{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T13:30:07Z","timestamp":1771680607652,"version":"3.50.1"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2004,11,24]],"date-time":"2004-11-24T00:00:00Z","timestamp":1101254400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"},{"start":{"date-parts":[[2004,11,24]],"date-time":"2004-11-24T00:00:00Z","timestamp":1101254400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Respir Res"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                        <jats:title>Background<\/jats:title>\n                        <jats:p>Biologically variable ventilation (return of physiological variability in rate and tidal volume using a computer-controller) was compared to control mode ventilation with and without a recruitment manoeuvre \u2013 40 cm H<jats:sub>2<\/jats:sub>O for 40 sec performed hourly; in a porcine oleic acid acute lung injury model.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Methods<\/jats:title>\n                        <jats:p>We compared gas exchange, respiratory mechanics, and measured bronchoalveolar fluid for inflammatory cytokines, cell counts and surfactant function. Lung injury was scored by light microscopy. Pigs received mechanical ventilation (F<jats:sub>I<\/jats:sub>O<jats:sub>2<\/jats:sub> = 0.3; PEEP 5 cm H<jats:sub>2<\/jats:sub>O) in control mode until PaO<jats:sub>2<\/jats:sub> decreased to 60 mm Hg with oleic acid infusion (PaO<jats:sub>2<\/jats:sub>\/F<jats:sub>I<\/jats:sub>O<jats:sub>2<\/jats:sub> &lt;200 mm Hg). Additional PEEP to 10 cm H<jats:sub>2<\/jats:sub>O was added after injury. Animals were randomized to one of the 3 modes of ventilation and followed for 5 hr after injury.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Results<\/jats:title>\n                        <jats:p>PaO<jats:sub>2<\/jats:sub> and respiratory system compliance was significantly greater with biologically variable ventilation compared to the other 2 groups. Mean and mean peak airway pressures were also lower. There were no differences in cell counts in bronchoalveolar fluid by flow cytometry, or interleukin-8 and -10 levels between groups. Lung injury scoring revealed no difference between groups in the regions examined. No differences in surfactant function were seen between groups by capillary surfactometry.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Conclusions<\/jats:title>\n                        <jats:p>In this porcine model of acute lung injury, various indices to measure injury or inflammation did not differ between the 3 approaches to ventilation. However, when using a low tidal volume strategy with moderate levels of PEEP, sustained improvements in arterial oxygen tension and respiratory system compliance were only seen with BVV when compared to CMV or CMV with a recruitment manoeuvre.<\/jats:p>\n                     <\/jats:sec>","DOI":"10.1186\/1465-9921-5-22","type":"journal-article","created":{"date-parts":[[2005,1,13]],"date-time":"2005-01-13T07:24:48Z","timestamp":1105601088000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["A comparison of biologically variable ventilation to recruitment manoeuvres in a porcine model of acute lung injury"],"prefix":"10.1186","volume":"5","author":[{"given":"Duane J","family":"Funk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M Ruth","family":"Graham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda G","family":"Girling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James A","family":"Thliveris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce M","family":"McManus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth KY","family":"Walker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward S","family":"Rector","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig","family":"Hillier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J Elliott","family":"Scott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W Alan C","family":"Mutch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2004,11,24]]},"reference":[{"key":"231_CR1_231","first-page":"193","volume":"69","author":"JJ Marini","year":"2003","unstructured":"Marini JJ: How to recruit the injured lung.\n                           Minerva Anestesiol 2003, 69:193\u2013200.","journal-title":"Minerva Anestesiol"},{"key":"231_CR2_231","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1097\/00000542-200204000-00005","volume":"96","author":"S Grasso","year":"2002","unstructured":"Grasso S, Mascia L, Del Turco M, Malacarne P, Giunta F, Brochard L, Slutsky AS, Marco Ranieri V: Effects of recruiting maneuvers in patients with acute respiratory distress syndrome ventilated with protective ventilatory strategy.\n                           Anesthesiology 2002, 96:795\u2013802.","journal-title":"Anesthesiology"},{"key":"231_CR3_231","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1097\/01.CCM.0000048632.81351.8B","volume":"31","author":"JJ Marini","year":"2003","unstructured":"Marini JJ: Efficacy of lung recruiting maneuvers: it's all relative.\n                           Crit Care Med 2003, 31:641\u2013642.","journal-title":"Crit Care Med"},{"key":"231_CR4_231","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1097\/00000542-200307000-00003","volume":"99","author":"JJ Rouby","year":"2003","unstructured":"Rouby JJ: Lung overinflation. 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