{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T14:39:51Z","timestamp":1770993591706,"version":"3.50.1"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2005,3,7]],"date-time":"2005-03-07T00:00:00Z","timestamp":1110153600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"},{"start":{"date-parts":[[2005,3,7]],"date-time":"2005-03-07T00:00:00Z","timestamp":1110153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Bioinformatics"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                        <jats:title>Background<\/jats:title>\n                        <jats:p>wFleaBase is a database with the necessary infrastructure to curate, archive and share genetic, molecular and functional genomic data and protocols for an emerging model organism, the microcrustacean <jats:italic>Daphnia<\/jats:italic>. Commonly known as the water-flea, <jats:italic>Daphnia<\/jats:italic>'s ecological merit is unequaled among metazoans, largely because of its sentinel role within freshwater ecosystems and over 200 years of biological investigations. By consequence, the <jats:italic>Daphnia<\/jats:italic> Genomics Consortium (DGC) has launched an interdisciplinary research program to create the resources needed to study genes that affect ecological and evolutionary success in natural environments.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Discussion<\/jats:title>\n                        <jats:p>These tools include the genome database wFleaBase, which currently contains functions to search and extract information from expressed sequenced tags, genome survey sequences and full genome sequencing projects. This new database is built primarily from core components of the Generic Model Organism Database project, and related bioinformatics tools.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Summary<\/jats:title>\n                        <jats:p>Over the coming year, preliminary genetic maps and the nearly complete genomic sequence of <jats:italic>Daphnia pulex<\/jats:italic> will be integrated into wFleaBase, including gene predictions and ortholog assignments based on sequence similarities with eukaryote genes of known function. wFleaBase aims to serve a large ecological and evolutionary research community. Our challenge is to rapidly expand its content and to ultimately integrate genetic and functional genomic information with population-level responses to environmental challenges. URL: <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/wfleabase.org\/\">http:\/\/wfleabase.org\/<\/jats:ext-link>.<\/jats:p>\n                     <\/jats:sec>","DOI":"10.1186\/1471-2105-6-45","type":"journal-article","created":{"date-parts":[[2005,3,8]],"date-time":"2005-03-08T12:49:09Z","timestamp":1110286149000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":114,"title":["wFleaBase: the Daphnia genome database"],"prefix":"10.1186","volume":"6","author":[{"given":"John K","family":"Colbourne","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasanth R","family":"Singan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Don G","family":"Gilbert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2005,3,7]]},"reference":[{"key":"370_CR1","first-page":"163","volume-title":"Molecular Evolution and Adaptive Radiation","author":"JK Colbourne","year":"1997","unstructured":"Colbourne JK, Hebert PDN, Taylor DJ: Evolutionary origins of phenotypic diversity in Daphnia. 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