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The aim of this study was to determine the diagnostic utility of combination measurements of BNP and C-reactive protein (CRP) in critically ill patients with pulmonary edema.<\/jats:p>\n          <jats:p>\n            <jats:bold>Methods<\/jats:bold>\n          <\/jats:p>\n          <jats:p>This was a cross-sectional study. BNP and CRP data from 147 patients who presented to the emergency department due to acute respiratory failure with bilateral pulmonary infiltrates were analyzed.<\/jats:p>\n          <jats:p>\n            <jats:bold>Results<\/jats:bold>\n          <\/jats:p>\n          <jats:p>There were 53 patients with ALI\/ARDS, 71 with CPE, and 23 with mixed edema. Median BNP and CRP levels were 202 (interquartile range 95-439) pg\/mL and 119 (62-165) mg\/L in ALI\/ARDS, and 691 (416-1,194) pg\/mL (p &lt; 0.001) and 8 (2-42) mg\/L (p &lt; 0.001) in CPE. BNP or CRP alone offered good discriminatory performance (C-statistics 0.831 and 0.887), but the combination offered greater one [C-statistics 0.931 (p &lt; 0.001 versus BNP) (p = 0.030 versus CRP)]. In multiple logistic-regression, BNP and CRP were independent predictors for the diagnosis after adjusting for other variables.<\/jats:p>\n          <jats:p>\n            <jats:bold>Conclusions<\/jats:bold>\n          <\/jats:p>\n          <jats:p>Measurement of CRP is useful as well as that of BNP for distinguishing ALI\/ARDS from CPE. Furthermore, a combination of BNP and CRP can provide higher accuracy for the diagnosis.<\/jats:p>","DOI":"10.1186\/1465-9921-12-83","type":"journal-article","created":{"date-parts":[[2011,6,23]],"date-time":"2011-06-23T06:22:02Z","timestamp":1308810122000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Diagnostic utility of C-reactive Protein combined with brain natriuretic peptide in acute pulmonary edema: a cross sectional study"],"prefix":"10.1186","volume":"12","author":[{"given":"Kosaku","family":"Komiya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Ishii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Teramoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuoki","family":"Eshima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ou","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriyuki","family":"Ebi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junji","family":"Murakami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidehiko","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-ichi","family":"Kadota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,12,1]]},"reference":[{"key":"1109_CR1","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.1378\/chest.120.4.1347","volume":"120","author":"RG Brower","year":"2001","unstructured":"Brower RG, Ware LB, Berthiaume Y, Matthay MA: Treatment of ARDS. 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