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In recent years, the application of global approaches to the study of A-to-I editing, including high throughput sequencing, has led to important advances. However, in spite of enormous efforts, the real biological mechanism underlying this phenomenon remains unknown.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Description<\/jats:title>\n            <jats:p>In this work, we present VIRGO (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/atlas.dmi.unict.it\/virgo\/\" ext-link-type=\"uri\">http:\/\/atlas.dmi.unict.it\/virgo\/<\/jats:ext-link>), a web-based tool that maps Ato-G mismatches between genomic and EST sequences as candidate A-to-I editing sites. VIRGO is built on top of a knowledge-base integrating information of genes from UCSC, EST of NCBI, SNPs, DARNED, and Next Generations Sequencing data. The tool is equipped with a user-friendly interface allowing users to analyze genomic sequences in order to identify candidate A-to-I editing sites.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>VIRGO is a powerful tool allowing a systematic identification of putative A-to-I editing sites in genomic sequences. The integration of NGS data allows the computation of p-values and adjusted p-values to measure the mapped editing sites confidence. The whole knowledge base is available for download and will be continuously updated as new NGS data becomes available.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2105-14-s7-s5","type":"journal-article","created":{"date-parts":[[2013,4,22]],"date-time":"2013-04-22T10:15:20Z","timestamp":1366625720000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["VIRGO: visualization of A-to-I RNA editing sites in genomic sequences"],"prefix":"10.1186","volume":"14","author":[{"given":"Rosario","family":"Distefano","sequence":"first","affiliation":[]},{"given":"Giovanni","family":"Nigita","sequence":"additional","affiliation":[]},{"given":"Valentina","family":"Macca","sequence":"additional","affiliation":[]},{"given":"Alessandro","family":"Lagan\u00e0","sequence":"additional","affiliation":[]},{"given":"Rosalba","family":"Giugno","sequence":"additional","affiliation":[]},{"given":"Alfredo","family":"Pulvirenti","sequence":"additional","affiliation":[]},{"given":"Alfredo","family":"Ferro","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2013,4,22]]},"reference":[{"key":"5815_CR1","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1146\/annurev-biochem-060208-105251","volume":"79","author":"K Nishikura","year":"2010","unstructured":"Nishikura K: Functions and regulation of RNA editing by ADAR deaminases. 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