{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T13:50:02Z","timestamp":1648734602283},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Bioinformatics"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>The notion that genes are non-randomly organized within the chromosomes of eukaryotic organisms has recently received strong experimental support. Clusters of co-expressed and co-localized genes have been recognized as playing key roles in a number of functional pathways and adaptive responses including organism development, differentiation, disease states and aging. The identification of genes arranged in close proximity with each other within a particular temporal and spatial transcriptional program is anticipated to unravel possible functional links and reciprocal interactions.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>We developed a novel software tool <jats:italic>Gepoclu<\/jats:italic> (Gene Positional Clustering) that automatically selects genes based on expression values from multiple sources, including microarray, EST and qRT-PCR, and performs positional clustering. <jats:italic>Gepoclu<\/jats:italic> provides expression-based gene selection from multiple experimental sources, position-based gene clustering and cluster visualization functionalities, all as parts of the same fully integrated, and interactive, package. This means rapid iterations while exploring for emergent behavior, and full programmability of the filtering and clustering steps.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>\n              <jats:italic>Gepoclu<\/jats:italic> is a useful data-mining tool for exploring relationships among transcriptional data deriving form different sources. It provides an easy interactive environment for analyzing positional clustering behavior of co-expressed genes, and at the same time it is fully programmable, so that it can be customized and extended to support specific analysis needs.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2105-12-34","type":"journal-article","created":{"date-parts":[[2011,2,8]],"date-time":"2011-02-08T14:43:37Z","timestamp":1297176217000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Gepoclu: a software tool for identifying and analyzing gene positional clusters in large-scale gene expression analysis"],"prefix":"10.1186","volume":"12","author":[{"given":"Tania","family":"Dottorini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Senin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"Mazzoleni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kalle","family":"Magnusson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Crisanti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2011,1,26]]},"reference":[{"issue":"23","key":"4350_CR1","doi-asserted-by":"publisher","first-page":"3755","DOI":"10.1007\/s00018-009-0114-3","volume":"66","author":"AE Osbourn","year":"2009","unstructured":"Osbourn AE, Field B: Operons. Cell Mol Life Sci 2009, 66(23):3755\u20133775. 10.1007\/s00018-009-0114-3","journal-title":"Cell Mol Life Sci"},{"issue":"4","key":"4350_CR2","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1038\/nrg1319","volume":"5","author":"LD Hurst","year":"2004","unstructured":"Hurst LD, Pal C, Lercher MJ: The evolutionary dynamics of eukaryotic gene order. Nat Rev Genet 2004, 5(4):299\u2013310. 10.1038\/nrg1319","journal-title":"Nat Rev Genet"},{"issue":"2","key":"4350_CR3","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/j.biocel.2008.09.015","volume":"41","author":"EV Koonin","year":"2009","unstructured":"Koonin EV: Evolution of genome architecture. Int J Biochem Cell Biol 2009, 41(2):298\u2013306. 10.1016\/j.biocel.2008.09.015","journal-title":"Int J Biochem Cell Biol"},{"issue":"4","key":"4350_CR4","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/S0092-8674(02)00900-5","volume":"110","author":"JG Lawrence","year":"2002","unstructured":"Lawrence JG: Shared strategies in gene organization among prokaryotes and eukaryotes. Cell 2002, 110(4):407\u2013413. 10.1016\/S0092-8674(02)00900-5","journal-title":"Cell"},{"issue":"3","key":"4350_CR5","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.ygeno.2007.11.002","volume":"91","author":"P Michalak","year":"2008","unstructured":"Michalak P: Coexpression, coregulation, and cofunctionality of neighboring genes in eukaryotic genomes. Genomics 2008, 91(3):243\u2013248. 10.1016\/j.ygeno.2007.11.002","journal-title":"Genomics"},{"issue":"10","key":"4350_CR6","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1038\/nrg1688","volume":"6","author":"D Sproul","year":"2005","unstructured":"Sproul D, Gilbert N, Bickmore WA: The role of chromatin structure in regulating the expression of clustered genes. Nat Rev Genet 2005, 6(10):775\u2013781. 10.1038\/nrg1688","journal-title":"Nat Rev Genet"},{"issue":"5507","key":"4350_CR7","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1126\/science.1056794","volume":"291","author":"H Caron","year":"2001","unstructured":"Caron H, van Schaik B, van der Mee M, Baas F, Riggins G, van Sluis P, Hermus MC, van Asperen R, Boon K, Voute PA, Heisterkamp S, van Kampen A, Versteeg R: The human transcriptome map: clustering of highly expressed genes in chromosomal domains. Science 2001, 291(5507):1289\u20131292. 10.1126\/science.1056794","journal-title":"Science"},{"issue":"41","key":"4350_CR8","doi-asserted-by":"publisher","first-page":"15761","DOI":"10.1073\/pnas.0806317105","volume":"105","author":"SC Janga","year":"2008","unstructured":"Janga SC, Collado-Vides J, Babu MM: Transcriptional regulation constrains the organization of genes on eukaryotic chromosomes. Proc Natl Acad Sci USA 2008, 105(41):15761\u201315766. 10.1073\/pnas.0806317105","journal-title":"Proc Natl Acad Sci USA"},{"issue":"5","key":"4350_CR9","doi-asserted-by":"publisher","first-page":"1435","DOI":"10.1093\/nar\/gki281","volume":"33","author":"AI Kalmykova","year":"2005","unstructured":"Kalmykova AI, Nurminsky DI, Ryzhov DV, Shevelyov YY: Regulated chromatin domain comprising cluster of co-expressed genes in Drosophila melanogaster. Nucleic Acids Res 2005, 33(5):1435\u20131444. 10.1093\/nar\/gki281","journal-title":"Nucleic Acids Res"},{"issue":"2","key":"4350_CR10","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1101\/gr.553803","volume":"13","author":"MJ Lercher","year":"2003","unstructured":"Lercher MJ, Blumenthal T, Hurst LD: Coexpression of neighboring genes in Caenorhabditis elegans is mostly due to operons and duplicate genes. Genome Res 2003, 13(2):238\u2013243. 10.1101\/gr.553803","journal-title":"Genome Res"},{"issue":"1","key":"4350_CR11","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1186\/1471-2164-6-68","volume":"6","author":"S Nelander","year":"2005","unstructured":"Nelander S, Larsson E, Kristiansson E, Mansson R, Nerman O, Sigvardsson M, Mostad P, Lindahl P: Predictive screening for regulators of conserved functional gene modules (gene batteries) in mammals. BMC Genomics 2005, 6(1):68. 10.1186\/1471-2164-6-68","journal-title":"BMC Genomics"},{"issue":"5","key":"4350_CR12","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1016\/j.ygeno.2007.01.010","volume":"89","author":"A Purmann","year":"2007","unstructured":"Purmann A, Toedling J, Schueler M, Carninci P, Lehrach H, Hayashizaki Y, Huber W, Sperling S: Genomic organization of transcriptomes in mammals: Coregulation and cofunctionality. Genomics 2007, 89(5):580\u2013587. 10.1016\/j.ygeno.2007.01.010","journal-title":"Genomics"},{"issue":"2","key":"4350_CR13","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1104\/pp.104.055673","volume":"138","author":"XY Ren","year":"2005","unstructured":"Ren XY, Fiers MW, Stiekema WJ, Nap JP: Local coexpression domains of two to four genes in the genome of Arabidopsis. Plant Physiol 2005, 138(2):923\u2013934. 10.1104\/pp.104.055673","journal-title":"Plant Physiol"},{"issue":"6901","key":"4350_CR14","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/nature01012","volume":"418","author":"PJ Roy","year":"2002","unstructured":"Roy PJ, Stuart JM, Lund J, Kim SK: Chromosomal clustering of muscle-expressed genes in Caenorhabditis elegans. Nature 2002, 418(6901):975\u2013979.","journal-title":"Nature"},{"issue":"5","key":"4350_CR15","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1038\/ng1543","volume":"37","author":"M Schmid","year":"2005","unstructured":"Schmid M, Davison TS, Henz SR, Pape UJ, Demar M, Vingron M, Scholkopf B, Weigel D, Lohmann JU: A gene expression map of Arabidopsis thaliana development. Nat Genet 2005, 37(5):501\u2013506. 10.1038\/ng1543","journal-title":"Nat Genet"},{"issue":"9","key":"4350_CR16","doi-asserted-by":"publisher","first-page":"1715","DOI":"10.1093\/molbev\/msl034","volume":"23","author":"M Semon","year":"2006","unstructured":"Semon M, Duret L: Evolutionary origin and maintenance of coexpressed gene clusters in mammals. Mol Biol Evol 2006, 23(9):1715\u20131723. 10.1093\/molbev\/msl034","journal-title":"Mol Biol Evol"},{"issue":"3","key":"4350_CR17","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1093\/molbev\/msi062","volume":"22","author":"GA Singer","year":"2005","unstructured":"Singer GA, Lloyd AT, Huminiecki LB, Wolfe KH: Clusters of co-expressed genes in mammalian genomes are conserved by natural selection. Mol Biol Evol 2005, 22(3):767\u2013775. 10.1093\/molbev\/msi062","journal-title":"Mol Biol Evol"},{"issue":"1","key":"4350_CR18","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/1475-4924-1-5","volume":"1","author":"PT Spellman","year":"2002","unstructured":"Spellman PT, Rubin GM: Evidence for large domains of similarly expressed genes in the Drosophila genome. J Biol 2002, 1(1):5. 10.1186\/1475-4924-1-5","journal-title":"J Biol"},{"key":"4350_CR19","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1186\/1471-2105-6-230","volume":"6","author":"JH Vogel","year":"2005","unstructured":"Vogel JH, von Heydebreck A, Purmann A, Sperling S: Chromosomal clustering of a human transcriptome reveals regulatory background. BMC Bioinformatics 2005, 6: 230. 10.1186\/1471-2105-6-230","journal-title":"BMC Bioinformatics"},{"issue":"6","key":"4350_CR20","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1101\/gr.2131104","volume":"14","author":"EJ Williams","year":"2004","unstructured":"Williams EJ, Bowles DJ: Coexpression of neighboring genes in the genome of Arabidopsis thaliana. Genome Res 2004, 14(6):1060\u20131067. 10.1101\/gr.2131104","journal-title":"Genome Res"},{"issue":"4","key":"4350_CR21","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1007\/s00239-001-0043-8","volume":"54","author":"EJ Williams","year":"2002","unstructured":"Williams EJ, Hurst LD: Clustering of tissue-specific genes underlies much of the similarity in rates of protein evolution of linked genes. J Mol Evol 2002, 54(4):511\u2013518. 10.1007\/s00239-001-0043-8","journal-title":"J Mol Evol"},{"issue":"3","key":"4350_CR22","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1111\/j.1365-313X.2005.02619.x","volume":"45","author":"S Zhan","year":"2006","unstructured":"Zhan S, Horrocks J, Lukens LN: Islands of co-expressed neighbouring genes in Arabidopsis thaliana suggest higher-order chromosome domains. Plant J 2006, 45(3):347\u2013357. 10.1111\/j.1365-313X.2005.02619.x","journal-title":"Plant J"},{"key":"4350_CR23","first-page":"464","volume":"2452","author":"A Bergeron","year":"2002","unstructured":"Bergeron A, Corteel S, Raffinot M: The algorithmic of gene teams. LectNotes in Comput Sci 2002, 2452: 464\u2013476.","journal-title":"LectNotes in Comput Sci"},{"issue":"Suppl 1","key":"4350_CR24","doi-asserted-by":"publisher","first-page":"i74","DOI":"10.1093\/bioinformatics\/btg1008","volume":"19","author":"PP Calabrese","year":"2003","unstructured":"Calabrese PP, Chakravarty S, Vision TJ: Fast identification and statistical evaluation of segmental homologies in comparative maps. Bioinformatics 2003, 19(Suppl 1):i74\u201380. 10.1093\/bioinformatics\/btg1008","journal-title":"Bioinformatics"},{"key":"4350_CR25","first-page":"638","volume":"12","author":"X He","year":"2005","unstructured":"He X, Goldwasser MH: Identifying conserved gene clusters in the presence of homology families. JComputBiol 2005, 12: 638\u2013656.","journal-title":"JComputBiol"},{"issue":"2","key":"4350_CR26","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1038\/ng887","volume":"31","author":"MJ Lercher","year":"2002","unstructured":"Lercher MJ, Urrutia AO, Hurst LD: Clustering of housekeeping genes provides a unified model of gene order in the human genome. Nat Genet 2002, 31(2):180\u2013183. 10.1038\/ng887","journal-title":"Nat Genet"},{"issue":"1","key":"4350_CR27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1365-2583.2006.00610.x","volume":"15","author":"O Marinotti","year":"2006","unstructured":"Marinotti O, Calvo E, Nguyen QK, Dissanayake S, Ribeiro JM, James AA: Genome-wide analysis of gene expression in adult Anopheles gambiae. Insect Mol Biol 2006, 15(1):1\u201312. 10.1111\/j.1365-2583.2006.00610.x","journal-title":"Insect Mol Biol"},{"issue":"41","key":"4350_CR28","doi-asserted-by":"publisher","first-page":"16215","DOI":"10.1073\/pnas.0703904104","volume":"104","author":"T Dottorini","year":"2007","unstructured":"Dottorini T, Nicolaides L, Ranson H, Rogers DW, Crisanti A, Catteruccia F: A genome-wide analysis in Anopheles gambiae mosquitoes reveals 46 male accessory gland genes, possible modulators of female behavior. Proc Natl Acad Sci USA 2007, 104(41):16215\u201316220. 10.1073\/pnas.0703904104","journal-title":"Proc Natl Acad Sci USA"},{"issue":"5461","key":"4350_CR29","doi-asserted-by":"publisher","first-page":"2185","DOI":"10.1126\/science.287.5461.2185","volume":"287","author":"MD Adams","year":"2000","unstructured":"Adams MD, Celniker SE, Holt RA, Evans CA, Gocayne JD, Amanatides PG, Scherer SE, Li PW, Hoskins RA, Galle RF, George RA, Lewis SE, Richards S, Ashburner M, Henderson SN, Sutton GG, Wortman JR, Yandell MD, Zhang Q, Chen LX, Brandon RC, Rogers YH, Blazej RG, Champe M, Pfeiffer BD, Wan KH, Doyle C, Baxter EG, Helt G, Nelson CR, et al.: The genome sequence of Drosophila melanogaster. Science 2000, 287(5461):2185\u20132195. 10.1126\/science.287.5461.2185","journal-title":"Science"},{"issue":"5591","key":"4350_CR30","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1126\/science.1076181","volume":"298","author":"RA Holt","year":"2002","unstructured":"Holt RA, Subramanian GM, Halpern A, Sutton GG, Charlab R, Nusskern DR, Wincker P, Clark AG, Ribeiro JM, Wides R, Salzberg SL, Loftus B, Yandell M, Majoros WH, Rusch DB, Lai Z, Kraft CL, Abril JF, Anthouard V, Arensburger P, Atkinson PW, Baden H, de Berardinis V, Baldwin D, Benes V, Biedler J, Blass C, Bolanos R, Boscus D, Barnstead M, et al.: The genome sequence of the malaria mosquito Anopheles gambiae. Science 2002, 298(5591):129\u2013149. 10.1126\/science.1076181","journal-title":"Science"},{"issue":"1","key":"4350_CR31","doi-asserted-by":"publisher","first-page":"R5.","DOI":"10.1186\/gb-2007-8-1-r5","volume":"8","author":"MV Sharakhova","year":"2007","unstructured":"Sharakhova MV, Hammond MP, Lobo NF, Krzywinski J, Unger MF, Hillenmeyer ME, Bruggner RV, Birney E, Collins FH: Update of the Anopheles gambiae PEST genome assembly. Genome Biol 2007, 8(1):R5.. 10.1186\/gb-2007-8-1-r5","journal-title":"Genome Biol"},{"key":"4350_CR32","unstructured":"MatlabThe MathWorks, Inc. Natick, MA (US); [http:\/\/www.mathworks.com]"},{"issue":"2","key":"4350_CR33","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1038\/79896","volume":"26","author":"BA Cohen","year":"2000","unstructured":"Cohen BA, Mitra RD, Hughes JD, Church GM: A computational analysis of whole-genome expression data reveals chromosomal domains of gene expression. Nat Genet 2000, 26(2):183\u2013186. 10.1038\/79896","journal-title":"Nat Genet"},{"issue":"1","key":"4350_CR34","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/1471-2164-6-7","volume":"6","author":"Q Li","year":"2005","unstructured":"Li Q, Lee BT, Zhang L: Genome-scale analysis of positional clustering of mouse testis-specific genes. BMC Genomics 2005, 6(1):7. 10.1186\/1471-2164-6-7","journal-title":"BMC Genomics"},{"issue":"4","key":"4350_CR35","doi-asserted-by":"publisher","first-page":"e44","DOI":"10.1371\/journal.pgen.0020044","volume":"2","author":"S Seno","year":"2006","unstructured":"Seno S, Takenaka Y, Kai C, Kawai J, Carninci P, Hayashizaki Y, Matsuda H: A method for similarity search of genomic positional expression using CAGE. PLoS Genet 2006, 2(4):e44. 10.1371\/journal.pgen.0020044","journal-title":"PLoS Genet"},{"issue":"6916","key":"4350_CR36","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1038\/nature01216","volume":"420","author":"AM Boutanaev","year":"2002","unstructured":"Boutanaev AM, Kalmykova AI, Shevelyov YY, Nurminsky DI: Large clusters of co-expressed genes in the Drosophila genome. Nature 2002, 420(6916):666\u2013669. 10.1038\/nature01216","journal-title":"Nature"},{"key":"4350_CR37","unstructured":"SPSSIBM Corporation. Somers, NY (US); [http:\/\/www.spss.com]"},{"issue":"1","key":"4350_CR38","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1534\/genetics.105.043844","volume":"171","author":"JL Mueller","year":"2005","unstructured":"Mueller JL, Ravi Ram K, McGraw LA, Bloch Qazi MC, Siggia ED, Clark AG, Aquadro CF, Wolfner MF: Cross-species comparison of Drosophila male accessory gland protein genes. Genetics 2005, 171(1):131\u2013143. 10.1534\/genetics.105.043844","journal-title":"Genetics"},{"issue":"1","key":"4350_CR39","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/0965-1748(94)00034-F","volume":"25","author":"E Simmerl","year":"1995","unstructured":"Simmerl E, Schafer M, Schafer U: Structure and regulation of a gene cluster for male accessory gland transcripts in Drosophila melanogaster. Insect Biochem Mol Biol 1995, 25(1):127\u2013137. 10.1016\/0965-1748(94)00034-F","journal-title":"Insect Biochem Mol Biol"},{"issue":"13","key":"4350_CR40","doi-asserted-by":"publisher","first-page":"7375","DOI":"10.1073\/pnas.131568198","volume":"98","author":"WJ Swanson","year":"2001","unstructured":"Swanson WJ, Clark AG, Waldrip-Dail HM, Wolfner MF, Aquadro CF: Evolutionary EST analysis identifies rapidly evolving male reproductive proteins in Drosophila. Proc Natl Acad Sci USA 2001, 98(13):7375\u20137379. 10.1073\/pnas.131568198","journal-title":"Proc Natl Acad Sci USA"},{"key":"4350_CR41","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/1477-5956-4-9","volume":"4","author":"MJ Walker","year":"2006","unstructured":"Walker MJ, Rylett CM, Keen JN, Audsley N, Sajid M, Shirras AD, Isaac RE: Proteomic identification of Drosophila melanogaster male accessory gland proteins, including a pro-cathepsin and a soluble gamma-glutamyl transpeptidase. Proteome Sci 2006, 4: 9. 10.1186\/1477-5956-4-9","journal-title":"Proteome Sci"},{"issue":"10","key":"4350_CR42","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1016\/S0965-1748(97)00056-8","volume":"27","author":"MF Wolfner","year":"1997","unstructured":"Wolfner MF, Harada HA, Bertram MJ, Stelick TJ, Kraus KW, Kalb JM, Lung YO, Neubaum DM, Park M, Tram U: New genes for male accessory gland proteins in Drosophila melanogaster. Insect Biochem Mol Biol 1997, 27(10):825\u2013834. 10.1016\/S0965-1748(97)00056-8","journal-title":"Insect Biochem Mol Biol"}],"container-title":["BMC Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2105-12-34.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T12:18:17Z","timestamp":1630498697000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcbioinformatics.biomedcentral.com\/articles\/10.1186\/1471-2105-12-34"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1,26]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["4350"],"URL":"https:\/\/doi.org\/10.1186\/1471-2105-12-34","relation":{},"ISSN":["1471-2105"],"issn-type":[{"value":"1471-2105","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,1,26]]},"assertion":[{"value":"8 November 2010","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 January 2011","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 January 2011","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"34"}}