{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:23:34Z","timestamp":1792697014736,"version":"4.5.0"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2007,10,30]],"date-time":"2007-10-30T00:00:00Z","timestamp":1193702400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"},{"start":{"date-parts":[[2007,10,30]],"date-time":"2007-10-30T00:00:00Z","timestamp":1193702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Respir Res"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In the present study, we used tumor necrosis factor-R1 knock out mice (TNF-\u03b1R1KO) to understand the roles of TNF-\u03b1 on epithelial function in models of carrageenan-induced acute lung inflammation. In order to elucidate whether the observed anti-inflammatory status is related to the inhibition of TNF-\u03b1, we also investigated the effect of etanercept, a TNF-\u03b1 soluble receptor construct, on lung TJ function. Pharmacological and genetic TNF-\u03b1 inhibition significantly reduced the degree of (1) TNF-\u03b1 production in pleural exudates and in the lung tissues, (2) the inflammatory cell infiltration in the pleural cavity as well as in the lung tissues (evaluated by MPO activity), (3) the alteration of ZO-1, Claudin-2, Claudin-4, Claudin-5 and \u03b2-catenin (immunohistochemistry) and (4) apoptosis (TUNEL staining, Bax, Bcl-2 expression). Taken together, our results demonstrate that inhibition of TNF-\u03b1 reduces the tight junction permeability in the lung tissues associated with acute lung inflammation, suggesting a possible role of TNF-\u03b1 on lung barrier dysfunction.<\/jats:p>","DOI":"10.1186\/1465-9921-8-75","type":"journal-article","created":{"date-parts":[[2007,10,30]],"date-time":"2007-10-30T16:13:42Z","timestamp":1193760822000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":129,"title":["Role of TNF-\u03b1 in lung tight junction alteration in mouse model of acute lung inflammation"],"prefix":"10.1186","volume":"8","author":[{"given":"Emanuela","family":"Mazzon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Cuzzocrea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2007,10,30]]},"reference":[{"issue":"4","key":"613_CR1_613","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1164\/ajrccm.163.4.2006116","volume":"163","author":"ED Crandall","year":"2001","unstructured":"Crandall ED, Matthay MA: Alveolar epithelial transport. 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