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Models accounting for this combinatorial variety become impractical for many applications.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>Our results show that under realistic assumptions on domain interactions, the dynamics of signaling pathways can be exactly described by reduced, hierarchically structured models. The method presented here provides a rigorous way to model a large class of signaling networks using macro-states (macroscopic quantities such as the levels of occupancy of the binding domains) instead of micro-states (concentrations of individual species). The method is described using generic multidomain proteins and is applied to the molecule LAT.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion:<\/jats:title>\n            <jats:p>The presented method is a systematic and powerful tool to derive reduced model structures describing the dynamics of multiprotein complex formation accurately.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2105-7-34","type":"journal-article","created":{"date-parts":[[2006,1,23]],"date-time":"2006-01-23T12:46:16Z","timestamp":1138020376000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["A domain-oriented approach to the reduction of combinatorial complexity in signal transduction networks"],"prefix":"10.1186","volume":"7","author":[{"given":"Holger","family":"Conzelmann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio","family":"Saez-Rodriguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Sauter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boris N","family":"Kholodenko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernst D","family":"Gilles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2006,1,23]]},"reference":[{"issue":"7","key":"773_CR1","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1002\/bit.10842","volume":"84","author":"WS Hlavacek","year":"2004","unstructured":"Hlavacek WS, Faeder JR, Blinov ML, Perelson AS, Goldstein B: The complexity of complexes in signal transduction. 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