL, Hughes JP, Feng Q, Xi LF, Cherne S, O\u2019Reilly S, Kiviat NB, Koutsky LA: Early natural history of incident, type-specific human papillomavirus infections in newly sexually active young women. Cancer Epidemiol Biomarkers Prev. 2011, 20 (4): 699-707. 10.1158\/1055-9965.EPI-10-1108.","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"2","key":"507_CR16","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1002\/1097-0339(200102)24:2<117::AID-DC1021>3.0.CO;2-P","volume":"24","author":"EE Calore","year":"2001","unstructured":"Calore EE, Pereira SM, Cavaliere MJ: Progression of cervical lesions in HIV-seropositive women: a cytological study. Diagn Cytopathol. 2001, 24 (2): 117-119. 10.1002\/1097-0339(200102)24:2<117::AID-DC1021>3.0.CO;2-P.","journal-title":"Diagn Cytopathol"},{"key":"507_CR17","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/1471-2334-11-8","volume":"11","author":"A Chalermchockcharoenkit","year":"2011","unstructured":"Chalermchockcharoenkit A, Chayachinda C, Thamkhantho M, Komoltri C: Prevalence and cumulative incidence of abnormal cervical cytology among HIV-infected Thai women: a 5.5-year retrospective cohort study. BMC Infect Dis. 2011, 11: 8-10.1186\/1471-2334-11-8.","journal-title":"BMC Infect Dis"},{"issue":"5","key":"507_CR18","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1097\/00001622-200309000-00007","volume":"15","author":"JM Palefsky","year":"2003","unstructured":"Palefsky JM: Cervical human papillomavirus infection and cervical intraepithelial neoplasia in women positive for human immunodeficiency virus in the era of highly active antiretroviral therapy. Curr Opin Oncol. 2003, 15 (5): 382-388. 10.1097\/00001622-200309000-00007.","journal-title":"Curr Opin Oncol"},{"issue":"10","key":"507_CR19","doi-asserted-by":"publisher","first-page":"e47755","DOI":"10.1371\/journal.pone.0047755","volume":"7","author":"V Stuardo","year":"2012","unstructured":"Stuardo V, Agusti C, Godinez JM, Montoliu A, Torne A, Tarrats A, Alcalde C, Martin D, Fernandez-Montoli E, Vanrell C: Human papillomavirus infection in HIV-1 infected women in Catalonia (Spain): implications for prevention of cervical cancer. PLoS One. 2012, 7 (10): e47755-10.1371\/journal.pone.0047755.","journal-title":"PLoS One"},{"issue":"5","key":"507_CR20","first-page":"483","volume":"11","author":"AS Kadish","year":"2002","unstructured":"Kadish AS, Timmins P, Wang Y, Ho GY, Burk RD, Ketz J, He W, Romney SL, Johnson A, Angeletti R: Regression of cervical intraepithelial neoplasia and loss of human papillomavirus (HPV) infection is associated with cell-mediated immune responses to an HPV type 16 E7 peptide. Cancer Epidemiol Biomarkers Prev. 2002, 11 (5): 483-488.","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"1","key":"507_CR21","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1158\/1078-0432.CCR-07-1881","volume":"14","author":"GG Kenter","year":"2008","unstructured":"Kenter GG, Welters MJ, Valentijn AR, Lowik MJ, der Meer DM B-v, Vloon AP, Drijfhout JW, Wafelman AR, Oostendorp J, Fleuren GJ: Phase I immunotherapeutic trial with long peptides spanning the E6 and E7 sequences of high-risk human papillomavirus 16 in end-stage cervical cancer patients shows low toxicity and robust immunogenicity. Clin Cancer Res. 2008, 14 (1): 169-177. 10.1158\/1078-0432.CCR-07-1881.","journal-title":"Clin Cancer Res"},{"issue":"2","key":"507_CR22","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1038\/sj.bjc.6602679","volume":"93","author":"JC Steele","year":"2005","unstructured":"Steele JC, Mann CH, Rookes S, Rollason T, Murphy D, Freeth MG, Gallimore PH, Roberts S: T-cell responses to human papillomavirus type 16 among women with different grades of cervical neoplasia. Br J Cancer. 2005, 93 (2): 248-259. 10.1038\/sj.bjc.6602679.","journal-title":"Br J Cancer"},{"issue":"155","key":"507_CR23","doi-asserted-by":"publisher","first-page":"155ra138","DOI":"10.1126\/scitranslmed.3004414","volume":"4","author":"ML Bagarazzi","year":"2012","unstructured":"Bagarazzi ML, Yan J, Morrow MP, Shen X, Parker RL, Lee JC, Giffear M, Pankhong P, Khan AS, Broderick KE: Immunotherapy against HPV16\/18 generates potent TH1 and cytotoxic cellular immune responses. Sci Transl Med. 2012, 4 (155): 155ra138-10.1126\/scitranslmed.3004414.","journal-title":"Sci Transl Med"},{"issue":"4","key":"507_CR24","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1111\/j.1365-2567.2008.02912.x","volume":"126","author":"FG Delgado","year":"2009","unstructured":"Delgado FG, Martinez E, Cespedes MA, Bravo MM, Navas MC, Combita Rojas AL: Increase of human papillomavirus-16 E7-specific T helper type 1 response in peripheral blood of cervical cancer patients after radiotherapy. Immunology. 2009, 126 (4): 523-534. 10.1111\/j.1365-2567.2008.02912.x.","journal-title":"Immunology"},{"issue":"10","key":"507_CR25","doi-asserted-by":"publisher","first-page":"7176","DOI":"10.4049\/jimmunol.179.10.7176","volume":"179","author":"S Seresini","year":"2007","unstructured":"Seresini S, Origoni M, Lillo F, Caputo L, Paganoni AM, Vantini S, Longhi R, Taccagni G, Ferrari A, Doglioni C: IFN-gamma produced by human papilloma virus-18 E6-specific CD4+ T cells predicts the clinical outcome after surgery in patients with high-grade cervical lesions. J Immunol. 2007, 179 (10): 7176-7183.","journal-title":"J Immunol"},{"issue":"1","key":"507_CR26","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1158\/1078-0432.CCR-07-1880","volume":"14","author":"MJ Welters","year":"2008","unstructured":"Welters MJ, Kenter GG, Piersma SJ, Vloon AP, Lowik MJ, der Meer DM B-v, Drijfhout JW, Valentijn AR, Wafelman AR, Oostendorp J: Induction of tumor-specific CD4+ and CD8+ T-cell immunity in cervical cancer patients by a human papillomavirus type 16 E6 and E7 long peptides vaccine. Clin Cancer Res. 2008, 14 (1): 178-187. 10.1158\/1078-0432.CCR-07-1880.","journal-title":"Clin Cancer Res"},{"issue":"10","key":"507_CR27","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1136\/jcp.2004.025072","volume":"58","author":"AG Bais","year":"2005","unstructured":"Bais AG, Beckmann I, Lindemans J, Ewing PC, Meijer CJ, Snijders PJ, Helmerhorst TJ: A shift to a peripheral Th2-type cytokine pattern during the carcinogenesis of cervical cancer becomes manifest in CIN III lesions. J Clin Pathol. 2005, 58 (10): 1096-1100. 10.1136\/jcp.2004.025072.","journal-title":"J Clin Pathol"},{"issue":"2","key":"507_CR28","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1084\/jem.149.2.485","volume":"149","author":"C Feighery","year":"1979","unstructured":"Feighery C, Stastny P: HLA-D region-associated determinants serve as targets for human cell-mediated lysis. J Exp Med. 1979, 149 (2): 485-494. 10.1084\/jem.149.2.485.","journal-title":"J Exp Med"},{"issue":"7","key":"507_CR29","doi-asserted-by":"publisher","first-page":"2365","DOI":"10.1073\/pnas.79.7.2365","volume":"79","author":"AM Krensky","year":"1982","unstructured":"Krensky AM, Reiss CS, Mier JW, Strominger JL, Burakoff SJ: Long-term human cytolytic T-cell lines allospecific for HLA-DR6 antigen are OKT4+. Proc Natl Acad Sci U S A. 1982, 79 (7): 2365-2369. 10.1073\/pnas.79.7.2365.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"14","key":"507_CR30","doi-asserted-by":"publisher","first-page":"4395","DOI":"10.1073\/pnas.79.14.4395","volume":"79","author":"SC Meuer","year":"1982","unstructured":"Meuer SC, Schlossman SF, Reinherz EL: Clonal analysis of human cytotoxic T lymphocytes: T4+ and T8+ effector T cells recognize products of different major histocompatibility complex regions. Proc Natl Acad Sci U S A. 1982, 79 (14): 4395-4399. 10.1073\/pnas.79.14.4395.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"507_CR31","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1007\/s12026-007-0060-9","volume":"40","author":"SJ Burgess","year":"2008","unstructured":"Burgess SJ, Maasho K, Masilamani M, Narayanan S, Borrego F, Coligan JE: The NKG2D receptor: immunobiology and clinical implications. Immunol Res. 2008, 40 (1): 18-34. 10.1007\/s12026-007-0060-9.","journal-title":"Immunol Res"},{"issue":"5428","key":"507_CR32","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1126\/science.285.5428.727","volume":"285","author":"S Bauer","year":"1999","unstructured":"Bauer S, Groh V, Wu J, Steinle A, Phillips JH, Lanier LL, Spies T: Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. Science. 1999, 285 (5428): 727-729. 10.1126\/science.285.5428.727.","journal-title":"Science"},{"issue":"4","key":"507_CR33","doi-asserted-by":"publisher","first-page":"2144","DOI":"10.4049\/jimmunol.175.4.2144","volume":"175","author":"B Rincon-Orozco","year":"2005","unstructured":"Rincon-Orozco B, Kunzmann V, Wrobel P, Kabelitz D, Steinle A, Herrmann T: Activation of V gamma 9V delta 2 T cells by NKG2D. J Immunol. 2005, 175 (4): 2144-2151.","journal-title":"J Immunol"},{"issue":"21","key":"507_CR34","doi-asserted-by":"publisher","first-page":"7641","DOI":"10.1073\/pnas.0502439102","volume":"102","author":"D Garrity","year":"2005","unstructured":"Garrity D, Call ME, Feng J, Wucherpfennig KW: The activating NKG2D receptor assembles in the membrane with two signaling dimers into a hexameric structure. Proc Natl Acad Sci U S A. 2005, 102 (21): 7641-7646. 10.1073\/pnas.0502439102.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"507_CR35","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/87757","volume":"2","author":"P Li","year":"2001","unstructured":"Li P, Morris DL, Willcox BE, Steinle A, Spies T, Strong RK: Complex structure of the activating immunoreceptor NKG2D and its MHC class I-like ligand MICA. Nat Immunol. 2001, 2 (5): 443-451.","journal-title":"Nat Immunol"},{"issue":"6","key":"507_CR36","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1038\/ni929","volume":"4","author":"DD Billadeau","year":"2003","unstructured":"Billadeau DD, Upshaw JL, Schoon RA, Dick CJ, Leibson PJ: NKG2D-DAP10 triggers human NK cell-mediated killing via a Syk-independent regulatory pathway. Nat Immunol. 2003, 4 (6): 557-564. 10.1038\/ni929.","journal-title":"Nat Immunol"},{"issue":"5","key":"507_CR37","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1038\/ni1325","volume":"7","author":"JL Upshaw","year":"2006","unstructured":"Upshaw JL, Arneson LN, Schoon RA, Dick CJ, Billadeau DD, Leibson PJ: NKG2D-mediated signaling requires a DAP10-bound Grb2-Vav1 intermediate and phosphatidylinositol-3-kinase in human natural killer cells. Nat Immunol. 2006, 7 (5): 524-532. 10.1038\/ni1325.","journal-title":"Nat Immunol"},{"issue":"3","key":"507_CR38","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1038\/85321","volume":"2","author":"V Groh","year":"2001","unstructured":"Groh V, Rhinehart R, Randolph-Habecker J, Topp MS, Riddell SR, Spies T: Costimulation of CD8alphabeta T cells by NKG2D via engagement by MIC induced on virus-infected cells. Nat Immunol. 2001, 2 (3): 255-260. 10.1038\/85321.","journal-title":"Nat Immunol"},{"issue":"11","key":"507_CR39","doi-asserted-by":"publisher","first-page":"6933","DOI":"10.4049\/jimmunol.0803840","volume":"182","author":"CM Segovis","year":"2009","unstructured":"Segovis CM, Schoon RA, Dick CJ, Nacusi LP, Leibson PJ, Billadeau DD: PI3K links NKG2D signaling to a CrkL pathway involved in natural killer cell adhesion, polarity, and granule secretion. J Immunol. 2009, 182 (11): 6933-6942. 10.4049\/jimmunol.0803840.","journal-title":"J Immunol"},{"issue":"16","key":"507_CR40","doi-asserted-by":"publisher","first-page":"9452","DOI":"10.1073\/pnas.1632807100","volume":"100","author":"V Groh","year":"2003","unstructured":"Groh V, Bruhl A, El-Gabalawy H, Nelson JL, Spies T: Stimulation of T cell autoreactivity by anomalous expression of NKG2D and its MIC ligands in rheumatoid arthritis. Proc Natl Acad Sci U S A. 2003, 100 (16): 9452-9457. 10.1073\/pnas.1632807100.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"507_CR41","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1002\/eji.200939399","volume":"40","author":"AE Fasth","year":"2010","unstructured":"Fasth AE, Bjorkstrom NK, Anthoni M, Malmberg KJ, Malmstrom V: Activating NK-cell receptors co-stimulate CD4(+)CD28(\u2212) T cells in patients with rheumatoid arthritis. Eur J Immunol. 2010, 40 (2): 378-387. 10.1002\/eji.200939399.","journal-title":"Eur J Immunol"},{"issue":"4","key":"507_CR42","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1007\/s00251-006-0082-9","volume":"58","author":"N Azimi","year":"2006","unstructured":"Azimi N, Jacobson S, Tanaka Y, Corey L, Groh V, Spies T: Immunostimulation by induced expression of NKG2D and its MIC ligands in HTLV-1-associated neurologic disease. Immunogenetics. 2006, 58 (4): 252-258. 10.1007\/s00251-006-0082-9.","journal-title":"Immunogenetics"},{"issue":"12","key":"507_CR43","doi-asserted-by":"publisher","first-page":"3198","DOI":"10.1002\/eji.200636682","volume":"36","author":"A Saez-Borderias","year":"2006","unstructured":"Saez-Borderias A, Guma M, Angulo A, Bellosillo B, Pende D, Lopez-Botet M: Expression and function of NKG2D in CD4+ T cells specific for human cytomegalovirus. Eur J Immunol. 2006, 36 (12): 3198-3206. 10.1002\/eji.200636682.","journal-title":"Eur J Immunol"},{"issue":"4","key":"507_CR44","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1084\/jem.20081648","volume":"206","author":"Z Dai","year":"2009","unstructured":"Dai Z, Turtle CJ, Booth GC, Riddell SR, Gooley TA, Stevens AM, Spies T, Groh V: Normally occurring NKG2D\u2009+\u2009CD4+ T cells are immunosuppressive and inversely correlated with disease activity in juvenile-onset lupus. J Exp Med. 2009, 206 (4): 793-805. 10.1084\/jem.20081648.","journal-title":"J Exp Med"},{"issue":"7","key":"507_CR45","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1038\/ni1350","volume":"7","author":"V Groh","year":"2006","unstructured":"Groh V, Smythe K, Dai Z, Spies T: Fas-ligand-mediated paracrine T cell regulation by the receptor NKG2D in tumor immunity. Nat Immunol. 2006, 7 (7): 755-762. 10.1038\/ni1350.","journal-title":"Nat Immunol"},{"issue":"5","key":"507_CR46","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1158\/1055-9965.EPI-04-0812","volume":"14","author":"GM Clifford","year":"2005","unstructured":"Clifford GM, Rana RK, Franceschi S, Smith JS, Gough G, Pimenta JM: Human papillomavirus genotype distribution in low-grade cervical lesions: comparison by geographic region and with cervical cancer. Cancer Epidemiol Biomarkers Prev. 2005, 14 (5): 1157-1164. 10.1158\/1055-9965.EPI-04-0812.","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"2","key":"507_CR47","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.ygyno.2008.04.012","volume":"110","author":"JL Pretet","year":"2008","unstructured":"Pretet JL, Jacquard AC, Saunier M, Clavel C, Dachez R, Gondry J, Pradat P, Soubeyrand B, Leocmach Y, Mougin C: Human papillomavirus genotype distribution in low-grade squamous intraepithelial lesions in France and comparison with CIN2\/3 and invasive cervical cancer: the EDiTH III study. Gynecol Oncol. 2008, 110 (2): 179-184. 10.1016\/j.ygyno.2008.04.012.","journal-title":"Gynecol Oncol"},{"issue":"3","key":"507_CR48","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1067\/mob.2003.164","volume":"188","author":"C Mao","year":"2003","unstructured":"Mao C, Hughes JP, Kiviat N, Kuypers J, Lee SK, Adam DE, Koutsky LA: Clinical findings among young women with genital human papillomavirus infection. Am J Obstet Gynecol. 2003, 188 (3): 677-684. 10.1067\/mob.2003.164.","journal-title":"Am J Obstet Gynecol"},{"key":"507_CR49","doi-asserted-by":"crossref","unstructured":"Ault KA: Epidemiology and natural history of human papillomavirus infections in the female genital tract. Infect Dis Obstet Gynecol. 2006 (Article ID 40470): 1-5. 10.1155\/IDOG\/2006\/40470.","DOI":"10.1155\/IDOG\/2006\/40470"},{"issue":"7","key":"507_CR50","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1097\/00000478-199207000-00002","volume":"16","author":"C Bergeron","year":"1992","unstructured":"Bergeron C, Barrasso R, Beaudenon S, Flamant P, Croissant O, Orth G: Human papillomaviruses associated with cervical intraepithelial neoplasia. Great diversity and distinct distribution in low- and high-grade lesions. Am J Surg Pathol. 1992, 16 (7): 641-649. 10.1097\/00000478-199207000-00002.","journal-title":"Am J Surg Pathol"},{"issue":"4","key":"507_CR51","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1086\/341782","volume":"186","author":"AR Giuliano","year":"2002","unstructured":"Giuliano AR, Harris R, Sedjo RL, Baldwin S, Roe D, Papenfuss MR, Abrahamsen M, Inserra P, Olvera S, Hatch K: Incidence, prevalence, and clearance of type-specific human papillomavirus infections: the young Women\u2019s health study. J Infect Dis. 2002, 186 (4): 462-469. 10.1086\/341782.","journal-title":"J Infect Dis"},{"issue":"4","key":"507_CR52","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1111\/j.1365-2567.2006.02465.x","volume":"119","author":"JA Passmore","year":"2006","unstructured":"Passmore JA, Milner M, Denny L, Sampson C, Marais DJ, Allan B, Gumbi PP, Hitzeroth II, Rybicki EP, Williamson AL: Comparison of cervical and blood T-cell responses to human papillomavirus-16 in women with human papillomavirus-associated cervical intraepithelial neoplasia. Immunology. 2006, 119 (4): 507-514. 10.1111\/j.1365-2567.2006.02465.x.","journal-title":"Immunology"},{"issue":"Pt 3","key":"507_CR53","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1099\/vir.0.82678-0","volume":"88","author":"S Dillon","year":"2007","unstructured":"Dillon S, Sasagawa T, Crawford A, Prestidge J, Inder MK, Jerram J, Mercer AA, Hibma M: Resolution of cervical dysplasia is associated with T-cell proliferative responses to human papillomavirus type 16 E2. J Gen Virol. 2007, 88 (Pt 3): 803-813.","journal-title":"J Gen Virol"},{"issue":"1","key":"507_CR54","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.immuni.2009.04.020","volume":"31","author":"S Sanjabi","year":"2009","unstructured":"Sanjabi S, Mosaheb MM, Flavell RA: Opposing effects of TGF-beta and IL-15 cytokines control the number of short-lived effector CD8+ T cells. Immunity. 2009, 31 (1): 131-144. 10.1016\/j.immuni.2009.04.020.","journal-title":"Immunity"},{"issue":"3","key":"507_CR55","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.4049\/jimmunol.1100331","volume":"187","author":"GA Lee","year":"2011","unstructured":"Lee GA, Liou YH, Wang SW, Ko KL, Jiang ST, Liao NS: Different NK cell developmental events require different levels of IL-15 trans-presentation. J Immunol. 2011, 187 (3): 1212-1221. 10.4049\/jimmunol.1100331.","journal-title":"J Immunol"},{"issue":"2","key":"507_CR56","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.imlet.2009.09.009","volume":"127","author":"SW Stonier","year":"2010","unstructured":"Stonier SW, Schluns KS: Trans-presentation: a novel mechanism regulating IL-15 delivery and responses. Immunol Lett. 2010, 127 (2): 85-92. 10.1016\/j.imlet.2009.09.009.","journal-title":"Immunol Lett"},{"issue":"4","key":"507_CR57","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1093\/jmcb\/mjq012","volume":"2","author":"Z Wu","year":"2010","unstructured":"Wu Z, Xu Y: IL-15R alpha-IgG1-Fc enhances IL-2 and IL-15 anti-tumor action through NK and CD8+ T cells proliferation and activation. J Mol Cell Biol. 2010, 2 (4): 217-222. 10.1093\/jmcb\/mjq012.","journal-title":"J Mol Cell Biol"},{"issue":"7","key":"507_CR58","doi-asserted-by":"publisher","first-page":"2921","DOI":"10.1158\/0008-5472.CAN-04-2108","volume":"65","author":"BC Sheu","year":"2005","unstructured":"Sheu BC, Chiou SH, Lin HH, Chow SN, Huang SC, Ho HN, Hsu SM: Up-regulation of inhibitory natural killer receptors CD94\/NKG2A with suppressed intracellular perforin expression of tumor-infiltrating CD8+ T lymphocytes in human cervical carcinoma. Cancer Res. 2005, 65 (7): 2921-2929. 10.1158\/0008-5472.CAN-04-2108.","journal-title":"Cancer Res"},{"issue":"7","key":"507_CR59","doi-asserted-by":"publisher","first-page":"2116","DOI":"10.1002\/art.30355","volume":"63","author":"M de Menthon","year":"2011","unstructured":"de Menthon M, Lambert M, Guiard E, Tognarelli S, Bienvenu B, Karras A, Guillevin L, Caillat-Zucman S: Excessive interleukin-15 transpresentation endows NKG2D\u2009+\u2009CD4+ T cells with innate-like capacity to lyse vascular endothelium in granulomatosis with polyangiitis (Wegener\u2019s). Arthritis Rheum. 2011, 63 (7): 2116-2126. 10.1002\/art.30355.","journal-title":"Arthritis Rheum"},{"issue":"9","key":"507_CR60","doi-asserted-by":"publisher","first-page":"2617","DOI":"10.1002\/art.30460","volume":"63","author":"AK Andersson","year":"2011","unstructured":"Andersson AK, Sumariwalla PF, McCann FE, Amjadi P, Chang C, McNamee K, Tornehave D, Haase C, Agerso H, Stennicke VW: Blockade of NKG2D ameliorates disease in mice with collagen-induced arthritis: a potential pathogenic role in chronic inflammatory arthritis. Arthritis Rheum. 2011, 63 (9): 2617-2629. 10.1002\/art.30460.","journal-title":"Arthritis Rheum"},{"issue":"5","key":"507_CR61","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1007\/s00262-008-0635-x","volume":"58","author":"C Maccalli","year":"2009","unstructured":"Maccalli C, Scaramuzza S, Parmiani G: TNK cells (NKG2D\u2009+\u2009CD8+ or CD4+ T lymphocytes) in the control of human tumors. Cancer Immunol Immunother. 2009, 58 (5): 801-808. 10.1007\/s00262-008-0635-x.","journal-title":"Cancer Immunol Immunother"},{"issue":"12","key":"507_CR62","doi-asserted-by":"publisher","first-page":"7335","DOI":"10.4049\/jimmunol.172.12.7335","volume":"172","author":"JC Lee","year":"2004","unstructured":"Lee JC, Lee KM, Kim DW, Heo DS: Elevated TGF-beta1 secretion and down-modulation of NKG2D underlies impaired NK cytotoxicity in cancer patients. J Immunol. 2004, 172 (12): 7335-7340.","journal-title":"J Immunol"},{"key":"507_CR63","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/1471-2407-8-16","volume":"8","author":"NA Arreygue-Garcia","year":"2008","unstructured":"Arreygue-Garcia NA, Daneri-Navarro A, del Toro-Arreola A, Cid-Arregui A, Gonzalez-Ramella O, Jave-Suarez LF, Aguilar-Lemarroy A, Troyo-Sanroman R, Bravo-Cuellar A, Delgado-Rizo V: Augmented serum level of major histocompatibility complex class I-related chain A (MICA) protein and reduced NKG2D expression on NK and T cells in patients with cervical cancer and precursor lesions. BMC Cancer. 2008, 8: 16-10.1186\/1471-2407-8-16.","journal-title":"BMC Cancer"},{"issue":"12","key":"507_CR64","doi-asserted-by":"publisher","first-page":"6891","DOI":"10.4049\/jimmunol.171.12.6891","volume":"171","author":"ES Doubrovina","year":"2003","unstructured":"Doubrovina ES, Doubrovin MM, Vider E, Sisson RB, O\u2019Reilly RJ, Dupont B, Vyas YM: Evasion from NK cell immunity by MHC class I chain-related molecules expressing colon adenocarcinoma. J Immunol. 2003, 171 (12): 6891-6899.","journal-title":"J Immunol"},{"issue":"6","key":"507_CR65","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1016\/j.jhep.2005.05.026","volume":"43","author":"M Jinushi","year":"2005","unstructured":"Jinushi M, Takehara T, Tatsumi T, Hiramatsu N, Sakamori R, Yamaguchi S, Hayashi N: Impairment of natural killer cell and dendritic cell functions by the soluble form of MHC class I-related chain a in advanced human hepatocellular carcinomas. J Hepatol. 2005, 43 (6): 1013-1020. 10.1016\/j.jhep.2005.05.026.","journal-title":"J Hepatol"}],"container-title":["Journal of Biomedical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1423-0127-20-60.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T01:07:22Z","timestamp":1630544842000},"score":1,"resource":{"primary":{"URL":"https:\/\/jbiomedsci.biomedcentral.com\/articles\/10.1186\/1423-0127-20-60"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,16]]},"references-count":65,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["507"],"URL":"https:\/\/doi.org\/10.1186\/1423-0127-20-60","relation":{},"ISSN":["1423-0127"],"issn-type":[{"value":"1423-0127","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,16]]},"assertion":[{"value":"22 April 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 August 2013","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 August 2013","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"60"}}