{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T20:44:13Z","timestamp":1770151453574,"version":"3.49.0"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2007,8,20]],"date-time":"2007-08-20T00:00:00Z","timestamp":1187568000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMC Bioinformatics"],"published-print":{"date-parts":[[2007,12]]},"DOI":"10.1186\/1471-2105-8-301","type":"journal-article","created":{"date-parts":[[2007,8,21]],"date-time":"2007-08-21T06:13:34Z","timestamp":1187676814000},"source":"Crossref","is-referenced-by-count":39,"title":["Genome bioinformatic analysis of nonsynonymous SNPs"],"prefix":"10.1186","volume":"8","author":[{"given":"David F","family":"Burke","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine L","family":"Worth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva-Maria","family":"Priego","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tammy","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luc J","family":"Smink","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A","family":"Todd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom L","family":"Blundell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2007,8,20]]},"reference":[{"issue":"12","key":"1673_CR1","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1101\/gr.8.12.1229","volume":"8","author":"FS Collins","year":"1998","unstructured":"Collins FS, Brooks LD, Chakravarti A: A DNA Polymorphism Discovery Resource for Research on Human Genetic Variation. Genome Research 1998, 8(12):1229\u20131231.","journal-title":"Genome Research"},{"key":"1673_CR2","first-page":"4371299","volume-title":"Nature","author":"The International HapMap Consortium","year":"2005","unstructured":"The International HapMap Consortium: A haplotype map of the human genome. Nature 2005, 4371299\u20131320."},{"key":"1673_CR3","unstructured":"The Hapmap database[ http:\/\/www.hapmap.org ]"},{"issue":"11","key":"1673_CR4","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1038\/ng1653","volume":"37","author":"DG Clayton","year":"2005","unstructured":"Clayton DG, Walker NM, Smyth DJ, Pask R, Cooper JD, Maier LM, Smink LJ, Lam AC, Ovington NR, Stevens HE, Nutland S, Howson JM, Faham M, Moorhead M, Jones HB, Falkowski M, Hardenbol P, Willis TD, Todd JA: Population structure, differential bias and genomic control in a large-scale, case-control association study. Nat Genet 2005, 37(11):1243\u20136. 10.1038\/ng1653","journal-title":"Nat Genet"},{"issue":"1","key":"1673_CR5","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1093\/nar\/30.1.387","volume":"30","author":"D Fredman","year":"2002","unstructured":"Fredman D, Siegfried M, Yuan YP, Bork P, Lehvaslaiho H, Brookes AJ: HGVbase: a human sequence variation database emphasizing data quality and a broad spectrum of data sources. Nucleic Acids Res 2002, 30(1):387\u201391. 10.1093\/nar\/30.1.387","journal-title":"Nucleic Acids Res"},{"key":"1673_CR6","unstructured":"The HGVbase database[ http:\/\/hgvbase.cgb.ki.se ]"},{"issue":"1","key":"1673_CR7","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1093\/nar\/28.1.352","volume":"28","author":"EM Smigielski","year":"2000","unstructured":"Smigielski EM, Sirotkin K, Ward M, Sherry ST: dbSNP: a database of single nucleotide polymorphisms. Nucleic Acids Res 2000, 28(1):352\u20135. 10.1093\/nar\/28.1.352","journal-title":"Nucleic Acids Res"},{"key":"1673_CR8","unstructured":"The dbSNP database[ http:\/\/www.ncbi.nlm.nih.gov\/projects\/SNP ]"},{"issue":"21","key":"1673_CR9","doi-asserted-by":"publisher","first-page":"3263","DOI":"10.1093\/hmg\/ddl401","volume":"15","author":"EL Webb","year":"2006","unstructured":"Webb EL, Rudd MF, Sellick GS, El Galta R, Bethke L, Wood W, Fletcher O, Penegar S, Withey L, Qureshi M, Johnson N, Tomlinson I, Gray R, Peto J, Houlston RS: Search for low penetrance alleles for colorectal cancer through a scan of 1467 non-synonymous SNPs in 2575 cases and 2707 controls with validation by kin-cohort analysis of 14 704 first-degree relatives. Hum Mol Genet 2006, 15(21):3263\u201371. 10.1093\/hmg\/ddl401","journal-title":"Hum Mol Genet"},{"issue":"2","key":"1673_CR10","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1086\/511051","volume":"80","author":"M Cargill","year":"2007","unstructured":"Cargill M, Schrodi SJ, Chang M, Garcia VE, Brandon R, Callis KP, Matsunami N, Ardlie KG, Honigberg LA, Civello D, Catanese JJ, Leong DU, Panko JM, McAllister LB, Hansen CB, Papenfuss J, Prescott SM, White TJ, Leppert MF, Krueger GG, Begovich AB: A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis risk genes. The American Journal of Human Genetics 2007, 80(2):273\u2013290. 10.1086\/511051","journal-title":"The American Journal of Human Genetics"},{"issue":"6","key":"1673_CR11","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1002\/humu.10212","volume":"21","author":"PD Stenson","year":"2003","unstructured":"Stenson PD, Ball EV, Mort M, Phillips AD, Shiel JA, Thomas NS, Abeysinghe S, Krawczak M, Cooper DN: Human Gene Mutation Database (HGMD). Hum Mutat 2003, 21(6):577\u201381. 10.1002\/humu.10212","journal-title":"Hum Mutat"},{"key":"1673_CR12","unstructured":"The HGMD database[ http:\/\/www.hgmd.cf.ac.uk ]"},{"key":"1673_CR13","unstructured":"The GAD database[ http:\/\/geneticassociationdb.nih.gov ]"},{"key":"1673_CR14","volume-title":"A Catalog of Human Genes and Genetic Disorders","author":"VA McKusick","year":"1998","unstructured":"McKusick VA, Mendelian Inheritance in Man: A Catalog of Human Genes and Genetic Disorders. 12th edition. Baltimore: Johns Hopkins University Press; 1998.","edition":"12"},{"key":"1673_CR15","unstructured":"The Omim database[ http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=OMIM ]"},{"issue":"1","key":"1673_CR16","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1093\/protein\/10.1.7","volume":"10","author":"CM Topham","year":"1997","unstructured":"Topham CM, Srinivasan N, Blundell TL: Prediction of the stability of protein mutants based on structural environment-dependent amino acid substitution and propensity tables. Protein Eng 1997, 10(1):7\u201321. 10.1093\/protein\/10.1.7","journal-title":"Protein Eng"},{"issue":"4","key":"1673_CR17","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1002\/prot.20810","volume":"62","author":"J Cheng","year":"2006","unstructured":"Cheng J, Randall A, Baldi P: Prediction of protein stability changes for single-site mutations using support vector machines. Proteins 2006, 62(4):1125\u201332. 10.1002\/prot.20810","journal-title":"Proteins"},{"issue":"2","key":"1673_CR18","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1093\/bioinformatics\/bti1109","volume":"21","author":"E Capriotti","year":"2005","unstructured":"Capriotti E, Fariselli P, Calabrese R, Casadio R: Predicting protein stability changes from sequences using support vector machines. Bioinformatics 2005, 21(2):54\u201358. 10.1093\/bioinformatics\/bti1109","journal-title":"Bioinformatics"},{"key":"1673_CR19","unstructured":"The Imutant server[ http:\/\/gpcr2.biocomp.unibo.it\/cgi\/predictors\/I-Mutant2.0\/I-Mutant2.0.cgi ]"},{"issue":"5","key":"1673_CR20","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1101\/gr.176601","volume":"11","author":"PC Ng","year":"2001","unstructured":"Ng PC, Henikoff S: Predicting deleterious amino acid substitutions. Genome Res 2001, 11(5):863\u201374. 10.1101\/gr.176601","journal-title":"Genome Res"},{"issue":"13","key":"1673_CR21","doi-asserted-by":"publisher","first-page":"3812","DOI":"10.1093\/nar\/gkg509","volume":"31","author":"PC Ng","year":"2003","unstructured":"Ng PC, Henikoff S: SIFT: Predicting amino acid changes that affect protein function. Nucl Acids Res 2003, 31(13):3812\u20134. 10.1093\/nar\/gkg509","journal-title":"Nucl Acids Res"},{"key":"1673_CR22","unstructured":"The Sift method[ http:\/\/blocks.fhcrc.org\/sift ]"},{"key":"1673_CR23","doi-asserted-by":"publisher","first-page":"2814","DOI":"10.1093\/bioinformatics\/bti442","volume":"21","author":"R Karchin","year":"2005","unstructured":"Karchin R, Diekhans M, Kelly L, Thomas D, Pieper U, Eswar N, Haussler D, Sali A: LS-SNP: Large-scale annotation of coding non-synonymous SNPs based on multiple information sources. Bioinformatics 2005, 21: 2814\u20132820. 10.1093\/bioinformatics\/bti442","journal-title":"Bioinformatics"},{"key":"1673_CR24","unstructured":"The LS-SNP database[ http:\/\/alto.compbio.ucsf.edu\/LS-SNP ]"},{"key":"1673_CR25","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1093\/hmg\/10.6.591","volume":"10","author":"S Sunyaev","year":"2001","unstructured":"Sunyaev S, Ramensky V, Koch I, Lathe W III, Kondrashov AS, Bork P: Prediction of deleterious human alleles. Hum Mol Genet 2001, 10: 591\u2013597. 10.1093\/hmg\/10.6.591","journal-title":"Hum Mol Genet"},{"issue":"17","key":"1673_CR26","doi-asserted-by":"publisher","first-page":"3894","DOI":"10.1093\/nar\/gkf493","volume":"30","author":"V Ramensky","year":"2002","unstructured":"Ramensky V, Bork P, Sunyaev S: Human non-synonymous SNPs: server and survey. Nucleic Acids Res 2002, 30(17):3894\u2013900. 10.1093\/nar\/gkf493","journal-title":"Nucleic Acids Res"},{"key":"1673_CR27","unstructured":"The Polyphen database[ http:\/\/coot.embl.de\/PolyPhen ]"},{"key":"1673_CR28","doi-asserted-by":"publisher","first-page":"D129","DOI":"10.1093\/nar\/gkh028","volume":"32","author":"CT Porter","year":"2004","unstructured":"Porter CT, Bartlett GJ, Thornton JM: The Catalytic Site Atlas: a resource of catalytic sites and residues identified in enzymes using structural data. Nucl Acids Res 2004, 32: D129\u201333. 10.1093\/nar\/gkh028","journal-title":"Nucl Acids Res"},{"key":"1673_CR29","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.1006\/jmbi.2001.4540","volume":"307","author":"R Landgraf","year":"2001","unstructured":"Landgraf R, Xenarios I, Eisenberg D: Three-dimensional Cluster Analysis Identifies Interfaces and Functional residue Clusters in Proteins. J Mol Biol 2001, 307: 1487\u20131502. 10.1006\/jmbi.2001.4540","journal-title":"J Mol Biol"},{"issue":"5","key":"1673_CR30","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.1016\/j.jmb.2004.08.022","volume":"342","author":"V Chelliah","year":"2004","unstructured":"Chelliah V, Chen L, Blundell TL, Lovell SC: Distinguishing structural and functional restraints in evolution in order to identify interaction sites. J Mol Biol 2004, 342(5):1487\u2013504. 10.1016\/j.jmb.2004.08.022","journal-title":"J Mol Biol"},{"issue":"41","key":"1673_CR31","doi-asserted-by":"publisher","first-page":"14754","DOI":"10.1073\/pnas.0404569101","volume":"101","author":"F Pazos","year":"2004","unstructured":"Pazos F, Sternberg MJE: Automated prediction of protein function and detection of functional sites from structure. PNAS 2004, 101(41):14754\u201314759. 10.1073\/pnas.0404569101","journal-title":"PNAS"},{"issue":"1","key":"1673_CR32","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.str.2004.10.015","volume":"13","author":"D Pal","year":"2005","unstructured":"Pal D, Eisenberg D: Inference of protein function from protein structure. Structure (Camb) 2005, 13(1):121\u201330. 10.1016\/j.str.2004.10.015","journal-title":"Structure (Camb)"},{"issue":"1","key":"1673_CR33","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/S0959-440X(02)00284-1","volume":"12","author":"O Lichtarge","year":"2002","unstructured":"Lichtarge O, Sowa ME: Evolutionary predictions of binding surfaces and interactions. Curr Opin Struct Biol 2002, 12(1):21\u20137. 10.1016\/S0959-440X(02)00284-1","journal-title":"Curr Opin Struct Biol"},{"issue":"12","key":"1673_CR34","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1093\/protein\/13.12.839","volume":"13","author":"CA Innis","year":"2000","unstructured":"Innis CA, Shi J, Blundell TL: Evolutionary trace analysis of TGF-beta and related growth factors: implications for site-directed mutagenesis. Protein Eng 2000, 13(12):839\u2013847. 10.1093\/protein\/13.12.839","journal-title":"Protein Eng"},{"issue":"2","key":"1673_CR35","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1006\/jmbi.1996.0167","volume":"257","author":"O Lichtarge","year":"1996","unstructured":"Lichtarge O, Bourne HR, Cohen FE: An evolutionary trace method defines binding surfaces common to protein families. J Mol Biol 1996, 257(2):342\u201358. 10.1006\/jmbi.1996.0167","journal-title":"J Mol Biol"},{"key":"1673_CR36","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1098\/rspb.1990.0077","volume":"241","author":"J Overington","year":"1990","unstructured":"Overington J, Sali Andrej TL, Blundell TL: Tertiary structural constraints on protein evolutionary diversity: templates, key residues and structure prediction. Proc Roy Soc B 1990, 241: 132\u2013145. 10.1098\/rspb.1990.0077","journal-title":"Proc Roy Soc B"},{"key":"1673_CR37","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1002\/pro.5560010203","volume":"2","author":"J Overington","year":"1992","unstructured":"Overington J, Donnelly D, Johnson MS, Sali A, Blundell TL: Environment-specific amino acid substitution tables: Tertiary templates and prediction of protein folds. Protein Science 1992, 2: 216\u2013226.","journal-title":"Protein Science"},{"key":"1673_CR38","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1006\/jmbi.2001.4762","volume":"310","author":"J Shi","year":"2001","unstructured":"Shi J, Blundell TL, Mizuguchi K: FUGUE : sequence-structure homology recognition using environment-specific substitution tables and structure-dependent gap penalties. J Mol Biol 2001, 310: 243\u2013257. 10.1006\/jmbi.2001.4762","journal-title":"J Mol Biol"},{"key":"1673_CR39","unstructured":"The Fugue server[ http:\/\/www-cryst.bioc.cam.ac.uk\/~fugue ]"},{"key":"1673_CR40","unstructured":"The Homstrad database[ http:\/\/www-cryst.bioc.cam.ac.uk\/~homstrad ]"},{"issue":"3","key":"1673_CR41","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1006\/jmbi.1993.1626","volume":"234","author":"A Sali","year":"1993","unstructured":"Sali A, Blundell TL: Comparative protein modelling by satisfaction of spatial restraints. J Mol Biol 1993, 234(3):779\u2013815. 10.1006\/jmbi.1993.1626","journal-title":"J Mol Biol"},{"key":"1673_CR42","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1146\/annurev.biophys.29.1.291","volume":"29","author":"MA Marti-Renom","year":"2000","unstructured":"Marti-Renom MA, Stuart A, Fiser A, S\u00e1nchez R, Melo F, Sali A: Comparative protein structure modeling of genes and genomes. Annu Rev Biophys Biomol Struct 2000, 29: 291\u2013325. 10.1146\/annurev.biophys.29.1.291","journal-title":"Annu Rev Biophys Biomol Struct"},{"key":"1673_CR43","unstructured":"The Modeller website[ http:\/\/www.salilab.org\/modeller ]"},{"issue":"9","key":"1673_CR44","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/S0168-9525(03)00195-1","volume":"19","author":"RE Steward","year":"2003","unstructured":"Steward RE, MacArthur MW, Laskowski RA, Thornton JM: Molecular basis of inherited diseases: a structural perspective. Trends in Genetics 2003, 19(9):505\u2013513. 10.1016\/S0168-9525(03)00195-1","journal-title":"Trends in Genetics"},{"issue":"3","key":"1673_CR45","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1101\/gr.212802","volume":"12","author":"PC Ng","year":"2002","unstructured":"Ng PC, Henikoff S: Accounting for human polymorphisms predicted to affect protein function. Genome Res 2002, 12(3):436\u201346. 10.1101\/gr.212802","journal-title":"Genome Res"},{"key":"1673_CR46","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1039\/fd9929300025","volume":"93","author":"D Eisenberg","year":"1992","unstructured":"Eisenberg D, Bowie JU, Luthy R, Choe S: Three-dimensional profiles for analysing protein sequence-structure relationships. Faraday Discuss 1992, 93: 25\u201334. 10.1039\/fd9929300025","journal-title":"Faraday Discuss"},{"issue":"5016","key":"1673_CR47","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1126\/science.1853201","volume":"253","author":"JU Bowie","year":"1991","unstructured":"Bowie JU, Luthy R, Eisenberg D: A method to identify protein sequences that fold into a known three-dimensional structure. Science 1991, 253(5016):164\u201370. 10.1126\/science.1853201","journal-title":"Science"},{"key":"1673_CR48","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1038\/sj.gene.6364171","volume":"6","author":"Z Zhang","year":"2005","unstructured":"Zhang Z, Duvefelt K, Svensson F, Masterman T, Jonasdottir G, Salter H, Emahazion T, Hellgren D, Falk G, Olsson T, Hillert J, Anvret M: Two genes encoding immune-regulatory molecules (LAG3 and IL7R) confer susceptibility to multiple sclerosis. Genes Immun 2005, 6: 145\u2013152. 10.1038\/sj.gene.6364171","journal-title":"Genes Immun"},{"issue":"6","key":"1673_CR49","doi-asserted-by":"publisher","first-page":"1579","DOI":"10.2337\/diabetes.52.6.1579","volume":"52","author":"JA Noble","year":"2003","unstructured":"Noble JA, White AM, Lazzeroni LC, Valdes AM, Mirel DB, Reynolds R, Grupe A, Aud D, Peltz G, Erlich HA: A polymorphism in the TCF7 gene, C883A, is associated with type 1 diabetes. Diabetes 2003, 52(6):1579\u201382. 10.2337\/diabetes.52.6.1579","journal-title":"Diabetes"},{"key":"1673_CR50","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1038\/76048","volume":"25","author":"NC Arbour","year":"2000","unstructured":"Arbour NC, Lorenz E, Schutte BC, Zabner J, Klein JN, Jones M, Frees K, Watt JL, Schwartz DA: TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nature Genet 2000, 25: 187\u2013191. 10.1038\/76048","journal-title":"Nature Genet"},{"key":"1673_CR51","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1146\/annurev.immunol.16.1.495","volume":"16","author":"MK Gately","year":"1998","unstructured":"Gately MK, Renzetti LM, Magram J, Stern AS, Adorini L, Gubler U, Presky DH: The interleukin-12\/interleukin-12-receptor system: role in normal and pathologic immune responses. Annu Rev Immunol 1998, 16: 495\u2013521. 10.1146\/annurev.immunol.16.1.495","journal-title":"Annu Rev Immunol"},{"issue":"11","key":"1673_CR52","doi-asserted-by":"publisher","first-page":"2598","DOI":"10.1158\/1055-9965.EPI-05-0469","volume":"14","author":"MF Rudd","year":"2005","unstructured":"Rudd MF, Williams RD, Webb EL, Schmidt S, Sellick GS, Houlston RS: The Predicted Impact of Coding Single Nucleotide Polymorphisms Database. Cancer Epidemiol Biomarkers 2005, 14(11):2598\u20132604. 10.1158\/1055-9965.EPI-05-0469","journal-title":"Cancer Epidemiol Biomarkers"},{"key":"1673_CR53","volume-title":"Proteins","author":"MG Williams","year":"2001","unstructured":"Williams MG, Shirai H, Shi J, Nagendra HG, Mueller J, Mizuguchi K, Miguel RN, Lovell SC, Innis CA, Deane CM, Chen L, Campillo N, Burke DF, de Bakker PIW, Blundell TL: Homologue Recognition by Iterative Alignment Refinement and Comparative Modelling. Proteins 2001, (Suppl 5):92\u20137. 10.1002\/prot.1169"},{"issue":"5","key":"1673_CR54","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1093\/bioinformatics\/bti087","volume":"21","author":"J Ding","year":"2005","unstructured":"Ding J, Berleant D: MedKit: a helper toolkit for automatic mining of MEDLINE\/PubMed citations. Bioinformatics 2005, 21(5):694\u20135. 10.1093\/bioinformatics\/bti087","journal-title":"Bioinformatics"},{"issue":"17","key":"1673_CR55","doi-asserted-by":"publisher","first-page":"3206","DOI":"10.1093\/bioinformatics\/bth386","volume":"20","author":"DP Corney","year":"2004","unstructured":"Corney DP, Buxton BF, Langdon WB, Jones DT: BioRAT: extracting biological information from full-length papers. Bioinformatics 2004, 20(17):3206\u201313. 10.1093\/bioinformatics\/bth386","journal-title":"Bioinformatics"},{"key":"1673_CR56","volume-title":"Proteins Structure, Functions and Genetics","author":"DF Burke","year":"1999","unstructured":"Burke DF, Deane CM, Nagarajaram HA, Campillo N, Martin-Martinez M, Mendes J, Molina F, Perry J, Reddy BVB, Soares CM, Steward RE, Williams MG, Carrondo M-A, Blundell TL, Mizuguchi K: An Improved Structure Assisted Approach to Sequence Alignment and Comparative Modelling. Proteins Structure, Functions and Genetics 1999, (suppl 3):1\u20136."},{"issue":"1","key":"1673_CR57","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1006\/jmbi.1993.1018","volume":"229","author":"CM Topham","year":"1993","unstructured":"Topham CM, McLeod A, Eisenmenger F, Overington JP, Johnson MS, Blundell TL: Fragment ranking in modelling of protein structure. Conformationally constrained environmental amino acid substitution tables. J Mol Biol 1993, 229(1):194\u2013220. 10.1006\/jmbi.1993.1018","journal-title":"J Mol Biol"}],"container-title":["BMC Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2105-8-301.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-2105-8-301\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2105-8-301.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,22]],"date-time":"2021-08-22T02:41:52Z","timestamp":1629600112000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcbioinformatics.biomedcentral.com\/articles\/10.1186\/1471-2105-8-301"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8,20]]},"references-count":57,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["1673"],"URL":"https:\/\/doi.org\/10.1186\/1471-2105-8-301","relation":{},"ISSN":["1471-2105"],"issn-type":[{"value":"1471-2105","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,8,20]]},"article-number":"301"}}