{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T06:43:06Z","timestamp":1790318586402,"version":"4.1.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2005,6,8]],"date-time":"2005-06-08T00:00:00Z","timestamp":1118188800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Respir Res"],"published-print":{"date-parts":[[2005,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>We have previously shown that the bronchodilatory effect of deep inspiration is attenuated in individuals with COPD. This study was designed to investigate whether the impairment in this effect is associated with loss of alveolar attachments.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>We measured deep inspiration (DI)-induced bronchodilation in 15 individuals with and without COPD (67 \u00b1 2.2 yrs of age, mean \u00b1 SEM) undergoing lobar resection for peripheral pulmonary nodule. Prior to surgery, we measured TLCO and determined the bronchodilatory effect of deep inspiration after constricting the airways with methacholine. The number of destroyed alveolar attachments, as well as airway wall area and airway smooth muscle area, were determined in tumor-free, peripheral lung tissue.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The bronchodilatory effect of deep inspiration correlated inversely with the % destroyed attachments (r = -0.51, p = 0.05) and directly with the airway smooth muscle area (r = 0.59, p = 0.03), but not with the total wall area (r = 0.39, p = 0.15).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>We postulate that attenuation of airway stretch due to loss of alveolar attachments contributes to the loss of the bronchodilatory effect of lung inflation in COPD.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1465-9921-6-55","type":"journal-article","created":{"date-parts":[[2005,6,8]],"date-time":"2005-06-08T18:13:40Z","timestamp":1118254420000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Association between reduced bronchodilatory effect of deep inspiration and loss of alveolar attachments"],"prefix":"10.1186","volume":"6","author":[{"given":"Nicola","family":"Scichilone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreina","family":"Bruno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Marchese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Maurizio","family":"Vignola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alkis","family":"Togias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Bellia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2005,6,8]]},"reference":[{"issue":"6","key":"293_CR1_293","doi-asserted-by":"publisher","first-page":"2029","DOI":"10.1378\/chest.125.6.2029","volume":"125","author":"N Scichilone","year":"2004","unstructured":"Scichilone N, Marchese R, Catalano F, Vignola AM, Togias A, Bellia V: Bronchodilatory effect of deep inspiration is absent in subjects with mild COPD.\nChest 2004,125(6):2029\u201335.","journal-title":"Chest"},{"issue":"2","key":"293_CR2_293","first-page":"119","volume":"22","author":"RD Fairshter","year":"1986","unstructured":"Fairshter RD: Effect of a deep inspiration on expiratory flow in normals and patients with chronic obstructive pulmonary disease.\nBull Eur Physiopathol Respir 1986,22(2):119\u201325.","journal-title":"Bull Eur Physiopathol Respir"},{"key":"293_CR3_293","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1164\/ajrccm.162.3.9907048","volume":"162","author":"N Scichilone","year":"2000","unstructured":"Scichilone N, Kapsali T, Permutt S, Togias A: Deep inspiration-induced bronchoprotection is stronger than bronchodilation.\nAm J Respir Crit Care Med 2000, 162:910\u2013916.","journal-title":"Am J Respir Crit Care Med"},{"issue":"2","key":"293_CR4_293","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1164\/ajrccm.163.2.2003119","volume":"163","author":"N Scichilone","year":"2001","unstructured":"Scichilone N, Permutt S, Togias A: The lack of the bronchoprotective and not the bronchodilatory ability of deep inspiration is associated with airway hyperresponsiveness.\nAm J Respir Crit Care Med 2001,163(2):413\u20139.","journal-title":"Am J Respir Crit Care Med"},{"key":"293_CR5_293","first-page":"551","volume":"104","author":"SF Boushy","year":"1971","unstructured":"Boushy SF, Aboumrad MH, North LB, Helgason AH: Lung recoil pressure, airway resistance, and forced flows related to morphologic emphysema.\nAm Rev Respir Dis 1971, 104:551\u201361.","journal-title":"Am Rev Respir Dis"},{"key":"293_CR6_293","first-page":"894","volume":"132","author":"M Saetta","year":"1985","unstructured":"Saetta M, Ghezzo H, Kim WD, King M, Angus G, Wang N, Cosio G: Loss of alveolar attachments in smokers.\nAm Rev Respir Dis 1985, 132:894\u2013900.","journal-title":"Am Rev Respir Dis"},{"key":"293_CR7_293","first-page":"182","volume":"132","author":"GL Snider","year":"1985","unstructured":"Snider GL, Kleinerman J, Thurlbeck WM, Bengali ZH: The definition of emphysema. Report of a National Hearth, Lung and Blood Institute, Division of Lung Disease Workshop.\nAm Rev Respir Dis 1985, 132:182\u20135.","journal-title":"Am Rev Respir Dis"},{"key":"293_CR8_293","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1164\/ajrccm.163.5.2101039","volume":"163","author":"RA Pauwels","year":"2001","unstructured":"Pauwels RA, Buist AS, Calverley PM, Jenkins CR, Hurd SS: Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary diseases.\nAm J Resp Crit Care Med 2001, 163:1256\u20131276.","journal-title":"Am J Resp Crit Care Med"},{"key":"293_CR9_293","doi-asserted-by":"publisher","first-page":"129","DOI":"10.3109\/02770909109082737","volume":"28","author":"MJ Abramson","year":"1991","unstructured":"Abramson MJ, Hensley MJ, Saunders NA, Wlodarczyk JJ: Evaluation of a new asthma questionnaire.\nJ Asthma 1991, 28:129\u2013139.","journal-title":"J Asthma"},{"key":"293_CR10_293","first-page":"457","volume":"79","author":"H Goldman","year":"1959","unstructured":"Goldman H, Becklake M: Respiratory function tests. Normal values at median altitudes and the prediction of normal results.\nAm Rev Respir Dis 1959, 79:457\u2013467.","journal-title":"Am Rev Respir Dis"},{"issue":"9","key":"293_CR11_293","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1016\/j.rmed.2004.02.023","volume":"98","author":"N Scichilone","year":"2004","unstructured":"Scichilone N, Marchese R, Catalano F, Togias A, Vignola AM, Bellia V: The bronchodilatory effect of deep inspiration diminishes with aging.\nRespir Med 2004,98(9):838\u201343.","journal-title":"Respir Med"},{"key":"293_CR12_293","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1152\/jappl.1986.61.6.2144","volume":"61","author":"J Kirby","year":"1986","unstructured":"Kirby J, Juniper E, Hargreave F, Zamel N: Total lung capacity does not change during methacholine-stimulated airway narrowing.\nJ Appl Physiol 1986, 61:2144\u20132147.","journal-title":"J Appl Physiol"},{"key":"293_CR13_293","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1164\/rccm.2111084","volume":"166","author":"G Turato","year":"2002","unstructured":"Turato G, Zuin R, Miniati M, Baraldo S, Rea F, Beghe B, Monti S, Formichi B, Boschetto P, Harari S, Papi A, Maestrelli P, Fabbri LM, Saetta M: Airway inflammation in severe chronic obstructive pulmonary disease: relationship with lung function and radiologic emphysema.\nAm J Respir Crit Care Med 2002, 166:105\u201310.","journal-title":"Am J Respir Crit Care Med"},{"key":"293_CR14_293","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1152\/jappl.1970.28.5.596","volume":"28","author":"J Mead","year":"1970","unstructured":"Mead J, Takishima T, Leith D: Stress distribution in lungs: a model of pulmonary elasticity.\nJ Appl Physiol 1970, 28:596\u2013608.","journal-title":"J Appl Physiol"},{"issue":"6","key":"293_CR15_293","first-page":"1171","volume":"133","author":"RH Moreno","year":"1986","unstructured":"Moreno RH, Hogg JC, Pare PD: Mechanics of airway narrowing.\nAm Rev Respir Dis 1986,133(6):1171\u201380.","journal-title":"Am Rev Respir Dis"},{"issue":"3","key":"293_CR16_293","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1152\/jappl.1968.25.3.244","volume":"25","author":"HF Froeb","year":"1968","unstructured":"Froeb HF, Mead J: Relative hysteresis of the dead space and lung in vivo.\nJ Appl Physiol 1968,25(3):244\u20138.","journal-title":"J Appl Physiol"},{"key":"293_CR17_293","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1063\/1.336084","volume":"58","author":"R Fairshter","year":"1985","unstructured":"Fairshter R: Airway hysteresis in normal subjects and individuals with chronic airflow obstruction.\nJ Appl Physiol 1985, 58:1505\u20131510.","journal-title":"J Appl Physiol"},{"issue":"1","key":"293_CR18_293","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1152\/japplphysiol.01018.2002","volume":"95","author":"A Corsico","year":"2003","unstructured":"Corsico A, Milanese M, Baraldo S, Casoni GL, Papi A, Riccio AM, Cerveri I, Saetta M, Brusasco V: Small airway morphology and lung function in the transition from normality to chronic airway obstruction.\nJ Appl Physiol 2003,95(1):441\u20137.","journal-title":"J Appl Physiol"},{"key":"293_CR19_293","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1164\/ajrccm.152.1.7599834","volume":"152","author":"R Finkelstein","year":"1995","unstructured":"Finkelstein R, Ma H, Ghezzo H, Whittaker K, Fraser R, Cosio M: Morphometry of small airways in smokers and its relationship to emphysema type and hyperresponsiveness.\nAm J Respir Crit Care Med 1995, 152:267\u2013276.","journal-title":"Am J Respir Crit Care Med"},{"key":"293_CR20_293","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1164\/ajrccm.159.supplement_2.mfa-1","volume":"159","author":"PM O'Byrne","year":"1999","unstructured":"O'Byrne PM, Postma DS: The many faces of airway inflammation. Asthma and Chronic Obstructive Diseases.\nAm J Resp Crit Care Med 1999, 159:541\u2013566.","journal-title":"Am J Resp Crit Care Med"},{"key":"293_CR21_293","doi-asserted-by":"publisher","first-page":"1720","DOI":"10.1164\/ajrccm.161.5.9903102","volume":"161","author":"J Bousquet","year":"2000","unstructured":"Bousquet J, Jeffery P, Busse W, Johnson M, Vignola A: From bronchoconstriction to airways inflammation and remodeling (State of the Art).\nAm J Respir Crit Care Med 2000, 161:1720\u20131745.","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"293_CR22_293","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1164\/ajrccm.153.1.8542167","volume":"153","author":"PT Macklem","year":"1996","unstructured":"Macklem PT: A theoretical analysis of the effect of airway smooth muscle load on airway narrowing.\nAm J Respir Crit Care Med 1996,153(1):83\u20139.","journal-title":"Am J Respir Crit Care Med"}],"container-title":["Respiratory Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1465-9921-6-55.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1465-9921-6-55\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1465-9921-6-55","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1465-9921-6-55.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T09:46:12Z","timestamp":1630489572000},"score":1,"resource":{"primary":{"URL":"https:\/\/respiratory-research.biomedcentral.com\/articles\/10.1186\/1465-9921-6-55"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,6,8]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,12]]}},"alternative-id":["293"],"URL":"https:\/\/doi.org\/10.1186\/1465-9921-6-55","relation":{},"ISSN":["1465-993X"],"issn-type":[{"value":"1465-993X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,6,8]]},"assertion":[{"value":"7 March 2005","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 June 2005","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 June 2005","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"55"}}