{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:52:46Z","timestamp":1790887966610,"version":"4.1.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2009,10,7]],"date-time":"2009-10-07T00:00:00Z","timestamp":1254873600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respir Res"],"published-print":{"date-parts":[[2009,12]]},"DOI":"10.1186\/1465-9921-10-93","type":"journal-article","created":{"date-parts":[[2009,10,7]],"date-time":"2009-10-07T18:15:50Z","timestamp":1254939350000},"source":"Crossref","is-referenced-by-count":38,"title":["GITR signaling potentiates airway hyperresponsiveness by enhancing Th2 cell activity in a mouse model of asthma"],"prefix":"10.1186","volume":"10","author":[{"given":"Alexandre C","family":"Motta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joost LM","family":"Vissers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9e","family":"Gras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betty CAM","family":"Van Esch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoon JM","family":"Van Oosterhout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martijn C","family":"Nawijn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,10,7]]},"reference":[{"key":"807_CR1_807","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1016\/S0140-6736(06)69290-8","volume":"368","author":"SE Wenzel","year":"2006","unstructured":"Wenzel SE: Asthma: defining of the persistent adult phenotypes. Lancet 2006, 368:804\u2013813.","journal-title":"Lancet"},{"key":"807_CR2_807","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1084\/jem.20051166","volume":"202","author":"J Kearley","year":"2005","unstructured":"Kearley J, Barker JE, Robinson DS, Lloyd CM: Resolution of airway inflammation and hyperreactivity after in vivo transfer of CD4+CD25+ regulatory T cells is interleukin 10 dependent. J Exp Med 2005, 202:1539\u20131547.","journal-title":"J Exp Med"},{"key":"807_CR3_807","doi-asserted-by":"publisher","first-page":"3842","DOI":"10.4049\/jimmunol.172.6.3842","volume":"172","author":"Z Jaffar","year":"2004","unstructured":"Jaffar Z, Sivakuru T, Roberts K: CD4+CD25+ T cells regulate airway eosinophilic inflammation by modulating the Th2 cell phenotype. J Immunol 2004, 172:3842\u20133849.","journal-title":"J Immunol"},{"key":"807_CR4_807","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.1084\/jem.20051506","volume":"202","author":"IP Lewkowich","year":"2005","unstructured":"Lewkowich IP, Herman NS, Schleifer KW, Dance MP, Chen BL, Dienger KM, Sproles AA, Shah JS, Kohl J, Belkaid Y, et al.: CD4+CD25+ T cells protect against experimentally induced asthma and alter pulmonary dendritic cell phenotype and function. J Exp Med 2005, 202:1549\u20131561.","journal-title":"J Exp Med"},{"key":"807_CR5_807","doi-asserted-by":"publisher","first-page":"L307","DOI":"10.1152\/ajplung.00521.2007","volume":"296","author":"JT Burchell","year":"2009","unstructured":"Burchell JT, Wikstrom ME, Stumbles PA, Sly PD, Turner DJ: Attenuation of allergen-induced airway hyperresponsiveness is mediated by airway regulatory T cells. Am J Physiol Lung Cell Mol Physiol 2009, 296:L307-L319.","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"807_CR6_807","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1097\/ACI.0b013e3282f14d7c","volume":"7","author":"E Xystrakis","year":"2007","unstructured":"Xystrakis E, Urry Z, Hawrylowicz CM: Regulatory T cell therapy as individualized medicine for asthma and allergy. Curr Opin Allergy Clin Immunol 2007, 7:535\u2013541.","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"807_CR7_807","doi-asserted-by":"publisher","first-page":"6216","DOI":"10.1073\/pnas.94.12.6216","volume":"94","author":"G Nocentini","year":"1997","unstructured":"Nocentini G, Giunchi L, Ronchetti S, Krausz LT, Bartoli A, Moraca R, Migliorati G, Riccardi C: A new member of the tumor necrosis factor\/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis. Proc Natl Acad Sci USA 1997, 94:6216\u20136221.","journal-title":"Proc Natl Acad Sci USA"},{"key":"807_CR8_807","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/S1074-7613(02)00280-7","volume":"16","author":"RS McHugh","year":"2002","unstructured":"McHugh RS, Whitters MJ, Piccirillo CA, Young DA, Shevach EM, Collins M, Byrne MC: CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor. Immunity 2002, 16:311\u2013323.","journal-title":"Immunity"},{"key":"807_CR9_807","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1038\/ni759","volume":"3","author":"J Shimizu","year":"2002","unstructured":"Shimizu J, Yamazaki S, Takahashi T, Ishida Y, Sakaguchi S: Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance. Nat Immunol 2002, 3:135\u2013142.","journal-title":"Nat Immunol"},{"key":"807_CR10_807","doi-asserted-by":"publisher","first-page":"7306","DOI":"10.4049\/jimmunol.172.12.7306","volume":"172","author":"F Kanamaru","year":"2004","unstructured":"Kanamaru F, Youngnak P, Hashiguchi M, Nishioka T, Takahashi T, Sakaguchi S, Ishikawa I, Azuma M: Costimulation via glucocorticoid-induced TNF receptor in both conventional and CD25+ regulatory CD4+ T cells. J Immunol 2004, 172:7306\u20137314.","journal-title":"J Immunol"},{"key":"807_CR11_807","doi-asserted-by":"publisher","first-page":"4686","DOI":"10.4049\/jimmunol.172.8.4686","volume":"172","author":"AP Kohm","year":"2004","unstructured":"Kohm AP, Williams JS, Miller SD: Cutting edge: ligation of the glucocorticoid-induced TNF receptor enhances autoreactive CD4+ T cell activation and experimental autoimmune encephalomyelitis. J Immunol 2004, 172:4686\u20134690.","journal-title":"J Immunol"},{"key":"807_CR12_807","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1002\/eji.200324804","volume":"34","author":"S Ronchetti","year":"2004","unstructured":"Ronchetti S, Zollo O, Bruscoli S, Agostini M, Bianchini R, Nocentini G, Ayroldi E, Riccardi C: GITR, a member of the TNF receptor superfamily, is costimulatory to mouse T lymphocyte subpopulations. Eur J Immunol 2004, 34:613\u2013622.","journal-title":"Eur J Immunol"},{"key":"807_CR13_807","doi-asserted-by":"publisher","first-page":"5008","DOI":"10.4049\/jimmunol.173.8.5008","volume":"173","author":"GL Stephens","year":"2004","unstructured":"Stephens GL, McHugh RS, Whitters MJ, Young DA, Luxenberg D, Carreno BM, Collins M, Shevach EM: Engagement of glucocorticoid-induced TNFR family-related receptor on effector T cells by its ligand mediates resistance to suppression by CD4+CD25+ T cells. J Immunol 2004, 173:5008\u20135020.","journal-title":"J Immunol"},{"key":"807_CR14_807","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1093\/intimm\/dxh134","volume":"16","author":"Y Zhan","year":"2004","unstructured":"Zhan Y, Funda DP, Every AL, Fundova P, Purton JF, Liddicoat DR, Cole TJ, Godfrey DI, Brady JL, Mannering SI, et al.: TCR-mediated activation promotes GITR upregulation in T cells and resistance to glucocorticoid-induced death. Int Immunol 2004, 16:1315\u20131321.","journal-title":"Int Immunol"},{"key":"807_CR15_807","doi-asserted-by":"publisher","first-page":"5823","DOI":"10.4049\/jimmunol.172.10.5823","volume":"172","author":"HB Ji","year":"2004","unstructured":"Ji HB, Liao G, Faubion WA, badia-Molina AC, Cozzo C, Laroux FS, Caton A, Terhorst C: Cutting edge: the natural ligand for glucocorticoid-induced TNF receptor-related protein abrogates regulatory T cell suppression. J Immunol 2004, 172:5823\u20135827.","journal-title":"J Immunol"},{"key":"807_CR16_807","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1038\/nri1867","volume":"6","author":"EM Shevach","year":"2006","unstructured":"Shevach EM, Stephens GL: The GITR-GITRL interaction: co-stimulation or contrasuppression of regulatory activity? Nat Rev Immunol 2006, 6:613\u2013618.","journal-title":"Nat Rev Immunol"},{"key":"807_CR17_807","doi-asserted-by":"publisher","first-page":"3581","DOI":"10.1002\/eji.200535421","volume":"35","author":"M Patel","year":"2005","unstructured":"Patel M, Xu D, Kewin P, Choo-Kang B, McSharry C, Thomson NC, Liew FY: Glucocorticoid-induced TNFR family-related protein (GITR) activation exacerbates murine asthma and collagen-induced arthritis. Eur J Immunol 2005, 35:3581\u20133590.","journal-title":"Eur J Immunol"},{"key":"807_CR18_807","doi-asserted-by":"publisher","first-page":"15059","DOI":"10.1073\/pnas.2334901100","volume":"100","author":"M Tone","year":"2003","unstructured":"Tone M, Tone Y, Adams E, Yates SF, Frewin MR, Cobbold SP, Waldmann H: Mouse glucocorticoid-induced tumor necrosis factor receptor ligand is costimulatory for T cells. Proc Natl Acad Sci USA 2003, 100:15059\u201315064.","journal-title":"Proc Natl Acad Sci USA"},{"key":"807_CR19_807","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1084\/jem.20040116","volume":"200","author":"SJ Muriglan","year":"2004","unstructured":"Muriglan SJ, Ramirez-Montagut T, Alpdogan O, Van Huystee TW, Eng JM, Hubbard VM, Kochman AA, Tjoe KH, Riccardi C, Pandolfi PP, et al.: GITR activation induces an opposite effect on alloreactive CD4(+) and CD8(+) T cells in graft-versus-host disease. J Exp Med 2004, 200:149\u2013157.","journal-title":"J Exp Med"},{"key":"807_CR20_807","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1038\/emm.2005.26","volume":"37","author":"S La","year":"2005","unstructured":"La S, Kim E, Kwon B: In vivo ligation of glucocorticoid-induced TNF receptor enhances the T-cell immunity to herpes simplex virus type 1. Exp Mol Med 2005, 37:193\u2013198.","journal-title":"Exp Mol Med"},{"key":"807_CR21_807","doi-asserted-by":"publisher","first-page":"11935","DOI":"10.1128\/JVI.79.18.11935-11942.2005","volume":"79","author":"S Suvas","year":"2005","unstructured":"Suvas S, Kim B, Sarangi PP, Tone M, Waldmann H, Rouse BT: In vivo kinetics of GITR and GITR ligand expression and their functional significance in regulating viral immunopathology. J Virol 2005, 79:11935\u201311942.","journal-title":"J Virol"},{"key":"807_CR22_807","doi-asserted-by":"publisher","first-page":"3301","DOI":"10.4049\/jimmunol.176.6.3301","volume":"176","author":"AP Kohm","year":"2006","unstructured":"Kohm AP, McMahon JS, Podojil JR, Begolka WS, DeGutes M, Kasprowicz DJ, Ziegler SF, Miller SD: Cutting Edge: Anti-CD25 monoclonal antibody injection results in the functional inactivation, not depletion, of CD4+CD25+ T regulatory cells. J Immunol 2006, 176:3301\u20133305.","journal-title":"J Immunol"},{"key":"807_CR23_807","doi-asserted-by":"publisher","first-page":"4668","DOI":"10.4049\/jimmunol.167.8.4668","volume":"167","author":"DM Walter","year":"2001","unstructured":"Walter DM, McIntire JJ, Berry G, McKenzie AN, Donaldson DD, DeKruyff RH, Umetsu DT: Critical role for IL-13 in the development of allergen-induced airway hyperreactivity. J Immunol 2001, 167:4668\u20134675.","journal-title":"J Immunol"},{"key":"807_CR24_807","doi-asserted-by":"crossref","first-page":"L667","DOI":"10.1152\/ajplung.2000.278.4.L667","volume":"278","author":"MR van Scott","year":"2000","unstructured":"van Scott MR, Justice JP, Bradfield JF, Enright E, Sigounas A, Sur S: IL-10 reduces Th2 cytokine production and eosinophilia but augments airway reactivity in allergic mice. Am J Physiol Lung Cell Mol Physiol 2000, 278:L667-L674.","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"807_CR25_807","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/rr197","volume":"4","author":"MA Birrell","year":"2003","unstructured":"Birrell MA, Battram CH, Woodman P, McCluskie K, Belvisi MG: Dissociation by steroids of eosinophilic inflammation from airway hyperresponsiveness in murine airways. Respir Res 2003, 4:3.","journal-title":"Respir Res"},{"key":"807_CR26_807","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1038\/sj.gene.6364354","volume":"8","author":"B Piavaux","year":"2007","unstructured":"Piavaux B, Jeurink PV, Groot PC, Hofman GA, Demant P, Van Oosterhout AJ: Mouse genetic model for antigen-induced airway manifestations of asthma. Genes Immun 2007, 8:28\u201334.","journal-title":"Genes Immun"},{"key":"807_CR27_807","doi-asserted-by":"publisher","first-page":"1496","DOI":"10.1111\/j.1365-2222.2005.02362.x","volume":"35","author":"BN Melgert","year":"2005","unstructured":"Melgert BN, Postma DS, Kuipers I, Geerlings M, Luinge MA, Strate BW, Kerstjens HA, Timens W, Hylkema MN: Female mice are more susceptible to the development of allergic airway inflammation than male mice. Clin Exp Allergy 2005, 35:1496\u20131503.","journal-title":"Clin Exp Allergy"},{"key":"807_CR28_807","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1158\/1078-0432.CCR-07-0940","volume":"14","author":"P Hu","year":"2008","unstructured":"Hu P, Arias RS, Sadun RE, Nien YC, Zhang N, Sabzevari H, Lutsiak ME, Khawli LA, Epstein AL: Construction and preclinical characterization of Fc-mGITRL for the immunotherapy of cancer. Clin Cancer Res 2008, 14:579\u2013588.","journal-title":"Clin Cancer Res"}],"container-title":["Respiratory Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1465-9921-10-93.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1465-9921-10-93\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1465-9921-10-93","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T02:03:24Z","timestamp":1558577004000},"score":1,"resource":{"primary":{"URL":"http:\/\/respiratory-research.biomedcentral.com\/articles\/10.1186\/1465-9921-10-93"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10,7]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["807"],"URL":"https:\/\/doi.org\/10.1186\/1465-9921-10-93","relation":{},"ISSN":["1465-993X"],"issn-type":[{"value":"1465-993X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,10,7]]},"article-number":"93"}}