{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T06:30:03Z","timestamp":1778481003994,"version":"3.51.4"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2009,11,25]],"date-time":"2009-11-25T00:00:00Z","timestamp":1259107200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMC Bioinformatics"],"published-print":{"date-parts":[[2009,12]]},"DOI":"10.1186\/1471-2105-10-387","type":"journal-article","created":{"date-parts":[[2009,11,26]],"date-time":"2009-11-26T00:02:07Z","timestamp":1259193727000},"source":"Crossref","is-referenced-by-count":46,"title":["Modeling lymphocyte homing and encounters in lymph nodes"],"prefix":"10.1186","volume":"10","author":[{"given":"Valentina","family":"Baldazzi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Paci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Bernaschi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filippo","family":"Castiglione","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2009,11,25]]},"reference":[{"key":"3117_CR1","doi-asserted-by":"publisher","first-page":"2098","DOI":"10.1126\/science.286.5447.2098","volume":"286","author":"J Cyster","year":"1999","unstructured":"Cyster J: Chemokines and cell migration in secondary lymphoid organs. Science 1999, 286: 2098\u20132102. 10.1126\/science.286.5447.2098","journal-title":"Science"},{"key":"3117_CR2","doi-asserted-by":"publisher","first-page":"16315","DOI":"10.1073\/pnas.0506190102","volume":"102","author":"KA Soderberg","year":"2005","unstructured":"Soderberg KA, Payne GW, Sato A, Medzhitov R, Segal SS, Iwasaki A: Innate control of adaptive immunity via remodeling of lymph node feed arteriole. Proc Natl Acad Sci USA 2005, 102: 16315\u201316320. 10.1073\/pnas.0506190102","journal-title":"Proc Natl Acad Sci USA"},{"issue":"5373","key":"3117_CR3","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1126\/science.281.5373.96","volume":"281","author":"P Garside","year":"1998","unstructured":"Garside P, Ingulli E, Merica RR, Johnson JG, Noelle RJ, Jenkins MK: Visualization of Specific B and T Lymphocyte Interactions in the Lymph Node. Science 1998, 281(5373):96\u201399. 10.1126\/science.281.5373.96","journal-title":"Science"},{"key":"3117_CR4","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1038\/84219","volume":"2","author":"B Moser","year":"2001","unstructured":"Moser B, Loetscher P: Lymphocyte traffic control by chemokines. Nat Immunol 2001, 2: 123\u2013128. 10.1038\/84219","journal-title":"Nat Immunol"},{"key":"3117_CR5","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.immuni.2004.08.007","volume":"21","author":"DM Catron","year":"2004","unstructured":"Catron DM, Itano AA, Pape KA, Mueller DL, Jenkins MK: Visualizing the First 50 Hr of the Primary Immune Response to a Soluble Antigen. Immunity 2004, 21: 341\u2013347. 10.1016\/j.immuni.2004.08.007","journal-title":"Immunity"},{"issue":"5","key":"3117_CR6","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1080\/01926230600867727","volume":"34","author":"CL Willard-Mack","year":"2006","unstructured":"Willard-Mack CL: Normal structure, function, and histology of lymph nodes. Toxicol Pathol 2006, 34(5):409\u201324. 10.1080\/01926230600867727","journal-title":"Toxicol Pathol"},{"key":"3117_CR7","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1073\/pnas.0306407101","volume":"101","author":"MJ Miller","year":"2004","unstructured":"Miller MJ, Wei SH, Cahalan MD, Parker I: T cell repertoire scanning is promoted by dynamic dendritic cell behavior and random T cell motility in the lymph node. Proc Natl Acad Sci USA 2004, 101: 998\u20131003. 10.1073\/pnas.0306407101","journal-title":"Proc Natl Acad Sci USA"},{"issue":"5780","key":"3117_CR8","doi-asserted-by":"publisher","first-page":"1672","DOI":"10.1126\/science.1125703","volume":"312","author":"H Qi","year":"2006","unstructured":"Qi H, Egen JG, Huang AYC, Germain RN: Extrafollicular Activation of Lymph Node B Cells by Antigen-Bearing Dendritic Cells. Science 2006, 312(5780):1672\u20131676. 10.1126\/science.1125703","journal-title":"Science"},{"key":"3117_CR9","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.immuni.2004.11.013","volume":"22","author":"M Sixt","year":"2005","unstructured":"Sixt M, Kanazawa N, Selg M, Samson T, Roos G, Reinhardt DP, Pabst R, Lutz MB, Sorokin L: The Conduit System Transports Soluble Antigens from the Afferent Lymph to Resident Dendritic Cells in the T Cell Area of the Lymph Node. Immunity 2005, 22: 19\u201329. 10.1016\/j.immuni.2004.11.013","journal-title":"Immunity"},{"issue":"11","key":"3117_CR10","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1038\/nri1222","volume":"3","author":"UH von Andrian","year":"2003","unstructured":"von Andrian UH, Mempel TR: Homing and cellular traffic in lymph nodes. Nat Rev Immunol 2003, 3(11):867\u2013878. 10.1038\/nri1222","journal-title":"Nat Rev Immunol"},{"issue":"4","key":"3117_CR11","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1016\/S0002-9440(10)64077-1","volume":"158","author":"F Katou","year":"2001","unstructured":"Katou F, Ohtani H, Nakayama T, Ono K, Matsushima K, Saaristo A, Nagura H, Yoshie O, Motegi K: Macrophage-Derived Chemokine (MDC\/CCL22) and CCR4 Are Involved in the Formation of T Lymphocyte-Dendritic Cell Clusters in Human Inflamed Skin and Secondary Lymphoid Tissue. Am J Pathol 2001, 158(4):1263\u20131270.","journal-title":"Am J Pathol"},{"issue":"4","key":"3117_CR12","doi-asserted-by":"publisher","first-page":"2349","DOI":"10.4049\/jimmunol.175.4.2349","volume":"175","author":"A Kaiser","year":"2005","unstructured":"Kaiser A, Donnadieu E, Abastado JP, Trautmann A, Nardin A: CC Chemokine Ligand 19 Secreted by Mature Dendritic Cells Increases Naive T Cell Scanning Behavior and Their Response to Rare Cognate Antigen. J Immunol 2005, 175(4):2349\u20132356.","journal-title":"J Immunol"},{"issue":"5","key":"3117_CR13","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/j.immuni.2005.09.013","volume":"23","author":"A Bergtold","year":"2005","unstructured":"Bergtold A, Desai DD, Gavhane A, Clynes R: Cell Surface Recycling of Internalized Antigen Permits Dendritic Cell Priming of B Cells. Immunity 2005, 23(5):503\u2013514. 10.1016\/j.immuni.2005.09.013","journal-title":"Immunity"},{"issue":"3","key":"3117_CR14","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1016\/j.coi.2006.02.005","volume":"18","author":"T Okada","year":"2006","unstructured":"Okada T, Cyster J: B cell migration and interactions in the early phase of antibody responses. Curr Opin Immunol 2006, 18(3):278\u2013285. 10.1016\/j.coi.2006.02.005","journal-title":"Curr Opin Immunol"},{"key":"3117_CR15","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1038\/416094a","volume":"416","author":"K Reif","year":"2002","unstructured":"Reif K, Ekland E, Ohl L, Nakano H, Lipp M, F\u00f6rster R, Cyster J: Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position. Nature 2002, 416: 94\u201399. 10.1038\/416094a","journal-title":"Nature"},{"issue":"6","key":"3117_CR16","doi-asserted-by":"publisher","first-page":"1924","DOI":"10.1182\/blood-2004-11-4494","volume":"106","author":"S Hardtke","year":"2005","unstructured":"Hardtke S, Ohl L, Forster R: Balanced expression of CXCR5 and CCR7 on follicular T helper cells determines their transient positioning to lymph node follicles and is essential for efficient B-cell help. Blood 2005, 106(6):1924\u20131931. 10.1182\/blood-2004-11-4494","journal-title":"Blood"},{"issue":"6972","key":"3117_CR17","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1038\/nature02284","volume":"427","author":"M Matloubian","year":"2004","unstructured":"Matloubian M, Lo CG, Cinamon G, Lesneski MJ, Xu Y, Brinkmann V, Allende ML, Proia RL, Cyster JG: Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature 2004, 427(6972):355\u2013360. 10.1038\/nature02284","journal-title":"Nature"},{"issue":"15","key":"3117_CR18","doi-asserted-by":"publisher","first-page":"15396","DOI":"10.1074\/jbc.M314291200","volume":"279","author":"ML Allende","year":"2004","unstructured":"Allende ML, Dreier JL, Mandala S, Proia RL: Expression of the Sphingosine 1-Phosphate Receptor, S1P1, on T-cells Controls Thymic Emigration. J Biol Chem 2004, 279(15):15396\u201315401. 10.1074\/jbc.M314291200","journal-title":"J Biol Chem"},{"issue":"12","key":"3117_CR19","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.1038\/ni1269","volume":"6","author":"SH Wei","year":"2005","unstructured":"Wei SH, Rosen H, Matheu MP, Sanna GM, Wang SK, Jo E, Wong CH, Parker I, Cahalan MD: Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses. Nat Immunol 2005, 6(12):1228\u20131235. 10.1038\/ni1269","journal-title":"Nat Immunol"},{"issue":"5","key":"3117_CR20","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.4049\/jimmunol.163.5.2463","volume":"163","author":"C Kesmir","year":"1999","unstructured":"Kesmir C, De Boer RJ: A Mathematical Model on Germinal Center Kinetics and Termination. J Immunol 1999, 163(5):2463\u20132469.","journal-title":"J Immunol"},{"key":"3117_CR21","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1006\/jtbi.2001.2344","volume":"211","author":"SH Kleinstein","year":"2001","unstructured":"Kleinstein SH, Singh JP: Toward Quantitative Simulation of Germinal Center Dynamics: Biological and Modeling Insights from Experimental Validation. J Theor Biol 2001, 211: 253\u2013275. 10.1006\/jtbi.2001.2344","journal-title":"J Theor Biol"},{"key":"3117_CR22","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1038\/sj.icb.7100054","volume":"85","author":"JB Beltman","year":"2007","unstructured":"Beltman JB, Maree AF, de Boer RJ: Spatial modelling of brief and long interactions between T cells and dendritic cells. Immunol Cell Biol 2007, 85: 306\u2013314. 10.1038\/sj.icb.7100054","journal-title":"Immunol Cell Biol"},{"key":"3117_CR23","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/0167-5699(92)90135-T","volume":"13","author":"F Celada","year":"1992","unstructured":"Celada F, Seiden P: A computer model of cellular interaction in the immune system. Immunol Today 1992, 13: 56\u201362. 10.1016\/0167-5699(92)90135-T","journal-title":"Immunol Today"},{"key":"3117_CR24","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/S0010-4825(01)00011-7","volume":"31","author":"M Bernaschi","year":"2001","unstructured":"Bernaschi M, Castiglione F: Design and implementation of an immune system simulator. Comput Biol Med 2001, 31: 303\u2013331. 10.1016\/S0010-4825(01)00011-7","journal-title":"Comput Biol Med"},{"issue":"3","key":"3117_CR25","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.jtbi.2004.06.031","volume":"231","author":"JL Segovia-Juarez","year":"2004","unstructured":"Segovia-Juarez JL, Ganguli S, Kirschner D: Identifying control mechanisms of granuloma formation during M. tuberculosis infection using an agent-based model. J Theor Biol 2004, 231(3):357\u2013376. 10.1016\/j.jtbi.2004.06.031","journal-title":"J Theor Biol"},{"issue":"23","key":"3117_CR26","doi-asserted-by":"publisher","first-page":"12258","DOI":"10.1073\/pnas.94.23.12258","volume":"94","author":"K Francis","year":"1997","unstructured":"Francis K, Palsson BO: Effective intercellular communication distances are determined by the relative time constants for cyto\/chemokine secretion and diffusion. Proc Natl Acad Sci USA 1997, 94(23):12258\u201312262. 10.1073\/pnas.94.23.12258","journal-title":"Proc Natl Acad Sci USA"},{"issue":"5574","key":"3117_CR27","doi-asserted-by":"publisher","first-page":"1869","DOI":"10.1126\/science.1070051","volume":"296","author":"MJ Miller","year":"2002","unstructured":"Miller MJ, Wei SH, Parker I, Cahalan MD: Two-Photon Imaging of Lymphocyte Motility and Antigen Response in Intact Lymph Node. Science 2002, 296(5574):1869\u20131873. 10.1126\/science.1070051","journal-title":"Science"},{"key":"3117_CR28","doi-asserted-by":"publisher","first-page":"2604","DOI":"10.1073\/pnas.2628040100","volume":"100","author":"MJ Miller","year":"2003","unstructured":"Miller MJ, Wei SH, Cahalan MD, Parker I: Autonomous T cell trafficking examined in vivo with intravital two-photon microscopy. Proc Natl Acad Sci USA 2003, 100: 2604\u20132609. 10.1073\/pnas.2628040100","journal-title":"Proc Natl Acad Sci USA"},{"issue":"6","key":"3117_CR29","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1371\/journal.pbio.0030150","volume":"3","author":"T Okada","year":"2005","unstructured":"Okada T, Miller M, Parker I, Krummel M, Neighbors Ma: Antigen-Engaged B Cells Undergo Chemotaxis toward the T Zone and Form Motile Conjugates with Helper T Cells. Plos Biol 2005, 3(6):1047\u20131061. 10.1371\/journal.pbio.0030150","journal-title":"Plos Biol"},{"key":"3117_CR30","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1034\/j.1600-065X.2003.00076.x","volume":"195","author":"SH Wei","year":"2003","unstructured":"Wei SH, Parker I, Miller MJ, Cahalan MD: A stochastic view of lymphocyte motility and trafficking within the lymph node. Immunol Rev 2003, 195: 136\u2013159. 10.1034\/j.1600-065X.2003.00076.x","journal-title":"Immunol Rev"},{"issue":"2","key":"3117_CR31","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1006\/smim.1999.0163","volume":"11","author":"AJ Young","year":"1999","unstructured":"Young AJ: The physiology of lymphocyte migration through the single lymph node in vivo. Seminars in Immunology 1999, 11(2):73\u201383. 10.1006\/smim.1999.0163","journal-title":"Seminars in Immunology"},{"issue":"6970","key":"3117_CR32","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1038\/nature02238","volume":"427","author":"TR Mempel","year":"2004","unstructured":"Mempel TR, Henrickson SE, Von Andrian UH: T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases. Nature 2004, 427(6970):154\u2013159. 10.1038\/nature02238","journal-title":"Nature"},{"issue":"5489","key":"3117_CR33","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1126\/science.290.5489.89","volume":"290","author":"S Fagarasan","year":"2000","unstructured":"Fagarasan S, Honjo T: T-Independent Immune Response: New Aspects of B Cell Biology. Science 2000, 290(5489):89\u201392. 10.1126\/science.290.5489.89","journal-title":"Science"},{"key":"3117_CR34","volume-title":"Kuby Immunology","author":"R Goldsby","year":"2003","unstructured":"Goldsby R, TJ TK, Osborne B: Kuby Immunology. IV edition. New York: W.H. Freeman and Company; 2003.","edition":"IV"},{"key":"3117_CR35","doi-asserted-by":"crossref","DOI":"10.1007\/b98869","volume-title":"Mathematical Biology","author":"JD Murray","year":"2003","unstructured":"Murray JD: Mathematical Biology. Volume II. springer; 2003."}],"container-title":["BMC Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2105-10-387.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-2105-10-387\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2105-10-387.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,27]],"date-time":"2023-05-27T17:34:33Z","timestamp":1685208873000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcbioinformatics.biomedcentral.com\/articles\/10.1186\/1471-2105-10-387"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11,25]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["3117"],"URL":"https:\/\/doi.org\/10.1186\/1471-2105-10-387","relation":{},"ISSN":["1471-2105"],"issn-type":[{"value":"1471-2105","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,11,25]]},"article-number":"387"}}