{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T12:08:08Z","timestamp":1775304488305,"version":"3.50.1"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Bioinformatics"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Several high-throughput searches for ppotential natural antisense transcripts (NATs) have been performed recently, but most of the reports were focused on <jats:italic>cis<\/jats:italic> type. A thorough <jats:italic>in silico<\/jats:italic> analysis of human transcripts will help expand our knowledge of NATs.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>We have identified 568 NATs from human RefSeq RNA sequences. Among them, 403 NATs are reported for the first time, and at least 157 novel NATs are <jats:italic>trans<\/jats:italic> type. According to the pairing region of a sense and antisense RNA pair, hNATs are divided into 6 classes, of which about 87% involve 5' or 3' UTR sequences, supporting the regulatory role of UTRs. Among a total of 535 NAT pairs related with splice variants, 77.4% (414\/535) have their pairing regions affected or completely eliminated by alternative splicing, suggesting significant relationship of alternative splicing and antisense-directed regulation. The extensive occurrence of splice variants in hNATs and other multiple pairing patterns results in a one-to-many relationship, allowing the formation of complex regulation networks. Based on microarray data from Stanford Microarray Database, two hNAT pairs were found to display significant inverse expression patterns before and after insulin injection.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>NATs might carry out more extensive and complex functions than previously thought. Combined with endogenous micro RNAs, hNATs could be regarded as a special group of transcripts contributing to the complex regulation networks.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2105-7-18","type":"journal-article","created":{"date-parts":[[2006,1,23]],"date-time":"2006-01-23T12:43:10Z","timestamp":1138020190000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["In silico discovery of human natural antisense transcripts"],"prefix":"10.1186","volume":"7","author":[{"given":"Yuan-Yuan","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zong-Ming","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei","family":"Hao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiong","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yixiang","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Zhong","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Xue","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2006,1,13]]},"reference":[{"issue":"5842","key":"757_CR1","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1038\/294623a0","volume":"294","author":"RM Lacatena","year":"1981","unstructured":"Lacatena RM, Cesareni G: Base pairing of RNA I with its complementary sequence in the primer precursor inhibits ColE1 replication. Nature 1981, 294(5842):623\u2013626. 10.1038\/294623a0","journal-title":"Nature"},{"key":"757_CR2","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1146\/annurev.mi.48.100194.003433","volume":"48","author":"EG Wagner","year":"1994","unstructured":"Wagner EG, Simons RW: Antisense RNA control in bacteria, phages, and plasmids. Annu Rev Microbiol 1994, 48: 713\u2013742. 10.1146\/annurev.mi.48.100194.003433","journal-title":"Annu Rev Microbiol"},{"key":"757_CR3","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1038\/321702a0","volume":"321","author":"DL Bentley","year":"1986","unstructured":"Bentley DL, Groudine M: A block to elongation is largely responsible for decreased transcription of c-myc in differentiated HL60 cells. Nature 1986, 321: 702\u2013706. 10.1038\/321702a0","journal-title":"Nature"},{"key":"757_CR4","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1016\/S0168-9525(02)02749-X","volume":"18","author":"C Rougeulle","year":"2002","unstructured":"Rougeulle C, Heard E: Antisense RNA in imprinting: spreading silence through Air. Trends Genet 2002, 18: 434\u2013437. 10.1016\/S0168-9525(02)02749-X","journal-title":"Trends Genet"},{"issue":"1\u20133","key":"757_CR5","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/S0167-4781(02)00280-4","volume":"1575","author":"S Brantl","year":"2002","unstructured":"Brantl S: Antisense-RNA regulation and RNA interference. Biochim Biophys Acta 2002, 1575(1\u20133):15\u201325.","journal-title":"Biochim Biophys Acta"},{"key":"757_CR6","doi-asserted-by":"publisher","first-page":"4296","DOI":"10.1093\/nar\/25.21.4296","volume":"25","author":"ML Hastings","year":"1997","unstructured":"Hastings ML, Milcarek C, Martincic K, Peterson ML, Munroe SH: Expression of the thyroid hormone receptor gene, erbAalpha, in B lymphocytes: alternative mRNA processing is independent of differentiation but correlates with antisense RNA levels. Nucleic Acids Res 1997, 25: 4296\u20134300. 10.1093\/nar\/25.21.4296","journal-title":"Nucleic Acids Res"},{"key":"757_CR7","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1038\/7734","volume":"21","author":"JT Lee","year":"1999","unstructured":"Lee JT, Davidow LS, Warshawsky D: Tsix, a gene antisense to Xist at the X-inactivation centre. Nat Genet 1999, 21: 400\u2013404. 10.1038\/7734","journal-title":"Nat Genet"},{"issue":"6","key":"757_CR8","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1261\/rna.2120703","volume":"9","author":"NT Peters","year":"2003","unstructured":"Peters NT, Rohrbach JA, Zalewski BA, Byrkett CM, Vaughn JC: RNA editing and regulation of Drosophila 4f-rnp expression by sas-10 antisense readthrough mRNA transcripts. Rna 2003, 9(6):698\u2013710. 10.1261\/rna.2120703","journal-title":"Rna"},{"key":"757_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0378-1119(98)00093-6","volume":"211","author":"C Vanhee-Brossollet","year":"1998","unstructured":"Vanhee-Brossollet C, Vaquero C: Do natural antisense transcripts make sense in eukaryotes? Gene 1998, 211: 1\u20139. 10.1016\/S0378-1119(98)00093-6","journal-title":"Gene"},{"issue":"9","key":"757_CR10","doi-asserted-by":"publisher","first-page":"RESEARCH0044","DOI":"10.1186\/gb-2002-3-9-research0044","volume":"3","author":"J Shendure","year":"2002","unstructured":"Shendure J, Church GM: Computational discovery of sense-antisense transcription in the human and mouse genomes. Genome Biol 2002, 3(9):RESEARCH0044. 10.1186\/gb-2002-3-9-research0044","journal-title":"Genome Biol"},{"issue":"2","key":"757_CR11","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/S0168-9525(02)02598-2","volume":"18","author":"B Lehner","year":"2002","unstructured":"Lehner B, Williams G, Campbell RD, Sanderson CM: Antisense transcripts in the human genome. Trends Genet 2002, 18(2):63\u201365. 10.1016\/S0168-9525(02)02598-2","journal-title":"Trends Genet"},{"issue":"4","key":"757_CR12","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1038\/nbt808","volume":"21","author":"R Yelin","year":"2003","unstructured":"Yelin R, Dahary D, Sorek R, Levanon EY, Goldstein O, Shoshan A, Diber A, Biton S, Tamir Y, Khosravi R, et al.: Widespread occurrence of antisense transcription in the human genome. Nat Biotechnol 2003, 21(4):379\u2013386. 10.1038\/nbt808","journal-title":"Nat Biotechnol"},{"key":"757_CR13","doi-asserted-by":"publisher","first-page":"4812","DOI":"10.1093\/nar\/gkh818","volume":"32","author":"J Chen","year":"2004","unstructured":"Chen J, Sun M, Kent WJ, Huang X, Xie H, Wang W, Zhou G, Shi RZ, Rowley JD: Over 20% of human transcripts might form sense-antisense pairs. Nucleic Acids Res 2004, 32: 4812\u20134820. 10.1093\/nar\/gkh818","journal-title":"Nucleic Acids Res"},{"issue":"5806","key":"757_CR14","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1038\/290457a0","volume":"290","author":"S Anderson","year":"1981","unstructured":"Anderson S, Bankier AT, Barrell BG, de Bruijn MH, Coulson AR, Drouin J, Eperon IC, Nierlich DP, Roe BA, Sanger F, et al.: Sequence and organization of the human mitochondrial genome. Nature 1981, 290(5806):457\u2013465. 10.1038\/290457a0","journal-title":"Nature"},{"issue":"2 Pt 2","key":"757_CR15","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/0092-8674(81)90300-7","volume":"26","author":"MJ Bibb","year":"1981","unstructured":"Bibb MJ, Van Etten RA, Wright CT, Walberg MW, Clayton DA: Sequence and gene organization of mouse mitochondrial DNA. Cell 1981, 26(2 Pt 2):167\u2013180. 10.1016\/0092-8674(81)90300-7","journal-title":"Cell"},{"issue":"6076","key":"757_CR16","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1038\/322279a0","volume":"322","author":"CA Spencer","year":"1986","unstructured":"Spencer CA, Gietz RD, Hodgetts RB: Overlapping transcription units in the dopa decarboxylase region of Drosophila. Nature 1986, 322(6076):279\u2013281. 10.1038\/322279a0","journal-title":"Nature"},{"key":"757_CR17","doi-asserted-by":"publisher","first-page":"1324","DOI":"10.1101\/gr.982903","volume":"13","author":"H kiyosawa","year":"2003","unstructured":"kiyosawa H, Yamanaka I, Osato N, Kondo S, Hayashizaki Y: Antisense transcripts with FANTOM2 clone set and their implications for gene regulation. Genome Res 2003, 13: 1324\u20131334. 10.1101\/gr.982903","journal-title":"Genome Res"},{"key":"757_CR18","unstructured":"RefSeq[http:\/\/www.ncbi.nlm.nih.gov\/RefSeq]"},{"key":"757_CR19","unstructured":"Stanford Microarray Database (SMD)[http:\/\/genome-www5.stanford.edu\/]"},{"issue":"2","key":"757_CR20","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/S0092-8674(02)00718-3","volume":"109","author":"T Kiss","year":"2002","unstructured":"Kiss T: Small nucleolar RNAs: an abundant group of noncoding RNAs with diverse cellular functions. Cell 2002, 109(2):145\u2013148. 10.1016\/S0092-8674(02)00718-3","journal-title":"Cell"},{"issue":"2","key":"757_CR21","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","volume":"116","author":"DP Bartel","year":"2004","unstructured":"Bartel DP: MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004, 116(2):281\u2013297. 10.1016\/S0092-8674(04)00045-5","journal-title":"Cell"},{"issue":"2","key":"757_CR22","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.tibs.2003.12.002","volume":"29","author":"G Lavorgna","year":"2004","unstructured":"Lavorgna G, Dahary D, Lehner B, Sorek R, Sanderson CM, Casari G: In search of antisense. Trends Biochem Sci 2004, 29(2):88\u201394. 10.1016\/j.tibs.2003.12.002","journal-title":"Trends Biochem Sci"},{"issue":"1","key":"757_CR23","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/0092-8674(89)90169-4","volume":"57","author":"N Miyajima","year":"1989","unstructured":"Miyajima N, Horiuchi R, Shibuya Y, Fukushige S, Matsubara K, Toyoshima K, Yamamoto T: Two erbA homologs encoding proteins with different T3 binding capacities are transcribed from opposite DNA strands of the same genetic locus. Cell 1989, 57(1):31\u201339. 10.1016\/0092-8674(89)90169-4","journal-title":"Cell"},{"issue":"10","key":"757_CR24","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1007\/s003359900870","volume":"9","author":"SS Potter","year":"1998","unstructured":"Potter SS, Branford WW: Evolutionary conservation and tissue-specific processing of Hoxa 11 antisense transcripts. Mamm Genome 1998, 9(10):799\u2013806. 10.1007\/s003359900870","journal-title":"Mamm Genome"},{"issue":"5","key":"757_CR25","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/0168-9525(96)10016-0","volume":"12","author":"J Ross","year":"1996","unstructured":"Ross J: Control of messenger RNA stability in higher eukaryotes. Trends Genet 1996, 12(5):171\u2013175. 10.1016\/0168-9525(96)10016-0","journal-title":"Trends Genet"},{"issue":"18","key":"757_CR26","doi-asserted-by":"publisher","first-page":"3580","DOI":"10.1093\/nar\/25.18.3580","volume":"25","author":"DJ Lipman","year":"1997","unstructured":"Lipman DJ: Making (anti)sense of non-coding sequence conservation. Nucleic Acids Res 1997, 25(18):3580\u20133583. 10.1093\/nar\/25.18.3580","journal-title":"Nucleic Acids Res"},{"key":"757_CR27","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/0168-9525(96)10027-5","volume":"12","author":"B Dujon","year":"1996","unstructured":"Dujon B: The yeast genome project: what did we learn? Trends Genet 1996, 12: 263\u2013270. 10.1016\/0168-9525(96)10027-5","journal-title":"Trends Genet"},{"key":"757_CR28","doi-asserted-by":"publisher","first-page":"8796","DOI":"10.1073\/pnas.132270899","volume":"99","author":"EM Prescott","year":"2002","unstructured":"Prescott EM, Proudfoot NJ: Transcriptional collision between convergent genes in budding yeast. Proc Natl Acad USA 2002, 99: 8796\u20138801. 10.1073\/pnas.132270899","journal-title":"Proc Natl Acad USA"},{"key":"757_CR29","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1159\/000077251","volume":"6","author":"M Yamada","year":"2003","unstructured":"Yamada M, Kabir MS, Tsunedomi R: Divergent promoter organization may be a preferred structure for gene control in Escherichia coli. J Mol Microbiol Biotechnol 2003, 6: 206\u2013210. 10.1159\/000077251","journal-title":"J Mol Microbiol Biotechnol"},{"key":"757_CR30","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1038\/nrg1451","volume":"5","author":"G Ast","year":"2004","unstructured":"Ast G: How did alternative splicing evolve? Nat Rev Genet 2004, 5: 773\u2013782. 10.1038\/nrg1451","journal-title":"Nat Rev Genet"},{"issue":"33","key":"757_CR31","doi-asserted-by":"crossref","first-page":"22083","DOI":"10.1016\/S0021-9258(18)54535-X","volume":"266","author":"SH Munroe","year":"1991","unstructured":"Munroe SH, Lazar MA: Inhibition of c-erbA mRNA splicing by a naturally occurring antisense RNA. J Biol Chem 1991, 266(33):22083\u201322086.","journal-title":"J Biol Chem"},{"key":"757_CR32","doi-asserted-by":"publisher","first-page":"4513","DOI":"10.1093\/nar\/25.22.4513","volume":"25","author":"A Sureau","year":"1997","unstructured":"Sureau A, Soret J, Guyon C, Gaillard C, Dumon S, Keller M, Crisanti P, Perbal B: Characterization of multiple alternative RNAs resulting from antisense transcription of the PR264\/SC35 splicing factor gene. Nucleic Acids Res 1997, 25: 4513\u20134522. 10.1093\/nar\/25.22.4513","journal-title":"Nucleic Acids Res"},{"key":"757_CR33","unstructured":"AceView[http:\/\/www.ncbi.nlm.nih.gov\/IEB\/Research\/Acembly\/index.html]"},{"key":"757_CR34","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.1128\/MCB.9.3.1128","volume":"9","author":"MA Lazar","year":"1989","unstructured":"Lazar MA, Hodin RA, Darling DS, Chin WW: A novel member of the thyroid\/steroid hormone receptor family is encoded by the opposite strand of the rat c-erbA alpha transcriptional unit. Mol Biol Cell 1989, 9: 1128\u20131136.","journal-title":"Mol Biol Cell"},{"issue":"8","key":"757_CR35","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1002\/j.1460-2075.1988.tb03100.x","volume":"7","author":"SH Munroe","year":"1988","unstructured":"Munroe SH: Antisense RNA inhibits splicing of pre-mRNA in vitro. Embo J 1988, 7(8):2523\u20132532.","journal-title":"Embo J"},{"issue":"5","key":"757_CR36","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1016\/0092-8674(93)90529-Y","volume":"75","author":"RC Lee","year":"1993","unstructured":"Lee RC, Feinbaum RL, Ambros V: The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 1993, 75(5):843\u2013854. 10.1016\/0092-8674(93)90529-Y","journal-title":"Cell"},{"issue":"3","key":"757_CR37","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/S0163-7258(97)00050-8","volume":"75","author":"BJ Dolnick","year":"1997","unstructured":"Dolnick BJ: Naturally occurring antisense RNA. Pharmacol Ther 1997, 75(3):179\u2013184. 10.1016\/S0163-7258(97)00050-8","journal-title":"Pharmacol Ther"},{"issue":"6","key":"757_CR38","doi-asserted-by":"publisher","first-page":"1929","DOI":"10.1091\/mbc.02-02-0023.","volume":"13","author":"X Chen","year":"2002","unstructured":"Chen X, Cheung ST, So S, Fan ST, Barry C, Higgins J, Lai KM, Ji J, Dudoit S, Ng IO, et al.: Gene expression patterns in human liver cancers. Mol Biol Cell 2002, 13(6):1929\u20131939. 10.1091\/mbc.02-02-0023.","journal-title":"Mol Biol Cell"},{"issue":"7","key":"757_CR39","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1210\/me.8.7.852","volume":"8","author":"PR Murphy","year":"1994","unstructured":"Murphy PR, Knee RS: Identification and characterization of an antisense RNA transcript (gfg) from the human basic fibroblast growth factor gene. Mol Endocrinol 1994, 8(7):852\u2013859. 10.1210\/me.8.7.852","journal-title":"Mol Endocrinol"},{"key":"757_CR40","doi-asserted-by":"publisher","first-page":"18063","DOI":"10.1074\/jbc.M300293200","volume":"278","author":"S Rome","year":"2003","unstructured":"Rome S, Clement K, Rabasa-Lhoret R, Loizon E, Poitou C, Barsh GS, Riou JP, Laville M, Vidal H: Microarray profiling of human skeletal muscle reveals that insulin regulates approximately 800 genes during a hyperinsulinemic clamp. J Biol Chem 2003, 278: 18063\u201318068. 10.1074\/jbc.M300293200","journal-title":"J Biol Chem"},{"key":"757_CR41","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1006\/geno.2001.6548","volume":"74","author":"M Mink","year":"2001","unstructured":"Mink M, Fogelgren B, Olszewski K, Maroy P, Csiszar K: A novel human gene (SARM) at chromosome 17q11 encodes a protein with a SAM motif and structural similarity to Armadillo\/beta-catenin that is conserved in mouse, Drosophila, and Caenorhabditis elegans. Genomics 2001, 74: 234\u2013244. 10.1006\/geno.2001.6548","journal-title":"Genomics"},{"issue":"5","key":"757_CR42","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1007\/BF01539922","volume":"12","author":"JJ Wasmuth","year":"1986","unstructured":"Wasmuth JJ, Carlock LR: Chromosomal localization of human gene for histidyl-tRNA synthetase: clustering of genes encoding aminoacyl-tRNA synthetases on human chromosome 5. Somat Cell Mol Genet 1986, 12(5):513\u2013517. 10.1007\/BF01539922","journal-title":"Somat Cell Mol Genet"},{"key":"757_CR43","first-page":"16899","volume-title":"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci USA","author":"RL Strausberg","year":"2002","unstructured":"Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, et al.: Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci USA. 2002, 16899\u201316903."},{"key":"757_CR44","unstructured":"Genome database at NCBI[ftp:\/\/ftp.ncbi.nih.gov\/genomes\/]"},{"issue":"9","key":"757_CR45","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1016\/S0168-9525(00)02093-X","volume":"16","author":"J Jurka","year":"2000","unstructured":"Jurka J: Repbase update: a database and an electronic journal of repetitive elements. Trends Genet 2000, 16(9):418\u2013420. 10.1016\/S0168-9525(00)02093-X","journal-title":"Trends Genet"}],"container-title":["BMC Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2105-7-18.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T03:26:16Z","timestamp":1630466776000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcbioinformatics.biomedcentral.com\/articles\/10.1186\/1471-2105-7-18"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1,13]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["757"],"URL":"https:\/\/doi.org\/10.1186\/1471-2105-7-18","relation":{},"ISSN":["1471-2105"],"issn-type":[{"value":"1471-2105","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,1,13]]},"assertion":[{"value":"12 July 2005","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 January 2006","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 January 2006","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"18"}}