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However, when primary models are applied to bacterial growth curves, the biological variability is reduced to a single curve defined by some kinetic parameters (lag time and growth rate), and sometimes the models give poor fits in some regions of the curve. The development of a prediction band (from a set of bacterial growth curves) using non-parametric and bootstrap methods permits to overcome that problem and include the biological variability of the microorganism into the modelling process.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Absorbance data from<jats:italic>Listeria monocytogenes<\/jats:italic>cultured at 22, 26, 38, and 42\u00b0C were selected under different environmental conditions of pH (4.5, 5.5, 6.5, and 7.4) and percentage of NaCl (2.5, 3.5, 4.5, and 5.5). Transformation of absorbance data to viable count data was carried out. A random effect multiplicative heteroscedastic model was considered to explain the dynamics of bacterial growth. The concept of a prediction band for microbial growth is proposed. The bootstrap method was used to obtain resamples from this model. An iterative procedure is proposed to overcome the computer intensive task of calculating simultaneous prediction intervals, along time, for bacterial growth. The bands were narrower below the inflection point (0-8 h at 22\u00b0C, and 0-5.5 h at 42\u00b0C), and wider to the right of it (from 9 h onwards at 22\u00b0C, and from 7 h onwards at 42\u00b0C). A wider band was observed at 42\u00b0C than at 22\u00b0C when the curves reach their upper asymptote. Similar bands have been obtained for 26 and 38\u00b0C.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The combination of nonparametric models and bootstrap techniques results in a good procedure to obtain reliable prediction bands in this context. Moreover, the new iterative algorithm proposed in this paper allows one to achieve exactly the prefixed coverage probability for the prediction band. The microbial growth bands reflect the influence of the different environmental conditions on the microorganism behaviour, helping in the interpretation of the biological meaning of the growth curves obtained experimentally.<\/jats:p><\/jats:sec>","DOI":"10.1186\/1471-2105-11-77","type":"journal-article","created":{"date-parts":[[2010,2,9]],"date-time":"2010-02-09T07:15:17Z","timestamp":1265699717000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["A random effect multiplicative heteroscedastic model for bacterial growth"],"prefix":"10.1186","volume":"11","author":[{"given":"Ricardo","family":"Cao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Francisco-Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emiliano J","family":"Quinto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,2,8]]},"reference":[{"key":"3534_CR1","volume-title":"Modeling microbial responses in food","author":"RC McKellar","year":"2004","unstructured":"McKellar RC, Lu X: Modeling microbial responses in food. 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