{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T19:49:59Z","timestamp":1771616999932,"version":"3.50.1"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Biochem"],"DOI":"10.1186\/1471-2091-2-16","type":"journal-article","created":{"date-parts":[[2005,8,5]],"date-time":"2005-08-05T18:14:12Z","timestamp":1123265652000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Isolation and characterization of a novel lepidopteran-selective toxin from the venom of South Indian red scorpion, Mesobuthus tamulus"],"prefix":"10.1186","volume":"2","author":[{"given":"Rajendra","family":"Wudayagiri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bora","family":"Inceoglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Herrmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maher","family":"Derbel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prabhakara V","family":"Choudary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce D","family":"Hammock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2001,12,17]]},"reference":[{"key":"19_CR1","volume-title":"Adv. Cytopharmacol, Edited by Ceccarelli, F. pp. 325\u2013334 New York: Raven;","author":"H Rochat","year":"1979","unstructured":"Rochat H, Bernard P, Couraud F: Scorpion toxins: Chemistry and mode of action. In: Adv. Cytopharmacol, Edited by Ceccarelli, F. pp. 325\u2013334 New York: Raven;. 1979"},{"key":"19_CR2","doi-asserted-by":"publisher","first-page":"4814","DOI":"10.1021\/bi00233a025","volume":"30","author":"E Zlotkin","year":"1991","unstructured":"Zlotkin E, Eitan M, Bindokas VP, Adams ME, Moyer M, Burkhart W, Fowler E: Functional duality and structural uniqueness of depressant insect-selective neurotoxins. Biochemistry. 1991, 30: 4814-4821.","journal-title":"Biochemistry"},{"key":"19_CR3","doi-asserted-by":"publisher","first-page":"7622","DOI":"10.1021\/bi00148a025","volume":"31","author":"D Gordon","year":"1992","unstructured":"Gordon D, Moskowitz H, Eitan M, Warner C, Catterall WA, Zlotkin E: Localization of receptor sites for insect-selective toxins on sodium channels by site-directed antibodies. Biochemistry. 1992, 31: 7622-7628.","journal-title":"Biochemistry"},{"key":"19_CR4","volume-title":"Arthropod Venoms Edited by Bettini, S. pp. 317\u2013369 New York: Springer-Verlag;","author":"E Zlotkin","year":"1978","unstructured":"Zlotkin E, Miranda F, Rochat C: Chemistry and pharmacology of Buthinae scorpion venoms. In: Arthropod Venoms Edited by Bettini, S. pp. 317\u2013369 New York: Springer-Verlag;. 1978"},{"key":"19_CR5","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1038\/296090a0","volume":"296","author":"E Carbone","year":"1982","unstructured":"Carbone E, Wanke E, Prestipino G, Possani LD, Maelicke A: Selective blockage of voltage-dependent K+ channels by a novel scorpion toxin. Nature. 1982, 296: 90-91.","journal-title":"Nature"},{"key":"19_CR6","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1038\/313316a0","volume":"313","author":"C Miller","year":"1985","unstructured":"Miller C, Moczydlowski E, Latore R, Philips M: Charybdotoxin, a potent inhibitor of single Ca2+-activated K+ channels from mammalian skeletal muscle. Nature. 1985, 313: 316-318.","journal-title":"Nature"},{"key":"19_CR7","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.1016\/S0006-291X(80)80082-9","volume":"95","author":"E Jover","year":"1980","unstructured":"Jover E, Couraud F, Rochat H: Two types of scorpion neurotoxins characterized by their binding to two separate receptor sites on rat brain synaptosomes. Biochem. Biophys. Res. Commun. 1980, 95: 1607-1614.","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"19_CR8","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/0041-0101(82)90138-6","volume":"20","author":"F Couraud","year":"1982","unstructured":"Couraud F, Jover E, Dubois JM, Rochat H: Two types of scorpion toxin receptor sites, one related to the activation, the other to the inactivation of the action potential sodium channel. Toxicon. 1982, 20: 9-16. 10.1016\/0041-0101(82)90138-6.","journal-title":"Toxicon"},{"key":"19_CR9","volume-title":"Molecular Action of Insecticides on Ion Channels, Edited by dark, J.M. pp. 56\u201385 Washington, D.C.: ACS;","author":"E Zlotkin","year":"1995","unstructured":"Zlotkin E, Moskowitz H, Herrmann R, Pelhate M, Gordon D: Insect sodium channel as the target for insect-selective neurotoxins from scorpion venom. In: Molecular Action of Insecticides on Ion Channels, Edited by dark, J.M. pp. 56\u201385 Washington, D.C.: ACS;. 1995"},{"key":"19_CR10","doi-asserted-by":"publisher","first-page":"2649","DOI":"10.1021\/bi9617116","volume":"36","author":"M Delepierre","year":"1997","unstructured":"Delepierre M, Prochnicka A, Possani LD: A novel potassium channel blocking toxin from the scorpion Pandinus imperator: A1 H NMR analysis using a nano-NMR probe. Biochemistry. 1997, 36: 2649-2658. 10.1021\/bi9617116.","journal-title":"Biochemistry"},{"key":"19_CR11","doi-asserted-by":"crossref","first-page":"C361","DOI":"10.1152\/ajpcell.1993.264.2.C361","volume":"264","author":"JA DeBin","year":"1993","unstructured":"DeBin JA, Maggio JE, Strichartz GR: Purification and characterization of chlorotoxin, a Cl- channel ligand from the venom of the scorpion. Am. J. Physiol. Cell. Physiol. 1993, 264: C361-C369.","journal-title":"Am. J. Physiol. Cell. Physiol"},{"key":"19_CR12","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1038\/352085a0","volume":"352","author":"LMD Stewart","year":"1991","unstructured":"Stewart LMD, Hirst M, Ferber ML, Merryweather AT, Cayley PJ, Posse RD: Construction of an improved baculovirus insecticide containing an insect-specific toxin gene. Nature. 1991, 352: 85-88. 10.1038\/352085a0.","journal-title":"Nature"},{"key":"19_CR13","volume-title":"Natural and Engineered Pest Management Agents, Edited by Hedin PA, Menn JJ, Hollingworth RM. pp. 348\u2013367 Washington, D.C: American Chemical Society Symp. Ser","author":"BF McCutchen","year":"1994","unstructured":"McCutchen BF, Hammock BD: Recombinant baculovirus expressing an insect-selective neurotoxin. In: Natural and Engineered Pest Management Agents, Edited by Hedin PA, Menn JJ, Hollingworth RM. pp. 348\u2013367 Washington, D.C: American Chemical Society Symp. Ser. 1994"},{"key":"19_CR14","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1146\/annurev.ento.44.1.429","volume":"44","author":"E Zlotkin","year":"1999","unstructured":"Zlotkin E: The insect voltage-gated sodium channel as target of insecticides. Ann. Rev. Entomol. 1999, 44: 429-455. 10.1146\/annurev.ento.44.1.429.","journal-title":"Ann. Rev. Entomol"},{"key":"19_CR15","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1111\/j.1432-1033.1997.t01-1-00496.x","volume":"246","author":"Y Nakagawa","year":"1997","unstructured":"Nakagawa Y, Lee YM, Lehmberg E, Herrmann R, Herrmann R, Moskowitz H, Jones AD, Hammock BD: Anti-insect toxin 5 (AaIT5) from A australis. Eur. J. Biochem. 1997, 246: 496-501.","journal-title":"Eur. J. Biochem"},{"key":"19_CR16","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1016\/S0021-9258(18)45993-5","volume":"267","author":"M Crest","year":"1992","unstructured":"Crest M, Jacquet G, Gola M, Zerrouk H, Benslimane A, Rochat H, Mansuelle P, Martin-Eauclaire MF: Kaliotoxin, a novel peptidyl inhibitor of neuronal BK-type Ca2+-activated K+ channels characterized from Androctonus mauretanicus mauretanicus venom. J. Biol. Chem. 1992, 267: 1640-1647.","journal-title":"J. Biol. Chem"},{"key":"19_CR17","doi-asserted-by":"publisher","first-page":"1521","DOI":"10.1126\/science.1720574","volume":"254","author":"F Bontems","year":"1991","unstructured":"Bontems F, Roumestand C, Gilquin B, Me'nez A, Toma F: Refined structure of chary bdotoxin: common motifs in scorpion toxins and insect defensins. Science. 1991, 254: 1521-1523.","journal-title":"Science"},{"key":"19_CR18","doi-asserted-by":"publisher","first-page":"339","DOI":"10.3109\/15569549509019468","volume":"14","author":"B Becerril","year":"1995","unstructured":"Becerril B, Corona M, Garcia C, Bolivar F, Possani LD: Cloning of genes encoding scorpion toxins: An interpretive review. J. Toxicol. Toxin Rev. 1995, 14: 339-357.","journal-title":"J. Toxicol. Toxin Rev"},{"key":"19_CR19","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1016\/0041-0101(81)90077-5","volume":"19","author":"GS Chhatwal","year":"1981","unstructured":"Chhatwal GS, Heberman E: Neurotoxins, protease inhibitors and histamine releasers in the venom of the Indian Red scorpion (Buthus tamulus): Isolation and partial characterization. Toxicon. 1981, 19: 807-823. 10.1016\/0041-0101(81)90077-5.","journal-title":"Toxicon"},{"key":"19_CR20","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/0041-0101(94)90085-X","volume":"32","author":"K Lala","year":"1994","unstructured":"Lala K, Narayanan P: Purification, N-terminal sequence and structural characterization of a toxic protein from the Indian scorpion venom, Buthus tamulus. Toxicon. 1994, 32: 325-338. 10.1016\/0041-0101(94)90085-X.","journal-title":"Toxicon"},{"key":"19_CR21","doi-asserted-by":"crossref","first-page":"11083","DOI":"10.1016\/S0021-9258(19)38560-6","volume":"265","author":"A Galvez","year":"1990","unstructured":"Galvez A, Gimenez-Gallego G, Reuben JP, Roy-Contancin L, Feigenbaum P, Kaczorowski GJ, Garcia ML: Purification and characterization of a unique, potent, peptidyl-probe for the high-conductance calcium-activated potassium channel from the venom of the scorpion, Buthus tamulus. J. Biol. Chem. 1990, 265: 11083-11090.","journal-title":"J. Biol. Chem"},{"key":"19_CR22","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/0014-5793(84)80014-9","volume":"165","author":"AS Arseniev","year":"1984","unstructured":"Arseniev AS, Kondakov VI, Maioro VN, Bystrov VF: NMR solution spatial structure of \"short\" insectotoxin I5A. Febs. Lett. 1984, 165: 57-62. 10.1016\/0014-5793(84)80014-9.","journal-title":"Febs. Lett"},{"key":"19_CR23","first-page":"155","volume":"8","author":"EV Grishin","year":"1982","unstructured":"Grishin EV, Volkova TM, Soldatova LN: Study of toxic components from the venom of Caucasus subspecies of scorpion Buthus eupeus. Bioorg. Khim. 1982, 8: 155-164.","journal-title":"Bioorg. Khim"},{"key":"19_CR24","first-page":"485","volume":"3","author":"TB Adamovich","year":"1977","unstructured":"Adamovich TB, Nasimov IV, Grishin EV, Ovchinnikov YA: Amino acid sequence of insectotoxin II from the venom of middle-asian scorpion Buthus eupeus. Bioorg. Khim. 1977, 3: 485-493.","journal-title":"Bioorg. Khim"},{"key":"19_CR25","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/0014-5793(89)81548-0","volume":"257","author":"A Fazal","year":"1989","unstructured":"Fazal A, Beg OU, Shafqat J, Zaidi ZH, Jornvall H: Characterization of two different peptides from the venom of the scorpion Buthus sindicus. Febs. Lett. 1989, 257: 260-262. 10.1016\/0014-5793(89)81548-0.","journal-title":"Febs. Lett"},{"key":"19_CR26","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/0041-0101(85)90114-X","volume":"23","author":"JP Rosso","year":"1985","unstructured":"Rosso JP, Rochat H: Characterization of ten proteins from the venom of the Moroccan scorpion Androctonus mauretanicus mauretanicus, six of which are toxic to mouse. Toxicon. 1985, 23: 113-125. 10.1016\/0041-0101(85)90114-X.","journal-title":"Toxicon"},{"key":"19_CR27","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1111\/j.1432-1033.1997.00218.x","volume":"246","author":"E Adjadj","year":"1997","unstructured":"Adjadj E, Naudat V, Quiniou E, Wouters D, Sautiere P, Craeseu CT: Solution structure of Lqh-8\/6, a toxin-like peptide from a scorpion venom-structural homogeneity induced by proline cis\/trans isomerization. Eur. J. Biochem. 1997, 246: 218-227.","journal-title":"Eur. J. Biochem"},{"key":"19_CR28","doi-asserted-by":"publisher","first-page":"3389","DOI":"10.1093\/nar\/25.17.3389","volume":"25","author":"SF Altschul","year":"1997","unstructured":"Altschul SF, Madden TL, Schaeffer AA, Zhang J, Zhang Z, Miller W, Lipman DJ: Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res. 1997, 25: 3389-3402. 10.1093\/nar\/25.17.3389.","journal-title":"Nucleic Acids Res"},{"key":"19_CR29","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.1016\/S0021-9258(19)85783-6","volume":"255","author":"J Drenth","year":"1980","unstructured":"Drenth J, Low BW, Richardson JS, Wright CS: The toxin-agglutinin fold. A new group of small protein structures organized around a four-disulfide core. J. Biol. Chem. 1980, 255: 2652-2655.","journal-title":"J. Biol. Chem"},{"key":"19_CR30","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1016\/S0021-9258(19)69652-3","volume":"256","author":"J Drenth","year":"1981","unstructured":"Drenth J: The structure of neurophysin. J. Biol. Chem. 1981, 256: 2601-2602.","journal-title":"J. Biol. Chem"},{"key":"19_CR31","doi-asserted-by":"publisher","first-page":"8151","DOI":"10.1021\/bi00150a006","volume":"31","author":"BA Johnson","year":"1992","unstructured":"Johnson BA, Sugg EE: Determination of the three-dimensional structure of iberiotoxin in solution by 1 H Nuclear magnetic resonance spectroscopy. Biochemistry. 1992, 31: 8151-8159.","journal-title":"Biochemistry"},{"key":"19_CR32","doi-asserted-by":"publisher","first-page":"14256","DOI":"10.1021\/bi00251a038","volume":"33","author":"I Fernandez","year":"1994","unstructured":"Fernandez I, Romi R, Szendeffy S, Martin-Eauclaire MF, Rochat H, Rietschoten JV, Pons M, Giralt E: Kaliotoxin (1\u201337) shows structural differences with related potasium channel blockers. Biochemistry. 1994, 33: 14256-14263.","journal-title":"Biochemistry"},{"key":"19_CR33","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1016\/0896-6273(95)90104-3","volume":"15","author":"J Aiyar","year":"1995","unstructured":"Aiyar J, Withka JM, Rizzi JP, Singleton DH, Andrews GC, Lin W, Boyd J, Hanson DC, Simon M, Dethlefs B, Lee CL, Hall JE, Gutman GA, Chandy KG: Topology of the pore-region of a K+ channel revealed by the NMR-derived structures of scorpion toxins. Neuron. 1995, 15: 1169-1181.","journal-title":"Neuron"},{"key":"19_CR34","doi-asserted-by":"publisher","first-page":"15061","DOI":"10.1021\/bi00254a015","volume":"33","author":"BA Johnson","year":"1994","unstructured":"Johnson BA, Stevens SP, Williamson JM: Determination of the three-dimensional structure of margatoxin by 1H, 13C, 15N triple-resonance nuclear resonance magnetic spectroscopy. Biochemistry. 1994, 33: 15061-15070.","journal-title":"Biochemistry"},{"key":"19_CR35","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/S0014-5793(97)00285-8","volume":"406","author":"R Kharrat","year":"1997","unstructured":"Kharrat R, Mansuelle P, Sampieri F, Crest M, Oughideni R, Rietschoten JV, Martin-Eauclaire MF, Rochat H, Ayub ME: Maurotoxin, a four disulfide bridge toxin from Scorpio maurus venom: Purification, structure and action on potassium channels. Febs. Lett. 1997, 406: 284-290. 10.1016\/S0014-5793(97)00285-8.","journal-title":"Febs. Lett"},{"key":"19_CR36","doi-asserted-by":"publisher","first-page":"1478","DOI":"10.1002\/pro.5560040805","volume":"4","author":"AM Krezel","year":"1995","unstructured":"Krezel AM, Kasibhatla C, Hidalgo P, Mackinnon R, Wagner G: Solution structure of the K+ channel inhibitor agitoxin2: Caliper for probing channel geometry. Protein. Sci. 1995, 4: 1478-1489.","journal-title":"Protein. Sci"},{"key":"19_CR37","doi-asserted-by":"publisher","first-page":"16563","DOI":"10.1021\/bi00051a004","volume":"34","author":"M Dauplais","year":"1995","unstructured":"Dauplais M, Gilquin B, Possani LD, Gurrola-Briones G, Roumestand C, Menez A: Determination of the three-dimensional solution structure of noxiustoxin: analysis of structural differences with related short-chain scorpion toxins. Biochemistry. 1995, 34: 16563-16573.","journal-title":"Biochemistry"},{"key":"19_CR38","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1021\/bi00001a003","volume":"34","author":"G Lippens","year":"1995","unstructured":"Lippens G, Najib S, Wodak J, Tartar A: NMR sequential assignments and solution structure of chlorotoxin, a small scorpion that blocks chloride channels. Biochemistry. 1995, 34: 13-21.","journal-title":"Biochemistry"},{"key":"19_CR39","doi-asserted-by":"publisher","first-page":"2714","DOI":"10.1002\/elps.1150181505","volume":"18","author":"N Guex","year":"1997","unstructured":"Guex N, Peitsch MC: SWISS-model and the SWISS-PDB viewer: An environment for comparative protein modeling. Electrophoresis. 1997, 18: 2714-2723.","journal-title":"Electrophoresis"},{"key":"19_CR40","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1038\/nbt0795-658","volume":"13","author":"MC Peitsch","year":"1995","unstructured":"Peitsch MC: Protein modeling by Email. Bio\/Technology. 1995, 13: 658-660.","journal-title":"Bio\/Technology"},{"key":"19_CR41","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1042\/bst0240274","volume":"24","author":"MC Peitsch","year":"1996","unstructured":"Peitsch MC: ProMod and SWISS-Model: Internet-based tools for automated comparative protein modeling. Biochem. Soc. Trans. 1996, 24: 274-279.","journal-title":"Biochem. Soc. Trans"},{"key":"19_CR42","volume-title":"Proteome research: New frontiers in functional genomics, Edited by Wilkins MR, Williams KL, Appel RD, Hochstrasser DF. pp. 177\u2013186 Berlin: Springer-Verlag;","author":"MC Peitsch","year":"1997","unstructured":"Peitsch MC, Guex N: Large scale comparative protein modeling. In: Proteome research: New frontiers in functional genomics, Edited by Wilkins MR, Williams KL, Appel RD, Hochstrasser DF. pp. 177\u2013186 Berlin: Springer-Verlag;. 1997"}],"container-title":["BMC Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2091-2-16.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T15:57:11Z","timestamp":1726243031000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcbiochem.biomedcentral.com\/articles\/10.1186\/1471-2091-2-16"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,12,17]]},"references-count":42,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2001,12]]}},"alternative-id":["19"],"URL":"https:\/\/doi.org\/10.1186\/1471-2091-2-16","relation":{},"ISSN":["1471-2091"],"issn-type":[{"value":"1471-2091","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,12,17]]},"assertion":[{"value":"19 September 2001","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 December 2001","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 December 2001","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"16"}}