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Due to their unique functions and binding specificity, there is a need for a transcription factor-specific, structure-based database and corresponding web service to facilitate structural bioinformatics studies of transcription factor-DNA interactions, such as development of knowledge-based interaction potential, transcription factor-DNA docking, binding induced conformational changes, and the thermodynamics of protein-DNA interactions.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Description<\/jats:title>\n            <jats:p>TFinDit is a relational database and a web search tool for studying transcription factor-DNA interactions. The database contains annotated transcription factor-DNA complex structures and related data, such as unbound protein structures, thermodynamic data, and binding sequences for the corresponding transcription factors in the complex structures. TFinDit also provides a user-friendly interface and allows users to either query individual entries or generate datasets through culling the database based on one or more search criteria.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>TFinDit is a specialized structural database with annotated transcription factor-DNA complex structures and other preprocessed data. We believe that this database\/web service can facilitate the development and testing of TF-DNA interaction potentials and TF-DNA docking algorithms, and the study of protein-DNA recognition mechanisms.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2105-13-220","type":"journal-article","created":{"date-parts":[[2012,9,3]],"date-time":"2012-09-03T16:14:13Z","timestamp":1346688853000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["TFinDit: transcription factor-DNA interaction data depository"],"prefix":"10.1186","volume":"13","author":[{"given":"Daniel","family":"Turner","sequence":"first","affiliation":[]},{"given":"RyangGuk","family":"Kim","sequence":"additional","affiliation":[]},{"given":"Jun-tao","family":"Guo","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2012,9,3]]},"reference":[{"key":"5413_CR1","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.tig.2009.12.003","volume":"26","author":"Y Pan","year":"2010","unstructured":"Pan Y, Tsai CJ, Ma B, Nussinov R: Mechanisms of transcription factor selectivity. 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