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Central elements of biological networks have been found to be, for example, essential for viability.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>CentiBiN (<jats:underline>Cent<\/jats:underline> ralities <jats:underline>i<\/jats:underline> n <jats:underline>Bi<\/jats:underline> ological <jats:underline>N<\/jats:underline> etworks) is a tool for the computation and exploration of centralities in biological networks such as protein-protein interaction networks. It computes 17 different centralities for directed or undirected networks, ranging from local measures, that is, measures that only consider the direct neighbourhood of a network element, to global measures. CentiBiN supports the exploration of the centrality distribution by visualising central elements within the network and provides several layout mechanisms for the automatic generation of graphical representations of a network. It supports different input formats, especially for biological networks, and the export of the computed centralities to other tools.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>CentiBiN helps systems biology researchers to identify crucial elements of biological networks. CentiBiN including a user guide and example data sets is available free of charge at <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/centibin.ipk-gatersleben.de\/\" ext-link-type=\"uri\">http:\/\/centibin.ipk-gatersleben.de\/<\/jats:ext-link>. CentiBiN is available in two different versions: a Java Web Start application and an installable Windows application.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2105-7-219","type":"journal-article","created":{"date-parts":[[2006,4,21]],"date-time":"2006-04-21T18:21:30Z","timestamp":1145643690000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":147,"title":["Exploration of biological network centralities with CentiBiN"],"prefix":"10.1186","volume":"7","author":[{"given":"Bj\u00f6rn H","family":"Junker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk","family":"Kosch\u00fctzki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Falk","family":"Schreiber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2006,4,21]]},"reference":[{"key":"958_CR1","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1103\/RevModPhys.74.47","volume":"74","author":"R Albert","year":"2002","unstructured":"Albert R, Barab\u00e1si AL: Statistical Mechanics of Complex Networks. 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