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More specifically, there is so far no sensitive and untargeted method to identify gene modules (also known as gene sets or clusters) that are differentially coexpressed between two conditions. Here, sensitive and untargeted means that the method should be able to construct<jats:italic>de novo<\/jats:italic>modules by grouping genes based on shared, but subtle, differential correlation patterns.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We present DiffCoEx, a novel method for identifying correlation pattern changes, which builds on the commonly used Weighted Gene Coexpression Network Analysis (WGCNA) framework for coexpression analysis. We demonstrate its usefulness by identifying biologically relevant, differentially coexpressed modules in a rat cancer dataset.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>DiffCoEx is a simple and sensitive method to identify gene coexpression differences between multiple conditions.<\/jats:p><\/jats:sec>","DOI":"10.1186\/1471-2105-11-497","type":"journal-article","created":{"date-parts":[[2010,10,6]],"date-time":"2010-10-06T18:14:26Z","timestamp":1286388866000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":216,"title":["DiffCoEx: a simple and sensitive method to find differentially coexpressed gene modules"],"prefix":"10.1186","volume":"11","author":[{"given":"Bruno M","family":"Tesson","sequence":"first","affiliation":[]},{"given":"Rainer","family":"Breitling","sequence":"additional","affiliation":[]},{"given":"Ritsert C","family":"Jansen","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2010,10,6]]},"reference":[{"issue":"5389","key":"4080_CR1","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1126\/science.282.5389.699","volume":"282","author":"S Chu","year":"1998","unstructured":"Chu S, DeRisi J, Eisen M, Mulholland J, Botstein D, Brown PO, Herskowitz I: The Transcriptional Program of Sporulation in Budding Yeast. 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