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The model describes in detail both the humoral and cellular response of the immune system to the tumor associate antigen and the recognition process between B cells, T cells and antigen presenting cells. The control of the tumor cells growth occurs through the definition of different vaccine protocols. The performed numerical simulations of the model are in agreement with in vivo experiments on transgenic mice.<\/jats:p>","DOI":"10.1186\/1471-2105-13-s17-s21","type":"journal-article","created":{"date-parts":[[2012,12,13]],"date-time":"2012-12-13T11:15:56Z","timestamp":1355397356000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Mathematical modeling of the immune system recognition to mammary carcinoma antigen"],"prefix":"10.1186","volume":"13","author":[{"given":"Carlo","family":"Bianca","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferdinando","family":"Chiacchio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Pappalardo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marzio","family":"Pennisi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,12,13]]},"reference":[{"key":"5485_CR1","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1136\/bmj.1.5023.841","volume":"1","author":"M Burnet","year":"1957","unstructured":"Burnet M: Cancer: a biological approach. 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