{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T06:25:45Z","timestamp":1779344745216,"version":"3.51.4"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2001,6,22]],"date-time":"2001-06-22T00:00:00Z","timestamp":993168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2001,6,22]],"date-time":"2001-06-22T00:00:00Z","timestamp":993168000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Bioinformatics"],"DOI":"10.1186\/1471-2105-2-2","type":"journal-article","created":{"date-parts":[[2002,10,11]],"date-time":"2002-10-11T18:40:44Z","timestamp":1034361644000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["mRNA:guanine-N 7 cap methyltransferases: identification of novel members of the family, evolutionary analysis, homology modeling, and analysis of sequence-structure-function relationships"],"prefix":"10.1186","volume":"2","author":[{"given":"Janusz M","family":"Bujnicki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcin","family":"Feder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Radlinska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leszek","family":"Rychlewski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2001,6,22]]},"reference":[{"key":"3_CR1","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1128\/mr.44.2.175-205.1980","volume":"44","author":"AK Banerjee","year":"1980","unstructured":"Banerjee AK: 5'-terminal cap structure in eucaryotic messenger ribonucleic acids. Microbiol. Rev. 1980, 44: 175\u2013205.","journal-title":"Microbiol. Rev"},{"key":"3_CR2","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1111\/j.1432-1033.1997.00461.x","volume":"247","author":"JD Lewis","year":"1997","unstructured":"Lewis JD, Izaurralde E: The role of the cap structure in RNA processing and nuclear export. Eur. J Biochem 1997, 247: 461\u2013469.","journal-title":"Eur. J Biochem"},{"key":"3_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0079-6603(00)66025-7","volume":"66","author":"S Shuman","year":"2000","unstructured":"Shuman S: Structure, mechanism, and evolution of the mRNA capping apparatus. Prog. Nucleic Acid. Res. Mol. Biol 2000, 66: 1\u201340.","journal-title":"Prog. Nucleic Acid. Res. Mol. Biol"},{"key":"3_CR4","doi-asserted-by":"publisher","first-page":"4328","DOI":"10.1073\/pnas.91.10.4328","volume":"91","author":"B Schwer","year":"1994","unstructured":"Schwer B, Shuman S: Mutational analysis of yeast mRNA capping enzyme. Proc. Natl. Acad. Sci U.S.A. 1994, 91: 4328\u20134332.","journal-title":"Proc. Natl. Acad. Sci U.S.A"},{"key":"3_CR5","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1128\/MCB.16.2.475","volume":"16","author":"X Mao","year":"1996","unstructured":"Mao X, Schwer B, Shuman S: Mutational analysis of the Saccharomyces cerevisiae ABD1 gene: cap methyltransferase activity is essential for cell growth. Mol. Cell Biol 1996, 16: 475\u2013480.","journal-title":"Mol. Cell Biol"},{"key":"3_CR6","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1006\/bbrc.1997.7439","volume":"239","author":"T Tsukamoto","year":"1997","unstructured":"Tsukamoto T, Shibagaki Y, Imajoh-Ohmi S, Murakoshi T, Suzuki M, Nakamura A, Gotoh H, Mizumoto K: Isolation and characterization of the yeast mRNA capping enzyme beta subunit gene encoding RNA 5'-triphosphatase, which is essential for cell viability. Biochem Biophys. Res. Commun. 1997, 239: 116\u2013122. 10.1006\/bbrc.1997.7439","journal-title":"Biochem Biophys. Res. Commun"},{"key":"3_CR7","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/S0092-8674(00)80236-6","volume":"89","author":"K Hakansson","year":"1997","unstructured":"Hakansson K, Doherty AJ, Shuman S, Wigley DB: X-ray crystallography reveals a large conformational change during guanyl transfer by mRNA capping enzymes. Cell 1997, 89: 545\u2013553.","journal-title":"Cell"},{"key":"3_CR8","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/S0092-8674(00)81541-X","volume":"99","author":"CD Lima","year":"1999","unstructured":"Lima CD, Wang LK, Shuman S: Structure and mechanism of yeast RNA triphosphatase: an essential component of the mRNA capping apparatus. Cell 1999, 99: 533\u2013543.","journal-title":"Cell"},{"key":"3_CR9","doi-asserted-by":"publisher","first-page":"9573","DOI":"10.1073\/pnas.94.18.9573","volume":"94","author":"SP Wang","year":"1997","unstructured":"Wang SP, Deng L, Ho CK, Shuman S: Phylogeny of mRNA capping enzymes. Proc. Natl. Acad. Sci U.S.A. 1997, 94: 9573\u20139578. 10.1073\/pnas.94.18.9573","journal-title":"Proc. Natl. Acad. Sci U.S.A"},{"key":"3_CR10","doi-asserted-by":"publisher","first-page":"1885","DOI":"10.1093\/nar\/28.9.1885","volume":"28","author":"Y Pei","year":"2000","unstructured":"Pei Y, Lehman K, Tian L, Shuman S: Characterization of Candida albicans RNA triphosphatase and mutational analysis of its active site. Nucleic Acids Res. 2000, 28: 1885\u20131892.","journal-title":"Nucleic Acids Res"},{"key":"3_CR11","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1093\/nar\/29.2.387","volume":"29","author":"Y Pei","year":"2001","unstructured":"Pei Y, Schwer B, Hausmann S, Shuman S: Characterization of Schizosaccharomyces pombe RNA triphosphatase. Nucleic Acids Res. 2001, 29: 387\u2013396. 10.1093\/nar\/29.2.387","journal-title":"Nucleic Acids Res"},{"key":"3_CR12","doi-asserted-by":"publisher","first-page":"6900","DOI":"10.1021\/bi960221a","volume":"35","author":"X Mao","year":"1996","unstructured":"Mao X, Shuman S: Vaccinia virus mRNA (guanine-7-)methyltransferase: mutational effects on cap methylation and AdoHcy-dependent photo-cross-linking of the cap to the methyl acceptor site. Biochemistry 1996, 35: 6900\u20136910. 10.1021\/bi960221a","journal-title":"Biochemistry"},{"key":"3_CR13","doi-asserted-by":"publisher","first-page":"14683","DOI":"10.1074\/jbc.272.23.14683","volume":"272","author":"SP Wang","year":"1997","unstructured":"Wang SP, Shuman S: Structure-function analysis of the mRNA cap methyltransferase of Saccharomyces cerevisiae. J Biol Chem. 1997, 272: 14683\u201314689. 10.1074\/jbc.272.23.14683","journal-title":"J Biol Chem"},{"key":"3_CR14","doi-asserted-by":"publisher","first-page":"16553","DOI":"10.1074\/jbc.274.23.16553","volume":"274","author":"N Saha","year":"1999","unstructured":"Saha N, Schwer B, Shuman S: Characterization of human, Schizosaccharomyces pombe, and Candida albicans mRNA cap methyltransferases and complete replacement of the yeast capping apparatus by mammalian enzymes. J Biol Chem. 1999, 274: 16553\u201316562. 10.1074\/jbc.274.23.16553","journal-title":"J Biol Chem"},{"key":"3_CR15","doi-asserted-by":"publisher","first-page":"3023","DOI":"10.1099\/00221287-145-11-3023","volume":"145 (Pt 11)","author":"T Yamada-Okabe","year":"1999","unstructured":"Yamada-Okabe T, Mio T, Kashima Y, Matsui M, Arisawa M, Yamada-Okabe H: The Candida albicans gene for mRNA 5-cap methyltransferase: identification of additional residues essential for catalysis. Microbiology. 1999, 145 (Pt 11): 3023\u20133033.","journal-title":"Microbiology"},{"key":"3_CR16","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1093\/genetics\/155.4.1561","volume":"155","author":"B Schwer","year":"2000","unstructured":"Schwer B, Saha N, Mao X, Chen HW, Shuman S: Structure-function analysis of yeast mRNA cap methyltransferase and high-copy suppression of conditional mutants by AdoMet synthase and the ubiquitin conjugating enzyme Cdc34p. Genetics 2000, 155: 1561\u20131576.","journal-title":"Genetics"},{"key":"3_CR17","volume-title":"Singapore, World Scientific Inc","author":"X Cheng","year":"1999","unstructured":"Cheng X, Blumenthal RM: S-adenosylmethionine-dependent methyltransferases: structures and functions. Singapore, World Scientific Inc. 1999."},{"key":"3_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1142\/9789812813077_0001","volume-title":"In S-Adenosylmethionine-dependent methyltransferases: structures and functions. (Edited by Cheng X, Blumenthal RM) Singapore, World Scientific Inc","author":"EB Fauman","year":"1999","unstructured":"Fauman EB, Blumenthal RM, Cheng X: Structure and evolution of AdoMet-dependent MTases. In S-Adenosylmethionine-dependent methyltransferases: structures and functions. (Edited by Cheng X, Blumenthal RM) Singapore, World Scientific Inc. 1999,:1\u201338."},{"key":"3_CR19","first-page":"1","volume":"1","author":"JM Bujnicki","year":"1999","unstructured":"Bujnicki JM: Comparison of protein structures reveals monophyletic origin of the AdoMet-dependent methyltransferase family and mechanistic convergence rather than recent differentiation of N4-cytosine and N6-adenine DNA methylation. In Silico Biol. 1999, 1: 1\u20138.","journal-title":"In Silico Biol"},{"key":"3_CR20","doi-asserted-by":"publisher","first-page":"3408","DOI":"10.1093\/nar\/25.17.3408","volume":"25","author":"SS Sturrock","year":"1997","unstructured":"Sturrock SS, Dryden DT: A prediction of the amino acids and structures involved in DNA recognition by type I DNA restriction and modification enzymes. Nucleic Acids Res. 1997, 25: 3408\u20133414. 10.1093\/nar\/25.17.3408","journal-title":"Nucleic Acids Res"},{"key":"3_CR21","doi-asserted-by":"publisher","first-page":"7118","DOI":"10.1093\/emboj\/17.23.7118","volume":"17","author":"M O'Neill","year":"1998","unstructured":"O'Neill M, Dryden DT, Murray NE: Localization of a protein-DNA interface by random mutagenesis. EMBO J. 1998, 17: 7118\u20137127. 10.1093\/emboj\/17.23.7118","journal-title":"EMBO J"},{"key":"3_CR22","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1110\/ps.9.2.232","volume":"9","author":"L Rychlewski","year":"2000","unstructured":"Rychlewski L, Jaroszewski L, Li W, Godzik A: Comparison of sequence profiles. Strategies for structural predictions using sequence information. Protein Sci 2000, 9: 232\u2013241.","journal-title":"Protein Sci"},{"key":"3_CR23","doi-asserted-by":"publisher","first-page":"2481","DOI":"10.1093\/nar\/28.13.2481","volume":"28","author":"C Venclovas","year":"2000","unstructured":"Venclovas C, Thelen MP: Structure-based predictions of Rad1, Rad9, Hus1 and Rad17 participation in sliding clamp and clamp-loading complexes. Nucleic Acids Res. 2000, 28: 2481\u20132493. 10.1093\/nar\/28.13.2481","journal-title":"Nucleic Acids Res"},{"key":"3_CR24","doi-asserted-by":"publisher","first-page":"11985","DOI":"10.1021\/bi961068n","volume":"35","author":"Z Fu","year":"1996","unstructured":"Fu Z, Hu Y, Konishi K, Takata Y, Ogawa H, Gomi T, Fujioka M, Tak U: Crystal structure of glycine N-methyltransferase from rat liver. Biochemistry 1996, 35: 11985\u201311993. 10.1021\/bi961068n","journal-title":"Biochemistry"},{"key":"3_CR25","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1038\/78941","volume":"7","author":"VH Weiss","year":"2000","unstructured":"Weiss VH, McBride AE, Soriano MA, Filman DJ, Silver PA, Hogle JM: The structure and oligomerization of the yeast arginine methyltransferase, HMT1. Nat. Struct. Biol. 2000, 7: 1165\u20131171. 10.1038\/82028","journal-title":"Nat. Struct. Biol"},{"key":"3_CR26","first-page":"328","volume-title":"Pac. Symp. Biocomput","author":"K Pawlowski","year":"1997","unstructured":"Pawlowski K, Jaroszewski L, Bierzynski A, Godzik A: Multiple model approach - dealing with alignment ambiguities in protein modeling. Pac. Symp. Biocomput. 1997,:328\u2013339."},{"key":"3_CR27","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1006\/jmbi.2000.3637","volume":"298","author":"Y Huang","year":"2000","unstructured":"Huang Y, Komoto J, Konishi K, Takata Y, Ogawa H, Gomi T, Fujioka M, Takusagawa F: Mechanisms for auto-inhibition and forced product release in glycine N-methyltransferase: crystal structures of wild-type, mutant R175K and S-adenosylhomocysteine-bound R175K enzymes. J Mol. Biol 2000, 298: 149\u2013162. 10.1006\/jmbi.2000.3637","journal-title":"J Mol. Biol"},{"key":"3_CR28","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/S1097-2765(00)00035-6","volume":"6","author":"H Bugl","year":"2000","unstructured":"Bugl H, Fauman EB, Staker BL, Zheng F, Kushner SR, Saper MA, Bardwell JC, Jakob U: RNA methylation under heat shock control. Mol. Cell 2000, 6: 349\u2013360.","journal-title":"Mol. Cell"},{"key":"3_CR29","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1142\/9789812813077_0004","volume-title":"In S-Adenosylmethionine-dependent methyltransferases: structures and functions. (Edited by Cheng X, Blumenthal RM) Singapore, World Scientific Inc","author":"F Takusagawa","year":"1999","unstructured":"Takusagawa F, Ogawa H, Fujioka M: Glycine N-methyltransferase, a tetrameric enzyme. In S-Adenosylmethionine-dependent methyltransferases: structures and functions. (Edited by Cheng X, Blumenthal RM) Singapore, World Scientific Inc. 1999,:93\u2013122."},{"key":"3_CR30","first-page":"389","volume":"379","author":"G Schluckebier","year":"1998","unstructured":"Schluckebier G, Labahn J, Granzin J, Saenger W: M. Taq I: possible catalysis via cation-pi interactions in N-specific DNA methyltransferases. Biol. Chem. 1998, 379: 389\u2013400.","journal-title":"Biol. Chem"},{"key":"3_CR31","doi-asserted-by":"publisher","first-page":"2702","DOI":"10.1093\/nar\/25.14.2702","volume":"25","author":"W Gong","year":"1997","unstructured":"Gong W, O'Gara M, Blumenthal RM, Cheng X: Structure of Pvu II DNA-(cytosine N4) methyltransferase, an example of domain permutation and protein fold assignment. Nucleic Acids Res. 1997, 25: 2702\u20132715. 10.1093\/nar\/25.14.2702","journal-title":"Nucleic Acids Res"},{"key":"3_CR32","doi-asserted-by":"publisher","first-page":"2365","DOI":"10.1096\/fj.00-0076com","volume":"14","author":"JM Bujnicki","year":"2000","unstructured":"Bujnicki JM: Phylogenomic analysis of 16S rRNA:(guanine-N2) methyltransferases suggests new family members and reveals highly conserved motifs and a domain structure similar to other nucleic acid amino-methyltransferases. FASEB J 2000, 14: 2365\u20132368. 10.1096\/fj.00-0076com","journal-title":"FASEB J"},{"key":"3_CR33","doi-asserted-by":"publisher","first-page":"7149","DOI":"10.1073\/pnas.96.13.7149","volume":"96","author":"G Hu","year":"1999","unstructured":"Hu G, Gershon PD, Hodel AE, Quiocho FA: mRNA cap recognition: dominant role of enhanced stacking interactions between methylated bases and protein aromatic side chains. Proc. Natl. Acad. Sci U.S.A. 1999, 96: 7149\u20137154. 10.1073\/pnas.96.13.7149","journal-title":"Proc. Natl. Acad. Sci U.S.A"},{"key":"3_CR34","doi-asserted-by":"publisher","first-page":"3389","DOI":"10.1093\/nar\/25.17.3389","volume":"25","author":"SF Altschul","year":"1997","unstructured":"Altschul SF, Madden TL, Schaffer AA, Zhang J, Zhang Z, Miller W, Lipman DJ: Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res. 1997, 25: 3389\u20133402. 10.1093\/nar\/25.17.3389","journal-title":"Nucleic Acids Res"},{"key":"3_CR35","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1093\/nar\/29.1.11","volume":"29","author":"DL Wheeler","year":"2001","unstructured":"Wheeler DL, Church DM, Lash AE, Leipe DD, Madden TL, Pontius JU, Schuler GD, Schriml LM, Tatusova TA, Wagner L, et al.: Database resources of the national center for biotechnology information. Nucleic Acids Res. 2001, 29: 11\u201316. 10.1093\/nar\/29.1.11","journal-title":"Nucleic Acids Res"},{"key":"3_CR36","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/S0022-2836(05)80360-2","volume":"215","author":"SF Altschul","year":"1990","unstructured":"Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ: Basic local alignment search tool. J. Mol. Biol. 1990, 215: 403\u2013410. 10.1006\/jmbi.1990.9999","journal-title":"J. Mol. Biol"},{"key":"3_CR37","doi-asserted-by":"publisher","first-page":"4876","DOI":"10.1093\/nar\/25.24.4876","volume":"25","author":"JD Thompson","year":"1997","unstructured":"Thompson JD, Gibson TJ, Plewniak F, Jeanmougin F, Higgins DG: The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. Nucleic Acids Res. 1997, 25: 4876\u20134882. 10.1093\/nar\/25.24.4876","journal-title":"Nucleic Acids Res"},{"key":"3_CR38","first-page":"275","volume":"8","author":"DT Jones","year":"1992","unstructured":"Jones DT, Taylor WR, Thornton JM: The rapid generation of mutation data matrices from protein sequences. Comput. Appl. Biosci. 1992, 8: 275\u2013282.","journal-title":"Comput. Appl. Biosci"},{"key":"3_CR39","first-page":"406","volume":"4","author":"N Saitou","year":"1987","unstructured":"Saitou N, Nei M: The neighbor-joining method: a new method for reconstructing phylogenetic trees. Mol. Biol. Evol. 1987, 4: 406\u2013425.","journal-title":"Mol. Biol. Evol"},{"key":"3_CR40","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1110\/ps.40501","volume":"10","author":"JM Bujnicki","year":"2001","unstructured":"Bujnicki JM, Elofsson A, Fischer D, Rychlewski L: LiveBench-1: continuous benchmarking of protein structure prediction servers. Protein Sci 2001, 10: 352\u2013361. 10.1110\/ps.40501","journal-title":"Protein Sci"},{"key":"3_CR41","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1006\/jmbi.2000.3741","volume":"299","author":"LA Kelley","year":"2000","unstructured":"Kelley LA, McCallum CM, Sternberg MJ: Enhanced genome annotation using structural profiles in the program 3D-PSSM. J. Mol. Biol 2000, 299: 501\u2013522. 10.1006\/jmbi.2000.3741","journal-title":"J. Mol. Biol"},{"key":"3_CR42","first-page":"119","volume-title":"Pac. Symp. Biocomput","author":"D Fischer","year":"2000","unstructured":"Fischer D: Hybrid fold recognition: combining sequence derived properties with evolutionary information. Pac. Symp. Biocomput. 2000, 119\u2013130."},{"key":"3_CR43","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1006\/jmbi.1999.2583","volume":"287","author":"DT Jones","year":"1999","unstructured":"Jones DT: GenTHREADER: an efficient and reliable protein fold recognition method for genomic sequences. J Mol. Biol 1999, 287: 797\u2013815. 10.1006\/jmbi.1999.2583","journal-title":"J Mol. Biol"},{"key":"3_CR44","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1093\/bioinformatics\/14.10.846","volume":"14","author":"K Karplus","year":"1998","unstructured":"Karplus K, Barrett C, Hughey R: Hidden Markov models for detecting remote protein homologies. Bioinformatics 1998, 14: 846\u2013856. 10.1093\/bioinformatics\/14.10.846","journal-title":"Bioinformatics"},{"key":"3_CR45","first-page":"53","volume-title":"Pac. Symp. Biocomput","author":"NN Alexandrov","year":"1996","unstructured":"Alexandrov NN, Nussinov R, Zimmer RM: Fast protein fold recognition via sequence to structure alignment and contact capacity potentials. Pac. Symp. Biocomput. 1996,:53\u201372."},{"key":"3_CR46","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1093\/bioinformatics\/16.4.404","volume":"16","author":"LJ McGuffin","year":"2000","unstructured":"McGuffin LJ, Bryson K, Jones DT: The PSIPRED protein structure prediction server. Bioinformatics 2000, 16: 404\u2013405. 10.1093\/bioinformatics\/16.4.404","journal-title":"Bioinformatics"},{"key":"3_CR47","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1093\/bioinformatics\/14.10.892","volume":"14","author":"JA Cuff","year":"1999","unstructured":"Cuff JA, Clamp ME, Siddiqui AS, Finlay M, Barton GJ: JPred: a consensus secondary structure prediction server. Bioinformatics 1999, 14: 892\u2013893. 10.1093\/bioinformatics\/14.10.892","journal-title":"Bioinformatics"},{"key":"3_CR48","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1042\/bst0240274","volume":"24","author":"MC Peitsch","year":"1996","unstructured":"Peitsch MC: ProMod and Swiss-Model: Internet-based tools for automated comparative protein modelling. Biochem. Soc. Trans. 1996, 24: 274\u2013279.","journal-title":"Biochem. Soc. Trans"},{"key":"3_CR49","doi-asserted-by":"publisher","first-page":"3596","DOI":"10.1021\/jp984217f","volume":"103","author":"WRP Scott","year":"1999","unstructured":"Scott WRP, Hunenberger PH, Tironi IG, Mark AE, Billeter SR, Fennen J, Torda AE, Huber T, Kruger P, van Gunsteren WF: The GROMOS biomolecular simulation program package. J. Phys. Chem. 1999, 103: 3596\u20133607. 10.1021\/jp984217f","journal-title":"J. Phys. Chem"},{"key":"3_CR50","doi-asserted-by":"publisher","first-page":"2714","DOI":"10.1002\/elps.1150181505","volume":"18","author":"N Guex","year":"1997","unstructured":"Guex N, Peitsch MC: SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling. Electrophoresis 1997, 18: 2714\u20132723.","journal-title":"Electrophoresis"},{"key":"3_CR51","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1038\/381272a0","volume":"381","author":"RW Hooft","year":"1996","unstructured":"Hooft RW, Vriend G, Sander C, Abola EE: Errors in protein structures. Nature 1996, 381: 272. 10.1038\/381272a0","journal-title":"Nature"},{"key":"3_CR52","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1002\/prot.340170404","volume":"17","author":"MJ Sippl","year":"1993","unstructured":"Sippl MJ: Recognition of errors in three-dimensional structures of proteins. Proteins 1993, 17: 355\u2013362.","journal-title":"Proteins"}],"container-title":["BMC Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2105-2-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/1471-2105-2-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2105-2-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T15:04:15Z","timestamp":1714057455000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcbioinformatics.biomedcentral.com\/articles\/10.1186\/1471-2105-2-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,6,22]]},"references-count":52,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2001,12]]}},"alternative-id":["3"],"URL":"https:\/\/doi.org\/10.1186\/1471-2105-2-2","relation":{},"ISSN":["1471-2105"],"issn-type":[{"value":"1471-2105","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,6,22]]},"assertion":[{"value":"21 May 2001","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 June 2001","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 June 2001","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"2"}}