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In this context, an analysis of the information is not possible without the integration of such data.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>KA-SB is a querying and analysis system for final users based on combining a data integration solution with a reasoner. Thus, the tool has been created with a process divided into two steps: 1) KOMF, the Khaos Ontology-based Mediator Framework, is used to retrieve information from heterogeneous and distributed databases; 2) the integrated information is crystallized in a (persistent and high performance) reasoner (DBOWL). This information could be further analyzed later (by means of querying and reasoning).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>In this paper we present a novel system that combines the use of a mediation system with the reasoning capabilities of a large scale reasoner to provide a way of finding new knowledge and of analyzing the integrated information from different databases, which is retrieved as a set of ontology instances. This tool uses a graphical query interface to build user queries easily, which shows a graphical representation of the ontology and allows users o build queries by clicking on the ontology concepts.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>These kinds of systems (based on KOMF) will provide users with very large amounts of information (interpreted as ontology instances once retrieved), which cannot be managed using traditional main memory-based reasoners. We propose a process for creating persistent and scalable knowledgebases from sets of OWL instances obtained by integrating heterogeneous data sources with KOMF. This process has been applied to develop a demo tool <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/khaos.uma.es\/KA-SB\" ext-link-type=\"uri\">http:\/\/khaos.uma.es\/KA-SB<\/jats:ext-link>, which uses the BioPax Level 3 ontology as the integration schema, and integrates UNIPROT, KEGG, CHEBI, BRENDA and SABIORK databases.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2105-10-s10-s5","type":"journal-article","created":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T18:14:53Z","timestamp":1254420893000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["KA-SB: from data integration to large scale reasoning"],"prefix":"10.1186","volume":"10","author":[{"given":"Mar\u00eda del Mar","family":"Rold\u00e1n-Garc\u00eda","sequence":"first","affiliation":[]},{"given":"Ismael","family":"Navas-Delgado","sequence":"additional","affiliation":[]},{"given":"Amine","family":"Kerzazi","sequence":"additional","affiliation":[]},{"given":"Othmane","family":"Chniber","sequence":"additional","affiliation":[]},{"given":"Joaqu\u00edn","family":"Molina-Castro","sequence":"additional","affiliation":[]},{"given":"Jos\u00e9 F","family":"Aldana-Montes","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2009,10,1]]},"reference":[{"key":"3373_CR1","first-page":"1","volume":"14","author":"T Risch","year":"2001","unstructured":"Risch T, Josifovski V: Distributed data integration by object-oriented mediator servers. 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