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Identifying co-evolving genes can thus shed light on ancestral genome structures and functional gene interactions.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>We devise a simple, fast and accurate probability method based on species tree-gene tree reconciliations to detect when two gene families have co-evolved. Our method observes the number and location of predicted macro-evolutionary events, and estimates the probability of having the observed number of common events by chance.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Simulation studies confirm that our method effectively identifies co-evolving families. This opens numerous perspectives on genome-scale analysis where this method could be used to pinpoint co-evolving gene families and thus help to unravel ancestral genome arrangements or undocumented gene interactions.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2105-14-332","type":"journal-article","created":{"date-parts":[[2013,11,20]],"date-time":"2013-11-20T08:02:12Z","timestamp":1384934532000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Reconciliation-based detection of co-evolving gene families"],"prefix":"10.1186","volume":"14","author":[{"given":"Yao-ban","family":"Chan","sequence":"first","affiliation":[]},{"given":"Vincent","family":"Ranwez","sequence":"additional","affiliation":[]},{"given":"Celine","family":"Scornavacca","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2013,11,20]]},"reference":[{"key":"6218_CR1","volume-title":"Statistical tests of host-parasite cospeciation","author":"JP Huelsenbeck","year":"1997","unstructured":"Huelsenbeck JP, Rannala B, Yang Z: Statistical tests of host-parasite cospeciation. 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