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It is usually a matter of extensive testing and unknown beforehand, which of the possible approaches for the functional analysis will be the most informative<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>To address this problem, we have developed the <jats:italic>Flexible Annotation and Correlation Tool<\/jats:italic> (FACT). FACT allows for detection of important patterns in large data sets by simplifying the integration of heterogeneous data sources and the subsequent application of different algorithms for statistical evaluation or visualization of the annotated data. The system is constantly extended to include additional annotation data and comparison methods.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>FACT serves as a highly flexible framework for the explorative analysis of large genomic and proteomic result sets. The program can be used online; open source code and supplementary information are available at <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.factweb.de\">http:\/\/www.factweb.de<\/jats:ext-link>.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/1471-2105-6-161","type":"journal-article","created":{"date-parts":[[2005,6,29]],"date-time":"2005-06-29T08:00:51Z","timestamp":1120032051000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["FACT \u2013 a framework for the functional interpretation of high-throughput experiments"],"prefix":"10.1186","volume":"6","author":[{"given":"Felix","family":"Kokocinski","sequence":"first","affiliation":[]},{"given":"Nicolas","family":"Delhomme","sequence":"additional","affiliation":[]},{"given":"Gunnar","family":"Wrobel","sequence":"additional","affiliation":[]},{"given":"Lars","family":"Hummerich","sequence":"additional","affiliation":[]},{"given":"Grischa","family":"Toedt","sequence":"additional","affiliation":[]},{"given":"Peter","family":"Lichter","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2005,6,28]]},"reference":[{"key":"486_CR1","doi-asserted-by":"crossref","unstructured":"Mangalam H, Stewart J, Zhou J, Schlauch K, Waugh M, Chen G, Farmer AD, Colello G, Weller JW: GeneX: An Open Source gene expression database and integrated tool set. 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