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Mice transgenic for rat Her2 (BALB-neuT mice) were studied to evaluate the stage in which vaccines can prevent the onset of Her2 driven mammary carcinomas. As Her2 is not overexpressed in all mammary carcinomas, definition of an additional set of tumor associated antigens (TAAs) expressed at defined stages by most breast carcinomas would allow a broader coverage of vaccination. To address this question, a meta-analysis was performed on two transcription profile studies [1, 2] to identify a set of new TAA targets to be used instead of or in conjunction with Her2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The five TAAs identified (Tes, Rcn2, Rnf4, Cradd, Galnt3) are those whose expression is linearly related to the tumor mass increase in BALB-neuT mammary glands. Moreover, they have a low expression in normal tissues and are generally expressed in human breast tumors, though at a lower level than Her2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although the number of putative TAAs identified is limited, this pilot study suggests that meta-analysis of expression profiles produces results that could assist in the designing of pre-clinical immunopreventive vaccines.<\/jats:p><\/jats:sec>","DOI":"10.1186\/1471-2105-6-s4-s7","type":"journal-article","created":{"date-parts":[[2005,12,3]],"date-time":"2005-12-03T19:13:49Z","timestamp":1133637229000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["An integrated approach of immunogenomics and bioinformatics to identify new Tumor Associated Antigens (TAA) for mammary cancer immunological prevention"],"prefix":"10.1186","volume":"6","author":[{"given":"Federica","family":"Cavallo","sequence":"first","affiliation":[]},{"given":"Annalisa","family":"Astolfi","sequence":"additional","affiliation":[]},{"given":"Manuela","family":"Iezzi","sequence":"additional","affiliation":[]},{"given":"Francesca","family":"Cordero","sequence":"additional","affiliation":[]},{"given":"Pier-Luigi","family":"Lollini","sequence":"additional","affiliation":[]},{"given":"Guido","family":"Forni","sequence":"additional","affiliation":[]},{"given":"Raffaele","family":"Calogero","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2005,12,1]]},"reference":[{"key":"722_CR1","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1172\/JCI19850","volume":"113","author":"E Quaglino","year":"2004","unstructured":"Quaglino E, Rolla S, Iezzi M, Spadaro M, Musiani P, De Giovanni C, Lollini PL, Lanzardo S, Forni G, Sanges R, Crispi S, De Luca P, Calogero R, Cavallo F: Concordant morphologic and gene expression data show that a vaccine halts HER-2\/neu preneoplastic lesions. 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