{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T17:07:16Z","timestamp":1791133636814,"version":"4.1.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2009,1,28]],"date-time":"2009-01-28T00:00:00Z","timestamp":1233100800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respir Res"],"published-print":{"date-parts":[[2009,12]]},"DOI":"10.1186\/1465-9921-10-7","type":"journal-article","created":{"date-parts":[[2012,7,2]],"date-time":"2012-07-02T10:56:16Z","timestamp":1341226576000},"source":"Crossref","is-referenced-by-count":58,"title":["Exercise intolerance and systemic manifestations of pulmonary emphysema in a mouse model"],"prefix":"10.1186","volume":"10","author":[{"given":"Lars","family":"L\u00fcthje","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Raupach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hellmuth","family":"Michels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Uns\u00f6ld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerd","family":"Hasenfuss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"K\u00f6gler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Andreas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,1,28]]},"reference":[{"issue":"10","key":"721_CR1_721","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1164\/rccm.2603005","volume":"173","author":"LM Fabbri","year":"2006","unstructured":"Fabbri LM, Luppi F, Beghe B, Rabe KF: Update in chronic obstructive pulmonary disease 2005. Am J Respir Crit Care Med 2006,173(10):1056\u201365.","journal-title":"Am J Respir Crit Care Med"},{"issue":"9356","key":"721_CR2_721","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/S0140-6736(03)12459-2","volume":"361","author":"P Calverley","year":"2003","unstructured":"Calverley P, Pauwels R, Vestbo J, Jones P, Pride N, Gulsvik A, Anderson J, Maden C: Combined salmeterol and fluticasone in the treatment of chronic obstructive pulmonary disease: a randomised controlled trial. Lancet 2003,361(9356):449\u201356.","journal-title":"Lancet"},{"issue":"10","key":"721_CR3_721","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1056\/NEJMoa021322","volume":"350","author":"BR Celli","year":"2004","unstructured":"Celli BR, Cote CG, Marin JM, Casanova C, Montes de Oca M, Mendez RA, Pinto Plata V, Cabral HJ: The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease. N Engl J Med 2004,350(10):1005\u201312.","journal-title":"N Engl J Med"},{"issue":"10","key":"721_CR4_721","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1164\/rccm.200412-1695OC","volume":"172","author":"RB Gorman","year":"2005","unstructured":"Gorman RB, McKenzie DK, Butler JE, Tolman JF, Gandevia SC: Diaphragm length and neural drive after lung volume reduction surgery. Am J Respir Crit Care Med 2005,172(10):1259\u201366.","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"721_CR5_721","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1183\/09031936.03.00034603","volume":"23","author":"VM Pinto-Plata","year":"2004","unstructured":"Pinto-Plata VM, Cote C, Cabral H, Taylor J, Celli BR: The 6-min walk distance: change over time and value as a predictor of survival in severe COPD. Eur Respir J 2004,23(1):28\u201333.","journal-title":"Eur Respir J"},{"issue":"1","key":"721_CR6_721","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1183\/09031936.00114307","volume":"31","author":"LM Fabbri","year":"2008","unstructured":"Fabbri LM, Luppi F, Beghe B, Rabe KF: Complex chronic comorbidities of COPD. Eur Respir J 2008,31(1):204\u201312.","journal-title":"Eur Respir J"},{"issue":"26","key":"721_CR7_721","doi-asserted-by":"publisher","first-page":"2645","DOI":"10.1056\/NEJMoa032158","volume":"350","author":"JC Hogg","year":"2004","unstructured":"Hogg JC, Chu F, Utokaparch S, Woods R, Elliott WM, Buzatu L, Cherniack RM, Rogers RM, Sciurba FC, Coxson HO, Pare PD: The nature of small-airway obstruction in chronic obstructive pulmonary disease. N Engl J Med 2004,350(26):2645\u201353.","journal-title":"N Engl J Med"},{"issue":"4","key":"721_CR8_721","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1093\/eurheartj\/ehi601","volume":"27","author":"T Raupach","year":"2006","unstructured":"Raupach T, Schafer K, Konstantinides S, Andreas S: Secondhand smoke as an acute threat for the cardiovascular system: a change in paradigm. Eur Heart J 2006,27(4):386\u201392.","journal-title":"Eur Heart J"},{"issue":"7","key":"721_CR9_721","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1164\/ajrccm.164.7.2108039a","volume":"164","author":"MB Reid","year":"2001","unstructured":"Reid MB: COPD as a muscle disease. Am J Respir Crit Care Med 2001,164(7):1101\u20132.","journal-title":"Am J Respir Crit Care Med"},{"issue":"7","key":"721_CR10_721","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1136\/thx.2005.042994","volume":"60","author":"JL Wright","year":"2005","unstructured":"Wright JL, Levy RD, Churg A: Pulmonary hypertension in chronic obstructive pulmonary disease: current theories of pathogenesis and their implications for treatment. Thorax 2005,60(7):605\u20139.","journal-title":"Thorax"},{"issue":"10","key":"721_CR11_721","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1136\/thx.49.10.995","volume":"49","author":"AG Stewart","year":"1994","unstructured":"Stewart AG, Waterhouse JC, Billings CG, Baylis P, Howard P: Effects of angiotensin converting enzyme inhibition on sodium excretion in patients with hypoxaemic chronic obstructive pulmonary disease. Thorax 1994,49(10):995\u20138.","journal-title":"Thorax"},{"issue":"2","key":"721_CR12_721","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1183\/09031936.00109607","volume":"32","author":"T Raupach","year":"2008","unstructured":"Raupach T, Bahr F, Herrmann P, Luethje L, Heusser K, Hasenfuss G, Bernardi L, Andreas S: Slow breathing reduces sympathoexcitation in COPD. Eur Respir J 2008,32(2):387\u201392.","journal-title":"Eur Respir J"},{"issue":"5","key":"721_CR13_721","doi-asserted-by":"publisher","first-page":"3618","DOI":"10.1378\/chest.128.5.3618","volume":"128","author":"S Andreas","year":"2005","unstructured":"Andreas S, Anker SD, Scanlon PD, Somers VK: Neurohumoral activation as a link to systemic manifestations of chronic lung disease. Chest 2005,128(5):3618\u201324.","journal-title":"Chest"},{"issue":"1","key":"721_CR14_721","doi-asserted-by":"publisher","first-page":"L1","DOI":"10.1152\/ajplung.90200.2008","volume":"295","author":"JL Wright","year":"2008","unstructured":"Wright JL, Cosio M, Churg A: Animal models of chronic obstructive pulmonary disease. Am J Physiol Lung Cell Mol Physiol 2008,295(1):L1\u201315.","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"10","key":"721_CR15_721","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1136\/thorax.57.10.908","volume":"57","author":"R Mahadeva","year":"2002","unstructured":"Mahadeva R, Shapiro SD: Chronic obstructive pulmonary disease * 3: Experimental animal models of pulmonary emphysema. Thorax 2002,57(10):908\u201314.","journal-title":"Thorax"},{"issue":"12","key":"721_CR16_721","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1136\/thorax.56.12.972","volume":"56","author":"PA Dawkins","year":"2001","unstructured":"Dawkins PA, Stockley RA: Animal models of chronic obstructive pulmonary disease. Thorax 2001,56(12):972\u20137.","journal-title":"Thorax"},{"issue":"6","key":"721_CR17_721","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1164\/rccm.200506-850OC","volume":"173","author":"RF Foronjy","year":"2006","unstructured":"Foronjy RF, Mirochnitchenko O, Propokenko O, Lemaitre V, Jia Y, Inouye M, Okada Y, D'Armiento JM: Superoxide dismutase expression attenuates cigarette smoke- or elastase-generated emphysema in mice. Am J Respir Crit Care Med 2006,173(6):623\u201331.","journal-title":"Am J Respir Crit Care Med"},{"key":"721_CR18_721","first-page":"17","volume":"146","author":"GL Snider","year":"1986","unstructured":"Snider GL: Experimental studies on emphysema and chronic bronchial injury. Eur J Respir Dis Suppl 1986, 146:17\u201335.","journal-title":"Eur J Respir Dis Suppl"},{"issue":"2","key":"721_CR19_721","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1183\/09031936.00087606","volume":"29","author":"SD Shapiro","year":"2007","unstructured":"Shapiro SD: Transgenic and gene-targeted mice as models for chronic obstructive pulmonary disease. Eur Respir J 2007,29(2):375\u20138.","journal-title":"Eur Respir J"},{"issue":"6","key":"721_CR20_721","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1152\/jappl.2000.88.6.2054","volume":"88","author":"LM Heunks","year":"2000","unstructured":"Heunks LM, Bast A, van Herwaarden CL, Haenen GR, Dekhuijzen PN: Effects of emphysema and training on glutathione oxidation in the hamster diaphragm. J Appl Physiol 2000,88(6):2054\u201361.","journal-title":"J Appl Physiol"},{"issue":"4","key":"721_CR21_721","doi-asserted-by":"publisher","first-page":"1214","DOI":"10.1172\/JCI111530","volume":"74","author":"GA Farkas","year":"1984","unstructured":"Farkas GA, Roussos C: Histochemical and biochemical correlates of ventilatory muscle fatigue in emphysematous hamsters. J Clin Invest 1984,74(4):1214\u201320.","journal-title":"J Clin Invest"},{"issue":"3","key":"721_CR22_721","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1152\/jappl.1976.41.3.332","volume":"41","author":"H Sahebjami","year":"1976","unstructured":"Sahebjami H, Vassallo CL: Exercise stress and enzyme-induced emphysema. J Appl Physiol 1976,41(3):332\u20135.","journal-title":"J Appl Physiol"},{"issue":"1","key":"721_CR23_721","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1152\/jappl.1998.85.1.210","volume":"85","author":"JP Mattson","year":"1998","unstructured":"Mattson JP, Poole DC: Pulmonary emphysema decreases hamster skeletal muscle oxidative enzyme capacity. J Appl Physiol 1998,85(1):210\u20134.","journal-title":"J Appl Physiol"},{"issue":"Pt 1","key":"721_CR24_721","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1042\/bj2990237","volume":"299","author":"C Gardi","year":"1994","unstructured":"Gardi C, Cavarra E, Calzoni P, Marcolongo P, de Santi M, Martorana PA, Lungarella G: Neutrophil lysosomal dysfunctions in mutant C57 Bl\/6J mice: interstrain variations in content of lysosomal elastase, cathepsin G and their inhibitors. Biochem J 1994,299(Pt 1):237\u201345.","journal-title":"Biochem J"},{"key":"721_CR25_721","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1136\/thx.19.5.443","volume":"19","author":"MS Dunnill","year":"1964","unstructured":"Dunnill MS: Evaluation of a Simple Method of Sampling the Lung for Quantitative Histological Analysis. Thorax 1964, 19:443\u20138.","journal-title":"Thorax"},{"issue":"6","key":"721_CR26_721","first-page":"H941","volume":"243","author":"FC Yin","year":"1982","unstructured":"Yin FC, Spurgeon HA, Rakusan K, Weisfeldt ML, Lakatta EG: Use of tibial length to quantify cardiac hypertrophy: application in the aging rat. Am J Physiol 1982,243(6):H941\u20137.","journal-title":"Am J Physiol"},{"key":"721_CR27_721","volume-title":"J Clin Invest","author":"N Frey","year":"2008","unstructured":"Frey N, Frank D, Lippl S, Kuhn C, K\u00f6gler H, Barrientos T, Rohr C, Will R, M\u00fcller O, Weiler H, Bassel-Duby R, Katus H, Olson E: Deficiency for calsarcin-2 increases exercise capacity in vivo by calcineurin\/NFAT activation. J Clin Invest 2008."},{"issue":"2","key":"721_CR28_721","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/0013-9351(84)90044-6","volume":"33","author":"RH Busch","year":"1984","unstructured":"Busch RH, Lauhala KE, Loscutoff SM, McDonald KE: Experimental pulmonary emphysema induced in the rat by intratracheally administered elastase: morphogenesis. Environ Res 1984,33(2):497\u2013513.","journal-title":"Environ Res"},{"issue":"1","key":"721_CR29_721","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1152\/japplphysiol.01246.2003","volume":"97","author":"S Ito","year":"2004","unstructured":"Ito S, Ingenito EP, Arold SP, Parameswaran H, Tgavalekos NT, Lutchen KR, Suki B: Tissue heterogeneity in the mouse lung: effects of elastase treatment. J Appl Physiol 2004,97(1):204\u201312.","journal-title":"J Appl Physiol"},{"issue":"4","key":"721_CR30_721","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1159\/000194082","volume":"38","author":"J Herget","year":"1979","unstructured":"Herget J, Palecek F, Cermakova M, Vizek M: Pulmonary hypertension in rats with papain emphysema. Respiration 1979,38(4):204\u201312.","journal-title":"Respiration"},{"issue":"3","key":"721_CR31_721","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1152\/jappl.1998.84.3.971","volume":"84","author":"WL Sexton","year":"1998","unstructured":"Sexton WL, Poole DC: Effects of emphysema on diaphragm blood flow during exercise. J Appl Physiol 1998,84(3):971\u20139.","journal-title":"J Appl Physiol"},{"issue":"3","key":"721_CR32_721","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1136\/thx.2003.010785","volume":"59","author":"M Fujita","year":"2004","unstructured":"Fujita M, Ye Q, Ouchi H, Nakashima N, Hamada N, Hagimoto N, Kuwano K, Mason RJ, Nakanishi Y: Retinoic acid fails to reverse emphysema in adult mouse models. Thorax 2004,59(3):224\u201330.","journal-title":"Thorax"},{"issue":"4","key":"721_CR33_721","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1159\/000092545","volume":"73","author":"T Ishikawa","year":"2006","unstructured":"Ishikawa T, Aoshiba K, Yokohori N, Nagai A: Macrophage colony-stimulating factor aggravates rather than regenerates emphysematous lungs in mice. Respiration 2006,73(4):538\u201345.","journal-title":"Respiration"},{"issue":"5","key":"721_CR34_721","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1164\/rccm.200409-1280OC","volume":"172","author":"S Murakami","year":"2005","unstructured":"Murakami S, Nagaya N, Itoh T, Iwase T, Fujisato T, Nishioka K, Hamada K, Kangawa K, Kimura H: Adrenomedullin regenerates alveoli and vasculature in elastase-induced pulmonary emphysema in mice. Am J Respir Crit Care Med 2005,172(5):581\u20139.","journal-title":"Am J Respir Crit Care Med"},{"issue":"6","key":"721_CR35_721","doi-asserted-by":"publisher","first-page":"1864","DOI":"10.1152\/japplphysiol.90924.2008","volume":"105","author":"Z Hantos","year":"2008","unstructured":"Hantos Z, Adamicza A, J\u00e1nosi TZ, Szabari MV, Tolnai J, Suki B: Lung volumes and respiratory mechanics in elastase-induced emphysema in mice. J Appl Physiol 2008,105(6):1864\u201372.","journal-title":"J Appl Physiol"},{"issue":"5 Suppl 1","key":"721_CR36_721","doi-asserted-by":"publisher","first-page":"223S","DOI":"10.1378\/chest.117.5_suppl_1.223S","volume":"117","author":"SD Shapiro","year":"2000","unstructured":"Shapiro SD: Animal models for COPD. Chest 2000,117(5 Suppl 1):223S-7S.","journal-title":"Chest"},{"issue":"1","key":"721_CR37_721","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1038\/labinvest.3780397","volume":"82","author":"EC Lucey","year":"2002","unstructured":"Lucey EC, Keane J, Kuang PP, Snider GL, Goldstein RH: Severity of elastase-induced emphysema is decreased in tumor necrosis factor-alpha and interleukin-1beta receptor-deficient mice. Lab Invest 2002,82(1):79\u201385.","journal-title":"Lab Invest"},{"issue":"3 Pt 1","key":"721_CR38_721","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1164\/ajrccm.162.3.9911096","volume":"162","author":"E Marchand","year":"2000","unstructured":"Marchand E, De Leyn P, Gayan-Ramirez G, Palecek F, de Bock V, Dom R, Decramer M: Lung volume reduction surgery does not improve diaphragmatic contractile properties or atrophy in hamsters with elastase-induced emphysema. Am J Respir Crit Care Med 2000,162(3 Pt 1):1052\u20137.","journal-title":"Am J Respir Crit Care Med"},{"issue":"5","key":"721_CR39_721","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1183\/09031936.04.00104504","volume":"23","author":"JP Mattson","year":"2004","unstructured":"Mattson JP, Delp MD, Poole DC: Differential effects of emphysema on skeletal muscle fibre atrophy in hamsters. Eur Respir J 2004,23(5):703\u20137.","journal-title":"Eur Respir J"},{"issue":"6","key":"721_CR40_721","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1038\/sj.ejcn.1600571","volume":"52","author":"EC Creutzberg","year":"1998","unstructured":"Creutzberg EC, Schols AM, Bothmer-Quaedvlieg FC, Wouters EF: Prevalence of an elevated resting energy expenditure in patients with chronic obstructive pulmonary disease in relation to body composition and lung function. Eur J Clin Nutr 1998,52(6):396\u2013401.","journal-title":"Eur J Clin Nutr"},{"issue":"2","key":"721_CR41_721","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1136\/heart.89.2.225","volume":"89","author":"E Weitzenblum","year":"2003","unstructured":"Weitzenblum E: Chronic cor pulmonale. Heart 2003,89(2):225\u201330.","journal-title":"Heart"},{"issue":"12","key":"721_CR42_721","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1164\/rccm.200701-020PP","volume":"175","author":"CA Ottenheijm","year":"2007","unstructured":"Ottenheijm CA, Heunks LM, Dekhuijzen PN: Diaphragm muscle fiber dysfunction in chronic obstructive pulmonary disease: toward a pathophysiological concept. Am J Respir Crit Care Med 2007,175(12):1233\u201340.","journal-title":"Am J Respir Crit Care Med"},{"issue":"9","key":"721_CR43_721","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1136\/thx.2005.040709","volume":"60","author":"WD Man","year":"2005","unstructured":"Man WD, Hopkinson NS, Harraf F, Nikoletou D, Polkey MI, Moxham J: Abdominal muscle and quadriceps strength in chronic obstructive pulmonary disease. Thorax 2005,60(9):718\u201322.","journal-title":"Thorax"},{"issue":"4","key":"721_CR44_721","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1152\/jappl.1999.87.4.1243","volume":"87","author":"C Coirault","year":"1999","unstructured":"Coirault C, Chemla D, Lecarpentier Y: Relaxation of diaphragm muscle. J Appl Physiol 1999,87(4):1243\u201352.","journal-title":"J Appl Physiol"},{"key":"721_CR45_721","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1152\/physiol.00027.2006","volume":"21","author":"DG Morris","year":"2006","unstructured":"Morris DG, Sheppard D: Pulmonary emphysema: when more is less. Physiology (Bethesda) 2006, 21:396\u2013403.","journal-title":"Physiology (Bethesda)"}],"container-title":["Respiratory Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1465-9921-10-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1465-9921-10-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1465-9921-10-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,30]],"date-time":"2019-06-30T09:14:02Z","timestamp":1561886042000},"score":1,"resource":{"primary":{"URL":"http:\/\/respiratory-research.biomedcentral.com\/articles\/10.1186\/1465-9921-10-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1,28]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["721"],"URL":"https:\/\/doi.org\/10.1186\/1465-9921-10-7","relation":{},"ISSN":["1465-993X"],"issn-type":[{"value":"1465-993X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,1,28]]},"article-number":"7"}}