{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T23:49:28Z","timestamp":1792453768038,"version":"4.5.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2006,1,17]],"date-time":"2006-01-17T00:00:00Z","timestamp":1137456000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Respir Res"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Complete tooth loss (edentulism) produces anatomical changes that may impair upper airway size and function. The aim of this study was to evaluate whether edentulism favours the occurrence of obstructive sleep apnoea (OSA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Polysomnography was performed in 48 edentulous subjects on two consecutive nights, one slept with and the other without dentures. Upper airway size was assessed by cephalometry and by recording forced mid-inspiratory airflow rate (FIF\n                      <jats:sub>50<\/jats:sub>\n                      ). Exhaled nitric oxide (eNO) and oral NO (oNO), were measured as markers of airway and oropharyngeal inflammation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The apnoea\/hypopnoea index (AHI) without dentures was significantly higher than with dentures (17\u00b74 \u00b1 3\u00b76 versus 11\u00b70 \u00b1 2\u00b73. p = 0\u00b7002), and was inversely related to FIF\n                      <jats:sub>50<\/jats:sub>\n                      (p = 0\u00b7017) and directly related to eNO (p = 0\u00b7042). Sleeping with dentures, 23 subjects (48%) had an AHI over 5, consistent with OSA, but sleeping without dentures the number of subjects with abnormal AHI rose to 34 (71%). At cephalometry, removing dentures produced a significant decrease in retropharyngeal space (from 1\u00b7522 \u00b1 0\u00b733 cm to 1\u00b727 \u00b1 0\u00b742 cm, p = 0\u00b7006). Both morning eNO and oNO were higher after the night slept without dentures (eNO 46\u00b71 \u00b1 8\u00b72 ppb versus 33\u00b77 \u00b1 6\u00b73 ppb, p = 0\u00b7035, oNO 84\u00b76 \u00b1 13\u00b77 ppb versus 59\u00b72 \u00b1 17\u00b74 ppb, p = 0\u00b7001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings suggest that complete tooth loss favours upper airway obstruction during sleep. This untoward effect seems to be due to decrease in retropharyngeal space and is associated with increased oral and exhaled NO concentration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/1465-9921-7-8","type":"journal-article","created":{"date-parts":[[2006,1,23]],"date-time":"2006-01-23T07:43:57Z","timestamp":1138002237000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":76,"title":["Tooth loss and obstructive sleep apnoea"],"prefix":"10.1186","volume":"7","author":[{"given":"Caterina","family":"Bucca","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Cicolin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Brussino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Arienti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Graziano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Erovigni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Pera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerio","family":"Gai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Mutani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Preti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Rolla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Carossa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2006,1,17]]},"reference":[{"key":"399_CR1_399","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1164\/ajrccm\/148.3.606","volume":"148","author":"DL Morrison","year":"1993","unstructured":"Morrison DL, Launois SH, Isono S: Pharyngeal narrowing and closing pressures in patients with obstructive sleep apnoea.\nAm Rev Respir Dis 1993, 148:606\u2013611.","journal-title":"Am Rev Respir Dis"},{"key":"399_CR2_399","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1164\/ajrccm.165.2.2009032","volume":"165","author":"T Watanabe","year":"2002","unstructured":"Watanabe T, Isono S, Tanaka A, Tanzawa H, Nishino T: Contribution of body habitus and craniofacial characteristics to segmental closing pressures of the passive pharynx in patients with sleep-disordered breathing.\nAm J Respir Crit Care Med 2002, 165:260\u2013265.","journal-title":"Am J Respir Crit Care Med"},{"key":"399_CR3_399","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1016\/S0022-3913(99)70010-7","volume":"82","author":"JR Ivanhoe","year":"1999","unstructured":"Ivanhoe JR, Cibirka RM, Lefebvre CA, Parr GR: Dental considerations in upper airway disorders: a review of the literature.\nJ Prosthet Dent 1999, 82:685\u2013698.","journal-title":"J Prosthet Dent"},{"key":"399_CR4_399","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/0022-3913(93)90105-W","volume":"69","author":"JB Douglass","year":"1993","unstructured":"Douglass JB, Meader L, Kaplan A, Ellinger CW: Cephalometric evaluation of the changes in patients wearing complete dentures. 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