{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T21:51:38Z","timestamp":1763070698926},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2011,8,17]],"date-time":"2011-08-17T00:00:00Z","timestamp":1313539200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMC Bioinformatics"],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1186\/1471-2105-12-342","type":"journal-article","created":{"date-parts":[[2011,8,17]],"date-time":"2011-08-17T18:18:11Z","timestamp":1313605091000},"source":"Crossref","is-referenced-by-count":15,"title":["Extracting quantitative genetic interaction phenotypes from matrix combinatorial RNAi"],"prefix":"10.1186","volume":"12","author":[{"given":"Elin","family":"Axelsson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Sandmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Horn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Boutros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Huber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernd","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2011,8,17]]},"reference":[{"issue":"10","key":"4753_CR1","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1038\/nrg910","volume":"3","author":"JL Badano","year":"2002","unstructured":"Badano JL, Katsanis N: Beyond Mendel: an evolving view of human genetic disease transmission. Nat Rev Gen 2002, 3(10):779\u201389.","journal-title":"Nat Rev Gen"},{"issue":"50","key":"4753_CR2","doi-asserted-by":"publisher","first-page":"19910","DOI":"10.1073\/pnas.0810388105","volume":"105","author":"H Shao","year":"2008","unstructured":"Shao H, Burrage LC, Sinasac DS, Hill AE, Ernest SR, O'Brien W, Courtland HW, Jepsen KJ, Kirby A, Kulbokas EJ, Daly MJ, Broman KW, Lander ES, Nadeau JH: Genetic architecture of complex traits: large phenotypic effects and pervasive epistasis. Proc Natl Acad Sci USA 2008, 105(50):19910\u20134. 10.1073\/pnas.0810388105","journal-title":"Proc Natl Acad Sci USA"},{"issue":"9","key":"4753_CR3","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1038\/nrc1691","volume":"5","author":"WG Kaelin","year":"2005","unstructured":"Kaelin WG: The concept of synthetic lethality in the context of anticancer therapy. Nat Rev Cancer 2005, 5(9):689\u201398. 10.1038\/nrc1691","journal-title":"Nat Rev Cancer"},{"issue":"2","key":"4753_CR4","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/jbiol23","volume":"4","author":"LV Zhang","year":"2005","unstructured":"Zhang LV, King OD, Wong SL, Goldberg DS, Tong AHY, Lesage G, Andrews B, Bussey H, Boone C, Roth FP: Motifs, themes and thematic maps of an integrated Saccharomyces cerevisiae interaction network. J Biol 2005, 4(2):6. 10.1186\/jbiol23","journal-title":"J Biol"},{"issue":"4","key":"4753_CR5","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1038\/ng1755","volume":"38","author":"P Yeh","year":"2006","unstructured":"Yeh P, Tschumi AI, Kishony R: Functional classification of drugs by properties of their pairwise interactions. Nat Genet 2006, 38(4):489\u201394. 10.1038\/ng1755","journal-title":"Nat Genet"},{"issue":"5659","key":"4753_CR6","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1126\/science.1091317","volume":"303","author":"AHY Tong","year":"2004","unstructured":"Tong AHY, Lesage G, Bader GD, Ding H, Xu H, Xin X, Young J, Berriz GF, Brost RL, Chang M, Chen Y, Cheng X, Chua G, Friesen H, Goldberg DS, Haynes J, Humphries C, He G, Hussein S, Ke L, Krogan N, Li Z, Levinson JN, Lu H, M\u00e9nard P, Munyana C, Parsons AB, Ryan O, Tonikian R, Roberts T, et al.: Global mapping of the yeast genetic interaction network. Science 2004, 303(5659):808\u201313. 10.1126\/science.1091317","journal-title":"Science"},{"issue":"39","key":"4753_CR7","doi-asserted-by":"publisher","first-page":"13956","DOI":"10.1073\/pnas.0503504102","volume":"102","author":"V Measday","year":"2005","unstructured":"Measday V, Baetz K, Guzzo J, Yuen K, Kwok T, Sheikh B, Ding H, Ueta R, Hoac T, Cheng B, Pot I, Tong A, Yamaguchi-Iwai Y, Boone C, Hieter P, Andrews B: Systematic yeast synthetic lethal and synthetic dosage lethal screens identify genes required for chromosome segregation. Proc Natl Acad Sci USA 2005, 102(39):13956\u201361. 10.1073\/pnas.0503504102","journal-title":"Proc Natl Acad Sci USA"},{"issue":"7137","key":"4753_CR8","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1038\/nature05649","volume":"446","author":"SR Collins","year":"2007","unstructured":"Collins SR, Miller KM, Maas NL, Roguev A, Fillingham J, Chu CS, Schuldiner M, Gebbia M, Recht J, Shales M, Ding H, Xu H, Han J, Ingvarsdottir K, Cheng B, Andrews B, Boone C, Berger SL, Hieter P, Zhang Z, Brown GW, Ingles CJ, Emili A, Allis CD, Toczyski DP, Weissman JS, Greenblatt JF, Krogan NJ: Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map. Nature 2007, 446(7137):806\u201310. 10.1038\/nature05649","journal-title":"Nature"},{"issue":"5964","key":"4753_CR9","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1126\/science.1180823","volume":"327","author":"M Costanzo","year":"2010","unstructured":"Costanzo M, Baryshnikova A, Bellay J, Kim Y, Spear ED, Sevier CS, Ding H, Koh JL, Toufighi K, Mostafavi S, Prinz J, Onge RPS, VanderSluis B, Makhnevych T, Vizeacoumar FJ, Alizadeh S, Bahr S, Brost RL, Chen Y, Coko M, Deshpande R, Li Z, Lin ZY, Liang W, Marback M, Paw J, Luis BJS, Shuteriqi E, Tong AHY, van Dyk N, et al.: The Genetic Landscape of a Cell. Science 2010, 327(5964):425. 10.1126\/science.1180823","journal-title":"Science"},{"issue":"5550","key":"4753_CR10","doi-asserted-by":"publisher","first-page":"2364","DOI":"10.1126\/science.1065810","volume":"294","author":"AH Tong","year":"2001","unstructured":"Tong AH, Evangelista M, Parsons AB, Xu H, Bader GD, Pag\u00e9 N, Robinson M, Raghibizadeh S, Hogue CWV, Bussey H, Andrews B, Tyers M, Boone C: Systematic genetic analysis with ordered arrays of yeast deletion mutants. Science 2001, 294(5550):2364\u20138. 10.1126\/science.1065810","journal-title":"Science"},{"issue":"3","key":"4753_CR11","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1038\/ng1258","volume":"35","author":"SL Ooi","year":"2003","unstructured":"Ooi SL, Shoemaker DD, Boeke JD: DNA helicase gene interaction network defined using synthetic lethality analyzed by microarray. Nat Genet 2003, 35(3):277\u201386. 10.1038\/ng1258","journal-title":"Nat Genet"},{"issue":"3","key":"4753_CR12","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/j.molcel.2004.09.035","volume":"16","author":"X Pan","year":"2004","unstructured":"Pan X, Yuan DS, Xiang D, Wang X, Sookhai-Mahadeo S, Bader JS, Hieter P, Spencer F, Boeke JD: A robust toolkit for functional profiling of the yeast genome. Mol Cell 2004, 16(3):487\u201396. 10.1016\/j.molcel.2004.09.035","journal-title":"Mol Cell"},{"issue":"3","key":"4753_CR13","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/j.cell.2005.08.031","volume":"123","author":"M Schuldiner","year":"2005","unstructured":"Schuldiner M, Collins SR, Thompson NJ, Denic V, Bhamidipati A, Punna T, Ihmels J, Andrews B, Boone C, Greenblatt JF, Weissman JS, Krogan NJ: Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile. Cell 2005, 123(3):507\u201319. 10.1016\/j.cell.2005.08.031","journal-title":"Cell"},{"issue":"15","key":"4753_CR14","doi-asserted-by":"publisher","first-page":"5821","DOI":"10.1073\/pnas.0710533105","volume":"105","author":"L Decourty","year":"2008","unstructured":"Decourty L, Saveanu C, Zemam K, Hantraye F, Frachon E, Rousselle JC, Fromont-Racine M, Jacquier A: Linking functionally related genes by sensitive and quantitative characterization of genetic interaction profiles. Proc Natl Acad Sci USA 2008, 105(15):5821\u20136. 10.1073\/pnas.0710533105","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"4753_CR15","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.1038\/nprot.2006.245","volume":"1","author":"B Lehner","year":"2006","unstructured":"Lehner B, Tischler J, Fraser AG: RNAi screens in Caenorhabditis elegans in a 96-well liquid format and their application to the systematic identification of genetic interactions. Nat Protoc 2006, 1(3):1617\u201320. 10.1038\/nprot.2006.245","journal-title":"Nat Protoc"},{"issue":"8","key":"4753_CR16","doi-asserted-by":"publisher","first-page":"R69","DOI":"10.1186\/gb-2006-7-8-r69","volume":"7","author":"J Tischler","year":"2006","unstructured":"Tischler J, Lehner B, Chen N, Fraser AG: Combinatorial RNA interference in Caenorhabditis elegans reveals that redundancy between gene duplicates can be maintained for more than 80 million years of evolution. Genome Biol 2006, 7(8):R69. 10.1186\/gb-2006-7-8-r69","journal-title":"Genome Biol"},{"issue":"7","key":"4753_CR17","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1038\/nrg2364","volume":"9","author":"M Boutros","year":"2008","unstructured":"Boutros M, Ahringer J: The art and design of genetic screens: RNA interference. Nat Rev Gen 2008, 9(7):554\u201366. 10.1038\/nrg2364","journal-title":"Nat Rev Gen"},{"key":"4753_CR18","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1038\/nmeth.1581","volume":"8","author":"T Horn","year":"2011","unstructured":"Horn T, Sandman T, Fischer B, Axelsson E, Huber W, Boutros M: Mapping of Signaling Networks through Synthetic Genetic Interaction Analysis by RNAi. Nat Methods 2011, 8: 341\u2013346. 10.1038\/nmeth.1581","journal-title":"Nat Methods"},{"key":"4753_CR19","volume-title":"Introduction to Calculus and Analysis","author":"R Courant","year":"1998","unstructured":"Courant R, John F: Introduction to Calculus and Analysis. Springer; 1998."},{"issue":"5913","key":"4753_CR20","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1126\/science.1166426","volume":"323","author":"J Gerke","year":"2009","unstructured":"Gerke J, Lorenz K, Cohen B: Genetic interactions between transcription factors cause natural variation in yeast. Science 2009, 323(5913):498\u2013501. 10.1126\/science.1166426","journal-title":"Science"},{"key":"4753_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.tpb.2009.10.002","volume":"77","author":"J Gertz","year":"2010","unstructured":"Gertz J, Gerke JP, Cohen BA: Epistasis in a quantitative trait captured by a molecular model of transcription factor interactions. Theor Popul Biol 2010, 77: 1\u20135. 10.1016\/j.tpb.2009.10.002","journal-title":"Theor Popul Biol"},{"key":"4753_CR22","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1038\/msb.2010.1","volume":"6","author":"GH Romano","year":"2010","unstructured":"Romano GH, Gurvich Y, Lavi O, Ulitsky I, Shamir R, Kupiec M: Different sets of QTLs influence fitness variation in yeast. Mol Syst Biol 2010, 6: 346\u2013346.","journal-title":"Mol Syst Biol"},{"key":"4753_CR23","first-page":"293","volume-title":"Genetics and Analysis of Quantitative Traits","author":"M Lynch","year":"1998","unstructured":"Lynch M, Walsh B: Matters of scale. In Genetics and Analysis of Quantitative Traits. Sinauer Associates, Inc; 1998:293\u2013317."},{"issue":"9","key":"4753_CR24","doi-asserted-by":"publisher","first-page":"3461","DOI":"10.1073\/pnas.0712255105","volume":"105","author":"R Mani","year":"2008","unstructured":"Mani R, Onge RPS, Hartman JL, Giaever G, Roth FP: Defining genetic interaction. Proc Natl Acad Sci USA 2008, 105(9):3461\u20136. 10.1073\/pnas.0712255105","journal-title":"Proc Natl Acad Sci USA"},{"key":"4753_CR25","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1126\/science.1091266","volume":"303","author":"M Boutros","year":"2004","unstructured":"Boutros M, Kiger AA, Armknecht S, Kerr K, Hild M, Koch B, A HS, Consortium HFA, Paro R, Perrimon N: Genome-wide RNAi analysis of growth and viability in Drosophila cells. Science 2004, 303: 832\u2013835. 10.1126\/science.1091266","journal-title":"Science"},{"issue":"4","key":"4753_CR26","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1002\/(SICI)1099-1638(199807\/08)14:4<197::AID-QRE194>3.0.CO;2-3","volume":"14","author":"G Milliken","year":"1998","unstructured":"Milliken G, Shi X, Mendicino M, Vasudev P: Strip-plot design for two-step processes. Quality and Reliability Engineering International 1998, 14(4):197\u2013210. 10.1002\/(SICI)1099-1638(199807\/08)14:4<197::AID-QRE194>3.0.CO;2-3","journal-title":"Quality and Reliability Engineering International"},{"issue":"7","key":"4753_CR27","doi-asserted-by":"publisher","first-page":"R66","DOI":"10.1186\/gb-2006-7-7-r66","volume":"7","author":"M Boutros","year":"2006","unstructured":"Boutros M, Bras LP, Huber W: Analysis of cell-based RNAi screens. Genome Biol 2006, 7(7):R66. 10.1186\/gb-2006-7-7-r66","journal-title":"Genome Biol"},{"issue":"2","key":"4753_CR28","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1038\/nbt1186","volume":"24","author":"N Malo","year":"2006","unstructured":"Malo N, Hanley JA, Cerquozzi S, Pelletier J, Nadon R: Statistical practice in high-throughput screening data analysis. Nat Biotech 2006, 24(2):167\u201375. 10.1038\/nbt1186","journal-title":"Nat Biotech"},{"key":"4753_CR29","doi-asserted-by":"publisher","DOI":"10.1002\/0471725382","volume-title":"Robust Regression and Outlier Detection","author":"PJ Rousseeuw","year":"1987","unstructured":"Rousseeuw PJ, Leroy AM: Robust Regression and Outlier Detection. New York: John Wiley & Sons; 1987."},{"key":"4753_CR30","doi-asserted-by":"publisher","DOI":"10.1002\/0471725250","volume-title":"Robust Statistics","author":"PJ Huber","year":"1981","unstructured":"Huber PJ: Robust Statistics. New York: John Wiley & Sons; 1981."},{"key":"4753_CR31","first-page":"31","volume":"12","author":"I L\u00f6nnstedt","year":"2002","unstructured":"L\u00f6nnstedt I, Speed T: Replicated microarray data. Statistica Sinica 2002, 12: 31\u201346.","journal-title":"Statistica Sinica"},{"key":"4753_CR32","doi-asserted-by":"crossref","first-page":"Article3","DOI":"10.2202\/1544-6115.1027","volume":"3","author":"GK Smyth","year":"2004","unstructured":"Smyth GK: Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol 2004, 3: Article3.","journal-title":"Stat Appl Genet Mol Biol"},{"key":"4753_CR33","volume-title":"PhD thesis","author":"R Bourgon","year":"2006","unstructured":"Bourgon R: Chromatin-immunoprecipitation and high-density tiling microarrays: a generative model, methods for analysis, and methodology assessment in the absence of a \"gold standard\". PhD thesis. University of California, Berkeley; 2006."},{"issue":"10","key":"4753_CR34","doi-asserted-by":"publisher","first-page":"1206","DOI":"10.1101\/gad.10.10.1206","volume":"10","author":"W Du","year":"1996","unstructured":"Du W, Vidal M, Xie JE, Dyson N: RBF, a novel RB-related gene that regulates E2F activity and interacts with cyclin E in Drosophila. Genes Dev 1996, 10(10):1206\u20131218. 10.1101\/gad.10.10.1206","journal-title":"Genes Dev"},{"key":"4753_CR35","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1186\/1471-2164-9-461","volume":"9","author":"J Yu","year":"2008","unstructured":"Yu J, Pacifico S, Liu G, Finley R: DroID: the Drosophila Interactions Database, a comprehensive resource for annotated gene and protein interactions. BMC Genomics 2008, 9: 461. 10.1186\/1471-2164-9-461","journal-title":"BMC Genomics"},{"issue":"5","key":"4753_CR36","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1016\/S1534-5807(03)00121-7","volume":"4","author":"S Doronkin","year":"2003","unstructured":"Doronkin S, Djagaeva I, Beckendorf S: The COP9 signalosome promotes degradation of Cyclin E during early Drosophila oogenesis. Dev Cell 2003, 4(5):699\u2013710. 10.1016\/S1534-5807(03)00121-7","journal-title":"Dev Cell"},{"issue":"3","key":"4753_CR37","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1093\/biomet\/69.3.493","volume":"69","author":"T Schweder","year":"1982","unstructured":"Schweder T, Spj\u00f8tvoll E: Plots of p-values to evaluate many tests simultaneously. Biometrika 1982, 69(3):493.","journal-title":"Biometrika"},{"issue":"4","key":"4753_CR38","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1038\/ng1986","volume":"39","author":"L Jasnos","year":"2007","unstructured":"Jasnos L, Korona R: Epistatic buffering of fitness loss in yeast double deletion strains. Nat Gen 2007, 39(4):550\u20134. 10.1038\/ng1986","journal-title":"Nat Gen"},{"key":"4753_CR39","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/ng1489","volume":"37","author":"D Segre","year":"2005","unstructured":"Segre D, Deluna A, Church GM, Kishony R: Modular epistasis in yeast metabolism. Nat Genet 2005, 37: 77\u201383.","journal-title":"Nat Genet"},{"issue":"6658","key":"4753_CR40","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1038\/37108","volume":"390","author":"SF Elena","year":"1997","unstructured":"Elena SF, Lenski RE: Test of synergistic interactions among deleterious mutations in bacteria. Nature 1997, 390(6658):395\u20138. 10.1038\/37108","journal-title":"Nature"},{"issue":"1-2","key":"4753_CR41","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1093\/biomet\/44.1-2.187","volume":"44","author":"D Lindley","year":"1957","unstructured":"Lindley D: A statistical paradox. Biometrika 1957, 44(1\u20132):187. 10.1093\/biomet\/44.1-2.187","journal-title":"Biometrika"},{"key":"4753_CR42","first-page":"289","volume-title":"Journal of the Royal Statistical Society. Series B (Methodological)","author":"Y Benjamini","year":"1995","unstructured":"Benjamini Y, Hochberg Y: Controlling the false discovery rate: a practical and powerful approach to multiple testing. Journal of the Royal Statistical Society. Series B (Methodological) 1995, 289\u2013300."},{"key":"4753_CR43","volume-title":"The Elements of Statistical Learning","author":"RT T Hastie","year":"2008","unstructured":"T Hastie RT, Friedman J: The Elements of Statistical Learning. 2nd edition. Springer-Verlag; 2008.","edition":"2"},{"issue":"4","key":"4753_CR44","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1038\/ng.114","volume":"40","author":"J Tischler","year":"2008","unstructured":"Tischler J, Lehner B, Fraser A: Evolutionary plasticity of genetic interaction networks. Nature genetics 2008, 40(4):390\u2013391. 10.1038\/ng.114","journal-title":"Nature genetics"},{"issue":"7289","key":"4753_CR45","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1038\/nature08869","volume":"464","author":"B Neumann","year":"2010","unstructured":"Neumann B, Walter T, Herich\u00e9 JK, Bulkescher J, Erfle H, Conrad C, Rogers P, Rogers P, Held M, Liebel U, Cetin C, Sieckmann F, Pau G, Kabbe R, W\u00fcnsche A, Satagopam V, Schmitz MHA, Chapuis C, Gerlich DW, Schneider R, Eils R, Huber W, Peters JM, Hyman AA, Durbin R, Pepperkok R, Ellenberg J: Phenotypic profiling of the human genome by time-lapse microscopy reveals genes required for cell division, survival or migration. Nature 2010, 464(7289):721\u2013727. 10.1038\/nature08869","journal-title":"Nature"},{"issue":"3","key":"4753_CR46","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1083\/jcb.200901105","volume":"186","author":"S Winograd-Katz","year":"2009","unstructured":"Winograd-Katz S, Itzkovitz S, Kam Z, Geiger B: Multiparametric analysis of focal adhesion formation by RNAi-mediated gene knockdown. Journal of Cell Biology 2009, 186(3):423. 10.1083\/jcb.200901105","journal-title":"Journal of Cell Biology"},{"key":"4753_CR47","volume-title":"Mol Syst Biol","author":"F Fuchs","year":"2010","unstructured":"Fuchs F, Pau G, Kranz D, Sklyar O, Budjan C, Steinbrink S, Horn T, Pedal A, Huber W, Boutros M: Clustering phenotype populations in a genome-wide RNAi screen identifies novel regulators for DNA damage response. Mol Syst Biol 2010., 6:"},{"issue":"10","key":"4753_CR48","doi-asserted-by":"publisher","first-page":"R80","DOI":"10.1186\/gb-2004-5-10-r80","volume":"5","author":"RC Gentleman","year":"2004","unstructured":"Gentleman RC, Carey VJ, Bates DM, Bolstad B, Dettling M, Dudoit S, Ellis B, Gautier L, Ge Y, Gentry J, Hornik K, Hothorn T, Huber W, Iacus S, Irizarry R, Leisch F, Li C, Maechler M, Rossini AJ, Sawitzki G, Smith C, Smyth G, Tierney L, Yang JY, Zhang J: Bioconductor: open software development for computational biology and bioinformatics. Genome Biol 2004, 5(10):R80. 10.1186\/gb-2004-5-10-r80","journal-title":"Genome Biol"},{"key":"4753_CR49","doi-asserted-by":"crossref","DOI":"10.1007\/b98858","volume-title":"Local Regression and Likelihood","author":"C Loader","year":"1999","unstructured":"Loader C: Local Regression and Likelihood. Springer; 1999."},{"issue":"2","key":"4753_CR50","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1177\/108705719900400206","volume":"4","author":"JH Zhang","year":"1999","unstructured":"Zhang JH, Chung TD, Oldenburg KR: A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays. J Biomol Screen 1999, 4(2):67\u201373. 10.1177\/108705719900400206","journal-title":"J Biomol Screen"}],"container-title":["BMC Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2105-12-342.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-2105-12-342\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2105-12-342.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T21:23:18Z","timestamp":1686259398000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcbioinformatics.biomedcentral.com\/articles\/10.1186\/1471-2105-12-342"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8,17]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["4753"],"URL":"https:\/\/doi.org\/10.1186\/1471-2105-12-342","relation":{},"ISSN":["1471-2105"],"issn-type":[{"value":"1471-2105","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,8,17]]},"article-number":"342"}}