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The aim of this study was to investigate whether Lp-PLA<jats:sub>2<\/jats:sub>gene deficiency increases the risk of PAF and IgE-mediated inflammatory responses<jats:italic>in vitro<\/jats:italic>and<jats:italic>in vivo<\/jats:italic>using mouse models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Lp-PLA<jats:sub>2<\/jats:sub>-\/- mice were generated and back crossed to the C57BL\/6 background. PAF-AH activity was measured using a hydrolysis assay in serum and bronchoalveolar lavage (BAL) samples obtained from mice.<jats:italic>Aspergillus fumigatus<\/jats:italic>(<jats:italic>Af<\/jats:italic>)-specific serum was prepared for passive allergic sensitization of mice<jats:italic>in vivo<\/jats:italic>and mast cells<jats:italic>in vitro<\/jats:italic>. \u03b2- hexosaminidase release was studied in bone marrow derived mast cells sensitized with<jats:italic>Af<\/jats:italic>-specific serum or DNP-IgE and challenged with<jats:italic>Af<\/jats:italic>or DNP, respectively. Mice were treated with lipopolysaccharide (LPS) and PAF intratracheally and studied 24 hours later. Mice were sensitized either passively or actively against<jats:italic>Af<\/jats:italic>and were studied 48 hours after a single intranasal<jats:italic>Af<\/jats:italic>challenge. Airway responsiveness to methacholine, inflammatory cell influx in the lung tissue and BAL, immunoglobulin (ELISA) and cytokine (Luminex) profiles were compared between the wild type (WT) and Lp-PLA<jats:sub>2<\/jats:sub>-\/- mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>PAF-AH activity was reduced but not completely abolished in Lp-PLA<jats:sub>2<\/jats:sub>-\/- serum or by<jats:italic>in vitro<\/jats:italic>treatment of serum samples with a high saturating concentration of the selective Lp-PLA<jats:sub>2<\/jats:sub>inhibitor, SB-435495. PAF inhalation significantly enhanced airway inflammation of LPS treated WT and Lp-PLA<jats:sub>2<\/jats:sub>-\/- mice to a similar extent. Sensitized WT and Lp-PLA<jats:sub>2<\/jats:sub>-\/- bone-marrow derived mast cells released \u03b2-hexosaminidase following stimulation by allergen or IgE crosslinking to equivalent levels. Wild type and Lp-PLA<jats:sub>2<\/jats:sub>-\/- mice responded to passive or active allergic sensitization by significant IgE production, airway inflammation and hyperresponsiveness after<jats:italic>Af<\/jats:italic>challenge. BAL cell influx was not different between these strains while IL-4, IL-5, IL-6 and eotaxin release was attenuated in Lp-PLA<jats:sub>2<\/jats:sub>-\/- mice. There were no differences in the amount of total IgE levels in the<jats:italic>Af<\/jats:italic>sensitized WT and Lp-PLA<jats:sub>2<\/jats:sub>-\/- mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We conclude that Lp-PLA<jats:sub>2<\/jats:sub>deficiency in C57BL\/6 mice did not result in a heightened airway inflammation or hyperresponsiveness after PAF\/LPS treatment or passive or active allergic sensitization and challenge.<\/jats:p><\/jats:sec>","DOI":"10.1186\/1465-9921-13-100","type":"journal-article","created":{"date-parts":[[2012,11,12]],"date-time":"2012-11-12T09:13:58Z","timestamp":1352711638000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The effect of lipoprotein-associated phospholipase A2 deficiency on pulmonary allergic responses in aspergillus fumigatus sensitized mice"],"prefix":"10.1186","volume":"13","author":[{"given":"Zhilong","family":"Jiang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melane L","family":"Fehrenbach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Ravaioli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blerina","family":"Kokalari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imre G","family":"Redai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven A","family":"Sheardown","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colin","family":"Macphee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Haczku","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,11,12]]},"reference":[{"key":"1292_CR1","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1016\/j.bbalip.2006.05.008","volume":"1761","author":"SA Karabina","year":"2006","unstructured":"Karabina SA, Ninio E: Plasma PAF-acetylhydrolase: an unfulfilled promise?. 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