{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T22:46:42Z","timestamp":1769381202096,"version":"3.49.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Bioinformatics"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Computational prediction methods are currently used to identify genes in prokaryote genomes. However, identification of the correct translation initiation sites remains a difficult task. Accurate translation initiation sites (TISs) are important not only for the annotation of unknown proteins but also for the prediction of operons, promoters, and small non-coding RNA genes, as this typically makes use of the intergenic distance. A further problem is that most existing methods are optimized for <jats:italic>Escherichia coli<\/jats:italic> data sets; applying these methods to newly sequenced bacterial genomes may not result in an equivalent level of accuracy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Based on a biological representation of the translation process, we applied Bayesian statistics to create a score function for predicting translation initiation sites. In contrast to existing programs, our combination of methods uses supervised learning to optimally use the set of known translation initiation sites. We combined the Ribosome Binding Site (RBS) sequence, the distance between the translation initiation site and the RBS sequence, the base composition of the start codon, the nucleotide composition (A-rich sequences) following start codons, and the expected distribution of the protein length in a Bayesian scoring function. To further increase the prediction accuracy, we also took into account the operon orientation. The outcome of the procedure achieved a prediction accuracy of 93.2% in 858 <jats:italic>E. coli<\/jats:italic> genes from the EcoGene data set and 92.7% accuracy in a data set of 1243 <jats:italic>Bacillus subtilis<\/jats:italic> 'non-y' genes. We confirmed the performance in the GC-rich Gamma-Proteobacteria <jats:italic>Herminiimonas arsenicoxydans, Pseudomonas aeruginosa<\/jats:italic>, and <jats:italic>Burkholderia pseudomallei<\/jats:italic> K96243.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Hon-yaku, being based on a careful choice of elements important in translation, improved the prediction accuracy in <jats:italic>B. subtilis<\/jats:italic> data sets and other bacteria except for <jats:italic>E. coli<\/jats:italic>. We believe that most remaining mispredictions are due to atypical ribosomal binding sequences used in specific translation control processes, or likely errors in the training data sets.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2105-8-47","type":"journal-article","created":{"date-parts":[[2007,2,8]],"date-time":"2007-02-08T07:36:22Z","timestamp":1170920182000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Hon-yaku: a biology-driven Bayesian methodology for identifying translation initiation sites in prokaryotes"],"prefix":"10.1186","volume":"8","author":[{"given":"Yuko","family":"Makita","sequence":"first","affiliation":[]},{"given":"Michiel JL","family":"de Hoon","sequence":"additional","affiliation":[]},{"given":"Antoine","family":"Danchin","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2007,2,8]]},"reference":[{"issue":"23","key":"1419_CR1","doi-asserted-by":"publisher","first-page":"4636","DOI":"10.1093\/nar\/27.23.4636","volume":"27","author":"AL Delcher","year":"1999","unstructured":"Delcher AL, Harmon D, Kasif S, White O, Salzberg SL: Improved microbial gene identification with GLIMMER. 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