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To achieve this, you must characterise users\u2019 requirements, design suitable interactions to meet their needs, and test your designs using prototypes and real life scenarios.<\/jats:p>\n          <jats:p>For bioinformatics, there is little practical information available regarding how to carry out UCD in practice. To address this we describe a complete, multi-stage UCD process used for creating a new bioinformatics resource for integrating enzyme information, called the Enzyme Portal (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.ebi.ac.uk\/enzymeportal\" ext-link-type=\"uri\">http:\/\/www.ebi.ac.uk\/enzymeportal<\/jats:ext-link>). This freely-available service mines and displays data about proteins with enzymatic activity from public repositories via a single search, and includes biochemical reactions, biological pathways, small molecule chemistry, disease information, 3D protein structures and relevant scientific literature.<\/jats:p>\n          <jats:p>We employed several UCD techniques, including: persona development, interviews, \u2018canvas sort\u2019 card sorting, user workflows, usability testing and others. Our hope is that this case study will motivate the reader to apply similar UCD approaches to their own software design for bioinformatics. Indeed, we found the benefits included more effective decision-making for design ideas and technologies; enhanced team-working and communication; cost effectiveness; and ultimately a service that more closely meets the needs of our target audience.<\/jats:p>","DOI":"10.1186\/1471-2105-14-103","type":"journal-article","created":{"date-parts":[[2013,3,20]],"date-time":"2013-03-20T17:22:51Z","timestamp":1363800171000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["The Enzyme Portal: a case study in applying user-centred design methods in bioinformatics"],"prefix":"10.1186","volume":"14","author":[{"given":"Paula","family":"de Matos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer A","family":"Cham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Alc\u00e1ntara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis","family":"Rowland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo","family":"Lopez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Steinbeck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,3,20]]},"reference":[{"key":"5787_CR1","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1039\/C1MB05340J","volume":"8","author":"R Goel","year":"2011","unstructured":"Goel R, Harsha HC, Pandey A, Prasad TSK: Human Protein Reference Database and Human Proteinpedia as resources for phosphoproteome analysis. 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