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While OPA1 has been characterized for its role in mitochondrial cristae structure and organelle fusion, possible effects of OPA1 on mitochondrial function have not been determined.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Mitochondria from six ADOA patients bearing <jats:italic>OPA1<\/jats:italic> mutations and ten ADOA patients with unidentified gene mutations were studied for respiratory capacity and electron transport complex function. Results suggest that the nuclear DNA mutations that give rise to ADOA in our patient population do not alter mitochondrial electron transport.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>We conclude that the pathophysiology of ADOA likely stems from the role of OPA1 in mitochondrial structure or fusion and not from OPA1 support of oxidative phosphorylation.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2091-9-22","type":"journal-article","created":{"date-parts":[[2008,9,26]],"date-time":"2008-09-26T18:15:15Z","timestamp":1222452915000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Mitochondrial oxidative phosphorylation in autosomal dominant optic atrophy"],"prefix":"10.1186","volume":"9","author":[{"given":"Vladimir I","family":"Mayorov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela J","family":"Lowrey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Biousse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy J","family":"Newman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan D","family":"Cline","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,9,10]]},"reference":[{"issue":"1\u20133","key":"208_CR1","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1007\/s10540-007-9045-0","volume":"27","author":"V Carelli","year":"2007","unstructured":"Carelli V, La Morgia C, Iommarini L, Carroccia R, Mattiazzi M, Sangiorgi S, Farne S, Maresca A, Foscarini B, Lanzi L, Amadori M, Bellan M, Valentino ML: Mitochondrial Optic Neuropathies: How Two Genomes may Kill the Same Cell Type?. 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