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To discover the differentially expressed genes associated with special biological progresses or functions, the scheme is given as follows. Firstly, the matrix D of expression data is decomposed into two adding matrices A and S by using RPCA. Secondly, the differentially expressed genes are identified based on matrix S. Finally, the differentially expressed genes are evaluated by the tools based on Gene Ontology. A larger number of experiments on hypothetical and real gene expression data are also provided and the experimental results show that our method is efficient and effective.<\/jats:p>","DOI":"10.1186\/1471-2105-14-s8-s3","type":"journal-article","created":{"date-parts":[[2013,5,9]],"date-time":"2013-05-09T10:15:14Z","timestamp":1368094514000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Robust PCA based method for discovering differentially expressed genes"],"prefix":"10.1186","volume":"14","author":[{"given":"Jin-Xing","family":"Liu","sequence":"first","affiliation":[]},{"given":"Yu-Tian","family":"Wang","sequence":"additional","affiliation":[]},{"given":"Chun-Hou","family":"Zheng","sequence":"additional","affiliation":[]},{"given":"Wen","family":"Sha","sequence":"additional","affiliation":[]},{"given":"Jian-Xun","family":"Mi","sequence":"additional","affiliation":[]},{"given":"Yong","family":"Xu","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2013,5,9]]},"reference":[{"issue":"10","key":"5856_CR1","doi-asserted-by":"publisher","first-page":"999","DOI":"10.2174\/092986606778777498","volume":"13","author":"B Wang","year":"2006","unstructured":"Wang B, Wong H, Huang DS: Inferring protein-protein interacting sites using residue conservation and evolutionary information. 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