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However, the network topological basis of developing such integrated responses remains poorly understood.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>By studying the TR network of the yeast <jats:italic>Saccharomyces cerevisiae<\/jats:italic> we show that an intermediate layer of transcription factors naturally segregates into distinct subnetworks. In these topological units transcription factors are densely interlinked in a largely hierarchical manner and respond to external signals by utilizing a fraction of these subnets.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>As transcriptional regulation represents the 'slow' component of overall information processing, the identified topology suggests a model in which successive waves of transcriptional regulation originating from distinct fractions of the TR network control robust integrated responses to complex stimuli.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2105-7-478","type":"journal-article","created":{"date-parts":[[2006,10,28]],"date-time":"2006-10-28T06:14:06Z","timestamp":1162016046000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Topological basis of signal integration in the transcriptional-regulatory network of the yeast, Saccharomyces cerevisiae"],"prefix":"10.1186","volume":"7","author":[{"given":"Ill\u00e9s J","family":"Farkas","sequence":"first","affiliation":[]},{"given":"Chuang","family":"Wu","sequence":"additional","affiliation":[]},{"given":"Chakra","family":"Chennubhotla","sequence":"additional","affiliation":[]},{"given":"Ivet","family":"Bahar","sequence":"additional","affiliation":[]},{"given":"Zolt\u00e1n N","family":"Oltvai","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2006,10,28]]},"reference":[{"key":"1217_CR1","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.sbi.2004.05.004","volume":"14","author":"MM Babu","year":"2004","unstructured":"Babu MM, Luscombe NM, Aravind L, Gerstein M, Teichmann SA: Structure and evolution of transcriptional regulatory networks. 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