{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:45:31Z","timestamp":1761561931168},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"S16","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Bioinformatics"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1186\/1471-2105-15-s16-s2","type":"journal-article","created":{"date-parts":[[2014,12,8]],"date-time":"2014-12-08T12:04:11Z","timestamp":1418040251000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["An integrative model of multi-organ drug-induced toxicity prediction using gene-expression data"],"prefix":"10.1186","volume":"15","author":[{"given":"Jinwoo","family":"Kim","sequence":"first","affiliation":[]},{"given":"Miyoung","family":"Shin","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2014,12,8]]},"reference":[{"issue":"4","key":"6735_CR1","doi-asserted-by":"publisher","first-page":"573","DOI":"10.2217\/pgs.10.37","volume":"11","author":"Y Cui","year":"2010","unstructured":"Cui Y, Paules RS: Use of transcriptomics in understanding mechanisms of drug-induced toxicity. Pharmacogenomics. 2010, 11 (4): 573-85. 10.2217\/pgs.10.37.","journal-title":"Pharmacogenomics"},{"issue":"1","key":"6735_CR2","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.cbi.2004.09.008","volume":"150","author":"AP Li","year":"2004","unstructured":"Li AP: Accurate prediction of human drug toxicity: a major challenge in drug development. Chem Biol Interact. 2004, 150 (1): 3-7. 10.1016\/j.cbi.2004.09.008.","journal-title":"Chem Biol Interact"},{"issue":"3","key":"6735_CR3","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1080\/01926230590927230","volume":"33","author":"SK Thukral","year":"2005","unstructured":"Thukral SK, Nordone PJ, Hu R, Sullivan L, Galambos E, Fitzpatrick VD, Healy L, Bass MB, Cosenza ME, Afshari CA: Prediction of Nephrotoxicant Action and Identification of Candidate Toxicity-Related Biomarkers. Toxicol Pathol. 2005, 33 (3): 343-55. 10.1080\/01926230590927230.","journal-title":"Toxicol Pathol"},{"key":"6735_CR4","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1186\/1471-2164-9-288","volume":"9","author":"L Huang","year":"2008","unstructured":"Huang L, Heinloth AN, Zeng ZB, Paules RS, Bushel PR: Genes related to apoptosis predict necrosis of the liver as a phenotype observed in rats exposed to a compendium of hepatotoxicants. BMC Genomics. 2008, 9: 288-10.1186\/1471-2164-9-288.","journal-title":"BMC Genomics"},{"issue":"2","key":"6735_CR5","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1016\/j.jtbi.2008.05.032","volume":"254","author":"K Kulkarni","year":"2008","unstructured":"Kulkarni K, Larsen P, Linninger AA: Assessing chronic liver toxicity based on relative gene-expression data. J Theor Biol. 2008, 254 (2): 308-18. 10.1016\/j.jtbi.2008.05.032.","journal-title":"J Theor Biol"},{"issue":"8","key":"6735_CR6","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1021\/tx200148a","volume":"24","author":"Y Low","year":"2011","unstructured":"Low Y, Uehara T, Minowa Y, Yamada H, Ohno Y, Urushidani T, Sedykh A, Muratov E, Kuz'min V, Fourches D, Zhu H, Rusyn I, Tropsha A: Predicting Drug-Induced Hepatotoxicity Using QSAR and Toxicogenomics Approaches. Chem Res Toxicol. 2011, 24 (8): 1251-62. 10.1021\/tx200148a.","journal-title":"Chem Res Toxicol"},{"issue":"1-3","key":"6735_CR7","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.tox.2012.03.014","volume":"297","author":"Y Minowa","year":"2012","unstructured":"Minowa Y, Kondo C, Uehara T, Morikawa Y, Okuno Y, Nakatsu N, Ono A, Maruyama T, Kato I, Yamate J, Yamada H, Ohno Y, Urushidani T: Toxicogenomic multigene biomarker for predicting the future onset of proximal tubular injury in rats. Toxicology. 2012, 297 (1-3): 47-56. 10.1016\/j.tox.2012.03.014.","journal-title":"Toxicology"},{"key":"6735_CR8","doi-asserted-by":"publisher","first-page":"144","DOI":"10.4161\/sysb.24254","volume":"1","author":"M Bowles","year":"2013","unstructured":"Bowles M, Shigeta R: Statistical models for predicting liver toxicity from genomic data. Systems Biomedicine. 2013, 1: 144-149. 10.4161\/sysb.24254.","journal-title":"Systems Biomedicine"},{"key":"6735_CR9","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1038\/tpj.2013.39","volume":"14","author":"JD Zhang","year":"2014","unstructured":"Zhang JD, Berntenis N, Roth A, Ebeling M: Data mining reveals a network of early-response genes as a consensus signature of drug-induced in vitro and in vivo toxicity. Pharmacogenomics J. 2014, 14: 208-216. 10.1038\/tpj.2013.39.","journal-title":"Pharmacogenomics J"},{"key":"6735_CR10","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1002\/mnfr.200900169","volume":"54","author":"T Uehara","year":"2010","unstructured":"Uehara T, Ono A, Maruyama T, Kato I, Yamada H, Ohno Y, Urushidani T: The Japanese toxicogenomics project: Application of toxicogenomics. Mol Nutr Food Res. 2010, 54: 218-227. 10.1002\/mnfr.200900169.","journal-title":"Mol Nutr Food Res"},{"issue":"18","key":"6735_CR11","doi-asserted-by":"publisher","first-page":"2493","DOI":"10.1093\/bioinformatics\/btm357","volume":"23","author":"C Harbron","year":"2007","unstructured":"Harbron C, Chang KM, South MC: RefPlus: an R package extending the RMA Algorithm. Bioinformatics. 2007, 23 (18): 2493-4. 10.1093\/bioinformatics\/btm357.","journal-title":"Bioinformatics"},{"issue":"1","key":"6735_CR12","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1093\/bib\/bbs006","volume":"14","author":"WJ Lin","year":"2013","unstructured":"Lin WJ, Chen JJ: Class-imbalanced classifiers for high-dimensional data. Brief Bionform. 2013, 14 (1): 13-26. 10.1093\/bib\/bbs006.","journal-title":"Brief Bionform"},{"issue":"e1","key":"6735_CR13","doi-asserted-by":"publisher","first-page":"e28","DOI":"10.1136\/amiajnl-2011-000699","volume":"19","author":"M Liu","year":"2012","unstructured":"Liu M, Wu Y, Chen Y, Sun J, Zhao Z, Chen XW, Matheny ME, Xu H: Large-scale prediction of adverse drug reactions using chemical, biological, and phenotypic properties of drugs. J Am Med Inform Assoc. 2012, 19 (e1): e28-35. 10.1136\/amiajnl-2011-000699.","journal-title":"J Am Med Inform Assoc"},{"key":"6735_CR14","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1146\/annurev-pharmtox-011112-140248","volume":"53","author":"JP Bai","year":"2013","unstructured":"Bai JP, Abernethy DR: Systems Pharmacology to Predict Drug Toxicity: Integration across Levels of Biological Organization. Annu Rev Pharmacol Toxicol. 2013, 53: 451-73. 10.1146\/annurev-pharmtox-011112-140248.","journal-title":"Annu Rev Pharmacol Toxicol"},{"issue":"11","key":"6735_CR15","doi-asserted-by":"publisher","first-page":"1975","DOI":"10.1007\/s00204-013-1053-1","volume":"87","author":"ZZ Fang","year":"2013","unstructured":"Fang ZZ, Krausz KW, Tanaka N, Li F, Qu A, Idle JR, Gonzalez FJ: Metabolomics reveals trichloroacetate as a major contributor to trichloroethylene-induced metabolic alterations in mouse urine and serum. Arch Toxicol. 2013, 87 (11): 1975-87. 10.1007\/s00204-013-1053-1.","journal-title":"Arch Toxicol"},{"issue":"2","key":"6735_CR16","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.cbi.2013.06.016","volume":"205","author":"A Hermenean","year":"2013","unstructured":"Hermenean A, Ardelean A, Stan M, Herman H, Mihali CV, Costache M, Dinischiotu A: Protective effects of naringenin on carbon tetrachloride-induced acute nephrotoxicity in mouse kidney. Chem Biol Interact. 2013, 205 (2): 138-47. 10.1016\/j.cbi.2013.06.016.","journal-title":"Chem Biol Interact"},{"issue":"1","key":"6735_CR17","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.etap.2011.05.014","volume":"34","author":"M Liao","year":"2012","unstructured":"Liao M, Liu H: Gene-expression profiling of nephrotoxicity from copper nanoparticles in rats after repeated oral administration. Environ Toxicol Pharmacol. 2012, 34 (1): 67-80. 10.1016\/j.etap.2011.05.014.","journal-title":"Environ Toxicol Pharmacol"},{"issue":"2","key":"6735_CR18","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1093\/toxsci\/kfs243","volume":"130","author":"WJ Bailey","year":"2012","unstructured":"Bailey WJ, Holder D, Patel H, Devlin P, Gonzalez RJ, Hamilton V, Muniappa N, Hamlin DM, Thomas CE, Sistare FD, Glaab WE: A performance evaluation of three drug-induced liver injury biomarkers in the rat: alpha-glutathione S-transferase, arginase 1, and 4-hydroxyphenyl-pyruvate dioxygenase. Toxicol Sci. 2012, 130 (2): 229-44. 10.1093\/toxsci\/kfs243.","journal-title":"Toxicol Sci"}],"container-title":["BMC Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2105-15-S16-S2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,23]],"date-time":"2019-01-23T01:43:23Z","timestamp":1548207803000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcbioinformatics.biomedcentral.com\/articles\/10.1186\/1471-2105-15-S16-S2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":18,"journal-issue":{"issue":"S16","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["6735"],"URL":"https:\/\/doi.org\/10.1186\/1471-2105-15-s16-s2","relation":{},"ISSN":["1471-2105"],"issn-type":[{"value":"1471-2105","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12]]},"assertion":[{"value":"8 December 2014","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"S2"}}