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Integration and exploration of these complex and heterogeneous data have become a major challenge.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The EXALT (<jats:bold>EX<\/jats:bold> pression signature <jats:bold>A<\/jats:bold> na<jats:bold>L<\/jats:bold> ysis <jats:bold>T<\/jats:bold> ool) online program enables meta-analysis of gene expression profiles derived from publically accessible sources. Searches can be executed online against two large databases currently containing more than 28,000 gene expression signatures derived from GEO (Gene Expression Omnibus) and published expression profiles of human cancer. Comparisons among gene expression signatures can be performed with homology analysis and co-expression analysis. Results can be visualized instantly in a plot or a heat map. Three typical use cases are illustrated.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>The EXALT online program is uniquely suited for discovering relationships among transcriptional profiles and searching gene expression patterns derived from diverse physiological and pathological settings. The EXALT online program is freely available for non-commercial users from <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/seq.mc.vanderbilt.edu\/exalt\/\" ext-link-type=\"uri\">http:\/\/seq.mc.vanderbilt.edu\/exalt\/<\/jats:ext-link>.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2105-10-420","type":"journal-article","created":{"date-parts":[[2009,12,15]],"date-time":"2009-12-15T07:17:23Z","timestamp":1260861443000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Web-based interrogation of gene expression signatures using EXALT"],"prefix":"10.1186","volume":"10","author":[{"given":"Jun","family":"Wu","sequence":"first","affiliation":[]},{"given":"Qingchao","family":"Qiu","sequence":"additional","affiliation":[]},{"given":"Lu","family":"Xie","sequence":"additional","affiliation":[]},{"given":"Joseph","family":"Fullerton","sequence":"additional","affiliation":[]},{"given":"Jian","family":"Yu","sequence":"additional","affiliation":[]},{"given":"Yu","family":"Shyr","sequence":"additional","affiliation":[]},{"suffix":"Jr","given":"Alfred L","family":"George","sequence":"additional","affiliation":[]},{"given":"Yajun","family":"Yi","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2009,12,14]]},"reference":[{"key":"3150_CR1","doi-asserted-by":"publisher","first-page":"D562","DOI":"10.1093\/nar\/gki022","volume":"33","author":"T Barrett","year":"2005","unstructured":"Barrett T, Suzek TO, Troup DB, Wilhite SE, Ngau WC, Ledoux P, et al.: NCBI GEO: mining millions of expression profiles-database and tools. 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