{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T04:15:16Z","timestamp":1728360916370},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2004,11,19]],"date-time":"2004-11-19T00:00:00Z","timestamp":1100822400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"},{"start":{"date-parts":[[2004,11,19]],"date-time":"2004-11-19T00:00:00Z","timestamp":1100822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Bioinformatics"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                        <jats:title>Background<\/jats:title>\n                        <jats:p>Public repositories of microarray data contain an incredible amount of information that is potentially relevant to explore functional relationships among genes by meta-analysis of expression profiles. However, the widespread use of this resource by the scientific community is at the moment limited by the limited availability of effective tools of analysis. We here describe CLOE, a simple cDNA microarray data mining strategy based on meta-analysis of datasets from pairs of species. The method consists in ranking EST probes in the datasets of the two species according to the similarity of their expression profiles with that of two EST probes from orthologous genes, and extracting orthologous EST pairs from a given top interval of the ranked lists. The Gene Ontology annotation of the obtained candidate partners is then analyzed for keywords overrepresentation.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Results<\/jats:title>\n                        <jats:p>We demonstrate the capabilities of the approach by testing its predictive power on three proteomically-defined mammalian protein complexes, in comparison with single and multiple species meta-analysis approaches. Our results show that CLOE can find candidate partners for a greater number of genes, if compared to multiple species co-expression analysis, but retains a comparable specificity even when applied to species as close as mouse and human. On the other hand, it is much more specific than single organisms co-expression analysis, strongly reducing the number of potential candidate partners for a given gene of interest.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Conclusions<\/jats:title>\n                        <jats:p>CLOE represents a simple and effective data mining approach that can be easily used for meta-analysis of cDNA microarray experiments characterized by very heterogeneous coverage. Importantly, it produces for genes of interest an average number of high confidence putative partners that is in the range of standard experimental validation techniques.<\/jats:p>\n                     <\/jats:sec>","DOI":"10.1186\/1471-2105-5-179","type":"journal-article","created":{"date-parts":[[2005,1,12]],"date-time":"2005-01-12T23:25:18Z","timestamp":1105572318000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["CLOE: Identification of putative functional relationships among genes by comparison of expression profiles between two species"],"prefix":"10.1186","volume":"5","author":[{"given":"Maurizio","family":"Pellegrino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Provero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Silengo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferdinando","family":"Di Cunto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2004,11,19]]},"reference":[{"key":"295_CR1","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1016\/j.tig.2003.08.009","volume":"19","author":"H Ge","year":"2003","unstructured":"Ge H, Walhout AJ, Vidal M: Integrating 'omic' information: a bridge between genomics and systems biology.\n                           Trends Genet 2003, 19: 551\u201360. 10.1016\/j.tig.2003.08.009","journal-title":"Trends Genet"},{"key":"295_CR2","doi-asserted-by":"publisher","first-page":"2579","DOI":"10.1093\/bioinformatics\/bth288","volume":"20","author":"S Gupta","year":"2004","unstructured":"Gupta S, Zink D, Korn B, Vingron M, Haas SA: Genome wide identification and classification of alternative splicing based on EST data.\n                           Bioinformatics 2004, 20: 2579\u201385. 10.1093\/bioinformatics\/bth288","journal-title":"Bioinformatics"},{"key":"295_CR3","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/S0168-9525(03)00023-4","volume":"19","author":"EV Kriventseva","year":"2003","unstructured":"Kriventseva EV, Koch I, Apweiler R, Vingron M, Bork P, Gelfand MS, Sunyaev S: Increase of functional diversity by alternative splicing.\n                           Trends Genet 2003, 19: 124\u20138. 10.1016\/S0168-9525(03)00023-4","journal-title":"Trends Genet"},{"key":"295_CR4","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/S0167-7799(02)02053-X","volume":"20","author":"P Brazhnik","year":"2002","unstructured":"Brazhnik P, de la Fuente A, Mendes P: Gene networks: how to put the function in genomics.\n                           Trends Biotechnol 2002, 20: 467\u201372. 10.1016\/S0167-7799(02)02053-X","journal-title":"Trends Biotechnol"},{"key":"295_CR5","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1093\/nar\/30.1.207","volume":"30","author":"R Edgar","year":"2002","unstructured":"Edgar R, Domrachev M, Lash AE: Gene Expression Omnibus: NCBI gene expression and hybridization array data repository.\n                           Nucleic Acids Res 2002, 30: 207\u201310. 10.1093\/nar\/30.1.207","journal-title":"Nucleic Acids Res"},{"key":"295_CR6","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1093\/nar\/gkg078","volume":"31","author":"J Gollub","year":"2003","unstructured":"Gollub J, Ball CA, Binkley G, Demeter J, Finkelstein DB, Hebert JM, Hernandez-Boussard T, Jin H, Kaloper M, Matese JC, Schroeder M, Brown PO, Botstein D, Sherlock G: The Stanford Microarray Database: data access and quality assessment tools.\n                           Nucleic Acids Res 2003, 31: 94\u20136. 10.1093\/nar\/gkg078","journal-title":"Nucleic Acids Res"},{"key":"295_CR7","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1101\/gr.1910904","volume":"14","author":"HK Lee","year":"2004","unstructured":"Lee HK, Hsu AK, Sajdak J, Qin J, Pavlidis P: Coexpression analysis of human genes across many microarray data sets.\n                           Genome Res 2004, 14: 1085\u201394. 10.1101\/gr.1910904","journal-title":"Genome Res"},{"key":"295_CR8","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1093\/bioinformatics\/bth011","volume":"20","author":"MN Price","year":"2004","unstructured":"Price MN, Rieffel E: Finding coexpressed genes in counts-based data: an improved measure with validation experiments.\n                           Bioinformatics 2004, 20: 945\u201352. 10.1093\/bioinformatics\/bth011","journal-title":"Bioinformatics"},{"key":"295_CR9","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/1471-2164-5-4","volume":"5","author":"Y Fukuoka","year":"2004","unstructured":"Fukuoka Y, Inaoka H, Kohane IS: Inter-species differences of co-expression of neighboring genes in eukaryotic genomes.\n                           BMC Genomics 2004, 5: 4. 10.1186\/1471-2164-5-4","journal-title":"BMC Genomics"},{"key":"295_CR10","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/1475-4924-1-5","volume":"1","author":"P Spellman","year":"2002","unstructured":"Spellman P, Rubin G: Evidence for large domains of similarly expressed genes in the Drosophila genome.\n                           Journal of Biology 2002, 1: 5. 10.1186\/1475-4924-1-5","journal-title":"Journal of Biology"},{"key":"295_CR11","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1126\/science.1087447","volume":"302","author":"JM Stuart","year":"2003","unstructured":"Stuart JM, Segal E, Koller D, Kim SK: A Gene-Coexpression Network for Global Discovery of Conserved Genetic Modules.\n                           Science 2003, 302: 249\u2013255. 10.1126\/science.1087447","journal-title":"Science"},{"key":"295_CR12","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1038\/35057062","volume":"409","author":"ES Lander","year":"2001","unstructured":"Lander ES, Linton LM, Birren B, Nusbaum C, Zody MC, Baldwin J, Devon K, Dewar K, Doyle M, FitzHugh W, Funke R, Gage D, Harris K, Heaford A, Howland J, Kann L, Lehoczky J, LeVine R, McEwan P, McKernan K, Meldrim J, Mesirov JP, Miranda C, Morris W, Naylor J, Raymond C, Rosetti M, Santos R, Sheridan A, Sougnez C, Stange-Thomann N, Stojanovic N, Subramanian A, Wyman D, Rogers J, Sulston J, Ainscough R, Beck S, Bentley D, Burton J, Clee C, Carter N, Coulson A, Deadman R, Deloukas P, Dunham A, Dunham I, Durbin R, French L, Grafham D, Gregory S, Hubbard T, Humphray S, Hunt A, Jones M, Lloyd C, McMurray A, Matthews L, Mercer S, Milne S, Mullikin JC, Mungall A, Plumb R, Ross M, Shownkeen R, Sims S, Waterston RH, Wilson RK, Hillier LW, McPherson JD, Marra MA, Mardis ER, Fulton LA, Chinwalla AT, Pepin KH, Gish WR, Chissoe SL, Wendl MC, Delehaunty KD, Miner TL, Delehaunty A, Kramer JB, Cook LL, Fulton RS, Johnson DL, Minx PJ, Clifton SW, Hawkins T, Branscomb E, Predki P, Richardson P, Wenning S, Slezak T, Doggett N, Cheng JF, Olsen A, Lucas S, Elkin C, Uberbacher E, Frazier M, Gibbs RA, Muzny DM, Scherer SE, Bouck JB, Sodergren EJ, Worley KC, Rives CM, Gorrell JH, Metzker ML, Naylor SL, Kucherlapati RS, Nelson DL, Weinstock GM, Sakaki Y, Fujiyama A, Hattori M, Yada T, Toyoda A, Itoh T, Kawagoe C, Watanabe H, Totoki Y, Taylor T, Weissenbach J, Heilig R, Saurin W, Artiguenave F, Brottier P, Bruls T, Pelletier E, Robert C, Wincker P, Smith DR, Doucette-Stamm L, Rubenfield M, Weinstock K, Lee HM, Dubois J, Rosenthal A, Platzer M, Nyakatura G, Taudien S, Rump A, Yang H, Yu J, Wang J, Huang G, Gu J, Hood L, Rowen L, Madan A, Qin S, Davis RW, Federspiel NA, Abola AP, Proctor MJ, Myers RM, Schmutz J, Dickson M, Grimwood J, Cox DR, Olson MV, Kaul R, Shimizu N, Kawasaki K, Minoshima S, Evans GA, Athanasiou M, Schultz R, Roe BA, Chen F, Pan H, Ramser J, Lehrach H, Reinhardt R, McCombie WR, de la Bastide M, Dedhia N, Blocker H, Hornischer K, Nordsiek G, Agarwala R, Aravind L, Bailey JA, Bateman A, Batzoglou S, Birney E, Bork P, Brown DG, Burge CB, Cerutti L, Chen HC, Church D, Clamp M, Copley RR, Doerks T, Eddy SR, Eichler EE, Furey TS, Galagan J, Gilbert JG, Harmon C, Hayashizaki Y, Haussler D, Hermjakob H, Hokamp K, Jang W, Johnson LS, Jones TA, Kasif S, Kaspryzk A, Kennedy S, Kent WJ, Kitts P, Koonin EV, Korf I, Kulp D, Lancet D, Lowe TM, McLysaght A, Mikkelsen T, Moran JV, Mulder N, Pollara VJ, Ponting CP, Schuler G, Schultz J, Slater G, Smit AF, Stupka E, Szustakowski J, Thierry-Mieg D, Thierry-Mieg J, Wagner L, Wallis J, Wheeler R, Williams A, Wolf YI, Wolfe KH, Yang SP, Yeh RF, Collins F, Guyer MS, Peterson J, Felsenfeld A, Wetterstrand KA, Patrinos A, Morgan MJ, Szustakowki J, de Jong P, Catanese JJ, Osoegawa K, Shizuya H, Choi S, Chen YJ: Initial sequencing and analysis of the human genome.\n                           Nature 2001, 409: 860\u2013921. 10.1038\/35057062","journal-title":"Nature"},{"key":"295_CR13","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1038\/nature01262","volume":"420","author":"RH Waterston","year":"2002","unstructured":"Waterston RH, Lindblad-Toh K, Birney E, Rogers J, Abril JF, Agarwal P, Agarwala R, Ainscough R, Alexandersson M, An P, Antonarakis SE, Attwood J, Baertsch R, Bailey J, Barlow K, Beck S, Berry E, Birren B, Bloom T, Bork P, Botcherby M, Bray N, Brent MR, Brown DG, Brown SD, Bult C, Burton J, Butler J, Campbell RD, Carninci P, Cawley S, Chiaromonte F, Chinwalla AT, Church DM, Clamp M, Clee C, Collins FS, Cook LL, Copley RR, Coulson A, Couronne O, Cuff J, Curwen V, Cutts T, Daly M, David R, Davies J, Delehaunty KD, Deri J, Dermitzakis ET, Dewey C, Dickens NJ, Diekhans M, Dodge S, Dubchak I, Dunn DM, Eddy SR, Elnitski L, Emes RD, Eswara P, Eyras E, Felsenfeld A, Fewell GA, Flicek P, Foley K, Frankel WN, Fulton LA, Fulton RS, Furey TS, Gage D, Gibbs RA, Glusman G, Gnerre S, Goldman N, Goodstadt L, Grafham D, Graves TA, Green ED, Gregory S, Guigo R, Guyer M, Hardison RC, Haussler D, Hayashizaki Y, Hillier LW, Hinrichs A, Hlavina W, Holzer T, Hsu F, Hua A, Hubbard T, Hunt A, Jackson I, Jaffe DB, Johnson LS, Jones M, Jones TA, Joy A, Kamal M, Karlsson EK, Karolchik D, Kasprzyk A, Kawai J, Keibler E, Kells C, Kent WJ, Kirby A, Kolbe DL, Korf I, Kucherlapati RS, Kulbokas EJ, Kulp D, Landers T, Leger JP, Leonard S, Letunic I, Levine R, Li J, Li M, Lloyd C, Lucas S, Ma B, Maglott DR, Mardis ER, Matthews L, Mauceli E, Mayer JH, McCarthy M, McCombie WR, McLaren S, McLay K, McPherson JD, Meldrim J, Meredith B, Mesirov JP, Miller W, Miner TL, Mongin E, Montgomery KT, Morgan M, Mott R, Mullikin JC, Muzny DM, Nash WE, Nelson JO, Nhan MN, Nicol R, Ning Z, Nusbaum C, O'Connor MJ, Okazaki Y, Oliver K, Overton-Larty E, Pachter L, Parra G, Pepin KH, Peterson J, Pevzner P, Plumb R, Pohl CS, Poliakov A, Ponce TC, Ponting CP, Potter S, Quail M, Reymond A, Roe BA, Roskin KM, Rubin EM, Rust AG, Santos R, Sapojnikov V, Schultz B, Schultz J, Schwartz MS, Schwartz S, Scott C, Seaman S, Searle S, Sharpe T, Sheridan A, Shownkeen R, Sims S, Singer JB, Slater G, Smit A, Smith DR, Spencer B, Stabenau A, Stange-Thomann N, Sugnet C, Suyama M, Tesler G, Thompson J, Torrents D, Trevaskis E, Tromp J, Ucla C, Ureta-Vidal A, Vinson JP, Von Niederhausern AC, Wade CM, Wall M, Weber RJ, Weiss RB, Wendl MC, West AP, Wetterstrand K, Wheeler R, Whelan S, Wierzbowski J, Willey D, Williams S, Wilson RK, Winter E, Worley KC, Wyman D, Yang S, Yang SP, Zdobnov EM, Zody MC, Lander ES: Initial sequencing and comparative analysis of the mouse genome.\n                           Nature 2002, 420: 520\u201362. 10.1038\/nature01262","journal-title":"Nature"},{"key":"295_CR14","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1016\/j.tig.2003.08.006","volume":"19","author":"Y Moreau","year":"2003","unstructured":"Moreau Y, Aerts S, De Moor B, De Strooper B, Dabrowski M: Comparison and meta-analysis of microarray data: from the bench to the computer desk.\n                           Trends Genet 2003, 19: 570\u20137. 10.1016\/j.tig.2003.08.006","journal-title":"Trends Genet"},{"key":"295_CR15","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.1101\/gr.220302","volume":"12","author":"H Kochiwa","year":"2002","unstructured":"Kochiwa H, Suzuki R, Washio T, Saito R, Bono H, Carninci P, Okazaki Y, Miki R, Hayashizaki Y, Tomita M: Inferring alternative splicing patterns in mouse from a full-length cDNA library and microarray data.\n                           Genome Res 2002, 12: 1286\u201393. 10.1101\/gr.220302","journal-title":"Genome Res"},{"key":"295_CR16","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/75556","volume":"25","author":"M Ashburner","year":"2000","unstructured":"Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, Harris MA, Hill DP, Issel-Tarver L, Kasarskis A, Lewis S, Matese JC, Richardson JE, Ringwald M, Rubin GM, Sherlock G: Gene ontology: tool for the unification of biology. The Gene Ontology Consortium.\n                           Nat Genet 2000, 25: 25\u20139. 10.1038\/75556","journal-title":"Nat Genet"},{"key":"295_CR17","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1038\/415141a","volume":"415","author":"AC Gavin","year":"2002","unstructured":"Gavin AC, Bosche M, Krause R, Grandi P, Marzioch M, Bauer A, Schultz J, Rick JM, Michon AM, Cruciat CM, Remor M, Hofert C, Schelder M, Brajenovic M, Ruffner H, Merino A, Klein K, Hudak M, Dickson D, Rudi T, Gnau V, Bauch A, Bastuck S, Huhse B, Leutwein C, Heurtier MA, Copley RR, Edelmann A, Querfurth E, Rybin V, Drewes G, Raida M, Bouwmeester T, Bork P, Seraphin B, Kuster B, Neubauer G, Superti-Furga G: Functional organization of the yeast proteome by systematic analysis of protein complexes.\n                           Nature 2002, 415: 141\u20137. 10.1038\/415141a","journal-title":"Nature"},{"key":"295_CR18","doi-asserted-by":"publisher","first-page":"1727","DOI":"10.1126\/science.1090289","volume":"302","author":"L Giot","year":"2003","unstructured":"Giot L, Bader JS, Brouwer C, Chaudhuri A, Kuang B, Li Y, Hao YL, Ooi CE, Godwin B, Vitols E, Vijayadamodar G, Pochart P, Machineni H, Welsh M, Kong Y, Zerhusen B, Malcolm R, Varrone Z, Collis A, Minto M, Burgess S, McDaniel L, Stimpson E, Spriggs F, Williams J, Neurath K, Ioime N, Agee M, Voss E, Furtak K, Renzulli R, Aanensen N, Carrolla S, Bickelhaupt E, Lazovatsky Y, DaSilva A, Zhong J, Stanyon CA, Finley RL Jr, White KP, Braverman M, Jarvie T, Gold S, Leach M, Knight J, Shimkets RA, McKenna MP, Chant J, Rothberg JM: A protein interaction map of Drosophila melanogaster.\n                           Science 2003, 302: 1727\u201336. 10.1126\/science.1090289","journal-title":"Science"},{"key":"295_CR19","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1126\/science.1091403","volume":"303","author":"S Li","year":"2004","unstructured":"Li S, Armstrong CM, Bertin N, Ge H, Milstein S, Boxem M, Vidalain PO, Han JD, Chesneau A, Hao T, Goldberg DS, Li N, Martinez M, Rual JF, Lamesch P, Xu L, Tewari M, Wong SL, Zhang LV, Berriz GF, Jacotot L, Vaglio P, Reboul J, Hirozane-Kishikawa T, Li Q, Gabel HW, Elewa A, Baumgartner B, Rose DJ, Yu H, Bosak S, Sequerra R, Fraser A, Mango SE, Saxton WM, Strome S, Van Den Heuvel S, Piano F, Vandenhaute J, Sardet C, Gerstein M, Doucette-Stamm L, Gunsalus KC, Harper JW, Cusick ME, Roth FP, Hill DE, Vidal M: A map of the interactome network of the metazoan C. elegans.\n                           Science 2004, 303: 540\u20133. 10.1126\/science.1091403","journal-title":"Science"},{"key":"295_CR20","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1038\/nature02166","volume":"426","author":"JS Andersen","year":"2003","unstructured":"Andersen JS, Wilkinson CJ, Mayor T, Mortensen P, Nigg EA, Mann M: Proteomic characterization of the human centrosome by protein correlation profiling.\n                           Nature 2003, 426: 570\u20134. 10.1038\/nature02166","journal-title":"Nature"},{"key":"295_CR21","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/S0169-328X(03)00282-1","volume":"117","author":"SM Stevens Jr","year":"2003","unstructured":"Stevens SM Jr, Zharikova AD, Prokai L: Proteomic analysis of the synaptic plasma membrane fraction isolated from rat forebrain.\n                           Brain Res Mol Brain Res 2003, 117: 116\u201328. 10.1016\/S0169-328X(03)00282-1","journal-title":"Brain Res Mol Brain Res"},{"key":"295_CR22","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1038\/ncb1086","volume":"6","author":"T Bouwmeester","year":"2004","unstructured":"Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G: A physical and functional map of the human TNF-alpha\/NF-kappa B signal transduction pathway.\n                           Nat Cell Biol 2004, 6: 97\u2013105. 10.1038\/ncb1086","journal-title":"Nat Cell Biol"},{"key":"295_CR23","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1006\/jmbi.2000.5197","volume":"314","author":"M Remm","year":"2001","unstructured":"Remm M, Storm CE, Sonnhammer EL: Automatic clustering of orthologs and in-paralogs from pairwise species comparisons.\n                           J Mol Biol 2001, 314: 1041\u201352. 10.1006\/jmbi.2000.5197","journal-title":"J Mol Biol"},{"key":"295_CR24","unstructured":"InParanoid[http:\/\/inparanoid.cgb.ki.se]"},{"issue":"Database","key":"295_CR25","doi-asserted-by":"publisher","first-page":"D115","DOI":"10.1093\/nar\/gkh131","volume":"32","author":"R Apweiler","year":"2004","unstructured":"Apweiler R, Bairoch A, Wu CH, Barker WC, Boeckmann B, Ferro S, Gasteiger E, Huang H, Lopez R, Magrane M, Martin MJ, Natale DA, O'Donovan C, Redaschi N, Yeh LS: UniProt: the Universal Protein knowledgebase.\n                           Nucleic Acids Res 2004, 32(Database):D115\u20139. 10.1093\/nar\/gkh131","journal-title":"Nucleic Acids Res"},{"key":"295_CR26","unstructured":"UniProt[http:\/\/www.ebi.ac.uk\/uniprot\/index.html]"},{"key":"295_CR27","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1093\/nar\/gkg033","volume":"31","author":"DL Wheeler","year":"2003","unstructured":"Wheeler DL, Church DM, Federhen S, Lash AE, Madden TL, Pontius JU, Schuler GD, Schriml LM, Sequeira E, Tatusova TA, Wagner L: Database resources of the National Center for Biotechnology.\n                           Nucl Acids Res 2003, 31: 28\u201333. 10.1093\/nar\/gkg033","journal-title":"Nucl Acids Res"},{"key":"295_CR28","unstructured":"UniGene[http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=unigene]"},{"key":"295_CR29","unstructured":"Stanford Microarray Database[http:\/\/genome-www.stanford.edu\/microarray]"},{"key":"295_CR30","unstructured":"Gene Ontology[http:\/\/www.geneontology.org]"}],"container-title":["BMC Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2105-5-179.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/1471-2105-5-179\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2105-5-179.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T12:20:57Z","timestamp":1728303657000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcbioinformatics.biomedcentral.com\/articles\/10.1186\/1471-2105-5-179"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11,19]]},"references-count":30,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2004,12]]}},"alternative-id":["295"],"URL":"https:\/\/doi.org\/10.1186\/1471-2105-5-179","relation":{},"ISSN":["1471-2105"],"issn-type":[{"type":"electronic","value":"1471-2105"}],"subject":[],"published":{"date-parts":[[2004,11,19]]},"assertion":[{"value":"11 August 2004","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 November 2004","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 November 2004","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"179"}}