{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T09:53:57Z","timestamp":1696931637112},"reference-count":11,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Bioinformatics"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Large-scale genetic mapping projects require data management systems that can handle complex phenotypes and detect and correct high-throughput genotyping errors, yet are easy to use.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Description<\/jats:title>\n            <jats:p>We have developed an Integrated Genotyping System (IGS) to meet this need. IGS securely stores, edits and analyses genotype and phenotype data. It stores information about DNA samples, plates, primers, markers and genotypes generated by a genotyping laboratory. Data are structured so that statistical genetic analysis of both case-control and pedigree data is straightforward.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>IGS can model complex phenotypes and contain genotypes from whole genome association studies. The database makes it possible to integrate genetic analysis with data curation. The IGS web site <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/bioinformatics.well.ox.ac.uk\/project-igs.shtml\" ext-link-type=\"uri\">http:\/\/bioinformatics.well.ox.ac.uk\/project-igs.shtml<\/jats:ext-link> contains further information.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2105-7-210","type":"journal-article","created":{"date-parts":[[2006,4,20]],"date-time":"2006-04-20T15:46:08Z","timestamp":1145547968000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["An integrated system for genetic analysis"],"prefix":"10.1186","volume":"7","author":[{"given":"Simon","family":"Fiddy","sequence":"first","affiliation":[]},{"given":"David","family":"Cattermole","sequence":"additional","affiliation":[]},{"given":"Dong","family":"Xie","sequence":"additional","affiliation":[]},{"given":"Xiao Yuan","family":"Duan","sequence":"additional","affiliation":[]},{"given":"Richard","family":"Mott","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2006,4,19]]},"reference":[{"issue":"2","key":"949_CR1","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1038\/sj.ejhg.5200594","volume":"9","author":"GR Abecasis","year":"2001","unstructured":"Abecasis GR, Cherny SS, Cardon LR: The impact of genotyping error on family-based analysis of quantitative traits. 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