{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T09:08:43Z","timestamp":1764493723640},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2011,9,23]],"date-time":"2011-09-23T00:00:00Z","timestamp":1316736000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMC Bioinformatics"],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1186\/1471-2105-12-376","type":"journal-article","created":{"date-parts":[[2011,9,23]],"date-time":"2011-09-23T14:16:18Z","timestamp":1316787378000},"source":"Crossref","is-referenced-by-count":48,"title":["EnzymeDetector: an integrated enzyme function prediction tool and database"],"prefix":"10.1186","volume":"12","author":[{"given":"Susanne","family":"Quester","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dietmar","family":"Schomburg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2011,9,23]]},"reference":[{"key":"4839_CR1","doi-asserted-by":"publisher","first-page":"D354","DOI":"10.1093\/nar\/gkj102","volume":"34","author":"M Kanehisa","year":"2006","unstructured":"Kanehisa M, Goto S, Hattori M, Aoki-Kinoshita KF, Itoh M, Kawashima S, Katayama T, Araki M, Hirakawa M: From genomics to chemical genomics: new developments in KEGG. Nucleic Acids Res 2006, 34: D354\u2013357. 10.1093\/nar\/gkj102","journal-title":"Nucleic Acids Res"},{"key":"4839_CR2","doi-asserted-by":"publisher","first-page":"D355","DOI":"10.1093\/nar\/gkp896","volume":"38","author":"M Kanehisa","year":"2010","unstructured":"Kanehisa M, Goto S, Furumichi M, Tanabe M, Hirakawa M: KEGG for representation and analysis of molecular networks involving diseases and drugs. Nucleic Acids Res 2010, 38: D355\u2013360. 10.1093\/nar\/gkp896","journal-title":"Nucleic Acids Res"},{"key":"4839_CR3","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","volume":"28","author":"M Kanehisa","year":"2000","unstructured":"Kanehisa M, Goto S: KEGG: kyoto encyclopedia of genes and genomes. Nucleic Acids Res 2000, 28: 27\u201330. 10.1093\/nar\/28.1.27","journal-title":"Nucleic Acids Res"},{"key":"4839_CR4","doi-asserted-by":"publisher","first-page":"D408","DOI":"10.1093\/nar\/gkn749","volume":"37","author":"MC Walter","year":"2009","unstructured":"Walter MC, Rattei T, Arnold R, G\u00fcldener U, M\u00fcnsterk\u00f6tter M, Nenova K, Kastenm\u00fcller G, Tischler P, W\u00f6lling A, Volz A, Pongratz N, Jost R, Mewes H-W, Frishman D: PEDANT covers all complete RefSeq genomes. Nucleic Acids Res 2009, 37: D408\u2013411. 10.1093\/nar\/gkn749","journal-title":"Nucleic Acids Res"},{"key":"4839_CR5","doi-asserted-by":"publisher","first-page":"D354","DOI":"10.1093\/nar\/gkl1005","volume":"35","author":"ML Riley","year":"2007","unstructured":"Riley ML, Schmidt T, Artamonova II, Wagner C, Volz A, Heumann K, Mewes H-W, Frishman D: PEDANT genome database: 10 years online. Nucleic Acids Res 2007, 35: D354\u2013357. 10.1093\/nar\/gkl1005","journal-title":"Nucleic Acids Res"},{"key":"4839_CR6","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1093\/nar\/gkg005","volume":"31","author":"D Frishman","year":"2003","unstructured":"Frishman D, Mokrejs M, Kosykh D, Kastenm\u00fcller G, Kolesov G, Zubrzycki I, Gruber C, Geier B, Kaps A, Albermann K, Volz A, Wagner C, Fellenberg M, Heumann K, Mewes H-W: The PEDANT genome database. Nucleic Acids Res 2003, 31: 207\u2013211. 10.1093\/nar\/gkg005","journal-title":"Nucleic Acids Res"},{"key":"4839_CR7","doi-asserted-by":"crossref","unstructured":"Ongoing and future developments at the Universal Protein Resource Nucleic Acids Res 2011, 39: D214\u2013219.","DOI":"10.1093\/nar\/gkq1020"},{"key":"4839_CR8","doi-asserted-by":"publisher","first-page":"D483","DOI":"10.1093\/nar\/gkn861","volume":"37","author":"GL Winsor","year":"2009","unstructured":"Winsor GL, Van Rossum T, Lo R, Khaira B, Whiteside MD, Hancock REW, Brinkman FSL: Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Nucleic Acids Res 2009, 37: D483\u2013488. 10.1093\/nar\/gkn861","journal-title":"Nucleic Acids Res"},{"key":"4839_CR9","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1186\/1471-2105-11-449","volume":"11","author":"D Soh","year":"2010","unstructured":"Soh D, Dong D, Guo Y, Wong L: Consistency, comprehensiveness, and compatibility of pathway databases. BMC Bioinformatics 2010, 11: 449. 10.1186\/1471-2105-11-449","journal-title":"BMC Bioinformatics"},{"key":"4839_CR10","doi-asserted-by":"publisher","first-page":"1909","DOI":"10.1099\/mic.0.033811-0","volume":"156","author":"MS Poptsova","year":"2010","unstructured":"Poptsova MS, Gogarten JP: Using comparative genome analysis to identify problems in annotated microbial genomes. Microbiology (Reading, Engl.) 2010, 156: 1909\u20131917. 10.1099\/mic.0.033811-0","journal-title":"Microbiology (Reading, Engl.)"},{"key":"4839_CR11","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1038\/nchembio0809-521","volume":"5","author":"N Furnham","year":"2009","unstructured":"Furnham N, Garavelli JS, Apweiler R, Thornton JM: Missing in action: enzyme functional annotations in biological databases. Nat Chem Biol 2009, 5: 521\u2013525.","journal-title":"Nat Chem Biol"},{"key":"4839_CR12","doi-asserted-by":"publisher","first-page":"6633","DOI":"10.1093\/nar\/gkg847","volume":"31","author":"C Claudel-Renard","year":"2003","unstructured":"Claudel-Renard C, Chevalet C, Faraut T, Kahn D: Enzyme-specific profiles for genome annotation: PRIAM. Nucleic Acids Res 2003, 31: 6633\u20136639. 10.1093\/nar\/gkg847","journal-title":"Nucleic Acids Res"},{"key":"4839_CR13","doi-asserted-by":"publisher","first-page":"6226","DOI":"10.1093\/nar\/gkh956","volume":"32","author":"W Tian","year":"2004","unstructured":"Tian W, Arakaki AK, Skolnick J: EFICAz: a comprehensive approach for accurate genome-scale enzyme function inference. Nucleic Acids Res 2004, 32: 6226\u20136239. 10.1093\/nar\/gkh956","journal-title":"Nucleic Acids Res"},{"key":"4839_CR14","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1186\/1471-2105-10-107","volume":"10","author":"AK Arakaki","year":"2009","unstructured":"Arakaki AK, Huang Y, Skolnick J: EFICAz2: enzyme function inference by a combined approach enhanced by machine learning. BMC Bioinformatics 2009, 10: 107. 10.1186\/1471-2105-10-107","journal-title":"BMC Bioinformatics"},{"key":"4839_CR15","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1093\/bioinformatics\/btp613","volume":"26","author":"Y Yang","year":"2010","unstructured":"Yang Y, Gilbert D, Kim S: Annotation confidence score for genome annotation: a genome comparison approach. Bioinformatics 2010, 26: 22\u201329. 10.1093\/bioinformatics\/btp613","journal-title":"Bioinformatics"},{"key":"4839_CR16","doi-asserted-by":"publisher","first-page":"1739","DOI":"10.1093\/bioinformatics\/btp309","volume":"25","author":"M Chitale","year":"2009","unstructured":"Chitale M, Hawkins T, Park C, Kihara D: ESG: extended similarity group method for automated protein function prediction. Bioinformatics 2009, 25: 1739\u20131745. 10.1093\/bioinformatics\/btp309","journal-title":"Bioinformatics"},{"key":"4839_CR17","first-page":"Unit 9.5","volume":"Chapter 9","author":"S Misra","year":"2006","unstructured":"Misra S, Harris N: Using Apollo to browse and edit genome annotations. Curr Protoc Bioinformatics 2006, Chapter 9: Unit 9.5.","journal-title":"Curr Protoc Bioinformatics"},{"key":"4839_CR18","volume-title":"Nucleic Acids Res","author":"PA Fujita","year":"2010","unstructured":"Fujita PA, Rhead B, Zweig AS, Hinrichs AS, Karolchik D, Cline MS, Goldman M, Barber GP, Clawson H, Coelho A, Diekhans M, Dreszer TR, Giardine BM, Harte RA, Hillman-Jackson J, Hsu F, Kirkup V, Kuhn RM, Learned K, Li CH, Meyer LR, Pohl A, Raney BJ, Rosenbloom KR, Smith KE, Haussler D, Kent WJ: The UCSC Genome Browser database: update 2011. Nucleic Acids Res 2010."},{"key":"4839_CR19","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1016\/j.resmic.2007.09.009","volume":"158","author":"C M\u00e9digue","year":"2007","unstructured":"M\u00e9digue C, Moszer I: Annotation, comparison and databases for hundreds of bacterial genomes. Res Microbiol 2007, 158: 724\u2013736. 10.1016\/j.resmic.2007.09.009","journal-title":"Res Microbiol"},{"key":"4839_CR20","doi-asserted-by":"publisher","first-page":"e1000605","DOI":"10.1371\/journal.pcbi.1000605","volume":"5","author":"AM Schnoes","year":"2009","unstructured":"Schnoes AM, Brown SD, Dodevski I, Babbitt PC: Annotation error in public databases: misannotation of molecular function in enzyme superfamilies. PLoS Comput Biol 2009, 5: e1000605. 10.1371\/journal.pcbi.1000605","journal-title":"PLoS Comput Biol"},{"key":"4839_CR21","doi-asserted-by":"publisher","first-page":"7835","DOI":"10.1073\/pnas.141222098","volume":"98","author":"Q She","year":"2001","unstructured":"She Q, Singh RK, Confalonieri F, Zivanovic Y, Allard G, Awayez MJ, Chan-Weiher CC, Clausen IG, Curtis BA, De Moors A, Erauso G, Fletcher C, Gordon PM, Heikamp-de Jong I, Jeffries AC, Kozera CJ, Medina N, Peng X, Thi-Ngoc HP, Redder P, Schenk ME, Theriault C, Tolstrup N, Charlebois RL, Doolittle WF, Duguet M, Gaasterland T, Garrett RA, Ragan MA, Sensen CW, Van der Oost J: The complete genome of the crenarchaeon Sulfolobus solfataricus P2. Proc Natl Acad Sci USA 2001, 98: 7835\u20137840. 10.1073\/pnas.141222098","journal-title":"Proc Natl Acad Sci USA"},{"key":"4839_CR22","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1186\/1471-2105-10-421","volume":"10","author":"C Camacho","year":"2009","unstructured":"Camacho C, Coulouris G, Avagyan V, Ma N, Papadopoulos J, Bealer K, Madden TL: BLAST+: architecture and applications. BMC Bioinformatics 2009, 10: 421. 10.1186\/1471-2105-10-421","journal-title":"BMC Bioinformatics"},{"key":"4839_CR23","doi-asserted-by":"publisher","first-page":"D588","DOI":"10.1093\/nar\/gkn820","volume":"37","author":"A Chang","year":"2009","unstructured":"Chang A, Scheer M, Grote A, Schomburg I, Schomburg D: BRENDA, AMENDA and FRENDA the enzyme information system: new content and tools in 2009. Nucleic Acids Res 2009, 37: D588\u2013592. 10.1093\/nar\/gkn820","journal-title":"Nucleic Acids Res"},{"key":"4839_CR24","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1186\/1471-2105-11-589","volume":"11","author":"C Bannert","year":"2010","unstructured":"Bannert C, Welfle A, Aus dem Spring C, Schomburg D: BrEPS: A flexible and automatic protocol to compute enzyme-specific sequence profiles for functional annotation. BMC Bioinformatics 2010, 11: 589. 10.1186\/1471-2105-11-589","journal-title":"BMC Bioinformatics"},{"key":"4839_CR25","doi-asserted-by":"publisher","first-page":"D473","DOI":"10.1093\/nar\/gkp875","volume":"38","author":"R Caspi","year":"2010","unstructured":"Caspi R, Altman T, Dale JM, Dreher K, Fulcher CA, Gilham F, Kaipa P, Karthikeyan AS, Kothari A, Krummenacker M, Latendresse M, Mueller LA, Paley S, Popescu L, Pujar A, Shearer AG, Zhang P, Karp PD: The MetaCyc database of metabolic pathways and enzymes and the BioCyc collection of pathway\/genome databases. Nucleic Acids Res 2010, 38: D473\u2013479. 10.1093\/nar\/gkp875","journal-title":"Nucleic Acids Res"}],"container-title":["BMC Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2105-12-376.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-2105-12-376\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2105-12-376.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,16]],"date-time":"2019-06-16T04:51:30Z","timestamp":1560660690000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcbioinformatics.biomedcentral.com\/articles\/10.1186\/1471-2105-12-376"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9,23]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["4839"],"URL":"https:\/\/doi.org\/10.1186\/1471-2105-12-376","relation":{},"ISSN":["1471-2105"],"issn-type":[{"value":"1471-2105","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9,23]]},"article-number":"376"}}