{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T06:03:08Z","timestamp":1746511388324},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"S17","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Bioinformatics"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1186\/1471-2105-15-s17-s6","type":"journal-article","created":{"date-parts":[[2015,6,18]],"date-time":"2015-06-18T11:47:17Z","timestamp":1434628037000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Mining hidden knowledge for drug safety assessment: topic modeling of LiverTox as a case study"],"prefix":"10.1186","volume":"15","author":[{"given":"Ke","family":"Yu","sequence":"first","affiliation":[]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[]},{"given":"Minjun","family":"Chen","sequence":"additional","affiliation":[]},{"given":"Xiaowei","family":"Xu","sequence":"additional","affiliation":[]},{"given":"Ayako","family":"Suzuki","sequence":"additional","affiliation":[]},{"given":"Katarina","family":"Ilic","sequence":"additional","affiliation":[]},{"given":"Weida","family":"Tong","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2014,12,16]]},"reference":[{"issue":"3","key":"6763_CR1","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1002\/hep.26175","volume":"57","author":"JH Hoofnagle","year":"2013","unstructured":"Hoofnagle JH, Serrano J, Knoben JE, Navarro VJ: LiverTox: a website on drug-induced liver injury. Hepatology. 2013, 57 (3): 873-874. 10.1002\/hep.26175.","journal-title":"Hepatology"},{"key":"6763_CR2","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1038\/msb.2009.98","volume":"6","author":"M Kuhn","year":"2010","unstructured":"Kuhn M, Campillos M, Letunic I, Jensen LJ, Bork P: A side effect resource to capture phenotypic effects of drugs. Mol Syst Biol. 2010, 6: 343-","journal-title":"Mol Syst Biol"},{"issue":"5886","key":"6763_CR3","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1126\/science.1158140","volume":"321","author":"M Campillos","year":"2008","unstructured":"Campillos M, Kuhn M, Gavin AC, Jensen LJ, Bork P: Drug target identification using side-effect similarity. Science. 2008, 321 (5886): 263-266. 10.1126\/science.1158140.","journal-title":"Science"},{"issue":"5","key":"6763_CR4","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1038\/clpt.2014.17","volume":"95","author":"H Fang","year":"2014","unstructured":"Fang H, Su Z, Wang Y, Miller A, Liu Z, Howard PC, Tong W, Lin SM: Exploring the FDA Adverse Event Reporting System to Generate Hypotheses for Monitoring of Disease Characteristics. Clin Pharmacol Ther. 2014, 95 (5): 496-498. 10.1038\/clpt.2014.17.","journal-title":"Clin Pharmacol Ther"},{"issue":"4-5","key":"6763_CR5","first-page":"993","volume":"3","author":"DM Blei","year":"2003","unstructured":"Blei DM, Ng AY, Jordan MI: Latent Dirichlet allocation. J Mach Learn Res. 2003, 3 (4-5): 993-1022.","journal-title":"J Mach Learn Res"},{"issue":"Suppl 10","key":"6763_CR6","doi-asserted-by":"publisher","first-page":"S11","DOI":"10.1186\/1471-2105-12-S10-S11","volume":"12","author":"H Bisgin","year":"2011","unstructured":"Bisgin H, Liu Z, Fang H, Xu X, Tong W: Mining FDA drug labels using an unsupervised learning technique--topic modeling. BMC Bioinformatics. 2011, 12 (Suppl 10): S11-10.1186\/1471-2105-12-S10-S11.","journal-title":"BMC Bioinformatics"},{"issue":"Suppl 15","key":"6763_CR7","doi-asserted-by":"publisher","first-page":"S6","DOI":"10.1186\/1471-2105-13-S15-S6","volume":"13","author":"H Bisgin","year":"2012","unstructured":"Bisgin H, Liu Z, Kelly R, Fang H, Xu X, Tong W: Investigating drug repositioning opportunities in FDA drug lables through topic modeling. BMC Bioinformatics. 2012, 13 (Suppl 15): S6-10.1186\/1471-2105-13-S15-S6.","journal-title":"BMC Bioinformatics"},{"key":"6763_CR8","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1145\/312624.312649","volume-title":"Proceedings of the Twenty-Second Annual International SIGIR Conference on Research and Development in Information Retrieval (SIGIR-99)","author":"T Hofmann","year":"1999","unstructured":"Hofmann T: Probabilistic Latent Semantic Indexing. Proceedings of the Twenty-Second Annual International SIGIR Conference on Research and Development in Information Retrieval (SIGIR-99). 1999, 50-57."},{"key":"6763_CR9","first-page":"381","volume-title":"Proceedings of the Twenty-Fourth Annual Conference of Cognitive Science Society","author":"TL Griffiths","year":"2002","unstructured":"Griffiths TL, Steyvers M: A probabilistic approach to semantic representation. Proceedings of the Twenty-Fourth Annual Conference of Cognitive Science Society. 2002, 381-386."},{"issue":"Suppl 1","key":"6763_CR10","doi-asserted-by":"publisher","first-page":"5228","DOI":"10.1073\/pnas.0307752101","volume":"101","author":"TL Griffiths","year":"2004","unstructured":"Griffiths TL, Steyvers M: Finding scientific topics. Proc Natl Acad Sci USA. 2004, 101 (Suppl 1): 5228-5235.","journal-title":"Proc Natl Acad Sci USA"},{"key":"6763_CR11","volume-title":"MALLET: a machine learning for language toolkit","author":"AK McCallum","year":"2002","unstructured":"McCallum AK: MALLET: a machine learning for language toolkit. 2002, [http:\/\/mallet.cs.umass.edu]"},{"issue":"6","key":"6763_CR12","doi-asserted-by":"publisher","first-page":"503","DOI":"10.2165\/11535340-000000000-00000","volume":"33","author":"A Suzuki","year":"2010","unstructured":"Suzuki A, Andrade RJ, Bjornsson E, Lucena MI, Lee WM, Yuen NA, Hunt CM, Freston JW: Drugs associated with hepatotoxicity and their reporting frequency of liver adverse events in VigiBase: unified list based on international collaborative work. Drug Saf. 2010, 33 (6): 503-522. 10.2165\/11535340-000000000-00000.","journal-title":"Drug Saf"},{"issue":"6","key":"6763_CR13","doi-asserted-by":"publisher","first-page":"2065","DOI":"10.1002\/hep.23937","volume":"52","author":"A Reuben","year":"2010","unstructured":"Reuben A, Koch DG, Lee WM, Acute Liver Failure Study G: Drug-induced acute liver failure: results of a U.S. multicenter, prospective study. Hepatology. 2010, 52 (6): 2065-2076. 10.1002\/hep.23937.","journal-title":"Hepatology"},{"issue":"7","key":"6763_CR14","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1002\/lt.21692","volume":"15","author":"AL Mindikoglu","year":"2009","unstructured":"Mindikoglu AL, Magder LS, Regev A: Outcome of liver transplantation for drug-induced acute liver failure in the United States: analysis of the United Network for Organ Sharing database. Liver Transpl. 2009, 15 (7): 719-729. 10.1002\/lt.21692.","journal-title":"Liver Transpl"},{"issue":"5","key":"6763_CR15","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1002\/hep.20703","volume":"41","author":"J Polson","year":"2005","unstructured":"Polson J, Lee WM, American Association for the Study of Liver D: AASLD position paper: the management of acute liver failure. Hepatology. 2005, 41 (5): 1179-1197. 10.1002\/hep.20703.","journal-title":"Hepatology"},{"key":"6763_CR16","volume-title":"Hepatotoxicity: the adverse effects of drugs and other chemicals on the liver","author":"HJ Zimmerman","year":"1999","unstructured":"Zimmerman HJ: Hepatotoxicity: the adverse effects of drugs and other chemicals on the liver. 1999, Philadelphia, Lippincott Williams & Wilkins, 2","edition":"2"},{"issue":"2","key":"6763_CR17","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1002\/hep.20081","volume":"39","author":"A Reuben","year":"2004","unstructured":"Reuben A: Hy's law. Hepatology. 2004, 39 (2): 574-578. 10.1002\/hep.20081.","journal-title":"Hepatology"},{"issue":"2","key":"6763_CR18","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1016\/j.gastro.2005.05.006","volume":"129","author":"RJ Andrade","year":"2005","unstructured":"Andrade RJ, Lucena MI, Fernandez MC, Pelaez G, Pachkoria K, Garcia-Ruiz E, Garcia-Munoz B, Gonzalez-Grande R, Pizarro A, Duran JA: Drug-induced liver injury: an analysis of 461 incidences submitted to the Spanish registry over a 10-year period. Gastroenterology. 2005, 129 (2): 512-521. 10.1016\/j.gastro.2005.05.006.","journal-title":"Gastroenterology"},{"issue":"2","key":"6763_CR19","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1002\/hep.20800","volume":"42","author":"E Bjornsson","year":"2005","unstructured":"Bjornsson E, Olsson R: Outcome and prognostic markers in severe drug-induced liver disease. Hepatology. 2005, 42 (2): 481-489. 10.1002\/hep.20800.","journal-title":"Hepatology"},{"key":"6763_CR20","volume-title":"Guidance for industry drug-induced liver injury: premarketing clinical evaluation","author":"U.S. Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research (CDER), Center for Biologics Evaluation and Research (CBER)","year":"2009","unstructured":"U.S. Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research (CDER), Center for Biologics Evaluation and Research (CBER): Guidance for industry drug-induced liver injury: premarketing clinical evaluation. 2009"},{"issue":"7","key":"6763_CR21","doi-asserted-by":"publisher","first-page":"692","DOI":"10.7326\/0003-4819-124-7-199604010-00014","volume":"124","author":"E Gomez-Gil","year":"1996","unstructured":"Gomez-Gil E, Salmeron JM, Mas A: Phenelzine-induced fulminant hepatic failure. Ann Intern Med. 1996, 124 (7): 692-693.","journal-title":"Ann Intern Med"},{"issue":"3","key":"6763_CR22","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/S0007-0971(68)80006-3","volume":"62","author":"K Hollinrake","year":"1968","unstructured":"Hollinrake K: Acute hepatic necrosis associated with ethionamide. Br J Dis Chest. 1968, 62 (3): 151-154. 10.1016\/S0007-0971(68)80006-3.","journal-title":"Br J Dis Chest"}],"container-title":["BMC Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2105-15-S17-S6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T19:05:14Z","timestamp":1630609514000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcbioinformatics.biomedcentral.com\/articles\/10.1186\/1471-2105-15-S17-S6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":22,"journal-issue":{"issue":"S17","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["6763"],"URL":"https:\/\/doi.org\/10.1186\/1471-2105-15-s17-s6","relation":{},"ISSN":["1471-2105"],"issn-type":[{"value":"1471-2105","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12]]},"assertion":[{"value":"16 December 2014","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"S6"}}