{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T12:32:20Z","timestamp":1769603540086,"version":"3.49.0"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"S16","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMC Bioinformatics"],"published-print":{"date-parts":[[2013,10]]},"DOI":"10.1186\/1471-2105-14-s16-s9","type":"journal-article","created":{"date-parts":[[2013,10,22]],"date-time":"2013-10-22T09:06:39Z","timestamp":1382432799000},"source":"Crossref","is-referenced-by-count":31,"title":["Agent based modeling of Treg-Teff cross regulation in relapsing-remitting multiple sclerosis"],"prefix":"10.1186","volume":"14","author":[{"given":"Marzio","family":"Pennisi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdul-Mateen","family":"Rajput","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Toldo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Pappalardo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,10,22]]},"reference":[{"key":"6128_CR1","unstructured":"Compston A, McDonald I, Noseworthy J, Lassmann H, Miller D, Smith K, Wekerle H, Confavreux C: McAlpine's Multiple Sclerosis. Elsevier, ISBN 9780443072710, 4"},{"issue":"2","key":"6128_CR2","doi-asserted-by":"publisher","first-page":"e1000369","DOI":"10.1371\/journal.pgen.1000369","volume":"5","author":"SV Ramagopalan","year":"2009","unstructured":"Ramagopalan SV, Maugeri NJ, Handunnetthi L, Lincoln MR, Orton SM, Dyment DA, DeLuca GC, Herrera BM, Chao MJ, Sadovnick AD, Ebers GC, Knight JC: Expression of the Multiple Sclerosis-Associated MHC Class II Allele HLA-DRB1*1501 Is Regulated by Vitamin D. PLoS Genet. 2009, 5 (2): e1000369-10.1371\/journal.pgen.1000369. doi:10.1371\/journal.pgen.1000369","journal-title":"PLoS Genet"},{"issue":"9313","key":"6128_CR3","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1016\/S0140-6736(02)08220-X","volume":"359","author":"A Compston","year":"2002","unstructured":"Compston A, Coles A: Multiple Sclerosis. Lancet. 2002, 359 (9313): 1221-1231. 10.1016\/S0140-6736(02)08220-X.","journal-title":"Lancet"},{"issue":"22","key":"6128_CR4","doi-asserted-by":"publisher","first-page":"12877","DOI":"10.1073\/pnas.1932604100","volume":"100","author":"CJ Willer","year":"2003","unstructured":"Willer CJ, Dyment DA, Risch NJ, Sadovick AD, Ebers GC: Twin Concordance and Sibling Recurrence Rates in Multiple Sclerosis. Proceedings of the National Academy of Sciences of the United States of America. 2003, 100 (22): 12877-12882. 10.1073\/pnas.1932604100.","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"24","key":"6128_CR5","doi-asserted-by":"publisher","first-page":"3083","DOI":"10.1001\/jama.286.24.3083","volume":"286","author":"A Ascherio","year":"2001","unstructured":"Ascherio A, Munger KL, Lennette ET, Spiegelman D, Hern\u00e1n MA, Olek MJ, Hankinson SE, Hunter DJ: Epstein-Barr Virus Antibodies and Risk of Multiple Sclerosis: a Prospective Study. Journal of the American Medical Association. 2001, 286 (24): 3083-3088. 10.1001\/jama.286.24.3083.","journal-title":"Journal of the American Medical Association"},{"issue":"4","key":"6128_CR6","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1001\/jama.293.4.463","volume":"293","author":"AL Ponsonby","year":"2005","unstructured":"Ponsonby AL, van der Mei I, Dwyer T, Blizzard L, Taylor B, Kemp A, Simmons R, Kilpatrick T: Exposure to Infant Siblings During Early Life and Risk of Multiple Sclerosis. Journal of the American Medical Association. 2005, 293 (4): 463-469. 10.1001\/jama.293.4.463.","journal-title":"Journal of the American Medical Association"},{"issue":"12","key":"6128_CR7","doi-asserted-by":"publisher","first-page":"2277","DOI":"10.1212\/01.WNL.0000130496.51156.D7","volume":"62","author":"P Sundstr\u00f6m","year":"2004","unstructured":"Sundstr\u00f6m P, Juto P, Wadell G, Hallmans G, Svenningsson A, Nystr\u00f6m L, Dillner J, Forsgren L: An Altered Immune Response to Epstein-Barr Virus in Multiple Sclerosis: a Prospective Study. it Neurology. 2004, 62 (12): 2277-2282. 10.1212\/01.WNL.0000130496.51156.D7.","journal-title":"it Neurology"},{"issue":"2","key":"6128_CR8","doi-asserted-by":"publisher","first-page":"e4565","DOI":"10.1371\/journal.pone.0004565","volume":"4","author":"DS Goodin","year":"2009","unstructured":"Goodin DS: The Causal Cascade to Multiple Sclerosis: A Model for MS Pathogenesis. PLoS ONE. 2009, 4 (2): e4565-10.1371\/journal.pone.0004565. doi:10.1371\/journal.pone.0004565","journal-title":"PLoS ONE"},{"issue":"2","key":"6128_CR9","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/S1474-4422(12)70309-5","volume":"12","author":"JL Huynh","year":"2013","unstructured":"Huynh JL, Casaccia P: Epigenetic Mechanisms in Multiple Sclerosis: Implications for Pathogenesis and Treatment. The Lancet Neurology. 2013, 12 (2): 195-206. 10.1016\/S1474-4422(12)70309-5. doi:10.1016\/S1474-4422(12)70309-5","journal-title":"The Lancet Neurology"},{"issue":"2","key":"6128_CR10","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1007\/s100720170011","volume":"22","author":"G Rosati","year":"2001","unstructured":"Rosati G: The prevalence of multiple sclerosis in the world: an update. Neurol Sci. 2001, 22 (2): 117-139. 10.1007\/s100720170011.","journal-title":"Neurol Sci"},{"key":"6128_CR11","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1146\/annurev.immunol.23.021704.115707","volume":"23","author":"M Sospedra","year":"2005","unstructured":"Sospedra M, Martin R: Immunology of multiple sclerosis. Annu Rev Immunol. 2005, 23: 683-747. 10.1146\/annurev.immunol.23.021704.115707.","journal-title":"Annu Rev Immunol"},{"issue":"3","key":"6128_CR12","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1093\/brain\/awh721","volume":"129","author":"M Kremenchutzky","year":"2006","unstructured":"Kremenchutzky M, Rice GPA, Baskerville J, Wingerchuk DM, Ebers GC: The Natural History of Multiple Sclerosis: a Geographically Based Study 9: Observations on the Progressive Phase of the Disease. Brain. 2006, 129 (3): 584-594. 10.1093\/brain\/awh721.","journal-title":"Brain"},{"key":"6128_CR13","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1186\/1752-0509-5-114","volume":"5","author":"N V\u00e9lez de Mendiz\u00e1bal","year":"2011","unstructured":"V\u00e9lez de Mendiz\u00e1bal N, Carneiro J, Sol\u00e9 RV, Go\u00f1i J, Bragard J, Martinez-Forero I, Martinez-Pasamar S, Sepulcre J, Torrealdea J, Bagnato F, Garcia-Ojalvo J, Villoslada P: Modeling the effector - regulatory T cell cross-regulation reveals the intrinsic character of relapses in Multiple Sclerosis. BMC Systems Biology. 2011, 5: 114-10.1186\/1752-0509-5-114. [ http:\/\/www.biomedcentral.com\/1752-0509\/5\/114 ]","journal-title":"BMC Systems Biology"},{"issue":"7","key":"6128_CR14","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1212\/WNL.59.7.1006","volume":"59","author":"A Boiko","year":"2002","unstructured":"Boiko A, Vorobeychik G, Paty D, Devonshire V, Sadovnick D: Early Onset Multiple Sclerosis: a Longitudinal Study. Neurology. 2002, 59 (7): 1006-1010. 10.1212\/WNL.59.7.1006.","journal-title":"Neurology"},{"issue":"9","key":"6128_CR15","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1038\/ni0901-762","volume":"2","author":"L Steinman","year":"2001","unstructured":"Steinman L: Multiple Sclerosis: a Two-stage Disease. Nature Immunology. 2001, 2 (9): 762-764. 10.1038\/ni0901-762.","journal-title":"Nature Immunology"},{"issue":"3","key":"6128_CR16","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1097\/00019052-199906000-00008","volume":"12","author":"BD Trapp","year":"1999","unstructured":"Trapp BD, Ransohoff R, Rudick R: Axonal pathology in multiple sclerosis: relationship to neurologic disability. Current Opinion in Neurology. 1999, 12 (3): 295-302. 10.1097\/00019052-199906000-00008.","journal-title":"Current Opinion in Neurology"},{"issue":"4","key":"6128_CR17","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1038\/ni1179","volume":"6","author":"JD Fontenot","year":"2005","unstructured":"Fontenot JD, Rudensky AY: A Well Adapted Regulatory Contrivance: Regulatory T Cell Development and the Forkhead Family Transcription Factor Foxp3. Nature Immunology. 2005, 6 (4): 331-337. 10.1038\/ni1179.","journal-title":"Nature Immunology"},{"issue":"5880","key":"6128_CR18","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.1126\/science.1155209","volume":"320","author":"JM Lund","year":"2008","unstructured":"Lund JM, Hsing L, Pham TT, Rudensky AY: Coordination of Early Protective Immunity to Viral Infection by Regulatory T Cells. Science. 2008, 320 (5880): 1220-1224. 10.1126\/science.1155209.","journal-title":"Science"},{"key":"6128_CR19","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1111\/j.1600-065X.2007.00487.x","volume":"216","author":"J Carneiro","year":"2007","unstructured":"Carneiro J, Leon K, Caramalho I, van den Dool C, Gardner R, Oliveira V, Bergman ML, Sep\u00falveda N, Paix\u00e3o T, Faro J, Demengeot J: When Three Is Not a Crowd: a Crossregulation Model of the Dynamics and Repertoire Selection of Regulatory CD4+ T Cells. Immunological Reviews. 2007, 216: 48-68.","journal-title":"Immunological Reviews"},{"issue":"3","key":"6128_CR20","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.4049\/jimmunol.155.3.1151","volume":"155","author":"S Sakaguchi","year":"1995","unstructured":"Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M: Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alphachains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol. 1995, 155 (3): 1151-1164.","journal-title":"J Immunol"},{"key":"6128_CR21","volume-title":"Briefings in Bioinformatics","author":"S Motta","year":"2012","unstructured":"Motta S, Pappalardo F: Mathematical modeling of biological systems. Briefings in Bioinformatics. 2012, doi:10.1093\/bib\/bbs061"},{"key":"6128_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/13873954.2011.601419","volume":"18","author":"M Read","year":"2012","unstructured":"Read M, Andrews PS, Timmis J, Kumar V: Techniques for grounding agent-based simulations in the real domain: a case study in experimental autoimmune encephalomyelitis. Mathematical and Computer Modelling of Dynamical Systems: Methods, Tools and Applications in Engineering and Related Sciences. 2012, 18: 1-67-86","journal-title":"Mathematical and Computer Modelling of Dynamical Systems: Methods, Tools and Applications in Engineering and Related Sciences"},{"issue":"2","key":"6128_CR23","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1084\/jem.188.2.287","volume":"188","author":"AM Thornton","year":"1998","unstructured":"Thornton AM, Shevach EM: CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J Exp Med. 1998, 188 (2): 287-296. 10.1084\/jem.188.2.287.","journal-title":"J Exp Med"},{"issue":"12","key":"6128_CR24","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1038\/ni1536","volume":"8","author":"P Pandiyan","year":"2007","unstructured":"Pandiyan P, Zheng L, Ishihara S, Reed J, Lenardo MJ: CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells. Nat Immunol. 2007, 8 (12): 1353-1362. 10.1038\/ni1536.","journal-title":"Nat Immunol"},{"issue":"2","key":"6128_CR25","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1084\/jem.20030315","volume":"198","author":"LS Walker","year":"2003","unstructured":"Walker LS, Chodos A, Eggena M, Dooms H, Abbas AK: Antigen-dependent proliferation of CD4+ CD25+ regulatory T cells in vivo. J Exp Med. 2003, 198 (2): 249-258. 10.1084\/jem.20030315.","journal-title":"J Exp Med"},{"issue":"13","key":"6128_CR26","doi-asserted-by":"publisher","first-page":"6777","DOI":"10.1128\/JVI.00153-07","volume":"81","author":"JD L\u00fcnemann","year":"2007","unstructured":"L\u00fcnemann JD, Kamradt T, Martin R, M\u00fcnz C: Epstein-Barr Virus: Environmental Trigger of Multiple Sclerosis?. J Virol. 2007, 81 (13): 6777-10.1128\/JVI.00153-07.","journal-title":"J Virol"},{"issue":"7","key":"6128_CR27","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1177\/1352458512466929","volume":"19","author":"JR Christensen","year":"2013","unstructured":"Christensen JR, B\u00f6rnsen L, Khademi M, Olsson T, Jensen PE, S\u00f8rensen PS, Sellebjerg F: CSF inflammation and axonal damage are increased and correlate in progressive multiple sclerosis. Mult Scler. 2013, 19 (7): 877-884. 10.1177\/1352458512466929.","journal-title":"Mult Scler"},{"key":"6128_CR28","doi-asserted-by":"publisher","first-page":"2426","DOI":"10.1212\/WNL.43.11.2426-a","volume":"43","author":"J Hillert","year":"2004","unstructured":"Hillert J, Olerup O: HLA and MS. Neurology. 2004, 43: 2426-2427.","journal-title":"Neurology"},{"key":"6128_CR29","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1034\/j.1600-065X.2001.1820102.x","volume":"182","author":"S Sakaguchi","year":"2001","unstructured":"Sakaguchi S, Sakaguchi N, Shimizu J, Yamazaki S, Sakihama T, Itoh M, Kuniyasu Y, Nomura T, Toda M, Takahashi T: Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance. Immunol Rev. 2001, 182: 18-32. 10.1034\/j.1600-065X.2001.1820102.x.","journal-title":"Immunol Rev"},{"issue":"2","key":"6128_CR30","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1084\/jem.188.2.287","volume":"188","author":"AM Thornton","year":"1998","unstructured":"Thornton AM, Shevach EM: CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J Exp Med. 1998, 188 (2): 287-296. 10.1084\/jem.188.2.287.","journal-title":"J Exp Med"},{"issue":"1","key":"6128_CR31","doi-asserted-by":"publisher","first-page":"183","DOI":"10.4049\/jimmunol.164.1.183","volume":"164","author":"AM Thornton","year":"2000","unstructured":"Thornton AM, Shevach EM: Suppressor effector function of CD4+CD25+ immunoregulatory T cells is antigen nonspecific. J Immunol. 2000, 164 (1): 183-190.","journal-title":"J Immunol"},{"key":"6128_CR32","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1034\/j.1600-065X.2001.1820104.x","volume":"182","author":"EM Shevach","year":"2001","unstructured":"Shevach EM, McHugh RS, Piccirillo CA, Thornton AM: Control of T-cell activation by CD4+ CD25+ suppressor T cells. Immunol Rev. 2001, 182: 58-67. 10.1034\/j.1600-065X.2001.1820104.x.","journal-title":"Immunol Rev"},{"key":"6128_CR33","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1111\/j.0105-2896.2006.00427.x","volume":"212","author":"S Sakaguchi","year":"2006","unstructured":"Sakaguchi S, Ono M, Setoguchi R, Yagi H, Hori S, Fehervari Z, Shimizu J, Takahashi T, Nomura T: Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease. Immunol Rev. 2006, 212: 8-27. 10.1111\/j.0105-2896.2006.00427.x.","journal-title":"Immunol Rev"},{"issue":"4","key":"6128_CR34","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1038\/ni1179","volume":"6","author":"JD Fontenot","year":"2005","unstructured":"Fontenot JD, Rudensky AY: A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3. Nat Immunol. 2005, 6 (4): 331-337. 10.1038\/ni1179.","journal-title":"Nat Immunol"},{"key":"6128_CR35","doi-asserted-by":"publisher","first-page":"89017","DOI":"10.1155\/2007\/89017","volume":"2007","author":"HJ Van der Vliet","year":"2007","unstructured":"Van der Vliet HJ, Nieuwenhuis EE: IPEX as a result of mutations in FOXP3. Clin Dev Immunol. 2007, 2007: 89017-","journal-title":"Clin Dev Immunol"},{"issue":"1-3","key":"6128_CR36","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1007\/s12026-007-0022-2","volume":"38","author":"HD Ochs","year":"2007","unstructured":"Ochs HD, Gambineri E, Torgerson TR: IPEX, FOXP3 and regulatory T-cells: a model for autoimmunity. Immunol Res. 2007, 38 (1-3): 112-121. 10.1007\/s12026-007-0022-2.","journal-title":"Immunol Res"},{"issue":"7","key":"6128_CR37","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1084\/jem.20031579","volume":"199","author":"V Viglietta","year":"2004","unstructured":"Viglietta V, Baecher-Allan C, Weiner HL, Hafler DA: Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis. JExpMed. 2004, 199 (7): 971-979. 10.1084\/jem.20031579.","journal-title":"JExpMed"},{"issue":"1","key":"6128_CR38","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1172\/JCI0213605","volume":"109","author":"A Kukreja","year":"2002","unstructured":"Kukreja A, Cost G, Marker J, Zhang C, Sun Z, Lin-Su K, Ten S, Sanz M, Exley M, Wilson B: Multiple immuno-regulatory defects in type-1 diabetes. J Clin Invest. 2002, 109 (1): 131-140.","journal-title":"J Clin Invest"},{"key":"6128_CR39","first-page":"305","volume-title":"Proc of the ACM Genetic and Evolutionary Computation Conference (GECCO'05)","author":"Z Guo","year":"2005","unstructured":"Guo Z, Han HK, Tay JC: Sufficiency verification of HIV-1 pathogenesis based on multi-agent simulation. Proc of the ACM Genetic and Evolutionary Computation Conference (GECCO'05). 2005, 305-312."},{"key":"6128_CR40","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1007\/11751540_65","volume":"3980","author":"D Perrin","year":"2006","unstructured":"Perrin D, Ruskin HJ, Burns J, Crane M: An agent-based approach to immune modelling. Lecture Notes in Computer Science. 2006, 3980: 612-621. 10.1007\/11751540_65.","journal-title":"Lecture Notes in Computer Science"},{"key":"6128_CR41","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/S0010-4825(01)00011-7","volume":"3","author":"M Bernaschi","year":"2001","unstructured":"Bernaschi M, Castiglione F: Design and implementation of an immune system simulator. Comp in Biol and Med. 2001, 3: 303-331.","journal-title":"Comp in Biol and Med"},{"key":"6128_CR42","doi-asserted-by":"publisher","first-page":"2891","DOI":"10.1093\/bioinformatics\/bti426","volume":"21","author":"F Pappalardo","year":"2005","unstructured":"Pappalardo F, Lollini P-L, Castiglione F, Motta S: Modelling and simulation of cancer immuno-prevention vaccine. Bioinformatics. 2005, 21: 2891-2897. 10.1093\/bioinformatics\/bti426.","journal-title":"Bioinformatics"},{"issue":"Suppl 7","key":"6128_CR43","doi-asserted-by":"publisher","first-page":"S13","DOI":"10.1186\/1471-2105-11-S7-S13","volume":"11","author":"M Pennisi","year":"2010","unstructured":"Pennisi M, Pappalardo M, Palladini A, Nicoletti G, Nanni P, Lollini P-L, Motta S: Modeling the competition between lung metastases and the immune system using agents. BMC Bioinformatics. 2010, 11 (Suppl 7): S13-10.1186\/1471-2105-11-S7-S13.","journal-title":"BMC Bioinformatics"},{"key":"6128_CR44","doi-asserted-by":"publisher","first-page":"7755","DOI":"10.1158\/0008-5472.CAN-10-0701","volume":"70","author":"A Palladini","year":"2010","unstructured":"Palladini A, Nicoletti G, Pappalardo F, Murgo A, Grosso V, Stivani V, Ianzano ML, Antognoli A, Croci S, Landuzzi L, De Giovanni C, Nanni P, Motta S, Lollini P-L: In silico modeling and in vivo efficacy of cancer preventive vaccinations. Cancer Research. 2010, 70: 7755-7763. 10.1158\/0008-5472.CAN-10-0701.","journal-title":"Cancer Research"},{"key":"6128_CR45","first-page":"386","volume":"5755","author":"F Pappalardo","year":"2009","unstructured":"Pappalardo F, Cincotti A, Motta S, Pennisi M: Agent based modeling of atherosclerosis: a concrete help in personalized treatments. Lecture Notes in Artificial Intelligence. 2009, 5755: 386-396.","journal-title":"Lecture Notes in Artificial Intelligence"},{"issue":"3","key":"6128_CR46","first-page":"303","volume":"13","author":"S Elizabeth","year":"2011","unstructured":"Elizabeth S: NetLogo, a multi-agent simulation environment. Artificial Life. 2011, 13 (3): 303-311.","journal-title":"Artificial Life"},{"issue":"15","key":"6128_CR47","doi-asserted-by":"publisher","first-page":"1740","DOI":"10.1093\/bioinformatics\/btn260","volume":"24","author":"M Pennisi","year":"2008","unstructured":"Pennisi M, Catanuto R, Pappalardo F, Motta S: Optimal vaccination schedules using simulated annealing. Bioinformatics. 2008, 24 (15): 1740-1743. 10.1093\/bioinformatics\/btn260.","journal-title":"Bioinformatics"},{"key":"6128_CR48","first-page":"223","volume":"3849","author":"F Pappalardo","year":"2006","unstructured":"Pappalardo F, Mastriani E, Lollini PL, Motta S: Genetic algorithm against cancer. LNCS. 2006, 3849: 223-228.","journal-title":"LNCS"},{"issue":"10","key":"6128_CR49","doi-asserted-by":"publisher","first-page":"e26523","DOI":"10.1371\/journal.pone.0026523","volume":"6","author":"F Pappalardo","year":"2011","unstructured":"Pappalardo F, Forero IM, Pennisi M, Palazon A, Melero I, Motta S: SimB16: Modeling induced immune system response against B16-melanoma. PLoS ONE. 2011, 6 (10): e26523-10.1371\/journal.pone.0026523.","journal-title":"PLoS ONE"},{"key":"6128_CR50","first-page":"1","volume":"5666","author":"M Pennisi","year":"2009","unstructured":"Pennisi M, Pappalardo F, Motta S: Agent based modeling of lung metastasis-immune system competition. LNCS. 2009, 5666: 1-3.","journal-title":"LNCS"},{"issue":"1-2","key":"6128_CR51","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.jim.2011.11.009","volume":"376","author":"D Alemani","year":"2012","unstructured":"Alemani D, Pappalardo F, Pennisi M, Motta S, Brusic V: Combining cellular automata and lattice Boltzmann method to model multi scale vascular timor growth coupled with nutrient diffusion and immune competition. Journal of Immunological Methods. 2012, 376 (1-2): 55-68. 10.1016\/j.jim.2011.11.009.","journal-title":"Journal of Immunological Methods"},{"key":"6128_CR52","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1145\/1854776.1854900","volume-title":"Proceedings of the First ACM International Conference on Bioinformatics and Computational Biology (ACM-BCB 2010)","author":"F Pappalardo","year":"2010","unstructured":"Pappalardo F, Pennisi M, Motta S: Universal Immune System Simulator framework (UISS). Proceedings of the First ACM International Conference on Bioinformatics and Computational Biology (ACM-BCB 2010). 2010, 649-650."},{"key":"6128_CR53","first-page":"504","volume-title":"Cambridge University Press","author":"S Yoav","year":"2009","unstructured":"Yoav S, Leyton-Brown K: Multiagent Systems: Algorithmic, Game-Theoretic, and Logical Foundations. Cambridge University Press. 2009, 504-ISBN 978-0-521-89943-7"},{"issue":"4 Pt 1","key":"6128_CR54","doi-asserted-by":"publisher","first-page":"041911","DOI":"10.1103\/PhysRevE.77.041911","volume":"77","author":"Y Wu","year":"2008","unstructured":"Wu Y, Zhu WQ: Stochastic analysis of a pulse-type prey-predator model. Phys Rev E Stat Nonlin Soft Matter Phys. 2008, 77 (4 Pt 1): 041911-","journal-title":"Phys Rev E Stat Nonlin Soft Matter Phys"},{"key":"6128_CR55","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1146\/annurev.immunol.23.021704.115601","volume":"24","author":"B Kyewski","year":"2006","unstructured":"Kyewski B, Klein L: A central role for central tolerance. Annu Rev Immunol. 2006, 24: 571-606. 10.1146\/annurev.immunol.23.021704.115601.","journal-title":"Annu Rev Immunol"},{"key":"6128_CR56","doi-asserted-by":"publisher","first-page":"2277","DOI":"10.1212\/01.WNL.0000130496.51156.D7","volume":"62","author":"P Sundstr\u00f6m","year":"2004","unstructured":"Sundstr\u00f6m P, Juto P, Wadell G, Hallmans G, Svenningsson A, Nystr\u00f6m L, Dillner J, Forsgren L: An altered immune response to Epstein-Barr virus in multiple sclerosis A prospective study. NEUROLOGY. 2004, 62: 2277-2282. 10.1212\/01.WNL.0000130496.51156.D7.","journal-title":"NEUROLOGY"},{"issue":"8","key":"6128_CR57","doi-asserted-by":"publisher","first-page":"4391","DOI":"10.4049\/jimmunol.0903918","volume":"184","author":"K Trandem","year":"2010","unstructured":"Trandem K, Anghelina D, Zhao J, Perlman S: Regulatory T cells inhibit T cell proliferation and decrease demyelination in mice chronically infected with a coronavirus. Journal of immunology. 2010, 184 (8): 4391-4400. 10.4049\/jimmunol.0903918.","journal-title":"Journal of immunology"},{"issue":"7042","key":"6128_CR58","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1038\/nature03724","volume":"435","author":"CC Goodnow","year":"2005","unstructured":"Goodnow CC, Sprent J, Fazekas de St Groth B, Vinuesa CG: Cellular and genetic mechanisms of self tolerance and autoimmunity. Nature. 2005, 435 (7042): 590-597. 10.1038\/nature03724.","journal-title":"Nature"}],"container-title":["BMC Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2105-14-S16-S9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-2105-14-S16-S9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2105-14-S16-S9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T13:13:44Z","timestamp":1688562824000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcbioinformatics.biomedcentral.com\/articles\/10.1186\/1471-2105-14-S16-S9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10]]},"references-count":58,"journal-issue":{"issue":"S16","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["6128"],"URL":"https:\/\/doi.org\/10.1186\/1471-2105-14-s16-s9","relation":{},"ISSN":["1471-2105"],"issn-type":[{"value":"1471-2105","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10]]},"article-number":"S9"}}