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One aspect of gene function, that is the expression profile in gene coexpression network, has been largely unexplored for duplicate genes.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Here we build a human gene coexpression network using human tissue-specific microarray data and investigate the divergence of duplicate genes in it. The topology of this network is scale-free. Interestingly, our analysis indicates that duplicate genes rapidly lose shared coexpressed partners: after approximately 50 million years since duplication, the two duplicate genes in a pair have only slightly higher number of shared partners as compared with two random singletons. We also show that duplicate gene pairs quickly acquire new coexpressed partners: the average number of partners for a duplicate gene pair is significantly greater than that for a singleton (the latter number can be used as a proxy of the number of partners for a parental singleton gene before duplication). The divergence in gene expression between two duplicates in a pair occurs asymmetrically: one gene usually has more partners than the other one. The network is resilient to both random and degree-based <jats:italic>in silico<\/jats:italic> removal of either singletons or duplicate genes. In contrast, the network is especially vulnerable to the removal of highly connected genes when duplicate genes and singletons are considered together.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Duplicate genes rapidly diverge in their expression profiles in the network and play similar role in maintaining the network robustness as compared with singletons.<\/jats:p>\n            <jats:p>\n              <jats:italic>Contact:<\/jats:italic>kdm16@psu.edu<\/jats:p>\n            <jats:p>\n              <jats:italic>Supplementary information:<\/jats:italic> Please see additional files.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2105-7-46","type":"journal-article","created":{"date-parts":[[2006,2,4]],"date-time":"2006-02-04T19:15:09Z","timestamp":1139080509000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Rapid and asymmetric divergence of duplicate genes in the human gene coexpression network"],"prefix":"10.1186","volume":"7","author":[{"given":"Wen-Yu","family":"Chung","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reka","family":"Albert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Istvan","family":"Albert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anton","family":"Nekrutenko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kateryna D","family":"Makova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2006,1,27]]},"reference":[{"issue":"6822","key":"785_CR1","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1038\/35057039","volume":"409","author":"WH Li","year":"2001","unstructured":"Li WH, Gu Z, Wang H, Nekrutenko A: Evolutionary analyses of the human genome. 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