{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:24:46Z","timestamp":1761863086613},"reference-count":64,"publisher":"Springer Science and Business Media LLC","issue":"S5","license":[{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMC Bioinformatics"],"published-print":{"date-parts":[[2009,5]]},"DOI":"10.1186\/1471-2105-10-s5-s4","type":"journal-article","created":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T05:59:55Z","timestamp":1335851995000},"source":"Crossref","is-referenced-by-count":52,"title":["Inferring novel disease indications for known drugs by semantically linking drug action and disease mechanism relationships"],"prefix":"10.1186","volume":"10","author":[{"given":"Xiaoyan A","family":"Qu","sequence":"first","affiliation":[]},{"given":"Ranga C","family":"Gudivada","sequence":"additional","affiliation":[]},{"given":"Anil G","family":"Jegga","sequence":"additional","affiliation":[]},{"given":"Eric K","family":"Neumann","sequence":"additional","affiliation":[]},{"given":"Bruce J","family":"Aronow","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2009,5,6]]},"reference":[{"issue":"8","key":"3293_CR1","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1038\/nrd1468","volume":"3","author":"TT Ashburn","year":"2004","unstructured":"Ashburn TT, Thor KB: Drug repositioning: identifying and developing new uses for existing drugs. Nat Rev Drug Discov 2004, 3(8):673\u2013683.","journal-title":"Nat Rev Drug Discov"},{"issue":"1","key":"3293_CR2","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1093\/nar\/30.1.163","volume":"30","author":"M Hewett","year":"2002","unstructured":"Hewett M, Oliver DE, Rubin DL, Easton KL, Stuart JM, Altman RB, Klein TE: PharmGKB: the Pharmacogenetics Knowledge Base. Nucleic Acids Res 2002, 30(1):163\u2013165.","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"3293_CR3","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","volume":"28","author":"M Kanehisa","year":"2000","unstructured":"Kanehisa M, Goto S: KEGG: kyoto encyclopedia of genes and genomes. Nucleic Acids Res 2000, 28(1):27\u201330.","journal-title":"Nucleic Acids Res"},{"key":"3293_CR4","first-page":"D668","volume-title":"Nucleic Acids Res","author":"DS Wishart","year":"2006","unstructured":"Wishart DS, Knox C, Guo AC, Shrivastava S, Hassanali M, Stothard P, Chang Z, Woolsey J: DrugBank: a comprehensive resource for in silico drug discovery and exploration. Nucleic Acids Res 2006, (34 Database):D668-D672."},{"issue":"5795","key":"3293_CR5","doi-asserted-by":"publisher","first-page":"1929","DOI":"10.1126\/science.1132939","volume":"313","author":"J Lamb","year":"2006","unstructured":"Lamb J, Crawford ED, Peck D, Modell JW, Blat IC, Wrobel MJ, Lerner J, Brunet JP, Subramanian A, Ross KN, Reich M, Hieronymus H, Wei G, Armstrong SA, Haggarty SJ, Clemons PA, Wei R, Carr SA, Lander ES, Golub TR: The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease. Science 2006, 313(5795):1929\u20131935.","journal-title":"Science"},{"key":"3293_CR6","first-page":"29","volume-title":"Scientific American","author":"T Berners-Liee","year":"2001","unstructured":"Berners-Liee T, Hendler J, Lassila O: The Semantic Web. Scientific American 2001, (284):29\u201337."},{"key":"3293_CR7","doi-asserted-by":"publisher","first-page":"D267","DOI":"10.1093\/nar\/gkh061","volume":"32","author":"O Bodenreider","year":"2004","unstructured":"Bodenreider O: The Unified Medical Language System (UMLS): integrating biomedical terminology. Nucleic Acids Res 2004, 32: D267-D270.","journal-title":"Nucleic Acids Res"},{"key":"3293_CR8","first-page":"351","volume-title":"AMIA Annu Symp Proc","author":"V Kashyap","year":"2003","unstructured":"Kashyap V: The UMLS Semantic Network and the Semantic Web. AMIA Annu Symp Proc 2003, 351\u2013355."},{"issue":"1","key":"3293_CR9","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1136\/jamia.2000.0070066","volume":"7","author":"H Gu","year":"2000","unstructured":"Gu H, Perl Y, Geller J, Halper M, Liu LM, Cimino J: Representing the UMLS as an object-oriented database: modeling issues and advantages. J Am Med Inform Assoc 2000, 7(1):66\u201380.","journal-title":"J Am Med Inform Assoc"},{"key":"3293_CR10","unstructured":"Medical Subject Headings[\n                    http:\/\/www.nlm.nih.gov\/mesh\/\n                    \n                  ]"},{"issue":"Pt 1","key":"3293_CR11","first-page":"33","volume":"107","author":"S de Coronado","year":"2004","unstructured":"de Coronado S, Haber MW, Sioutos N, Tuttle MS, Wright LW: NCI Thesaurus: using science-based terminology to integrate cancer research results. Stud Health Technol Inform. 2004, 107(Pt 1):33\u201337.","journal-title":"Stud Health Technol Inform"},{"key":"3293_CR12","unstructured":"The Anatomical Therapeutic Chemical Classification System[\n                    http:\/\/www.whocc.no\/atcddd\/\n                    \n                  ]"},{"key":"3293_CR13","unstructured":"Common Terminology Criteria for Adverse Events[\n                    http:\/\/ctep.cancer.gov\/reporting\/ctc.html\n                    \n                  ]"},{"issue":"1","key":"3293_CR14","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/75556","volume":"25","author":"M Ashburner","year":"2000","unstructured":"Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, Harris MA, Hill DP, Issel-Tarver L, Kasarskis A, Lewis S, Matese JC, Richardson JE, Ringwald M, Rubin GM, Sherlock G: Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat Genet 2000, 25(1):25\u201329.","journal-title":"Nat Genet"},{"key":"3293_CR15","first-page":"662","volume-title":"Proc AMIA Symp","author":"MQ Stearns","year":"2001","unstructured":"Stearns MQ, Price C, Spackman KA, Wang AY: SNOMED clinical terms: overview of the development process and project status. Proc AMIA Symp 2001, 662\u2013666."},{"key":"3293_CR16","unstructured":"ORACLE Spatial Database[\n                    http:\/\/www.oracle.com\/technology\/tech\/semantic_technologies\n                    \n                  ]"},{"key":"3293_CR17","doi-asserted-by":"publisher","first-page":"D514","DOI":"10.1093\/nar\/gki033","volume":"33","author":"A Hamosh","year":"2005","unstructured":"Hamosh A, Scott A, Amberger J, Bocchini C, McKusick V: Online Mendelian Inheritance in Man (OMIM), a knowledgebase of human genes and genetic disorders. Nucleic Acids Res 2005, 33: D514-D517.","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"3293_CR18","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1093\/nar\/gkg056","volume":"31","author":"GD Bader","year":"2003","unstructured":"Bader GD, Betel D, Hogue CW: BIND: the biomolecular interaction network database. Nucleic Acids Res 2003, 31(1):248\u2013250.","journal-title":"Nucleic Acids Res"},{"key":"3293_CR19","first-page":"D535","volume-title":"Nucleic Acids Res","author":"C Stark","year":"2006","unstructured":"Stark C, Breitkreutz BJ, Reguly T, Boucher L, Breitkreutz A, Tyers M: BioGRID: a general repository for interaction datasets. Nucleic Acids Res 2006, (34 Database):D535-D539."},{"key":"3293_CR20","first-page":"D497","volume-title":"Nucleic Acids Res","author":"S Peri","year":"2004","unstructured":"Peri S, Navarro JD, Kristiansen TZ, Amanchy R, Surendranath V, Muthusamy B, Gandhi TK, Chandrika KN, Deshpande N, Suresh S, Rashmi BP, Shanker K, Padma N, Niranjan V, Harsha HC, Talreja N, Vrushabendra BM, Ramya MA, Yatish AJ, Joy M, Shivashankar HN, Kavitha MP, Menezes M, Choudhury DR, Ghosh N, Saravana R, Chandran S, Mohan S, Jonnalagadda CK, Prasad CK, Kumar-Sinha C, Deshpande KS, Pandey A: Human protein reference database as a discovery resource for proteomics. Nucleic Acids Res 2004, (32 Database):D497-D501."},{"key":"3293_CR21","unstructured":"BioCarta[\n                    http:\/\/www.biocarta.com\n                    \n                  ]"},{"issue":"19","key":"3293_CR22","doi-asserted-by":"publisher","first-page":"6083","DOI":"10.1093\/nar\/gki892","volume":"33","author":"PD Karp","year":"2005","unstructured":"Karp PD, Ouzounis CA, Moore-Kochlacs C, Goldovsky L, Kaipa P, Ahren D, Tsoka S, Darzentas N, Kunin V, Lopez-Bigas N: Expansion of the BioCyc collection of pathway\/genome databases to 160 genomes. Nucleic Acids Res 2005, 33(19):6083\u20136089.","journal-title":"Nucleic Acids Res"},{"key":"3293_CR23","first-page":"D428","volume-title":"Nucleic Acids Res","author":"G Joshi-Tope","year":"2005","unstructured":"Joshi-Tope G, Gillespie M, Vastrik I, D'Eustachio P, Schmidt E, de Bono B, Jassal B, Gopinath GR, Wu GR, Matthews L, Lewis S, Birney E, Stein L: Reactome: a knowledgebase of biological pathways. Nucleic Acids Res 2005, (33 Database):D428-D432."},{"key":"3293_CR24","first-page":"215","volume-title":"Soc Networks","author":"LC Freeman","year":"1979","unstructured":"Freeman LC: Centrality in Social Networks: conceptual clarification. Soc Networks 1979, (1):215\u2013239."},{"issue":"4","key":"3293_CR25","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1136\/ard.62.4.341","volume":"62","author":"ZM Sthoeger","year":"2003","unstructured":"Sthoeger ZM, Zinger H, Mozes E: Beneficial effects of the anti-oestrogen tamoxifen on systemic lupus erythematosus of (NZBxNZW)F1 female mice are associated with specific reduction of IgG3 autoantibodies. Ann Rheum Dis 2003, 62(4):341\u2013346.","journal-title":"Ann Rheum Dis"},{"key":"3293_CR26","first-page":"67","volume":"305","author":"JF Cohen-Solal","year":"2006","unstructured":"Cohen-Solal JF, Jeganathan V, Grimaldi CM, Peeva E, Diamond B: Sex hormones and SLE: influencing the fate of autoreactive B cells. Curr Top Microbiol Immunol 2006, 305: 67\u201388.","journal-title":"Curr Top Microbiol Immunol"},{"issue":"5","key":"3293_CR27","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.biopha.2004.04.007","volume":"58","author":"E Peeva","year":"2004","unstructured":"Peeva E, Venkatesh J, Michael D, Diamond B: Prolactin as a modulator of B cell function: implications for SLE. Biomed Pharmacother 2004, 58(5):310\u2013319.","journal-title":"Biomed Pharmacother"},{"key":"3293_CR28","volume-title":"Springer","author":"U Brandes","year":"2005","unstructured":"Brandes U, Erlebach T: Network Analysis: Methodological Foundations. Springer 2005."},{"issue":"4","key":"3293_CR29","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1096\/fj.07-8652com","volume":"22","author":"I Mascanfroni","year":"2008","unstructured":"Mascanfroni I, Montesinos Mdel M, Susperreguy S, Cervi L, Ilarregui JM, Ramseyer VD, Masini-Repiso AM, Targovnik HM, Rabinovich GA, Pellizas CG: Control of dendritic cell maturation and function by triiodothyronine. FASEB J 2008, 22(4):1032\u20131042.","journal-title":"FASEB J"},{"issue":"6","key":"3293_CR30","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1177\/0961203307087982","volume":"17","author":"S Gorjestani","year":"2008","unstructured":"Gorjestani S, Rider V, Kimler BF, Greenwell C, Abdou NI: Extracellular signal-regulated kinase 1\/2 signalling in SLE T cells is influenced by oestrogen and disease activity. Lupus 2008, 17(6):548\u2013554.","journal-title":"Lupus"},{"issue":"2","key":"3293_CR31","doi-asserted-by":"publisher","first-page":"727","DOI":"10.4049\/jimmunol.180.2.727","volume":"180","author":"E Carreras","year":"2008","unstructured":"Carreras E, Turner S, Paharkova-Vatchkova V, Mao A, Dascher C, Kovats S: Estradiol acts directly on bone marrow myeloid progenitors to differentially regulate GM-CSF or Flt3 ligand-mediated dendritic cell differentiation. J Immunol 2008, 180(2):727\u2013738.","journal-title":"J Immunol"},{"issue":"2","key":"3293_CR32","doi-asserted-by":"publisher","first-page":"L585","DOI":"10.1152\/ajplung.00364.2006","volume":"292","author":"M Frink","year":"2007","unstructured":"Frink M, Thobe BM, Hsieh YC, Choudhry MA, Schwacha MG, Bland KI, Chaudry IH: 17beta-Estradiol inhibits keratinocyte-derived chemokine production following trauma-hemorrhage. Am J Physiol Lung Cell Mol Physiol 2007, 292(2):L585-L591.","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"2","key":"3293_CR33","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1006\/clin.1998.4604","volume":"89","author":"V Rider","year":"1998","unstructured":"Rider V, Foster RT, Evans M, Suenaga R, Abdou NI: Gender differences in autoimmune diseases: estrogen increases calcineurin expression in systemic lupus erythematosus. Clin Immunol Immunopathol 1998, 89(2):171\u2013180.","journal-title":"Clin Immunol Immunopathol"},{"issue":"6","key":"3293_CR34","first-page":"1093","volume":"33","author":"V Rider","year":"2006","unstructured":"Rider V, Li X, Peterson G, Dawson J, Kimler BF, Abdou NI: Differential expression of estrogen receptors in women with systemic lupus erythematosus. J Rheumatol 2006, 33(6):1093\u20131101.","journal-title":"J Rheumatol"},{"issue":"3","key":"3293_CR35","first-page":"531","volume":"121","author":"S Ansar Ahmed","year":"1985","unstructured":"Ansar Ahmed S, Penhale WJ, Talal N: Sex hormones, immune responses, and autoimmune diseases. Mechanisms of sex hormone action. Am J Pathol 1985, 121(3):531\u2013551.","journal-title":"Am J Pathol"},{"issue":"3","key":"3293_CR36","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1002\/art.1780300301","volume":"30","author":"RG Lahita","year":"1987","unstructured":"Lahita RG, Bradlow HL, Ginzler E, Pang S, New M: Low plasma androgens in women with systemic lupus erythematosus. Arthritis Rheum 1987, 30(3):241\u2013248.","journal-title":"Arthritis Rheum"},{"key":"3293_CR37","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1136\/ard.2003.014274","volume":"63","author":"RH Straub","year":"2004","unstructured":"Straub RH, Weidler C, Demmel B: Renal clearance and daily excretion of cortisol and adrenal androgens in patients with rheumatoid arthritis and systemic lupus erythematosus. Ann Rheum Dis 2004, 63: 961\u20138.","journal-title":"Ann Rheum Dis"},{"issue":"5","key":"3293_CR38","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1097\/00002281-199709000-00006","volume":"9","author":"V Strand","year":"1997","unstructured":"Strand V: Approaches to the management of systemic lupus erythematosus. Curr Opin Rheumatol 1997, 9(5):410\u2013420.","journal-title":"Curr Opin Rheumatol"},{"issue":"10","key":"3293_CR39","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.1007\/s10067-007-0568-3","volume":"26","author":"A Inui","year":"2007","unstructured":"Inui A, Ogasawara H, Naito T, Sekigawa I, Takasaki Y, Hayashida Y, Takamori K, Ogawa H: Estrogen receptor expression by peripheral blood mononuclear cells of patients with systemic lupus erythematosus. Clin Rheumatol 2007, 26(10):1675\u20131678.","journal-title":"Clin Rheumatol"},{"issue":"6","key":"3293_CR40","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1016\/0022-4731(84)90027-X","volume":"21","author":"JD Albert","year":"1984","unstructured":"Albert JD, Geller J, Liu JD, Faber LE: Tamoxifen decreases progesterone and nuclear androgen receptors in the human prostate. J Steroid Biochem 1984, 21(6):659\u2013662.","journal-title":"J Steroid Biochem"},{"issue":"Suppl 1","key":"3293_CR41","doi-asserted-by":"publisher","first-page":"i85","DOI":"10.1093\/bioinformatics\/bti1026","volume":"21","author":"KH Cheung","year":"2005","unstructured":"Cheung KH, Yip KY, Smith A, Deknikker R, Masiar A, Gerstein M: YeastHub: a semantic web use case for integrating data in the life sciences domain. Bioinformatics 2005, 21(Suppl 1):i85-i96.","journal-title":"Bioinformatics"},{"key":"3293_CR42","first-page":"1063","volume-title":"The Semantic Web-ISWC2005","author":"A Shaban-Nejad","year":"2005","unstructured":"Shaban-Nejad A, Baker C, Haarslev V, Buter G: The FungalWeb Ontology: semantic web challenges in bioinformatics and genomics. The Semantic Web-ISWC2005 2005, (3729):1063\u20131066."},{"issue":"Pt 2","key":"3293_CR43","first-page":"1260","volume":"129","author":"SS Sahoo","year":"2007","unstructured":"Sahoo SS, Zeng K, Bodenreider O, Sheth A: From \"glycosyltransferase\" to \"congenital muscular dystrophy\": integrating knowledge from NCBI Entrez Gene and the Gene Ontology. Stud Health Technol Inform 2007, 129(Pt 2):1260\u20131264.","journal-title":"Stud Health Technol Inform"},{"key":"3293_CR44","volume-title":"Proceedings of WWW","author":"S Satya","year":"2007","unstructured":"Satya S, Sahoo OB, Zeng K, Sheth A: An experiment in integrating large biomedical knowledge resources with RDF: Application to associating genotype and phenotype information. Proceedings of WWW 2007."},{"issue":"3","key":"3293_CR45","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.websem.2006.05.004","volume":"4","author":"S Stephens","year":"2006","unstructured":"Stephens S, Lavigna D, Dilascio M, Luciano J: Aggregation of Bioinformatics Data Using Semantic Web Technology. J Web Semantic 2006, 4(3):216\u2013221.","journal-title":"J Web Semantic"},{"key":"3293_CR46","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1196\/annals.1386.045","volume":"1089","author":"PL Harkonen","year":"2006","unstructured":"Harkonen PL, Vaananen HK: Monocyte-macrophage system as a target for estrogen and selective estrogen receptor modulators. Ann N Y Acad Sci 2006, 1089: 218\u2013227.","journal-title":"Ann N Y Acad Sci"},{"issue":"5","key":"3293_CR47","first-page":"797","volume":"35","author":"NI Abdou","year":"2008","unstructured":"Abdou NI, Rider V, Greenwell C, Li X, Kimler BF: Fulvestrant (Faslodex), an estrogen selective receptor downregulator, in therapy of women with systemic lupus erythematosus. clinical, serologic, bone density, and T cell activation marker studies: a double-blind placebo-controlled trial. J Rheumatol 2008, 35(5):797.","journal-title":"J Rheumatol"},{"issue":"2\u20133","key":"3293_CR48","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.tox.2003.09.012","volume":"195","author":"K Yamasaki","year":"2004","unstructured":"Yamasaki K, Sawaki M, Noda S, Muroi T, Takakura S, Mitoma H, Sakamoto S, Nakai M, Yakabe Y: Comparison of the Hershberger assay and androgen receptor binding assay of twelve chemicals. Toxicology 2004, 195(2\u20133):177\u2013186.","journal-title":"Toxicology"},{"issue":"4","key":"3293_CR49","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1016\/0277-5379(91)90385-Q","volume":"27","author":"G Leo","year":"1991","unstructured":"Leo G, Cappiello G, Poltronieri P, Giardina C, Manca C, Storelli C, Marsigliante S: Tamoxifen binding sites heterogeneity in breast cancer: a comparative study with steroid hormone receptors. Eur J Cancer 1991, 27(4):452\u2013456.","journal-title":"Eur J Cancer"},{"issue":"6","key":"3293_CR50","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1007\/s00240-004-0424-8","volume":"32","author":"H Kawashima","year":"2004","unstructured":"Kawashima H, Tanaka T, Cheng JS, Sugita S, Ezaki K, Kurisu T, Nakatani T: Effect of anti-estrogens on the androgen receptor activity and cell proliferation in prostate cancer cells. Urol Res 2004, 32(6):406\u2013410.","journal-title":"Urol Res"},{"issue":"12","key":"3293_CR51","doi-asserted-by":"publisher","first-page":"1725","DOI":"10.1096\/fj.99-0863com","volume":"14","author":"J Zhou","year":"2000","unstructured":"Zhou J, Ng S, Adesanya-Famuiya O, Anderson K, Bondy CA: Testosterone inhibits estrogen-induced mammary epithelial proliferation and suppresses estrogen receptor expression. FASEB J 2000, 14(12):1725\u20131730.","journal-title":"FASEB J"},{"issue":"5","key":"3293_CR52","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1016\/j.jbi.2008.03.004","volume":"41","author":"F Belleau","year":"2008","unstructured":"Belleau F, Nolin MA, Tourigny N, Rigault P, Morissette J: Bio2RDF: Towards a mashup to build bioinformatics knowledge systems. J Biomed Inform 2008, 41(5):706\u2013716.","journal-title":"J Biomed Inform"},{"key":"3293_CR53","volume-title":"The PageRank citation ranking: bringing order to the web","author":"L Page","year":"1999","unstructured":"Page L, Brin S, Motwani R, Winograd T: The PageRank citation ranking: bringing order to the web. Stanford University InfoLab, SIDL-WP-1999\u20130120; 1999."},{"issue":"5","key":"3293_CR54","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1016\/j.jbi.2008.07.004","volume":"41","author":"RC Gudivada","year":"2008","unstructured":"Gudivada RC, Qu XA, Chen J, Jegga AG, Neumann EK, Aronow BJ: Identifying disease-causal genes using Semantic Web-based representation of integrated genomic and phenomic knowledge. J Biomed Inform 2008, 41(5):717\u2013729.","journal-title":"J Biomed Inform"},{"key":"3293_CR55","volume-title":"Workshop on Healthcare and Life Sciences. BANFF: Proceedings of the WWW","author":"R Gudivada","year":"2007","unstructured":"Gudivada R, Qu AX, Jegga AG, Neumann EK, Aronow BJ: A genome \u2013 phenome integrated approach for mining disease genes using Semantic Web. Workshop on Healthcare and Life Sciences. BANFF: Proceedings of the WWW 2007."},{"key":"3293_CR56","volume-title":"Workshop on Healthcare and Life Sciences. BANFF: Proceedings of the WWW","author":"K Anyanwu","year":"2007","unstructured":"Anyanwu K, Maduko A, Sheth A: SPARQ2L: Towards support for subgraph extraction queries in RDF databases. Workshop on Healthcare and Life Sciences. BANFF: Proceedings of the WWW 2007."},{"key":"3293_CR57","first-page":"131","volume-title":"Proceedings of 2007 IEEE Bioinformatics and Biomedicine","author":"AX Qu","year":"2007","unstructured":"Qu AX, Gudivada R, Jegga A, Neumann E, Aronow B: Semantic Web-based data representation and reasoning applied to disease mechanism and pharmacology. Proceedings of 2007 IEEE Bioinformatics and Biomedicine 2007, 131\u2013143."},{"key":"3293_CR58","first-page":"953","volume-title":"AMIA Annu Symp Proc","author":"NF Noy","year":"2003","unstructured":"Noy NF, Crubezy M, Fergerson RW, Knublauch H, Tu SW, Vendetti J, Musen MA: Protege-2000: an open-source ontology-development and knowledge-acquisition environment. AMIA Annu Symp Proc 2003, 953."},{"key":"3293_CR59","unstructured":"PromptViz[\n                    http:\/\/www.thechiselgroup.org\/promptviz\n                    \n                  ]"},{"key":"3293_CR60","volume-title":"Springer","author":"P Chapman","year":"2000","unstructured":"Chapman P, Clinton J, Kerber R, Khabaza T, Reinartz T, Shearer C, Wirth R: CRISP-DM 1.0 step-by-step data mining guide. Springer 2000."},{"key":"3293_CR61","volume-title":"Ontology development 101: a guide to creating your first ontology. SMI-2001-0880","author":"NF Noy","year":"2001","unstructured":"Noy NF, McKusick VA: Ontology development 101: a guide to creating your first ontology. SMI-2001\u20130880. 2001."},{"key":"3293_CR62","first-page":"91","volume":"18","author":"V Haarslev","year":"2003","unstructured":"Haarslev V, Moller R: Racer: An OWL reasoning agent for the Semantic Web. Proceedings of the International Workshop on Applications, Products, and Services of Web-based Support Systems 2003, 18: 91\u201395.","journal-title":"Proceedings of the International Workshop on Applications, Products, and Services of Web-based Support Systems"},{"key":"3293_CR63","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511806452","volume-title":"Exploratory social network analysis with Pajek","author":"W Nooy","year":"2005","unstructured":"Nooy W, Mrvar A, Batagelj V: Exploratory social network analysis with Pajek. Cambridge University Press; 2005."},{"key":"3293_CR64","doi-asserted-by":"publisher","first-page":"35","DOI":"10.2307\/3033543","volume":"40","author":"LC Freeman","year":"1977","unstructured":"Freeman LC: A set of measures of centrality based on betweenness. Sociometry 1977, 40: 35\u201341.","journal-title":"Sociometry"}],"container-title":["BMC Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2105-10-S5-S4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-2105-10-S5-S4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2105-10-S5-S4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T05:35:45Z","timestamp":1548135345000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcbioinformatics.biomedcentral.com\/articles\/10.1186\/1471-2105-10-S5-S4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5]]},"references-count":64,"journal-issue":{"issue":"S5","published-print":{"date-parts":[[2009,5]]}},"alternative-id":["3293"],"URL":"https:\/\/doi.org\/10.1186\/1471-2105-10-s5-s4","relation":{},"ISSN":["1471-2105"],"issn-type":[{"value":"1471-2105","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,5]]},"article-number":"S4"}}