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A web gateway to integrate these resources will greatly facilitate <jats:italic>Brucella<\/jats:italic> research. <jats:italic>Brucella<\/jats:italic> genome data in current databases is largely derived from computational analysis without experimental validation typically found in peer-reviewed publications. It is partially due to the lack of a literature mining and curation system able to efficiently incorporate the large amount of literature data into genome annotation. It is further hypothesized that literature-based <jats:italic>Brucella<\/jats:italic> gene annotation would increase understanding of complicated <jats:italic>Brucella<\/jats:italic> pathogenesis mechanisms.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The <jats:italic>Brucella<\/jats:italic> Bioinformatics Portal (BBP) is developed to integrate existing <jats:italic>Brucella<\/jats:italic> genome data and analysis tools with literature mining and curation. The BBP InterBru database and <jats:italic>Brucella<\/jats:italic> Genome Browser allow users to search and analyze genes of 4 currently available <jats:italic>Brucella<\/jats:italic> genomes and link to more than 20 existing databases and analysis programs. <jats:italic>Brucella<\/jats:italic> literature publications in PubMed are extracted and can be searched by a TextPresso-powered natural language processing method, a MeSH browser, a keywords search, and an automatic literature update service. To efficiently annotate <jats:italic>Brucella<\/jats:italic> genes using the large amount of literature publications, a literature mining and curation system coined Limix is developed to integrate computational literature mining methods with a PubSearch-powered manual curation and management system. The Limix system is used to quickly find and confirm 107 <jats:italic>Brucella<\/jats:italic> gene mutations including 75 genes shown to be essential for <jats:italic>Brucella<\/jats:italic> virulence. The 75 genes are further clustered using COG. In addition, 62 <jats:italic>Brucella<\/jats:italic> genetic interactions are extracted from literature publications. These results make possible more comprehensive investigation of <jats:italic>Brucella<\/jats:italic> pathogenesis. Other BBP features include publication email alert service, <jats:italic>Brucella<\/jats:italic> researchers' contact database, and discussion forum.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>BBP is a gateway for <jats:italic>Brucella<\/jats:italic> researchers to search, analyze, and curate <jats:italic>Brucella<\/jats:italic> genome data originated from public databases and literature. <jats:italic>Brucella<\/jats:italic> gene mutations and genetic interactions are annotated using Limix leading to better understanding of <jats:italic>Brucella<\/jats:italic> pathogenesis.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2105-7-347","type":"journal-article","created":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T06:40:01Z","timestamp":1153204801000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["BBP: Brucella genome annotation with literature mining and curation"],"prefix":"10.1186","volume":"7","author":[{"given":"Zuoshuang","family":"Xiang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjie","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongqun","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2006,7,16]]},"reference":[{"issue":"2","key":"1086_CR1","doi-asserted-by":"publisher","first-page":"213","DOI":"10.3201\/eid0302.970219","volume":"3","author":"MJ Corbel","year":"1997","unstructured":"Corbel MJ: Brucellosis: an overview. 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