{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T02:29:04Z","timestamp":1773887344090,"version":"3.50.1"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2014,1,14]],"date-time":"2014-01-14T00:00:00Z","timestamp":1389657600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMC Bioinformatics"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1186\/1471-2105-15-10","type":"journal-article","created":{"date-parts":[[2014,1,14]],"date-time":"2014-01-14T16:08:38Z","timestamp":1389715718000},"source":"Crossref","is-referenced-by-count":41,"title":["Efficient haplotype block recognition of very long and dense genetic sequences"],"prefix":"10.1186","volume":"15","author":[{"given":"Daniel","family":"Taliun","sequence":"first","affiliation":[]},{"given":"Johann","family":"Gamper","sequence":"additional","affiliation":[]},{"given":"Cristian","family":"Pattaro","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2014,1,14]]},"reference":[{"issue":"6834","key":"6262_CR1","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1038\/35075590","volume":"411","author":"DE Reich","year":"2001","unstructured":"Reich DE, Cargill M, Bolk S, Ireland J, Sabeti PC, Richter DJ, Lavery T, Kouyoumjian R, Farhadian SF, Ward R, Lander ES: Linkage disequilibrium in the human genome. Nature. 2001, 411 (6834): 199-204. 10.1038\/35075590.","journal-title":"Nature"},{"key":"6262_CR2","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1093\/genetics\/49.1.49","volume":"49","author":"RC Lewontin","year":"1964","unstructured":"Lewontin RC: The interaction of selection and linkage. I. general considerations; heterotic models. Genetics. 1964, 49: 49-67.","journal-title":"Genetics"},{"issue":"6","key":"6262_CR3","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1007\/BF01245622","volume":"38","author":"W Hill","year":"1968","unstructured":"Hill W, Robertson A: Linkage disequilibrium in finite populations. Theo Appl Genet. 1968, 38 (6): 226-231. 10.1007\/BF01245622.","journal-title":"Theo Appl Genet"},{"issue":"20","key":"6262_CR4","doi-asserted-by":"publisher","first-page":"3938","DOI":"10.1093\/bioinformatics\/bti649","volume":"21","author":"S Gu","year":"2005","unstructured":"Gu S, Pakstis AJ, Kidd KK: HAPLOT: a graphical comparison of haplotype blocks, tagSNP sets and SNP variation for multiple populations. Bioinformatics. 2005, 21 (20): 3938-3939. 10.1093\/bioinformatics\/bti649.","journal-title":"Bioinformatics"},{"key":"6262_CR5","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1186\/1471-2164-9-405","volume":"9","author":"C Pattaro","year":"2008","unstructured":"Pattaro C, Ruczinski I, Fallin D, Parmigiani G: Haplotype block partitioning as a tool for dimensionality reduction in SNP association studies. BMC Genomics. 2008, 9: 405-10.1186\/1471-2164-9-405.","journal-title":"BMC Genomics"},{"issue":"3","key":"6262_CR6","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1159\/000327732","volume":"71","author":"C Zapata","year":"2011","unstructured":"Zapata C: On the uses and applications of the most commonly used measures of linkage disequilibrium from the comparative analysis of their statistical properties. Hum Hered. 2011, 71 (3): 186-195. 10.1159\/000327732.","journal-title":"Hum Hered"},{"key":"6262_CR7","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1093\/bioinformatics\/bth482","volume":"21","author":"K Zhang","year":"2005","unstructured":"Zhang K, Qin Z, Chen T, Liu JS, Waterman MS, Sun F: HapBlock: haplotype block partitioning and tag SNP selection software using a set of dynamic programming algorithms. Bioinformatics. 2005, 21: 131-134. 10.1093\/bioinformatics\/bth482.","journal-title":"Bioinformatics"},{"issue":"2","key":"6262_CR8","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1007\/s00439-012-1243-6","volume":"132","author":"J Gibson","year":"2013","unstructured":"Gibson J, Tapper W, Ennis S, Collins A: Exome-based linkage disequilibrium maps of individual genes: functional clustering and relationship to disease. Hum Genet. 2013, 132 (2): 233-243. 10.1007\/s00439-012-1243-6.","journal-title":"Hum Genet"},{"issue":"3","key":"6262_CR9","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1038\/ng.314","volume":"41","author":"DA Tregouet","year":"2009","unstructured":"Tregouet DA, Konig IR, Erdmann J, Munteanu A, Braund PS, Hall AS, Groszhennig A, Linsel-Nitschke P, Perret C, DeSuremain M, Meitinger T, Wright BJ, Preuss M, Balmforth AJ, Ball SG, Meisinger C, Germain C, Evans A, Arveiler D, Luc G, Ruidavets JB, Morrison C, van der Harst P, Schreiber S, Neureuther K, Schafer A, Bugert P, El Mokhtari NE, Schrezenmeir J, Stark K, et al: Genome-wide haplotype association study identifies the, SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease. Nat Genet. 2009, 41 (3): 283-285. 10.1038\/ng.314.","journal-title":"Nat Genet"},{"issue":"4","key":"6262_CR10","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1038\/mp.2012.14","volume":"18","author":"JC Lambert","year":"2013","unstructured":"Lambert JC, Grenier-Boley B, Harold D, Zelenika D, Chouraki V, Kamatani Y, Sleegers K, Ikram MA, Hiltunen M, Reitz C, Mateo I, Feulner T, Bullido M, Galimberti D, Concari L, Alvarez V, Sims R, Gerrish A, Chapman J, Deniz-Naranjo C, Solfrizzi V, Sorbi S, Arosio B, Spalletta G, Siciliano G, Epelbaum J, Hannequin D, Dartigues JF, Tzourio C, Berr C, et al: Genome-wide haplotype association study identifies the, FRMD4A gene as a risk locus for Alzheimer\u2019s disease. Mol Psychiatry. 2013, 18 (4): 461-470. 10.1038\/mp.2012.14.","journal-title":"Mol Psychiatry"},{"issue":"2","key":"6262_CR11","doi-asserted-by":"publisher","first-page":"e57298","DOI":"10.1371\/journal.pone.0057298","volume":"8","author":"C Song","year":"2013","unstructured":"Song C, Chen GK, Millikan RC, Ambrosone CB, John EM, Bernstein L, Zheng W, Hu JJ, Ziegler RG, Nyante S, Bandera EV, Ingles SA, Press MF, Deming SL, Rodriguez-Gil JL, Chanock SJ, Wan P, Sheng X, Pooler LC, Van Den Berg DJ, Le Marchand L, Kolonel LN, Henderson BE, Haiman CA, Stram DO: A Genome-wide scan for breast cancer risk haplotypes among African American women. PLoS ONE. 2013, 8 (2): e57298-10.1371\/journal.pone.0057298.","journal-title":"PLoS ONE"},{"issue":"S1","key":"6262_CR12","doi-asserted-by":"publisher","first-page":"S12","DOI":"10.1002\/gepi.20643","volume":"35","author":"C Dering","year":"2011","unstructured":"Dering C, Hemmelmann C, Pugh E, Ziegler A: Statistical analysis of rare sequence variants: an overview of collapsing methods. Genet Epidemiol. 2011, 35 (S1): S12-S17. 10.1002\/gepi.20643.","journal-title":"Genet Epidemiol"},{"issue":"6","key":"6262_CR13","doi-asserted-by":"publisher","first-page":"1278","DOI":"10.1086\/522374","volume":"81","author":"K Wang","year":"2007","unstructured":"Wang K, Li M, Bucan M: Pathway-based approaches for analysis of genomewide association studies. Am J Hum Genet. 2007, 81 (6): 1278-1283. 10.1086\/522374.","journal-title":"Am J Hum Genet"},{"issue":"5","key":"6262_CR14","doi-asserted-by":"publisher","first-page":"e62161","DOI":"10.1371\/journal.pone.0062161","volume":"8","author":"A Petersen","year":"2013","unstructured":"Petersen A, Alvarez C, DeClaire S, Tintle NL: Assessing methods for assigning SNPs to genes in gene-based tests of association using common variants. PLoS ONE. 2013, 8 (5): e62161-10.1371\/journal.pone.0062161.","journal-title":"PLoS ONE"},{"issue":"4","key":"6262_CR15","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1016\/j.ajhg.2012.02.025","volume":"90","author":"A Christoforou","year":"2012","unstructured":"Christoforou A, Dondrup M, Mattingsdal M, Mattheisen M, Giddaluru S, N\u00f6then MM, Rietschel M, Cichon S, Djurovic S, Andreassen OA, Jonassen I, Steen VM, Puntervoll P, Hellard SL: Linkage-disequilibrium-based binning affects the interpretation of GWASs. Am J Hum Genet. 2012, 90 (4): 727-733. 10.1016\/j.ajhg.2012.02.025.","journal-title":"Am J Hum Genet"},{"issue":"D1","key":"6262_CR16","doi-asserted-by":"publisher","first-page":"D48","DOI":"10.1093\/nar\/gks1236","volume":"41","author":"P Flicek","year":"2013","unstructured":"Flicek P, Ahmed I, Amode MR, Barrell D, Beal K, Brent S, Carvalho-Silva D, Clapham P, Coates G, Fairley S, Fitzgerald S, Gil L, Garc\u00eda-Gir\u00f3n C, Gordon L, Hourlier T, Hunt S, Juettemann T, K\u00e4h\u00e4ri AK, Keenan S, Komorowska M, Kulesha E, Longden I, Maurel T, McLaren WM, Muffato M, Nag R, Overduin B, Pignatelli M, Pritchard B, Pritchard E, et al: Ensembl 2013. Nucl Acids Res. 2013, 41 (D1): D48-D55. 10.1093\/nar\/gks1236.","journal-title":"Nucl Acids Res"},{"issue":"6","key":"6262_CR17","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1101\/gr.229102. Article published online before print in May 2002","volume":"12","author":"WJ Kent","year":"2002","unstructured":"Kent WJ, Sugnet CW, Furey TS, Roskin KM, Pringle TH, Zahler AM, Haussler D: The human genome browser at UCSC. Genome Res. 2002, 12 (6): 996-1006.","journal-title":"Genome Res"},{"issue":"2","key":"6262_CR18","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1038\/ng1001-229","volume":"29","author":"MJ Daly","year":"2001","unstructured":"Daly MJ, Rioux JD, Schaffner SF, Hudson TJ, Lander ES: High-resolution haplotype structure in the human genome. Nat Genet. 2001, 29 (2): 229-232. 10.1038\/ng1001-229.","journal-title":"Nat Genet"},{"issue":"5547","key":"6262_CR19","doi-asserted-by":"publisher","first-page":"1719","DOI":"10.1126\/science.1065573","volume":"294","author":"N Patil","year":"2001","unstructured":"Patil N, Berno AJ, Hinds DA, Barrett WA, Doshi JM, Hacker CR, Kautzer CR, Lee DH, Marjoribanks C, McDonough DP, Nguyen BTN, Norris MC, Sheehan JB, Shen N, Stern D, Stokowski RP, Thomas DJ, Trulson MO, Vyas KR, Frazer KA, Fodor SPA, Cox DR: Blocks of limited haplotype diversity revealed by high-resolution scanning of human chromosome 21. Science. 2001, 294 (5547): 1719-1723. 10.1126\/science.1065573.","journal-title":"Science"},{"issue":"11","key":"6262_CR20","doi-asserted-by":"publisher","first-page":"7335","DOI":"10.1073\/pnas.102186799","volume":"99","author":"K Zhang","year":"2002","unstructured":"Zhang K, Deng M, Chen T, Waterman MS, Sun F: A dynamic programming algorithm for haplotype block partitioning. Proc Natl Acad Sci USA. 2002, 99 (11): 7335-7339. 10.1073\/pnas.102186799.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"6262_CR21","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1086\/377106","volume":"73","author":"EC Anderson","year":"2003","unstructured":"Anderson EC, Novembre J: Finding haplotype block boundaries by using the minimum-description-length principle. Am J Human Genet. 2003, 73 (2): 336-354. 10.1086\/377106.","journal-title":"Am J Human Genet"},{"key":"6262_CR22","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1093\/bib\/bbr015","volume":"13","author":"R Mourad","year":"2012","unstructured":"Mourad R, Sinoquet C, Leray P: Probabilistic graphical models for genetic association studies. Brief Bioinformatics. 2012, 13: 20-33. 10.1093\/bib\/bbr015.","journal-title":"Brief Bioinformatics"},{"issue":"5576","key":"6262_CR23","doi-asserted-by":"publisher","first-page":"2225","DOI":"10.1126\/science.1069424","volume":"296","author":"SB Gabriel","year":"2002","unstructured":"Gabriel SB, Schaffner SF, Nguyen H, Moore JM, Roy J, Blumenstiel B, Higgins J, DeFelice M, Lochner A, Faggart M, Liu-Cordero SN, Rotimi C, Adeyemo A, Cooper R, Ward R, Lander ES, Daly MJ, Altshuler D: The structure of haplotype blocks in the human genome. Science. 2002, 296 (5576): 2225-2229. 10.1126\/science.1069424.","journal-title":"Science"},{"issue":"2","key":"6262_CR24","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1093\/bioinformatics\/bth457","volume":"21","author":"JC Barrett","year":"2005","unstructured":"Barrett JC, Fry B, Maller J, Daly MJ: Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics. 2005, 21 (2): 263-265. 10.1093\/bioinformatics\/bth457.","journal-title":"Bioinformatics"},{"issue":"3","key":"6262_CR25","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1086\/519795","volume":"81","author":"S Purcell","year":"2007","unstructured":"Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D, Maller J, Sklar P, de Bakker PI, Daly MJ, Sham PC: PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Human Genet. 2007, 81 (3): 559-575. 10.1086\/519795.","journal-title":"Am J Human Genet"},{"issue":"3","key":"6262_CR26","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1016\/S0002-9297(07)64342-0","volume":"61","author":"C Zapata","year":"1997","unstructured":"Zapata C, Alvarez G, Carollo C: Approximate variance of the standardized measure of gametic disequilibrium D\u2019. Am J Hum Genet. 1997, 61 (3): 771-774. 10.1016\/S0002-9297(07)64342-0.","journal-title":"Am J Hum Genet"},{"issue":"3","key":"6262_CR27","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1086\/378099","volume":"73","author":"JD Wall","year":"2003","unstructured":"Wall JD, Pritchard JK: Assessing the performance of the haplotype block model of linkage disequilibrium. Am J Hum Genet. 2003, 73 (3): 502-515. 10.1086\/378099.","journal-title":"Am J Hum Genet"},{"issue":"6968","key":"6262_CR28","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1038\/nature02168","volume":"426","author":"The International HapMap Consortium","year":"2003","unstructured":"The International HapMap Consortium: The international HapMap project. Nature. 2003, 426 (6968): 789-796. 10.1038\/nature02168.","journal-title":"Nature"},{"issue":"7319","key":"6262_CR29","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1038\/nature09534","volume":"467","author":"The 1000 Genomes Project Consortium","year":"2010","unstructured":"The 1000 Genomes Project Consortium: A map of human genome variation from population-scale sequencing. Nature. 2010, 467 (7319): 1061-1073. 10.1038\/nature09534.","journal-title":"Nature"},{"key":"6262_CR30","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1038\/ng1847","volume":"38","author":"AL Price","year":"2006","unstructured":"Price AL, Patterson NJ, Plenge RM, Weinblatt ME, Shadick NA, Reich D: Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet. 2006, 38: 904-909. 10.1038\/ng1847.","journal-title":"Nat Genet"},{"issue":"2","key":"6262_CR31","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1038\/nmeth.1785","volume":"9","author":"O Delaneau","year":"2011","unstructured":"Delaneau O, Marchini J, Zagury JF: A linear complexity phasing method for thousands of genomes. Nature Methods. 2011, 9 (2): 179-181. 10.1038\/nmeth.1785.","journal-title":"Nature Methods"},{"issue":"Suppl 7","key":"6262_CR32","doi-asserted-by":"publisher","first-page":"S35","DOI":"10.1186\/1753-6561-3-s7-s35","volume":"3","author":"H Shim","year":"2009","unstructured":"Shim H, Chun H, Engelman C, Payseur B: Genome-wide association studies using single-nucleotide polymorphisms versus haplotypes: an empirical comparison with data from the North American Rheumatoid Arthritis consortium. BMC Proceedings. 2009, 3 (Suppl 7): S35-10.1186\/1753-6561-3-s7-s35.","journal-title":"BMC Proceedings"},{"issue":"Suppl 7","key":"6262_CR33","doi-asserted-by":"publisher","first-page":"S34","DOI":"10.1186\/1753-6561-3-s7-s34","volume":"3","author":"J Park","year":"2009","unstructured":"Park J, Namkung J, Jhun M, Park T: Genome-wide analysis of haplotype interaction for the data from the North American Rheumatoid Arthritis Consortium. BMC Proceedings. 2009, 3 (Suppl 7): S34-10.1186\/1753-6561-3-s7-s34.","journal-title":"BMC Proceedings"},{"issue":"11","key":"6262_CR34","doi-asserted-by":"publisher","first-page":"e14079","DOI":"10.1371\/journal.pone.0014079","volume":"5","author":"AJ Lorenz","year":"2010","unstructured":"Lorenz AJ, Hamblin MT, Jannink JL: Performance of single nucleotide Polymorphisms versus Haplotypes for genome-wide association analysis in Barley. PLoS ONE. 2010, 5 (11): e14079-10.1371\/journal.pone.0014079.","journal-title":"PLoS ONE"},{"key":"6262_CR35","unstructured":"Hindorff LA, MacArthur J, Morales J, Junkins HA, Hall PN, Klemm AK, Manolio TA: A catalog of published genome-wide association studies. http:\/\/www.genome.gov\/gwastudies . [Accessed December 7,2013]"}],"container-title":["BMC Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2105-15-10.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-2105-15-10\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2105-15-10.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T13:51:37Z","timestamp":1648043497000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcbioinformatics.biomedcentral.com\/articles\/10.1186\/1471-2105-15-10"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,14]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["6262"],"URL":"https:\/\/doi.org\/10.1186\/1471-2105-15-10","relation":{},"ISSN":["1471-2105"],"issn-type":[{"value":"1471-2105","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,14]]},"article-number":"10"}}