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The objective of this study is to develop a novel meta-analysis approach, Consistent Differential Expression Pattern (CDEP), to identify genes with common differential expression patterns across different datasets.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>We combined False Discovery Rate (FDR) estimation and the non-parametric RankProd approach to estimate the Type I error rate in each microarray dataset of the meta-analysis. These Type I error rates from all datasets were then used to identify genes with common differential expression patterns. Our simulation study showed that CDEP achieved higher statistical power and maintained low Type I error rate when compared with two recently proposed meta-analysis approaches. We applied CDEP to analyze microarray data from different laboratories that compared transcription profiles between metastatic and primary cancer of different types. Many genes identified as differentially expressed consistently across different cancer types are in pathways related to metastatic behavior, such as ECM-receptor interaction, focal adhesion, and blood vessel development. We also identified novel genes such as <jats:italic>AMIGO2<\/jats:italic>, <jats:italic>Gem<\/jats:italic>, and <jats:italic>CXCL11<\/jats:italic> that have not been shown to associate with, but may play roles in, metastasis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>CDEP is a flexible approach that borrows information from each dataset in a meta-analysis in order to identify genes being differentially expressed consistently. We have shown that CDEP can gain higher statistical power than other existing approaches under a variety of settings considered in the simulation study, suggesting its robustness and insensitivity to data variation commonly associated with microarray experiments.<\/jats:p>\n            <jats:p>\n              <jats:bold>Availability<\/jats:bold>: CDEP is implemented in R and freely available at: <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/genomebioinfo.musc.edu\/CDEP\/\" ext-link-type=\"uri\">http:\/\/genomebioinfo.musc.edu\/CDEP\/<\/jats:ext-link>\n            <\/jats:p>\n            <jats:p>\n              <jats:bold>Contact<\/jats:bold>: zhengw@musc.edu<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2105-12-438","type":"journal-article","created":{"date-parts":[[2011,11,11]],"date-time":"2011-11-11T19:22:57Z","timestamp":1321039377000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Consistent Differential Expression Pattern (CDEP) on microarray to identify genes related to metastatic behavior"],"prefix":"10.1186","volume":"12","author":[{"given":"Lam C","family":"Tsoi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingting","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth H","family":"Slate","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W Jim","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2011,11,11]]},"reference":[{"key":"4982_CR1","first-page":"175","volume":"338","author":"T Barrett","year":"2006","unstructured":"Barrett T, Edgar R: Mining microarray data at NCBI's Gene Expression Omnibus (GEO)*. 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