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The method is used to construct gene co-expression subnetworks of highly significant edges.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The results shown here are for an adapted subset of a <jats:italic>Saccharomyces cerevisiae<\/jats:italic> gene expression data set with low temporal resolution and poor statistics. The method reveals common transcription factors with a high confidence level and allows the construction of subnetworks with high biological relevance that reveals characteristic features of the processes driving the organism adaptations to specific environmental conditions.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Our method allows a reliable and sophisticated analysis of microarray data even under severe constraints. The utilization of systems biology improves the biologists ability to elucidate the mechanisms underlying celular processes and to formulate new hypotheses.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2105-10-270","type":"journal-article","created":{"date-parts":[[2009,9,2]],"date-time":"2009-09-02T10:36:49Z","timestamp":1251887809000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A reliable measure of similarity based on dependency for short time series: an application to gene expression networks"],"prefix":"10.1186","volume":"10","author":[{"given":"M\u00f4nica G","family":"Campiteli","sequence":"first","affiliation":[]},{"given":"Frederico M","family":"Soriani","sequence":"additional","affiliation":[]},{"given":"Iran","family":"Malavazi","sequence":"additional","affiliation":[]},{"given":"Osame","family":"Kinouchi","sequence":"additional","affiliation":[]},{"given":"Carlos AB","family":"Pereira","sequence":"additional","affiliation":[]},{"given":"Gustavo H","family":"Goldman","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2009,8,28]]},"reference":[{"key":"3000_CR1","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.1016\/j.febslet.2008.02.015","volume":"582","author":"S Bader","year":"2008","unstructured":"Bader S, Kuhner S, Gavin AC: Interaction networks for systems biology. 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