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Although several existing methods combine multiple information resources, there is no study that integrates protein domain information and PPI networks to predict protein functions.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The domain context similarity can be a useful index to predict protein function similarity. The prediction accuracy of our method in yeast is between 63%-67%, which outperforms the other methods in terms of ROC curves.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>This paper presents a novel protein function prediction method that combines protein domain composition information and PPI networks. Performance evaluations show that this method outperforms existing methods.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2105-10-395","type":"journal-article","created":{"date-parts":[[2009,12,2]],"date-time":"2009-12-02T19:13:47Z","timestamp":1259781227000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Inferring protein function by domain context similarities in protein-protein interaction networks"],"prefix":"10.1186","volume":"10","author":[{"given":"Song","family":"Zhang","sequence":"first","affiliation":[]},{"given":"Hu","family":"Chen","sequence":"additional","affiliation":[]},{"given":"Ke","family":"Liu","sequence":"additional","affiliation":[]},{"given":"Zhirong","family":"Sun","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2009,12,2]]},"reference":[{"issue":"21","key":"3125_CR1","doi-asserted-by":"publisher","first-page":"5391","DOI":"10.1111\/j.1742-4658.2005.04973.x","volume":"272","author":"S Fields","year":"2005","unstructured":"Fields S: High-throughput two-hybrid analysis. 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