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However, they pay none or little attention to small protein ligands and solvent. They are key components and mediators of protein interactions and fundamental for a complete description of protein interfaces. Interactome profiling requires the development of computational tools to extract and analyze protein-protein, protein-ligand and detailed solvent interaction information from the PDB in an automatic and comparative fashion. Adding this information to the existing one on protein-protein interactions will allow us to better understand protein interaction networks and protein function.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Description<\/jats:title>\n            <jats:p>SCOWLP (<jats:underline>S<\/jats:underline> tructural <jats:underline>C<\/jats:underline> haracterization <jats:underline>O<\/jats:underline> f <jats:underline>W<\/jats:underline> ater, <jats:underline>L<\/jats:underline> igands and <jats:underline>P<\/jats:underline> roteins) is a user-friendly and publicly accessible web-based relational database for detailed characterization and visualization of the PDB protein interfaces. The SCOWLP database includes proteins, peptidic-ligands and interface water molecules as descriptors of protein interfaces. It contains currently 74,907 protein interfaces and 2,093,976 residue-residue interactions formed by 60,664 structural units (protein domains and peptidic-ligands) and their interacting solvent.<\/jats:p>\n            <jats:p>The SCOWLP web-server allows detailed structural analysis and comparisons of protein interfaces at atomic level by text query of PDB codes and\/or by navigating a SCOP-based tree. It includes a visualization tool to interactively display the interfaces and label interacting residues and interface solvent by atomic physicochemical properties. SCOWLP is automatically updated with every SCOP release.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>SCOWLP enriches substantially the description of protein interfaces by adding detailed interface information of peptidic-ligands and solvent to the existing protein-protein interaction databases. SCOWLP may be of interest to many structural bioinformaticians. It provides a platform for automatic global mapping of protein interfaces at atomic level, representing a useful tool for classification of protein interfaces, protein binding comparative studies, reconstruction of protein complexes and understanding protein networks. The web-server with the database and its additional summary tables used for our analysis are available at <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.scowlp.org\" ext-link-type=\"uri\">http:\/\/www.scowlp.org<\/jats:ext-link>.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2105-7-104","type":"journal-article","created":{"date-parts":[[2006,3,10]],"date-time":"2006-03-10T19:15:09Z","timestamp":1142018109000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["SCOWLP: a web-based database for detailed characterization and visualization of protein interfaces"],"prefix":"10.1186","volume":"7","author":[{"given":"Joan","family":"Teyra","sequence":"first","affiliation":[]},{"given":"Andreas","family":"Doms","sequence":"additional","affiliation":[]},{"given":"Michael","family":"Schroeder","sequence":"additional","affiliation":[]},{"given":"M Teresa","family":"Pisabarro","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2006,3,2]]},"reference":[{"issue":"1","key":"843_CR1","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1128\/mr.59.1.94-123.1995","volume":"59","author":"EM Phizicky","year":"1995","unstructured":"Phizicky EM, Fields S: Protein-protein interactions: methods for detection and analysis. 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