{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:08:15Z","timestamp":1761512895501},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"S9","license":[{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMC Bioinformatics"],"published-print":{"date-parts":[[2010,10]]},"DOI":"10.1186\/1471-2105-11-s9-s10","type":"journal-article","created":{"date-parts":[[2010,10,28]],"date-time":"2010-10-28T18:15:23Z","timestamp":1288289723000},"source":"Crossref","is-referenced-by-count":34,"title":["Feasibility of incorporating genomic knowledge into electronic medical records for pharmacogenomic clinical decision support"],"prefix":"10.1186","volume":"11","author":[{"given":"Casey Lynnette","family":"Overby","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Tarczy-Hornoch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James I","family":"Hoath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ira J","family":"Kalet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David L","family":"Veenstra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,10,28]]},"reference":[{"key":"4272_CR1","volume-title":"Priorities for Personalized Medicine","author":"President\u2019s Council of Advisors on Science and Technology","year":"2008","unstructured":"President\u2019s Council of Advisors on Science and Technology: Priorities for Personalized Medicine.2008. [\n                    http:\/\/www.ostp.gov\/galleries\/PCAST\/pcast_report_v2.pdf\n                    \n                  ] Available September. See"},{"key":"4272_CR2","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1146\/annurev.med.60.103007.132540","volume":"60","author":"SWJ Lamberts","year":"2009","unstructured":"Lamberts SWJ, Uitterlinden AG: Genetic Testing in Clinical Practice. Annu Rev Med 2009, 60: 431\u2013432. 10.1146\/annurev.med.60.103007.132540","journal-title":"Annu Rev Med"},{"issue":"1","key":"4272_CR3","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1197\/jamia.M2746","volume":"16","author":"SA Collins","year":"2009","unstructured":"Collins SA, Currie LM, Bakken S, Cimino JJ: Information Needs, Infobutton Manager Use, and Satisfaction by Clinician Type: A Case Study. J Am Med Inform Assoc. 2009, 16(1):140. 10.1197\/jamia.M2746","journal-title":"J Am Med Inform Assoc"},{"key":"4272_CR4","first-page":"809","volume-title":"Proc AMIA Annu Fall Symp","author":"P Tarczy-Hornoch","year":"1997","unstructured":"Tarczy-Hornoch P, Kwan-Gett TS, Fouche L, Hoath J, Fuller S, Ibrahim KN, Ketchell DS, LoGerfo JP, Goldberg HI: Meeting clinician information needs by integrating access to the medical record and knowledge resources via the Web. Proc AMIA Annu Fall Symp. 1997, 809\u2013813."},{"issue":"4","key":"4272_CR5","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1080\/03602530802413338","volume":"40","author":"K Sangkuhl","year":"2008","unstructured":"Sangkuhl K, Berlin DS, Altman RB, Klein TE: PharmGKB: Understanding the effects of individual genetic variants. Drug Metab Rev. 2008, 40(4):539\u2013551. 10.1080\/03602530802413338","journal-title":"Drug Metab Rev"},{"key":"4272_CR6","unstructured":"US Food and Drug Administration: Table of valid genomic biomarkers in the context of approved drug labels.[\n                    http:\/\/www.fda.gov\/Drugs\/ScienceResearch\/ResearchAreas\/Pharmacogenetics\/ucm083378.htm\n                    \n                  ] Available at:"},{"issue":"1","key":"4272_CR7","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1038\/sj.clpt.6100048","volume":"81","author":"AE Hodge","year":"2007","unstructured":"Hodge AE, Altman RB, Klein TE: The PharmGKB: integration, aggregation, and annotation of pharmacogenomic data and knowledge. Clin. Pharmacol. Ther. 2007, 81(1):21\u201324. 10.1038\/sj.clpt.6100048","journal-title":"Clin. Pharmacol. Ther"},{"key":"4272_CR8","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1038\/sj.tpj.6500284","volume":"4","author":"I Zineh","year":"2004","unstructured":"Zineh I, Gerhard T, Aquilante CL, Beitelshees AL, Beasley BN, Hartzema AG: Availability of pharmacogenomics-based prescribing information in drug package inserts for currently approved drugs. Pharmacogenomics J 2004, 4: 354\u2013358. 10.1038\/sj.tpj.6500284","journal-title":"Pharmacogenomics J"},{"key":"4272_CR9","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1345\/aph.1G464","volume":"40","author":"I Zineh","year":"2006","unstructured":"Zineh I, Pebanco GD, Aquilante CL, Gerhard T, Beitelshees AL, Beasley BN, Hartzema AG: Discordance between availability of pharmacogenetics studies and pharmacogenetics-based prescribing information for the top 200 drugs. Ann Pharmacother. 2006, 40: 639\u2013644. 10.1345\/aph.1G464","journal-title":"Ann Pharmacother"},{"key":"4272_CR10","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1592\/phco.28.8.992","volume":"28","author":"FW Frueh","year":"2008","unstructured":"Frueh FW, Amur S, Mummaneni P, Epstein RS, Aubert RE, DeLuca TM, Verbrugge RR, Burckart GJ, Lesko LJ: Pharmacogenomic biomarker information in drug labels approved by the United States food and drug administration: prevalence of related drug use. Pharmacotherapy 2008, 28: 992\u2013998. 10.1592\/phco.28.8.992","journal-title":"Pharmacotherapy"},{"key":"4272_CR11","unstructured":"DailyMed Web site [database on the Internet]. Bethesda (MD): National Library of Medicine (US)2006. [\n                    http:\/\/dailymed.nlm.nih.gov\/\n                    \n                  ] Available at:"},{"key":"4272_CR12","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1097\/GIM.0b013e318184137c","volume":"11","author":"SM Teutsch","year":"2009","unstructured":"Teutsch SM, Bradley LA, Palomaki GE, Haddow JE, Piper M, Calonge N, Dotson WD, Douglas MP, Berg AO: The Evaluation of Genomic Applications in Practice and Prevention (EGAPP) initiative: methods of the EGAPP Working Group. Genet Med. 2009, 11: 3\u201314. 10.1097\/GIM.0b013e318184137c","journal-title":"Genet Med"},{"key":"4272_CR13","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1016\/j.jbi.2009.05.001","volume":"42","author":"R Boyce","year":"2009","unstructured":"Boyce R, Collins C, Horn J, Kalet I: Computing with evidence part I: A drug-mechanism evidence taxonomy oriented toward con\u00ef\u00ac\u2122dence assignment. J Biomed Inform. 2009, 42: 979\u2013989. 10.1016\/j.jbi.2009.05.001","journal-title":"J Biomed Inform"},{"key":"4272_CR14","first-page":"307","volume-title":"AMIA Annu Symp Proc","author":"K Kawamoto","year":"2009","unstructured":"Kawamoto K, Orlando LA, Voora D, Lobach DF, Joy S, Cho A, Ginsburg GS: Evaluation of the PharmGKB Knowledge base as a resource for efficiently assessing the clinical validity and utility of pharmacogenetic assays. AMIA Annu Symp Proc. 2009, 307\u2013311."},{"key":"4272_CR15","doi-asserted-by":"publisher","first-page":"2091","DOI":"10.1200\/JCO.2009.21.9170","volume":"27","author":"CJ Allegra","year":"2009","unstructured":"Allegra CJ, Jessup JM, Somerfield MR, Hamilton SR, Hammond EH, Hayes DF, McAllister PK, Morton RF, Schilsky RL: American Society of Clinical Oncology Provisional Clinical Opinion: Testing for KRAS Gene Mutations in Patients With Metastatic Colorectal Carcinoma to Predict Response to Anti-Epidermal Growth Factor Receptor Monoclonal Antibody Therapy. J Clin Oncol 2009, 27: 2091\u20132096. 0: JCO.2009.21.9170 0: JCO.2009.21.9170 10.1200\/JCO.2009.21.9170","journal-title":"J Clin Oncol"},{"key":"4272_CR16","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1002\/humu.10069","volume":"19","author":"RA Pagon","year":"2002","unstructured":"Pagon RA, Tarczy-Hornoch P, Baskin PK, Edwards JE, Covington ML, Espeseth M, Beahler C, Bird TD, Popovich B, Nesbitt C, Dolan C, Marymee K, Hanson NB, Neufeld-Kaiser W, Grohs GM, Kicklighter T, Abair C, Malmin A, Barclay M, Palepu RD: GeneTests-GeneClinics: genetic testing information for a growing audience. Hum Mutat. 2002, 19: 501\u2013509. 10.1002\/humu.10069","journal-title":"Hum Mutat"},{"issue":"3","key":"4272_CR17","doi-asserted-by":"publisher","first-page":"282","DOI":"10.3414\/ME0570","volume":"48","author":"V Deshmukh","year":"2009","unstructured":"Deshmukh V, Hoffman M, Arnoldi C, Bray B, Mitchell J: Efficiency of CYP2C9 Genetic Test Representation for Automated Pharmacogenetic Decision Support. Methods Inf Med. 2009, 48(3):282\u201390.","journal-title":"Methods Inf Med"},{"issue":"6","key":"4272_CR18","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1197\/jamia.M2377","volume":"14","author":"W Hollingworth","year":"2007","unstructured":"Hollingworth W, Devine EB, Hansen RN, Lawless NM, Comstock BA, Wilson-Norton JL, Tharp KL, Sullivan SD: The Impact of e-Prescribing on Prescriber and Staff Time in Ambulatory Care Clinics: A Time\u2013Motion Study. Journal of the American Medical Informatics Association 2007, 14(6):722\u2013730. 10.1197\/jamia.M2377","journal-title":"Journal of the American Medical Informatics Association"},{"issue":"2","key":"4272_CR19","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1197\/jamia.M1809","volume":"13","author":"H van der Sijs","year":"2006","unstructured":"van der Sijs H, Aarts J, Vulto A, Berg M: Overriding of drug safety alerts in computerized physician order entry. J Am Med Inform Assoc 2006, 13(2):138\u201314. 10.1197\/jamia.M1809","journal-title":"J Am Med Inform Assoc"},{"issue":"21","key":"4272_CR20","doi-asserted-by":"publisher","first-page":"2625","DOI":"10.1001\/archinte.163.21.2625","volume":"163","author":"SN Weingart","year":"2003","unstructured":"Weingart SN, Toth M, Sands DZ, Aronson MD, Davis RB, Phillips RS: Physicians\u2019 decisions to override computerized drug alerts in primary care. Arch Intern Med. 2003, 163(21):2625\u20132631. 10.1001\/archinte.163.21.2625","journal-title":"Arch Intern Med"}],"container-title":["BMC Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2105-11-S9-S10.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-2105-11-S9-S10\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2105-11-S9-S10.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,23]],"date-time":"2019-01-23T07:45:37Z","timestamp":1548229537000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcbioinformatics.biomedcentral.com\/articles\/10.1186\/1471-2105-11-S9-S10"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10]]},"references-count":20,"journal-issue":{"issue":"S9","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["4272"],"URL":"https:\/\/doi.org\/10.1186\/1471-2105-11-s9-s10","relation":{},"ISSN":["1471-2105"],"issn-type":[{"value":"1471-2105","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,10]]},"article-number":"S10"}}