{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T23:24:46Z","timestamp":1792106686013,"version":"4.4.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Respir Res"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>The association between sensitizations and severity of allergic diseases is controversial.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Objective<\/jats:title>\n            <jats:p>This study was to investigate the association between severity of asthma and rhinitis and degree of specific allergic sensitization in allergic patients in China.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Method<\/jats:title>\n            <jats:p>A cross-sectional survey was performed in 6304 patients with asthma and\/or rhinitis from 4 regions of China. Patients completed a standardized questionnaire documenting their respiratory and allergic symptoms, their impact on sleep, daily activities, school and work. They also underwent skin prick tests with 13 common aeroallergens. Among the recruited subjects, 2268 provided blood samples for serum measurement of specific IgE (sIgE) against 16 common aeroallergens.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Significantly higher percentage of patients with moderate-severe intermittent rhinitis were sensitized to outdoor allergens while percentage of patients sensitized to indoor allergens was increased with increasing severity of asthma. Moderate-severe intermittent rhinitis was associated with the skin wheal size and the level of sIgE to <jats:italic>Artemisia vulgaris<\/jats:italic> and <jats:italic>Ambrosia artemisifolia<\/jats:italic> (p &lt; 0.001). Moderate-severe asthma was associated with increasing wheal size and sIgE response to <jats:italic>Dermatophagoides<\/jats:italic> (<jats:italic>D<\/jats:italic>.) <jats:italic>pteronyssinus<\/jats:italic> and <jats:italic>D. farinae<\/jats:italic> (p &lt; 0.001). Moderate-severe rhinitis and asthma were also associated with increase in number of positive skin prick test and sIgE.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>\n              <jats:italic>Artemisia vulgaris<\/jats:italic> and <jats:italic>Ambrosia artemisifolia<\/jats:italic> sensitizations are associated with the severity of intermittent rhinitis and <jats:italic>D. pteronyssinus<\/jats:italic> and <jats:italic>D. farinae<\/jats:italic> sensitizations are associated with increasing severity of asthma in China. Increase in number of allergens the patients are sensitized to may also increase the severity of rhinitis and asthma.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1465-9921-12-95","type":"journal-article","created":{"date-parts":[[2011,7,30]],"date-time":"2011-07-30T07:23:18Z","timestamp":1312010598000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Influence of degree of specific allergic sensitivity on severity of rhinitis and asthma in Chinese allergic patients"],"prefix":"10.1186","volume":"12","author":[{"given":"Jing","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deyu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guolin","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinzhun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changqing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D","family":"Spangfort","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanshan","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"China Alliance of Research on Respiratory Allergic Disease (CARRAD)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,12,1]]},"reference":[{"key":"1118_CR1","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1111\/j.1398-9995.2009.02283.x","volume":"65","author":"G Weinmayr","year":"2010","unstructured":"Weinmayr G, Genuneit J, Nagel G, Bjorksten B, van Hage M, Priftanji A, Cooper P, Rijkjarv MA, von Mutius E, Tsanakas J, Forastiere F, Doekes G, Garrido JB, Suarez-Varela M M, Braback L, Strachan DP: International variations in associations of allergic markers and diseases in children: ISAAC Phase Two. 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